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Research Output

2019

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

Singh, R., Fazal, Z., Corbet, A. K., Bikorimana, E., Rodriguez, J. C., Khan, E. M., Shahid, K., Spinella, S. J. & Spinella, M. J., Jun 8 2019, In : Cancers. 11, 6, 796.

Research output: Contribution to journalArticle

Open Access

The potential of retinoids for combination therapy of lung cancer: Updates and future directions

Tripathi, S. K., Pandey, K., Panda, M., Spinella, M. J., Rengasamy, K. RR. & Biswal, B. K., Sep 2019, In : Pharmacological Research. 147, 104331.

Research output: Contribution to journalReview article

2018

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review

Chovanec, M., Taza, F., Kalra, M., Hahn, N., Nephew, K. P., Spinella, M. J. & Albany, C., Feb 1 2018, In : Targeted Oncology. 13, 1, p. 49-60 12 p.

Research output: Contribution to journalReview article

2017

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

Yim, C. Y., Bikorimana, E., Khan, E., Warzecha, J. M., Shin, L., Rodriguez, J., Dmitrovsky, E., Freemantle, S. J. & Spinella, M. J., Nov 2 2017, In : Cell Cycle. 16, 21, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

Albany, C., Hever-Jardine, M. P., von Herrmann, K. M., Yim, C. Y., Tam, J., Warzecha, J. M., Shin, L., Bock, S. E., Curran, B. S., Chaudhry, A. S., Kim, F., Sandusky, G. E., Taverna, P., Freemantle, S. J., Christensen, B. C., Einhorn, L. H. & Spinella, M. J., Jan 1 2017, In : Oncotarget. 8, 2, p. 2949-2959 11 p.

Research output: Contribution to journalArticle

Retinoids

Dmitrovsky, E. & Spinella, M., Jan 1 2017, Cancer Therapeutic Targets. Springer New York, Vol. 2-2. p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Epigenetic targeting of platinum resistant testicular cancer

Sonnenburg, D., Spinella, M. J. & Albany, C., Nov 1 2016, In : Current Cancer Drug Targets. 16, 9, p. 789-795 7 p.

Research output: Contribution to journalReview article

GOS2 suppresses oncogenic transformation by repressing a MYC-regulated transcriptional program

Yim, C. Y., Sekula, D. J., Hever-Jardine, M. P., Liu, X., Warzecha, J. M., Tam, J., Freemantle, S. J., Dmitrovsky, E. & Spinella, M. J., Mar 1 2016, In : Cancer Research. 76, 5, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

2015

Advances in the Use of Retinoids in Cancer Therapy and Prevention

Spinella, M. J., Freemantle, S. J. & Dmitrovsky, E., Jun 12 2015, The Retinoids: Biology, Biochemistry, and Disease. Wiley-Blackwell, p. 557-574 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Natural products in the prevention of cancer: A review

Heim, K. C. & Spinella, M. J., Jan 1 2015, Nutraceuticals and Functional Foods in Human Health and Disease Prevention. CRC Press, p. 361-390 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

All-trans-retinoic acid antagonizes the hedgehog pathway by inducing patched

Busch, A. M., Galimberti, F., Nehls, K. E., Roengvoraphoj, M., Sekula, D., Li, B., Guo, Y., DiRenzo, J., Fiering, S. N., Spinella, M. J., Robbins, D. J., Memoli, V. A., Freemantle, S. J. & Dmitrovsky, E., Apr 2014, In : Cancer Biology and Therapy. 15, 4, p. 463-472 10 p.

Research output: Contribution to journalArticle

Headway and hurdles in the clinical development of dietary phytochemicals for cancer therapy and prevention: Lessons learned from vitamin A derivatives

Yim, C. Y., Mao, P. & Spinella, M. J., Mar 2014, In : AAPS Journal. 16, 2, p. 281-288 8 p.

Research output: Contribution to journalReview article

2013

Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma

Mao, P., Hever-Jardine, M. P., Rahme, G. J., Yang, E., Tam, J., Kodali, A., Biswal, B., Fadul, C. E., Gaur, A., Israel, M. A. & Spinella, M. J., Nov 28 2013, In : PloS one. 8, 11, e81803.

Research output: Contribution to journalArticle

2012

Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation

Biswal, B. K., Beyrouthy, M. J., Hever-Jardine, M. P., Armstrong, D., Tomlinson, C. R., Christensen, B. C., Marsit, C. J. & Spinella, M. J., Dec 27 2012, In : PloS one. 7, 12, e53003.

Research output: Contribution to journalArticle

2011

Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

Poliandri, A. H. B., Gamsby, J. J., Christian, M., Spinella, M. J., Loros, J. J., Dunlap, J. C. & Parker, M. G., Jun 1 2011, In : Journal of biological rhythms. 26, 3, p. 187-199 13 p.

Research output: Contribution to journalArticle

Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells

Mao, P., Hever, M. P., Niemaszyk, L. M., Haghkerdar, J. M., Yanco, E. G., Desai, D., Beyrouthy, M. J., Kerley-Hamilton, J. S., Freemantle, S. J. & Spinella, M. J., Jun 3 2011, In : Journal of Biological Chemistry. 286, 22, p. 19381-19391 11 p.

Research output: Contribution to journalArticle

2009

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors

Beyrouthy, M. J., Garner, K. M., Hever, M. P., Freemantle, S. J., Eastman, A., Dmitrovsky, E. & Spinella, M. J., Dec 15 2009, In : Cancer Research. 69, 24, p. 9360-9366 7 p.

Research output: Contribution to journalArticle

Retinoic acid mediates long-paced oscillationsin retinoid receptor activity: Evidence for a potential role for RIP140

Heim, K. C., Gamsby, J. J., Hever, M. P., Freemantle, S. J., Loros, J. J., Dunlap, J. C. & Spinella, M. J., Oct 28 2009, In : PloS one. 4, 10, e7639.

Research output: Contribution to journalArticle

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

Snow, G. E., Kasper, A. C., Busch, A. M., Schwarz, E., Ewings, K. E., Bee, T., Spinella, M. J., Dmitrovsky, E. & Freemantle, S. J., Oct 29 2009, In : BMC Cancer. 9, 1 p., 383.

Research output: Contribution to journalArticle

2007

Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors

Li, H., Cherukuri, P., Li, N., Cowling, V., Spinella, M., Cole, M., Godwin, A. K., Wells, W. & DiRenzo, J., Jan 15 2007, In : Cancer Research. 67, 2, p. 501-510 10 p.

Research output: Contribution to journalArticle

Repression of cyclin D1 as a target for germ cell tumors

Freemantle, S. J., Vaseva, A. V., Ewings, K. E., Bee, T., Krizan, K. A., Kelley, M. R., Hattab, E. M., Memoli, V. A., Black, C. C., Spinella, M. J. & Dmitrovsky, E., Feb 1 2007, In : International journal of oncology. 30, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

Heim, K. C., White, K. A., Deng, D., Tomlinson, C. R., Moore, J. H., Freemantle, S. J. & Spinella, M. J., Sep 19 2007, In : Molecular Cancer. 6, 57.

Research output: Contribution to journalArticle

The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins

Kerley-Hamilton, J. S., Pike, A. M., Hutchinson, J. A., Freemantle, S. J. & Spinella, M. J., Apr 1 2007, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1769, 4, p. 209-219 11 p.

Research output: Contribution to journalArticle

2006

Testicular germ cell tumors: A paradigm for the successful treatment of solid tumor stem cells

Giuliano, C. J., Freemantle, S. J. & Spinella, M. J., Aug 1 2006, In : Current Cancer Therapy Reviews. 2, 3, p. 255-270 16 p.

Research output: Contribution to journalReview article

2005

A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma

Kerley-Hamilton, J. S., Pike, A. M., Li, N., DiRenzo, J. & Spinella, M. J., Sep 8 2005, In : Oncogene. 24, 40, p. 6090-6100 11 p.

Research output: Contribution to journalArticle

Limiting effects of RIP140 in estrogen signaling: Potential mediation of anti-estrogenic effects of retinoic acid

White, K. A., Yore, M. M., Deng, D. & Spinella, M. J., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 7829-7835 7 p.

Research output: Contribution to journalArticle

p53 in human embryonal carcinoma: Identification of a transferable, transcriptional repression domain in the N-terminal region of p53

Curtin, J. C. & Spinella, M. J., Feb 24 2005, In : Oncogene. 24, 9, p. 1481-1490 10 p.

Research output: Contribution to journalArticle

Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity

Giuliano, C. J., Kerley-Hamilton, J. S., Bee, T., Freemantle, S. J., Manickaratnam, R., Dmitrovsky, E. & Spinella, M. J., Oct 15 2005, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1731, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

2003

Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140

White, K. A., Yore, M. M., Warburton, S. L., Vaseva, A. V., Rieder, E., Freemantle, S. J. & Spinella, M. J., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 43889-43892 4 p.

Research output: Contribution to journalArticle

Retinoids in cancer therapy and chemoprevention: Promise meets resistance

Freemantle, S. J., Spinella, M. J. & Dmitrovsky, E., Oct 20 2003, In : Oncogene. 22, 47 REV. ISS. 6, p. 7305-7315 11 p.

Research output: Contribution to journalReview article

Retinoid target gene activation during induced tumor cell differentiation: Human embryonal carcinoma as a model

Spinella, M. J., Kerley, J. S., White, K. A. & Curtin, J. C., Jan 1 2003, In : Journal of Nutrition. 133, 1, p. 273S-276S

Research output: Contribution to journalArticle

Open Access
2002

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

Freemantle, S. J., Portland, H. B., Ewings, K., Dmitrovsky, F., DiPetrillo, K., Spinella, M. J. & Dmitrovsky, E., May 29 2002, In : Gene. 291, 1-2, p. 17-27 11 p.

Research output: Contribution to journalArticle

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma

Freemantle, S. J., Kerley, J. S., Olsen, S. L., Gross, R. H. & Spinella, M. J., Jan 1 2002, In : Oncogene. 21, 18, p. 2880-2889 10 p.

Research output: Contribution to journalArticle

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma

Spinella, S. J., Kerley, J. S., Olsen, S. L., Gross, R. H. & Spinella, M. J., Jan 1 2002, In : Oncogene. 21, 18, p. 2880-2889 10 p.

Research output: Contribution to journalArticle

2001

Cyclin proteolysis as a retinoid cancer prevention mechanism

Dragnev, K. H., Freemantle, S. J., Spinella, M. J. & Dmitrovsky, E., Jan 1 2001, In : Annals of the New York Academy of Sciences. 952, p. 13-22 10 p.

Research output: Contribution to journalArticle

Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function

Curtin, J. C., Dragnev, K. H., Sekula, D., Christie, A. J., Dmitrovsky, E. & Spinella, M. J., May 3 2001, In : Oncogene. 20, 20, p. 2559-2569 11 p.

Research output: Contribution to journalArticle

2000

Aberrant retinoid signaling and breast cancer: The view from outside the nucleus

Spinella, M. J. & Dmitrovsky, E., Mar 15 2000, In : Journal of the National Cancer Institute. 92, 6, p. 438-440 3 p.

Research output: Contribution to journalEditorial

Aerosolized delivery and lung cancer prevention: Pre-clinical models show promise

Spinella, M. J. & Dmitrovsky, E., Aug 31 2000, In : Clinical Cancer Research. 6, 8, p. 2963-2964 2 p.

Research output: Contribution to journalEditorial

1999

4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARγ independent pathway

Kitareewan, S., Spinella, M. J., Allopenna, J., Reczek, P. R. & Dmitrovsky, E., Oct 14 1999, In : Oncogene. 18, 42, p. 5747-5755 9 p.

Research output: Contribution to journalArticle

A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9- dien-28-oic acid, with potent differentiating, antiproliferative, and anti- inflammatory activity

Suh, N., Wang, Y., Honda, T., Gribble, G. W., Dmitrovsky, E., Hickey, W. F., Maue, R. A., Place, A. E., Porter, D. M., Spinella, M. J., Williams, C. R., Wu, G., Dannenberg, A. J., Flanders, K. C., Letterio, J. J., Mangelsdorf, D. J., Nathan, C. F., Nguyen, L., Porter, W. W., Ren, R. F. & 4 others, Roberts, A. B., Roche, N. S., Subbaramaiah, K. & Sporn, M. B., Jan 16 1999, In : Cancer Research. 59, 2, p. 336-341 6 p.

Research output: Contribution to journalArticle

Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model

Hromas, R., Ye, H., Spinella, M., Dmitrovsky, E., Xu, D. & Costa, R. H., Sep 8 1999, In : Cell and Tissue Research. 297, 3, p. 371-382 12 p.

Research output: Contribution to journalArticle

Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation

Spinella, M. J., Freemantle, S. J., Sekula, D., Chang, J. H., Christie, A. J. & Dmitrovsky, E., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 22013-22018 6 p.

Research output: Contribution to journalArticle

1998

FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas

Maerz, W. J., Baselga, J., Reuter, V. E., Mellado, B., Myers, M. L., Bosl, G. J., Spinella, M. J. & Dmitrovsky, E., Aug 13 1998, In : Oncogene. 17, 6, p. 761-767 7 p.

Research output: Contribution to journalArticle

Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells

Spinella, M. J., Kitareewan, S., Mellado, B., Sekula, D., Khoo, K. S. & Dmitrovsky, E., Jul 2 1998, In : Oncogene. 16, 26, p. 3471-3480 10 p.

Research output: Contribution to journalArticle

1997

Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation

Lei, W., Hirose, T., Zhang, L. X., Adachi, H., Spinella, M. J., Dmitrovsky, E. & Jetten, A. M., Apr 1997, In : Journal of Molecular Endocrinology. 18, 2, p. 167-176 10 p.

Research output: Contribution to journalArticle

Organization of the murine reduced folate carrier gene and identification of variant splice forms

Brigle, K. E., Spinella, M. J., Sierra, E. E. & Goldman, I. D., Aug 7 1997, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1353, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH

Sierra, E. E., Brigle, K. E., Spinella, M. J. & Goldman, I. D., Jan 24 1997, In : Biochemical Pharmacology. 53, 2, p. 223-231 9 p.

Research output: Contribution to journalArticle

1996

Molecular cloning of murine folylpoly-γ-glutamate synthetase

Spinella, M. J., Brigle, K. E. & Goldman, I. D., Feb 7 1996, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1305, 1-2, p. 11-14 4 p.

Research output: Contribution to journalArticle