Michael J Spinella

1989 …2018
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Research Output 1989 2018

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review

Chovanec, M., Taza, F., Kalra, M., Hahn, N., Nephew, K. P., Spinella, M. J. & Albany, C., Feb 1 2018, In : Targeted Oncology. 13, 1, p. 49-60 12 p.

Research output: Contribution to journalReview article

Methyltransferases
DNA
Neoplasms
Tumor Suppressor Genes
Therapeutics

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

Yim, C. Y., Bikorimana, E., Khan, E., Warzecha, J. M., Shin, L., Rodriguez, J., Dmitrovsky, E., Freemantle, S. J. & Spinella, M. J., Nov 2 2017, In : Cell Cycle. 16, 21, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Switch Genes
Phosphatidylinositol 3-Kinases
Breast Neoplasms
Estrogen Receptor Modulators
Gene Expression

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

Albany, C., Hever-Jardine, M. P., von Herrmann, K. M., Yim, C. Y., Tam, J., Warzecha, J. M., Shin, L., Bock, S. E., Curran, B. S., Chaudhry, A. S., Kim, F., Sandusky, G. E., Taverna, P., Freemantle, S. J., Christensen, B. C., Einhorn, L. H. & Spinella, M. J., Jan 1 2017, In : Oncotarget. 8, 2, p. 2949-2959 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Embryonal Carcinoma Stem Cells
Cisplatin
Embryonal Carcinoma
Deoxycytidine

Retinoids

Dmitrovsky, E. & Spinella, M. J., Jan 1 2017, Cancer Therapeutic Targets. Springer New York, Vol. 2-2. p. 1039-1046 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Retinoids
Acute Promyelocytic Leukemia
Molecular Targeted Therapy
Neoplasms
Oncology

Epigenetic targeting of platinum resistant testicular cancer

Sonnenburg, D., Spinella, M. J. & Albany, C., Nov 1 2016, In : Current Cancer Drug Targets. 16, 9, p. 789-795 7 p.

Research output: Contribution to journalReview article

Testicular Neoplasms
Platinum
Epigenomics
DNA Methylation
Germ Cell and Embryonal Neoplasms