Research output per year
Research output per year
Personal profile
Research Interests
Research Topics
Immunology, Virology, Molecular Evolution, Protein Structure, Bioinformatics
Disease Research Interests
Infectious Diseases
Education
Postdoc, The Scripps Research Institute, 2020
Ph.D., University of California, Los Angeles, 2015
B.S., University of Virginia, 2010
Professional Information
The Wu lab focuses on three research questions:
- What are the constraints of virus evolution?
- Can we predict antibody specificity?
- Can we improve the quality and speed of vaccine design?
The Wu lab addresses these questions mainly in the context of influenza virus and SARS-CoV-2, using molecular virology, protein biochemistry, next-generation sequencing, high-throughput assays, x-ray crystallography, cryo-EM, and machine learning.
Honors & Awards
Viruses Early Career Investigator Award (2022)
UIUC MCB Outstanding Junior Faculty Award (2022)
ASV Ann Palmenberg Junior Investigator Award (2022)
Searle Scholar Award (2022)
Michelson Prize (2021)
ESWI Young Scientist Innovative Award (2021)
NIH Director's New Innovator Award (2021)
NIH Pathway to Independence Award (2019)
Croucher Postdoctoral Fellowship (2015-2017)
Office Phone
(217) 300-9239
Fingerprint
Fingerprint is based on mining the text of the expert's scholarly documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin
Lei, R., Liang, W., Ouyang, W. O., Hernandez Garcia, A., Kikuchi, C., Wang, S., McBride, R., Tan, T. J. C., Sun, Y., Chen, C., Graham, C. S., Rodriguez, L. A., Shen, I. R., Choi, D., Bruzzone, R., Paulson, J. C., Nair, S. K., Mok, C. K. P. & Wu, N. C., Dec 2024, In: Nature communications. 15, 1, 5175.Research output: Contribution to journal › Article › peer-review
Open Access -
Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike
Tan, T. J. C., Verma, A. K., Odle, A., Lei, R., Meyerholz, D. K., Matreyek, K. A., Perlman, S., Wong, L. Y. R. & Wu, N. C., Apr 9 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 15, e2317222121.Research output: Contribution to journal › Article › peer-review
Open Access -
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
Lei, R., Qing, E., Odle, A., Yuan, M., Gunawardene, C. D., Tan, T. J. C., So, N., Ouyang, W. O., Wilson, I. A., Gallagher, T., Perlman, S., Wu, N. C. & Wong, L. Y. R., Dec 2024, In: Nature communications. 15, 1, 4056.Research output: Contribution to journal › Article › peer-review
Open Access -
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin
Liu, T., Reiser, W. K., Tan, T. J. C., Lv, H., Rivera-Cardona, J., Heimburger, K., Wu, N. C. & Brooke, C. B., 2024, In: Virus Evolution. 10, 1, veae046.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting neuraminidase: the next frontier for broadly protective influenza vaccines
Wu, N. C. & Ellebedy, A. H., Jan 2024, In: Trends in Immunology. 45, 1, p. 11-19 9 p.Research output: Contribution to journal › Review article › peer-review
Press/Media
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Machine-learning model can distinguish antibody targets
4/21/22
1 item of Media coverage
Press/Media: Research
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Antibodies from original strain COVID-19 infection don't bind to variants, study finds
Stadtmueller, B. M., Brooke, C. B. & Wu, N. C. H.
9/17/21
1 Media contribution
Press/Media: Research