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Research Output 2005 2018

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2018

Dysregulation and restoration of homeostatic network plasticity in fragile X syndrome mice

Jewett, K. A., Lee, K. Y., Eagleman, D. E., Soriano, S. & Tsai, N-P., Aug 1 2018, In : Neuropharmacology. 138, p. 182-192 11 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Fragile X Mental Retardation Protein
Neurons
Ubiquitination
GABA-A Receptors

Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2

Lee, K. Y., Jewett, K. A., Chung, H. J. & Tsai, N-P., Jan 1 2018, In : Human molecular genetics. 27, 16, p. 2805-2816 12 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Ubiquitin-Protein Ligases
Neurons
Fragile X Syndrome
Ubiquitination

Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy

Kim, E. C., Zhang, J., Pang, W., Wang, S., Lee, K. Y., Cavaretta, J. P., Walters, J., Procko, E., Tsai, N-P. & Chung, H. J., Oct 1 2018, In : Neurobiology of Disease. 118, p. 76-93 18 p.

Research output: Contribution to journalArticle

Brain Diseases
Phosphatidylinositols
Calmodulin
Mutation
Voltage-Gated Potassium Channels
2017

Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors

Zhu, J., Lee, K. Y., Jewett, K. A., Man, H. Y., Chung, H. J. & Tsai, N-P., Feb 1 2017, In : PLoS Genetics. 13, 2, e1006634.

Research output: Contribution to journalArticle

AMPA Receptors
epilepsy
seizures
Epilepsy
Seizures

FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination

Tsai, N-P., Wilkerson, J. R., Guo, W. & Huber, K. M., Jan 1 2017, In : Human molecular genetics. 26, 2, p. 293-304 12 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Synapses
Neurons
Proteolysis
Peptide Elongation Factor 1

Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity

Liu, D. C., Seimetz, J., Lee, K. Y., Kalsotra, A., Chung, H. J., Lu, H. & Tsai, N-P., Oct 15 2017, In : Human molecular genetics. 26, 20, p. 3895-3908 14 p.

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
Protein Biosynthesis
Fragile X Syndrome
Neuronal Plasticity
Animal Behavior

Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels

Baculis, B. C., Weiss, A. C., Pang, W., Jeong, H. G., Lee, J. H., Liu, D. C., Tsai, N-P. & Chung, H. J., Dec 1 2017, In : Scientific Reports. 7, 1, 12313.

Research output: Contribution to journalArticle

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Inwardly Rectifying Potassium Channel
Caspases
Caspase 3
Seizures
2016

Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling

Jewett, K. A., Christian, C., Bacos, J. T., Lee, K. Y., Zhu, J. & Tsai, N-P., Mar 22 2016, In : Molecular Brain. 9, 1, 214.

Research output: Contribution to journalArticle

Picrotoxin
Seizures
GABA-A Receptor Antagonists
Kainic Acid
p53 Genes
2015

The tumor suppressor p53 guides GluA1 homeostasis through Nedd4-2 during chronic elevation of neuronal activity

Jewett, K. A., Zhu, J. & Tsai, N-P., Oct 1 2015, In : Journal of Neurochemistry. 135, 2, p. 226-233 8 p.

Research output: Contribution to journalArticle

Neurons
Tumors
Homeostasis
Ubiquitin-Protein Ligases
Genes
2014

A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination

Wilkerson, J. R., Tsai, N-P., Maksimova, M. A., Wu, H., Cabalo, N. P., Loerwald, K. W., Dictenberg, J. B., Gibson, J. R. & Huber, K. M., Jun 12 2014, In : Cell Reports. 7, 5, p. 1589-1600 12 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
MEF2 Transcription Factors
Synapses
Transcription Factors
Chemical activation
2013

Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression

Jakkamsetti, V., Tsai, N-P., Gross, C., Molinaro, G., Collins, K. A., Nicoletti, F., Wang, K. H., Osten, P., Bassell, G. J., Gibson, J. R. & Huber, K. M., Oct 2 2013, In : Neuron. 80, 1, p. 72-79 8 p.

Research output: Contribution to journalArticle

Long-Term Synaptic Depression
Metabotropic Glutamate Receptors
Pyramidal Cells
Neurons
Neuronal Plasticity
2012

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N-P., Guo, W., Birnbaum, S. G., Hu, J. H., Worley, P. F., Gibson, J. R. & Huber, K. M., Mar 1 2012, In : Nature Neuroscience. 15, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Fragile X Syndrome
Autistic Disorder
Phenotype
Long-Term Synaptic Depression

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

Tsai, N-P., Wilkerson, J. R., Guo, W., Maksimova, M. A., Demartino, G. N., Cowan, C. W. & Huber, K. M., Dec 21 2012, In : Cell. 151, 7, p. 1581-1594 14 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Fragile X Mental Retardation Protein
Autistic Disorder
Scaffolds
Synapses
2010

Dual action of epidermal growth factor: Extracellular signal-stimulated nuclear-cytoplasmic export and coordinated translation of selected messenger RNA

Tsai, N-P., Lin, Y. L., Tsui, Y. C. & Wei, L. N., Feb 8 2010, In : Journal of Cell Biology. 188, 3, p. 325-333 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
GRB7 Adaptor Protein
Epidermal Growth Factor
Messenger RNA
ELAV Proteins

Kappa opioid receptor contributes to EGF-stimulated neurite extension in development

Tsai, N-P., Tsui, Y. C., Pintar, J. E., Loh, H. H. & Wei, L. N., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3216-3221 6 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Neurites
Epidermal Growth Factor
Contactin 2
GAP-43 Protein

RhoA/ROCK1 signaling regulates stress granule formation and apoptosis

Tsai, N-P. & Wei, L. N., Apr 1 2010, In : Cellular Signalling. 22, 4, p. 668-675 8 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Apoptosis
Monomeric GTP-Binding Proteins
ras Genes
JNK Mitogen-Activated Protein Kinases
2009

Activation of testicular orphan receptor 4 by fatty acids

Tsai, N-P., Huq, M., Gupta, P., Yamamoto, K., Kagechika, H. & Wei, L. N., Nov 1 2009, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1789, 11-12, p. 734-740 7 p.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 2, Group C, Member 2
Linoleic Acid
Fatty Acids
Chemical activation
Cytoplasmic and Nuclear Receptors

Dynein motor contributes to stress granule dynamics in primary neurons

Tsai, N-P., Tsui, Y. C. & Wei, L. N., Mar 17 2009, In : Neuroscience. 159, 2, p. 647-656 10 p.

Research output: Contribution to journalArticle

Dyneins
Neurons
Protein Biosynthesis
Neurites
Small Interfering RNA

MicroRNA mir-346 targets the 5′-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression

Tsai, N-P., Lin, Y. L. & Wei, L. N., Dec 15 2009, In : Biochemical Journal. 424, 3, p. 411-418 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Co-Repressor 1
5' Untranslated Regions
MicroRNAs
Up-Regulation
Messenger RNA
2008

PKCε stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation

Gupta, P., Ho, P. C., Mostaqul Huq, M. D., Khan, A. A., Tsai, N-P. & Wei, L. N., Jul 16 2008, In : PloS one. 3, 7, e2658.

Research output: Contribution to journalArticle

Nuclear Receptor Co-Repressor 1
Methylation
Cell Nucleus Active Transport
adipocytes
Adipocytes

Regulation of stress granule dynamics by Grb7 and FAK signalling pathway

Tsai, N-P., Ho, P. C. & Wei, L. N., Mar 5 2008, In : EMBO Journal. 27, 5, p. 715-726 12 p.

Research output: Contribution to journalArticle

GRB7 Adaptor Protein
Focal Adhesion Protein-Tyrosine Kinases
ELAV Proteins
Protein Biosynthesis
RNA

Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression

Gupta, P., Ho, P. C., Huq, M. D. M., Sung, G. H., Sung, W. P., Amjad, A. K., Tsai, N-P. & Wei, L. N., Aug 12 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 32, p. 11424-11429 6 p.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 2, Group C, Member 1
Sumoylation
Mitogen-Activated Protein Kinase 1
Threonine
Tretinoin
2007

Copb1-facilitated axonal transport and translation of κ opioid-receptor mRNA

Bi, J., Tsai, N-P., Lu, H. Y., Loh, H. H. & Wei, L. N., Aug 21 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13810-13815 6 p.

Research output: Contribution to journalArticle

Axonal Transport
Opioid Receptors
Messenger RNA
Axons
Spinal Ganglia

Lysine trimethylation of retinoic acid receptor-α: A novel means to regulate receptor function

Huq, M. D. M., Tsai, N-P., Khan, S. A. & Wei, L. N., Apr 1 2007, In : Molecular and Cellular Proteomics. 6, 4, p. 677-688 12 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Lysine
Methylation
Hydrophobicity
Cytoplasmic and Nuclear Receptors

The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation

Tsai, N-P., Bi, J. & Wei, L. N., Mar 21 2007, In : EMBO Journal. 26, 6, p. 1522-1531 10 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Focal Adhesion Protein-Tyrosine Kinases
Messenger RNA
Machinery
kappa Opioid Receptor

Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation

Huq, M. D. M., Tsai, N-P., Lin, Y. P., Higgins, L. A. & Wei, L. N., Jan 1 2007, In : Nature chemical biology. 3, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

Nuclear Receptor Co-Repressor 1
Co-Repressor Proteins
Vitamin B 6
Pyridoxal Phosphate
Cytoplasmic and Nuclear Receptors
2006

Axonal mRNA transport and localized translational regulation of κ-opioid receptor in primary neurons of dorsal root ganglia

Bi, J., Tsai, N-P., Lin, Y. P., Loh, H. H. & Wei, L. N., Dec 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 52, p. 19919-19924 6 p.

Research output: Contribution to journalArticle

Axonal Transport
Spinal Ganglia
Opioid Receptors
Neurons
Messenger RNA

Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation

Huq, M. D. M., Gupta, P., Tsai, N-P. & Wei, L. N., Nov 1 2006, In : Molecular and Cellular Proteomics. 5, 11, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 2, Group C, Member 2
Phosphorylation
Mitogen-Activated Protein Kinases
Modulation
Chemical activation

Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7

Tsai, N-P., Wu, Y. C., Chen, J. W., Wu, C. F., Tzeng, C. M. & Syu, W., Jan 15 2006, In : Biochemical Journal. 393, 2, p. 591-599 9 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Genomic Islands
Escherichia coli O157
Enterocytes
Escherichia coli

Netrin-1 signaling regulates de novo protein synthesis of κ opioid receptor by facilitating polysomal partition of its mRNA

Tsai, N-P., Bi, J., Loh, H. H. & Wei, L. N., Sep 20 2006, In : Journal of Neuroscience. 26, 38, p. 9743-9749 7 p.

Research output: Contribution to journalArticle

Opioid Receptors
Focal Adhesion Protein-Tyrosine Kinases
Messenger RNA
Spinal Ganglia
Proteins

Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites

Huq, M. D. M., Tsai, N-P., Gupta, P. & Wei, L. N., Jul 12 2006, In : EMBO Journal. 25, 13, p. 3203-3213 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Sterol Regulatory Element Binding Protein 1
Metabolites
Tretinoin
Liver

Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation

Huq, M. D. M., Gupta, P., Tsai, N-P., White, R., Parker, M. G. & Wei, L. N., Nov 1 2006, In : EMBO Journal. 25, 21, p. 5094-5104 11 p.

Research output: Contribution to journalArticle

Nuclear Receptor Co-Repressor 1
Methylation
Arginine
Protein-Arginine N-Methyltransferases
Proteins
2005

Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation

Gupta, P., Huq, M., Khan, S. A., Tsai, N-P. & Wei, L. N., Nov 1 2005, In : Molecular and Cellular Proteomics. 4, 11, p. 1776-1784 9 p.

Research output: Contribution to journalArticle

Nuclear Receptor Co-Repressor 1
Phosphorylation
Histone Deacetylases
Mitogen-Activated Protein Kinases
Mutation