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Nicholas Ching Hai Wu

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Nicholas Ching Hai Wu

 https://orcid.org/0000-0002-9078-6697

Personal profile

Research Interests

Research Topics

Immunology, Virology, Molecular Evolution, Protein Structure, Bioinformatics

Disease Research Interests

Infectious Diseases

Education

Postdoc, The Scripps Research Institute, 2020
Ph.D., University of California, Los Angeles, 2015
B.S., University of Virginia, 2010

Professional Information

The Wu lab focuses on three research questions:

  1. What are the constraints of virus evolution?
  2. Can we predict antibody specificity?
  3. Can we improve the quality and speed of vaccine design?

The Wu lab addresses these questions mainly in the context of influenza virus and SARS-CoV-2, using molecular virology, protein biochemistry, next-generation sequencing, high-throughput assays, x-ray crystallography, cryo-EM, and machine learning.

Honors & Awards

UIUC I.C. Gunsalus Scholar Award (2025)
UIUC Distinguished Promotion Award (2025)
UIUC MCB Outstanding Graduate Student Mentor Award (2024)
Vallee Scholar Award (2024)
Viruses Early Career Investigator Award (2022)
UIUC MCB Outstanding Junior Faculty Award (2022)
ASV Ann Palmenberg Junior Investigator Award (2022)
Searle Scholar Award (2022)
Michelson Prize (2021)
ESWI Young Scientist Innovative Award (2021)
NIH Director's New Innovator Award (2021)
NIH Pathway to Independence Award (2019)
Croucher Postdoctoral Fellowship (2015-2017)

Office Phone

(217) 300-9239

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Collaborations and top research areas from the last five years

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  • B cell imprinting in children impairs antibodies to the haemagglutinin stalk

    Sun, J., Jo, G., Troxell, C. A., Fu, Y., Hoezl, R., Lv, H., Abozeid, H. H., Teo, Q. W., Pholcharee, T., McGrath, J. J. C., Changrob, S., Nelson, S. A., Yasuhara, A., Huang, M., Zheng, N. Y., Chervin, J. C., Li, L., Fernández-Quintero, M. L., Loeffler, J. R. & Rodriguez, A. J. & 17 others, Huang, J., Swanson, O. M., Balmaseda, A., Kuan, G., Campredon, L., Kaitlynn Allen, E., Neumann, G., Wu, N. C., Kawaoka, Y., Krammer, F., Mejias, A., Ramilo, O., Thomas, P. G., Gordon, A., Ward, A. B., Han, J. & Wilson, P. C., May 14 2026, In: Nature. 653, 8114, p. 528-537 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Experimental immunologists in the era of artificial intelligence

    Wang, Y., Ouyang, W. O., Wang, C., Nourmohammad, A., Liu, G. & Wu, N. C., 2026, (Accepted/In press) In: Trends in Immunology.

    Research output: Contribution to journal › Review article › peer-review

    Open Access

  • Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection

    Rivera-Cardona, J., Mahajan, T., Thayer, E. A., Kakuturu, N. R., Teo, Q. W., Lederer, J., Rowland, E. F., Heimburger, K., Sun, J., McDonald, C. A., Mickelson, C. K., Langlois, R. A., Wu, N. C., Milenkovic, O., Maslov, S. & Brooke, C. B., Jan 6 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 1, e2509560123.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Probing the role of membrane in neutralizing activity of antibodies against influenza virus

    Ozgulbas, D. G., Tan, T. J. C., Wen, P. C., Teo, Q. W., Lv, H., Ghaemi, Z., Frank, M., Wu, N. C. & Tajkhorshid, E., Feb 5 2026, In: Structure. 34, 2, p. 254-263.e5

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • SARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities

    Munteanu, V., Saldana, M. A., Dreifuss, D., Ouyang, W. O., Ferdous, J., Mohebbi, F., Roseberry, J. S., Ciorba, D., Bostan, V., Gordeev, V., Drabcinski, N., Su, J. M., Kasianchuk, N., Sharma, N. K., Knyazev, S., Aßmann, E., Lobiuc, A., Covasa, M., Crandall, K. A. & Wu, N. C. & 13 others, Mason, C. E., Tierney, B. T., Lucaci, A. G., Ophoff, R. A., Gibas, C., Rzymski, P., Skums, P., Solo-Gabriele, H., Niko, B., Zelikovsky, A., Hölzer, M., Smith, A. & Mangul, S., Dec 2026, In: Genome biology. 27, 1, 1.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
View all 138 Research outputs