Mengfei Ho

2024

Hierarchical determinants in cytotoxic necrotizing factor (CNF) toxins driving Rho G-protein deamidation versus transglutamination

Handy, N. B., Xu, Y., Moon, D., Sowizral, J. J., Moon, E., Ho, M. & Wilson, B. A., Jul 17 2024, In: mBio. 15, 7, p. e0122124 e01221-24.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of novel toxins associated with the extracellular contractile injection system using machine learning

Danov, A., Pollin, I., Moon, E., Ho, M., Wilson, B. A., Papathanos, P. A., Kaplan, T. & Levy, A., Aug 2 2024, In: Molecular Systems Biology. 20, 8, p. 859-879 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Insertion-trigger residues differentially modulate endosomal escape by cytotoxic necrotizing factor toxins

Haywood, E. E., Handy, N. B., Lopez, J. W., Ho, M. & Wilson, B. A., Nov 1 2021, In: Journal of Biological Chemistry. 297, 5, 101347.

Research output: Contribution to journal › Article › peer-review

Open Access

Recovery of microbial community profile information hidden in chimeric sequence reads

Ho, M., Moon, D., Pires-Alves, M., Thornton, P. D., McFarlin, B. L. & Wilson, B. A., Jan 2021, In: Computational and Structural Biotechnology Journal. 19, p. 5126-5139 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Comparative genome analysis of an extensively drug-resistant isolate of avian sequence type 167 Escherichia coli strain sanji with novel in silico serotype O89b:H9

Zeng, X., Chi, X., Ho, B. T., Moon, D., Lambert, C., Hall, R. J., Baybayan, P., Wang, S., Wilson, B. A. & Ho, M., Jan 2019, In: mSystems. 4, 1, e0024218.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

CNF1-like deamidase domains: Common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors

Ho, M., Mettouchi, A., Wilson, B. A. & Lemichez, E., Jul 1 2018, In: Pathogens and Disease. 76, 5, fty045.

Research output: Contribution to journal › Article › peer-review

Open Access

Cytosolic delivery of multidomain cargos by the N terminus of Pasteurella multocida toxin

Clemons, N. C., Bannai, Y., Haywood, E. E., Xu, Y., Buschbach, J. D., Ho, M. & Wilson, B. A., Aug 1 2018, In: Infection and immunity. 86, 8, e00248-18.

Research output: Contribution to journal › Article › peer-review

Open Access

Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells

Haywood, E. E., Ho, M. & Wilson, B. A., Mar 9 2018, In: Journal of Biological Chemistry. 293, 10, p. 3860-3870 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

The membrane localization domains of two distinct bacterial toxins form a 4-helix-bundle in solution

Hisao, G. S., Brothers, M. C., Ho, M., Wilson, B. A. & Rienstra, C. M., Mar 1 2017, In: Protein Science. 26, 3, p. 497-504 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Selective membrane redistribution and depletion of Gα_q-protein by Pasteurella multocida toxin

Clemons, N. C., Luo, S., Ho, M. & Wilson, B. A., Aug 1 2016, In: Toxins. 8, 8, 233.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Monoclonal antibodies targeting the alpha-exosite of botulinum neurotoxin serotype/a inhibit catalytic activity

Fan, Y., Geren, I. N., Dong, J., Lou, J., Wen, W., Conrad, F., Smith, T. J., Smith, L. A., Ho, M., Pires-Alves, M., Wilson, B. A. & Marks, J. D., Aug 14 2015, In: PloS one. 10, 8, e0135306.

Research output: Contribution to journal › Article › peer-review

Open Access

Monoclonal antibodies that inhibit the proteolytic activity of botulinum neurotoxin serotype/B

Fan, Y., Dong, J., Lou, J., Wen, W., Conrad, F., Geren, I. N., Garcia-Rodriguez, C., Smith, T. J., Smith, L. A., Ho, M., Pires-Alves, M., Wilson, B. A. & Marks, J. D., Aug 26 2015, In: Toxins. 7, 9, p. 3405-3423 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

Altered active zones, vesicle pools, nerve terminal conductivity, and morphology during experimental MuSK myasthenia gravis

Patel, V., Oh, A., Voit, A., Sultatos, L. G., Babu, G. J., Wilson, B. A., Ho, M. & McArdle, J. J., Dec 1 2014, In: PloS one. 9, 12, e110571.

Research output: Contribution to journal › Article › peer-review

Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism

Wilson, B. A. & Ho, M., Jan 1 2014, In: Current Topics in Medicinal Chemistry. 14, 18, p. 2081-2093 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance

Yildirim, S., Yeoman, C. J., Janga, S. C., Thomas, S. M., Ho, M., Leigh, S. R., Consortium, P. M., White, B. A., Wilson, B. A. & Stumpf, R. M., Jan 1 2014, In: ISME Journal. 8, 12, p. 2431-2444 14 p.

Research output: Contribution to journal › Article › peer-review

2013

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

Yeoman, C. J., Thomas, S. M., Miller, M. E. B., Ulanov, A. V., Torralba, M., Lucas, S., Gillis, M., Cregger, M., Gomez, A., Ho, M., Leigh, S. R., Stumpf, R., Creedon, D. J., Smith, M. A., Weisbaum, J. S., Nelson, K. E., Wilson, B. A. & White, B. A., Feb 6 2013, In: PloS one. 8, 2, e56111.

Research output: Contribution to journal › Article › peer-review

Determinants of pH-dependent modulation of translocation in dermonecrotic G-protein-deamidating toxins

Repella, T. L., Ho, M. & Wilson, B. A., Jun 14 2013, In: Toxins. 5, 6, p. 1167-1179 13 p.

Research output: Contribution to journal › Article › peer-review

Pasteurella multocida: From Zoonosis to cellular microbiology

Wilson, B. A. & Ho, M., Jul 2013, In: Clinical Microbiology Reviews. 26, 3, p. 631-655 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A

Ho, M., Goh, C. H., Brothers, M. C., Wang, S., Young, R. L., Ou, Y., Lui, J. N. M., Kalafatis, M., Lan, X., Wolf, A. E., Rienstra, C. & Wilson, B. A., Mar 2012, In: Protein Science. 21, 3, p. 318-326 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Rho/ROCK-dependent inhibition of 3T3-L1 adipogenesis by G-protein-deamidating dermonecrotic toxins: differential regulation of Notch1, Pref1/Dlk1, and β-catenin signaling.

Bannai, Y., Aminova, L. R., Faulkner, M. J., Ho, M. & Wilson, B. A., 2012, In: Frontiers in Cellular and Infection Microbiology. 2, p. 80 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

Membrane interaction of Pasteurella multocida toxin involves sphingomyelin

Brothers, M. C., Ho, M., Maharjan, R., Clemons, N. C., Bannai, Y., Waites, M. A., Faulkner, M. J., Kuhlenschmidt, T. B., Kuhlenschmidt, M. S., Blanke, S. R., Rienstra, C. & Wilson, B. A., Dec 2011, In: FEBS Journal. 278, 23, p. 4633-4648 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Recombinant botulinum neurotoxin A heavy chain-based delivery vehicles for neuronal cell targeting

Ho, M., Chang, L. H., Pires-Alves, M., Thyagarajan, B., Bloom, J. E., Gu, Z., Aberle, K. K., Teymorian, S. A., Bannai, Y., Johnson, S. C., McArdle, J. J. & Wilson, B. A., Mar 2011, In: Protein Engineering, Design and Selection. 24, 3, p. 247-253 7 p.

Research output: Contribution to journal › Article › peer-review

2010

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic α-exosite binding region

Dong, J., Thompson, A. A., Fan, Y., Lou, J., Conrad, F., Ho, M., Pires-Alves, M., Wilson, B. A., Stevens, R. C. & Marks, J. D., Apr 2010, In: Journal of Molecular Biology. 397, 4, p. 1106-1118 13 p.

Research output: Contribution to journal › Article › peer-review

2009

Heterogeneity of vaginal microbial communities within individuals

Kim, T. K., Thomas, S. M., Ho, M., Sharma, S., Reich, C. I., Frank, J. A., Yeater, K. M., Biggs, D. R., Nakamura, N., Stumpf, R., Leigh, S. R., Tapping, R. I., Blanke, S. R., Slauch, J. M., Gaskins, H. R., Weisbaum, J. S., Olsen, G. J., Hoyer, L. L. & Wilson, B. A., Apr 2009, In: Journal of Clinical Microbiology. 47, 4, p. 1181-1189 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity

Pires-Alves, M., Ho, M., Aberle, K. K., Janda, K. D. & Wilson, B. A., Mar 15 2009, In: Toxicon. 53, 4, p. 392-399 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2008

Application of intact cell-based NFAT-β-lactamase reporter assay for Pasteurella multocida toxin-mediated activation of calcium signaling pathway

Luo, S., Ho, M. & Wilson, B. A., Mar 15 2008, In: Toxicon. 51, 4, p. 597-605 9 p.

Research output: Contribution to journal › Article › peer-review

The C3 domain of Pasteurella multocida toxin is the minimal domain responsible for activation of G_q-dependent calcium and mitogenic signaling

Aminova, L. R., Luo, S., Bannai, Y., Ho, M. & Wilson, B. A., May 2008, In: Protein Science. 17, 5, p. 945-949 5 p.

Research output: Contribution to journal › Article › peer-review

2006

Distinct signaling functions for Shc isoforms in the heart

Obreztchikova, M., Elouardighi, H., Ho, M., Wilson, B. A., Gertsberg, Z. & Steinberg, S. F., Jul 21 2006, In: Journal of Biological Chemistry. 281, 29, p. 20197-20204 8 p.

Research output: Contribution to journal › Article › peer-review

2005

Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E

Baldwin, M. R., Tepp, W. H., Pier, C. L., Bradshaw, M., Ho, M., Wilson, B. A., Fritz, R. B., Johnson, E. A. & Barbieri, J. T., Oct 2005, In: Infection and immunity. 73, 10, p. 6998-7005 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2000

Differential modulation and subsequent blockade of mitogenic signaling and cell cycle progression by Pasteurella multocida toxin

Wilson, B. A., Aminova, L. R., Ponferrada, V. G. & Ho, M., 2000, In: Infection and immunity. 68, 8, p. 4531-4538 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1999

Bacterially expressed raf-1 catalytic domain is highly associated with GroEL

Ho, M., 1999, In: Journal of the Chinese Chemical Society. 46, 5, p. 735-742 8 p.

Research output: Contribution to journal › Article › peer-review

Localization of the intracellular activity domain of Pasteurella multocida toxin to the N terminus

Wilson, B. A., Ponferrada, V. G., Vallance, J. E. & Ho, M., Jan 1999, In: Infection and immunity. 67, 1, p. 80-87 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1998

Bacterially expressed catalytic domain of c-RAF-1 is tightly associated with GroEL

Peterson, J. W., Wilson, B. A., Bae, S. C. & Ho, M., 1998, In: FASEB Journal. 12, 8, p. A1407

Research output: Contribution to journal › Article › peer-review

1997

Pasteurella multocida toxin activates the inositol triphosphate signaling pathway in Xenopus oocytes via G(q)α-coupled phospholipase C-β1

Wilson, B. A., Zhu, X., Ho, M. & Lu, L., 1997, In: Journal of Biological Chemistry. 272, 2, p. 1268-1275 8 p.

Research output: Contribution to journal › Article › peer-review

1996

Adenine-arginine mimetics as bisubstrate analog inhibitors of cAMP-dependent protein kinase

Ho, M., Wilson, B. A. & Katampe, I., Apr 9 1996, In: Bioorganic and Medicinal Chemistry Letters. 6, 7, p. 899-902 4 p.

Research output: Contribution to journal › Article › peer-review

1994

An ether-based peptide analog as c-AMP-dependent protein kinase inhibitor/substrate

Ho, M., Uhrin, A. & Huang, M., Feb 24 1994, In: Bioorganic and Medicinal Chemistry Letters. 4, 4, p. 553-556 4 p.

Research output: Contribution to journal › Article › peer-review

1993

A convenient synthesis of chiral N-Boc-amino ethers as potential peptide bond surrogate units

Ho, M., Chung, J. K. K. & Tang, N., Oct 8 1993, In: Tetrahedron Letters. 34, 41, p. 6513-6516 4 p.

Research output: Contribution to journal › Article › peer-review

1991

Synapsin I is a highly surface-active molecule

Ho, M., Bähler, M., Czernik, A. J., Schiebler, W., Kézdy, F. J., Kaiser, E. T. & Greengard, P., 1991, In: Journal of Biological Chemistry. 266, 9, p. 5600-5607 8 p.

Research output: Contribution to journal › Article › peer-review

Synthesis of an ethylene glycol cross-linked amino acid

Ho, M., Wang, W., Douvlos, M., Pham, T. & Timothy, K., Mar 4 1991, In: Tetrahedron Letters. 32, 10, p. 1283-1286 4 p.

Research output: Contribution to journal › Article › peer-review

1988

Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase

Ho, M. F., Bramson, H. N., Hansen, D. E., Knowles, J. R. & Kaiser, E. T., Apr 1988, In: Journal of the American Chemical Society. 110, 8, p. 2680-2681 2 p.

Research output: Contribution to journal › Article › peer-review

1986

The stereochemical fate of (2RS,5R)- and (2RS,5S)-[5-³H] ornithine in clavulanic acid biosynthesis

Townsend, C. A., Ho, M. F. & Mao, S. S., 1986, In: Journal of the Chemical Society, Chemical Communications. 8, p. 638-639 2 p.

Research output: Contribution to journal › Article › peer-review

1985

Biosynthesis of Clavulanic Acid: Origin of the C₃ Unit

Townsend, C. A. & Ho, M. F., Feb 1985, In: Journal of the American Chemical Society. 107, 4, p. 1066-1068 3 p.

Research output: Contribution to journal › Article › peer-review

Biosynthesis of Clavulanic Acid: Origin of the C₅ Unit

Townsend, C. A. & Ho, M. F., Feb 1985, In: Journal of the American Chemical Society. 107, 4, p. 1065-1066 2 p.

Research output: Contribution to journal › Article › peer-review

Mengfei Ho

Research output

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