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Research Output

2020

A Computer Conquers Tactical Combinations

Blair, D. J. & Burke, M. D., Jan 9 2020, In : Chem. 6, 1, p. 12-13 2 p.

Research output: Contribution to journalArticle

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. & Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).

Research output: Working paper

2019

Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp 3 boronic acids

Lehmann, J. W., Crouch, I. T., Blair, D. J., Trobe, M., Wang, P., Li, J. & Burke, M. D., Dec 1 2019, In : Nature communications. 10, 1, 1263.

Research output: Contribution to journalArticle

Open Access

Modular Syntheses of Phenanthroindolizidine Natural Products

Jo, Y. I., Burke, M. D. & Cheon, C. H., Jun 7 2019, In : Organic Letters. 21, 11, p. 4201-4204 4 p.

Research output: Contribution to journalArticle

Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia

Muraglia, K. A., Chorghade, R. S., Kim, B. R., Tang, X. X., Shah, V. S., Grillo, A. S., Daniels, P. N., Cioffi, A. G., Karp, P. H., Zhu, L., Welsh, M. J. & Burke, M. D., Mar 21 2019, In : Nature. 567, 7748, p. 405-408 4 p.

Research output: Contribution to journalArticle

2018

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

Yien, Y. Y., Shi, J., Chen, C., Cheung, J. T. M., Grillo, A. S., Shrestha, R., Li, L., Zhang, X., Kafina, M. D., Kingsley, P. D., King, M. J., Ablain, J., Li, H., Zon, L. I., Palis, J., Burke, M. D., Bauer, D. E., Orkin, S. H., Koehler, C. M., Phillips, J. D. & 4 others, Kaplan, J., Ward, D. M., Lodish, H. F. & Paw, B. H., Dec 21 2018, In : Journal of Biological Chemistry. 293, 51, p. 19797-19811 15 p.

Research output: Contribution to journalArticle

Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation

Haley, H. M. S., Hill, A. G., Greenwood, A. I., Woerly, E. M., Rienstra, C. M. & Burke, M. D., Nov 14 2018, In : Journal of the American Chemical Society. 140, 45, p. 15227-15240 14 p.

Research output: Contribution to journalArticle

Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers

Della Ripa, L. A., Petros, Z. A., Cioffi, A. G., Piehl, D. W., Courtney, J. M., Burke, M. D. & Rienstra, C. M., Apr 1 2018, In : Methods. 138-139, p. 47-53 7 p.

Research output: Contribution to journalArticle

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

Trobe, M. & Burke, M. D., Apr 9 2018, In : Angewandte Chemie - International Edition. 57, 16, p. 4192-4214 23 p.

Research output: Contribution to journalReview article

Towards the generalized iterative synthesis of small molecules

Lehmann, J. W., Blair, D. J. & Burke, M. D., Jan 1 2018, In : Nature Reviews Chemistry. 2, 2, 0115.

Research output: Contribution to journalReview article

2017

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

Grillo, A. S., SantaMaria, A. M., Kafina, M. D., Cioffi, A. G., Huston, N. C., Han, M., Seo, Y. A., Yien, Y. Y., Nardone, C., Menon, A. V., Fan, J., Svoboda, D. C., Anderson, J. B., Hong, J. D., Nicolau, B. G., Subedi, K., Gewirth, A. A., Wessling-Resnick, M., Kim, J., Paw, B. H. & 1 others, Burke, M. D., May 12 2017, In : Science. 356, 6338, p. 608-616 9 p.

Research output: Contribution to journalArticle

The natural productome

Palazzolo, A. M. E., Simons, C. L. W. & Burke, M. D., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5564-5566 3 p.

Research output: Contribution to journalComment/debate

2016

MIDA boronates are hydrolysed fast and slow by two different mechanisms

Gonzalez, J. A., Ogba, O. M., Morehouse, G. F., Rosson, N., Houk, K. N., Leach, A. G., Cheong, P. H. Y., Burke, M. D. & Lloyd-Jones, G. C., Nov 1 2016, In : Nature Chemistry. 8, 11, p. 1067-1075 9 p.

Research output: Contribution to journalArticle

Our Path to Less Toxic Amphotericins

Endo, M. M., Cioffi, A. G. & Burke, M. D., Feb 12 2016, In : Synlett. 27, 3, p. 337-354 18 p.

Research output: Contribution to journalArticle

2015

C3-OH of Amphotericin B Plays an Important Role in Ion Conductance

Davis, S. A., Della Ripa, L. A., Hu, L., Cioffi, A. G., Pogorelov, T. V., Rienstra, C. M. & Burke, M. D., Dec 9 2015, In : Journal of the American Chemical Society. 137, 48, p. 15102-15104 3 p.

Research output: Contribution to journalArticle

From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks

Li, J., Grillo, A. S. & Burke, M. D., Jul 22 2015, In : Accounts of chemical research. 48, 8, p. 2297-2307 11 p.

Research output: Contribution to journalArticle

Nontoxic antimicrobials that evade drug resistance

Davis, S. A., Vincent, B. M., Endo, M. M., Whitesell, L., Marchillo, K., Andes, D. R., Lindquist, S. & Burke, M. D., Jul 20 2015, In : Nature chemical biology. 11, 7, p. 481-487 7 p.

Research output: Contribution to journalArticle

Restored physiology in protein-deficient yeast by a small molecule channel

Cioffi, A. G., Hou, J., Grillo, A. S., Diaz, K. A. & Burke, M. D., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10096-10099 4 p.

Research output: Contribution to journalArticle

Synthesis of many different types of organic small molecules using one automated process

Li, J., Ballmer, S. G., Gillis, E. P., Fujii, S., Schmidt, M. J., Palazzolo, A. M. E., Lehmann, J. W., Morehouse, G. F. & Burke, M. D., Mar 13 2015, In : Science. 347, 6227, p. 1221-1226 6 p.

Research output: Contribution to journalArticle

2014

Amphotericin forms an extramembranous and fungicidal sterol sponge

Anderson, T. M., Clay, M. C., Cioffi, A. G., Diaz, K. A., Hisao, G. S., Tuttle, M. D., Nieuwkoop, A. J., Comellas, G., Maryum, N., Wang, S., Uno, B. E., Wildeman, E. L., Gonen, T., Rienstra, C. M. & Burke, M. D., May 2014, In : Nature chemical biology. 10, 5, p. 400-406 7 p.

Research output: Contribution to journalArticle

Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

Woerly, E. M., Roy, J. & Burke, M. D., Jun 2014, In : Nature Chemistry. 6, 6, p. 484-491 8 p.

Research output: Contribution to journalArticle

C2′-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells

Wilcock, B. C., Endo, M. M., Uno, B. E. & Burke, M. D., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8488-8491 4 p.

Research output: Contribution to journalArticle

2012

A general solution for the 2-pyridyl problem

Dick, G. R., Woerly, E. M. & Burke, M. D., Mar 12 2012, In : Angewandte Chemie - International Edition. 51, 11, p. 2667-2672 6 p.

Research output: Contribution to journalArticle

Amphotericin primarily kills yeast by simply binding ergosterol

Gray, K. C., Palacios, D. S., Dailey, I., Endo, M. M., Uno, B. E., Wilcock, B. C. & Burke, M. D., Feb 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2234-2239 6 p.

Research output: Contribution to journalArticle

Electronic tuning of site-selectivity

Wilcock, B. C., Uno, B. E., Bromann, G. L., Clark, M. J., Anderson, T. M. & Burke, M. D., Dec 1 2012, In : Nature Chemistry. 4, 12, p. 996-1003 8 p.

Research output: Contribution to journalArticle

2011

(Z)-(2-bromovinyl)-MIDA boronate: A readily accessible and highly versatile building block for small molecule synthesis

Woerly, E. M., Struble, J. R., Palyam, N., O'Hara, S. P. & Burke, M. D., Jun 17 2011, In : Tetrahedron. 67, 24, p. 4333-4343 11 p.

Research output: Contribution to journalArticle

Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities

Palacios, D. S., Dailey, I., Siebert, D. M., Wilcock, B. C. & Burke, M. D., Apr 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6733-6738 6 p.

Research output: Contribution to journalArticle

Total synthesis of synechoxanthin through iterative cross-coupling

Fujii, S., Chang, S. Y. & Burke, M. D., Aug 16 2011, In : Angewandte Chemie - International Edition. 50, 34, p. 7862-7864 3 p.

Research output: Contribution to journalArticle

2010

A simple and general platform for generating stereochemically complex polyene frameworks by iterative cross-coupling

Lee, S. J., Anderson, T. M. & Burke, M. D., Nov 15 2010, In : Angewandte Chemie - International Edition. 49, 47, p. 8860-8863 4 p.

Research output: Contribution to journalArticle

Ethynyl MIDA boronate: A readily accessible and highly versatile building block for small molecule synthesis

Struble, J. R., Lee, S. J. & Burke, M. D., Jun 26 2010, In : Tetrahedron. 66, 26, p. 4710-4718 9 p.

Research output: Contribution to journalArticle

General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates

Dick, G. R., Knapp, D. M., Gillis, E. P. & Burke, M. D., May 21 2010, In : Organic Letters. 12, 10, p. 2314-2317 4 p.

Research output: Contribution to journalArticle

Stereoretentive suzuki-miyaura coupling of haloallenes enables fully stereocontrolled access to (-)-Peridinin

Woerly, E. M., Cherney, A. H., Davis, E. K. & Burke, M. D., May 26 2010, In : Journal of the American Chemical Society. 132, 20, p. 6941-6943 3 p.

Research output: Contribution to journalArticle

2009

A general solution for unstable boronic acids: Slow-release cross-coupling from air-stable MIDA boronates

Knapp, D. M., Gillis, E. P. & Burke, M. D., May 27 2009, In : Journal of the American Chemical Society. 131, 20, p. 6961-6963 3 p.

Research output: Contribution to journalArticle

B-protected haloboronic acids for iterative cross-coupling

Ballmer, S. G., Gillis, E. P., Burke, M. D., Morton, D. & Davies, H. M. L., Dec 1 2009, In : Organic Syntheses. 86, p. 344-359 16 p.

Research output: Contribution to journalArticle

Flexible tetracycline synthesis yields promising antibiotics

Burke, M. D., Feb 6 2009, In : Nature chemical biology. 5, 2, p. 77-79 3 p.

Research output: Contribution to journalShort survey

Iterative cross-coupling with MIDA boronates: Towards a general strategy for small-molecule synthesis

Gillis, E. P. & Burke, M. D., Nov 27 2009, In : Aldrichimica Acta. 42, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Vinyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis

Uno, B. E., Gillis, E. P. & Burke, M. D., Apr 18 2009, In : Tetrahedron. 65, 16, p. 3130-3138 9 p.

Research output: Contribution to journalArticle

2008

Multistep synthesis of complex boronic acids from simple MIDA boronates

Gillis, E. P. & Burke, M. D., Oct 29 2008, In : Journal of the American Chemical Society. 130, 43, p. 14084-14085 2 p.

Research output: Contribution to journalArticle

Simple, efficient, and modular syntheses of polyene natural products via iterative cross-coupling

Suk, J. L., Gray, K. C., Paek, J. S. & Burke, M. D., Jan 16 2008, In : Journal of the American Chemical Society. 130, 2, p. 466-468 3 p.

Research output: Contribution to journalArticle

2007

A post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity

Palacios, D. S., Anderson, T. M. & Burke, M. D., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 13804-13805 2 p.

Research output: Contribution to journalArticle

2004

A Planning Strategy for Diversity-Oriented Synthesis

Burke, M. D. & Schreiber, S. L., Dec 22 2004, In : Angewandte Chemie - International Edition. 43, 1, p. 46-58 13 p.

Research output: Contribution to journalReview article

A synthesis strategy yielding skeletally diverse small molecules combinatorially

Burke, M. D., Berger, E. M. & Schreiber, S. L., Nov 3 2004, In : Journal of the American Chemical Society. 126, 43, p. 14095-14104 10 p.

Research output: Contribution to journalArticle

2003

Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules

Kohli, R. M., Burke, M. D., Tao, J. & Walsh, C. T., Jun 18 2003, In : Journal of the American Chemical Society. 125, 24, p. 7160-7161 2 p.

Research output: Contribution to journalArticle

Generating Diverse Skeletons of Small Molecules Combinatorially

Burke, M. D., Berger, E. M. & Schreiber, S. L., Oct 24 2003, In : Science. 302, 5645, p. 613-618 6 p.

Research output: Contribution to journalArticle

2002

Teaching target-oriented and diversity-oriented organic synthesis at Harvard University

Burke, M. D. & Lalic, G., Jun 17 2002, In : Chemistry and Biology. 9, 5, p. 535-541 7 p.

Research output: Contribution to journalReview article