Manabu T Nakamura

1992 …2020
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Research Output 1992 2020

2020
Open Access
Ilex paraguariensis
Lipogenesis
lipogenesis
Phytochemicals
High Fat Diet
2019

Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency

Sarr, O., Payne, G. W., Hucik, B., Abdelmagid, S., Nakamura, M. T., Ma, D. W. L. & Mutch, D. M., Jan 2019, In : Journal of Nutritional Biochemistry. 63, p. 140-149 10 p.

Research output: Contribution to journalArticle

Oxylipins
Fatty Acid Desaturases
White Adipose Tissue
Eicosapentaenoic Acid
Docosahexaenoic Acids

Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance

Hucik, B., Sarr, O., Nakamura, M. T., Dyck, D. J. & Mutch, D. M., May 2019, In : Journal of Nutritional Biochemistry. 67, p. 173-181 9 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
High Fat Diet
Nutrition
Fats
Glucose
2018

Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Burns, J. L., Nakamura, M. T. & Ma, D. W. L., Aug 2018, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 135, p. 1-4 4 p.

Research output: Contribution to journalReview article

Linoleic Acid
Arachidonic Acid
Health
Fatty Acids
Omega-3 Fatty Acids

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Vazquez-vidal, I., Voruganti, V. ., Hannon, B., Andrade, F., Aradillas-garcía, C., Nakamura, M. & Terán-garcía, M., Jan 1 2018, In : Lifestyle Genomics. 11, 1, p. 40-48

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Cohort Studies
Students
Lipids
Single Nucleotide Polymorphism
2017

Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on brain development using artificial rearing of delta-6-desaturase knockout mice

Harauma, A., Hatanaka, E., Yasuda, H., Nakamura, M. T., Salem, N. & Moriguchi, T., Dec 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 127, p. 32-39 8 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Knockout Mice

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets

Suitor, K., Payne, G. W., Sarr, O., Abdelmagid, S., Nakamura, M. T., Ma, D. WL. & Mutch, D. M., Nov 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 126, p. 84-91 8 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
White Adipose Tissue
Fat-Restricted Diet
Linoleic Acid
Nutrition

The essentiality of arachidonic acid in addition to docosahexaenoic acid for brain growth and function

Harauma, A., Yasuda, H., Hatanaka, E., Nakamura, M. T., Salem, N. & Moriguchi, T., Jan 1 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 116, p. 9-18 10 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Arachidonic Acid
Brain
Growth
Linoleoyl-CoA Desaturase
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T., Jan 1 2016, In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Essentiality of arachidonic acid intake in murine early development

Hatanaka, E., Harauma, A., Yasuda, H., Watanabe, J., Nakamura, M. T., Salem, N. & Moriguchi, T., May 1 2016, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 108, p. 51-57 7 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Docosahexaenoic Acids
Linoleoyl-CoA Desaturase
Motor Activity
Nutrition

Improvements in recall and food choices using a graphical method to deliver information of select nutrients

Pratt, N. S., Ellison, B., Benjamin, A. S. & Nakamura, M. T., Jan 1 2016, In : Nutrition Research. 36, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Meals
Food
Fats
Restaurants
Proteins

The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion

Monk, J. M., Liddle, D. M., Cohen, D. J. A., Tsang, D. H., Hillyer, L. M., Abdelmagid, S. A., Nakamura, M. T., Power, K. A., Ma, D. W. L. & Robinson, L. E., Jun 1 2016, In : Journal of Nutritional Biochemistry. 32, p. 29-38 10 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Omega-3 Fatty Acids
Linoleic Acid
Knockout Mice
Arachidonic Acid
2014

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M. T., Yudell, B. E. & Loor, J. J., Jan 1 2014, In : Progress in Lipid Research. 53, 1, p. 124-144 21 p.

Research output: Contribution to journalReview article

Energy Metabolism
Fatty Acids
Skin
PPAR gamma
PPAR delta
2013

Fatty Acid Structure and Synthesis

Clarke, S. D. & Nakamura, M. T., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 285-289 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fatty Acids
Essential Fatty Acids
Intestines
Carbon
Malonyl Coenzyme A

Oils rich in Δ-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse1

Monteiro, J., Askarian, F., Nakamura, M. T., Moghadasian, M. H. & Ma, D. W. L., Jun 1 2013, In : Canadian Journal of Physiology and Pharmacology. 91, 6, p. 469-479 11 p.

Research output: Contribution to journalArticle

alpha-Linolenic Acid
Fatty Liver
Liver Diseases
Oils
Eicosapentaenoic Acid
2012

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Monteiro, J., Li, F. J., MacLennan, M., Rabalski, A., Moghadasian, M. H., Nakamura, M. T. & Ma, D. W. L., May 30 2012, In : Lipids in Health and Disease. 11, 60.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Safflower Oil
Soybean Oil
Unsaturated Fatty Acids
Fatty Acids
2011

Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice

Roqueta-Rivera, M., Abbott, T. L., Sivaguru, M., Hess, R. A. & Nakamura, M. T., Oct 1 2011, In : Biology of reproduction. 85, 4, p. 721-732 12 p.

Research output: Contribution to journalArticle

Acrosome
Omega-3 Fatty Acids
Docosahexaenoic Acids
Acrosin
Syntaxin 1
2010

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Roqueta-Rivera, M., Stroud, C. K., Haschek, W. M., Akare, S. J., Segre, M., Brush, R. S., Agbaga, M. P., Anderson, R. E., Hess, R. A. & Nakamura, M. T., Feb 1 2010, In : Journal of Lipid Research. 51, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Docosahexaenoic Acids
Spermatogenesis
Fertility
Arachidonic Acid

Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Δ6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid

Rosenblat, M., Volkova, N., Roqueta-Rivera, M., Nakamura, M. T. & Aviram, M., Jun 1 2010, In : Atherosclerosis. 210, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Arachidonic Acid
Knockout Mice
Macrophages
Cholesterol

Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits

Simon Cho, B. H., Park, J. R., Nakamura, M. T., Odintsov, B. M., Wallig, M. A. & Chung, B. H., Oct 2010, In : Experimental Biology and Medicine. 235, 10, p. 1194-1203 10 p.

Research output: Contribution to journalArticle

Dimyristoylphosphatidylcholine
HDL Lipoproteins
Liposomes
Cholesterol
Rabbits
2009

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Stroud, C. K., Nara, T. Y., Roqueta-Rivera, M., Radlowski, E. C., Lawrence, P., Zhang, Y., Cho, B. H., Segre, M., Hess, R. A., Brenna, J. T., Haschek, W. M. & Nakamura, M. T., Nov 2 2009, In : Journal of Lipid Research. 50, 9, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Reproduction
Genes
Skin
Linoleic Acid

Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus

Koo, H. Y., Miyashita, M., Simon Cho, B. H. & Nakamura, M. T., Dec 11 2009, In : Biochemical and Biophysical Research Communications. 390, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Fructose
Liver
Rats
Glucose
2008

Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver

Koo, H. Y., Wallig, M. A., Chung, B. H., Nara, T. Y., Cho, B. H. S. & Nakamura, M. T., May 1 2008, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1782, 5, p. 341-348 8 p.

Research output: Contribution to journalArticle

Carbohydrate Metabolism
Fructose
Lipid Metabolism
Liver
Genes
2006

A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats

Baum, J. I., Layman, D. K., Freund, G. G., Rahn, K. A., Nakamura, M. T. & Yudell, B. E., Jul 6 2006, In : Journal of Nutrition. 136, 7, p. 1855-1861 7 p.

Research output: Contribution to journalArticle

Adipose Tissue
Carbohydrates
Phosphatidylinositol 3-Kinase
Diet
Glucose

Dietary lycopene downregulates carotenoid 15,15′-monooxygenase and PPAR-γ in selected rat tissues

Zaripheh, S., Nara, T. Y., Nakamura, M. T. & Erdman, J. W., Apr 1 2006, In : Journal of Nutrition. 136, 4, p. 932-938 7 p.

Research output: Contribution to journalArticle

Carotenoids
Mixed Function Oxygenases
Down-Regulation
Kidney
Fatty Acid-Binding Proteins

Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase

Adamson, A. W., Suchankova, G., Rufo, C., Nakamura, M. T., Teran-Garcia, M., Clarke, S. D. & Gettys, T. W., Oct 15 2006, In : Biochemical Journal. 399, 2, p. 285-295 11 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 4
Fatty Acid Synthases
Transcriptional Activation
Chemical activation
Carbohydrates

Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats

Campbell, J. K., Stroud, C. K., Nakamura, M. T., Lila, M. A. & Erdman, J. W., Nov 1 2006, In : Journal of Nutrition. 136, 11, p. 2813-2819 7 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Lycopersicon esculentum
lycopene
Powders
testosterone
2005
Overlapping Genes
Peroxisome Proliferators
Peroxisome Proliferator-Activated Receptors
Clofibric Acid
Fasting

Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis

Li, Y., Nara, T. Y. & Nakamura, M. T., Nov 1 2005, In : Journal of Lipid Research. 46, 11, p. 2432-2440 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Unsaturated Fatty Acids
Essential Fatty Acids
Feedback
Sterol Regulatory Element Binding Protein 1
2004

Mechanisms of regulation of gene expression by fatty acids

Nakamura, M. T., Cheon, Y., Li, Y. & Nara, T. Y., Nov 1 2004, In : Lipids. 39, 11, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Gene Expression Regulation
Unsaturated Fatty Acids
Gene expression
Sterol Regulatory Element Binding Protein 1

Structure, function, and dietary regulation of Δ6, Δ5, and Δ9 desaturases

Nakamura, M. T. & Nara, T. Y., Jul 29 2004, In : Annual Review of Nutrition. 24, p. 345-376 32 p.

Research output: Contribution to journalReview article

Unsaturated Fatty Acids
Phospholipids
Fatty Acids
Mammals
Linoleoyl-CoA Desaturase
2003

Essential fatty acid synthesis and its regulation in mammals

Nakamura, M. T. & Nara, T. Y., Feb 1 2003, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 68, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

Essential Fatty Acids
Mammals
Linoleoyl-CoA Desaturase
Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids

Regulation of human Δ-6 desaturase gene transcription: Identification of a functional direct repeat-1 element

Tang, C., Cho, H. P., Nakamura, M. T. & Clarke, S. D., Apr 1 2003, In : Journal of Lipid Research. 44, 4, p. 686-695 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Nucleic Acid Repetitive Sequences
Transcription
Genes
Hep G2 Cells
2002

Delayed induction of Δ-6 and Δ-5 desaturases by a peroxisome proliferator

He, W. S., Nara, T. Y. & Nakamura, M. T., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 299, 5, p. 832-838 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
Unsaturated Fatty Acids
Fatty Acids
Genes
Liver

Gene regulation of mammalian desaturases

Nakamura, M. T. & Nara, T. Y., Nov 1 2002, In : Biochemical Society Transactions. 30, 6, p. 1076-1079 4 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
Gene expression
Unsaturated Fatty Acids
Stearoyl-CoA Desaturase
Sterol Regulatory Element Binding Protein 1

NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription

Teran-Garcia, M. D. L., Rufo, C., Nakamura, M. T., Clarke, S. D. & Osborne, T. F., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 290, 4, p. 1295-1299 5 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Transcription
Genes
Fats
Stearoyl-CoA Desaturase

The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids

Nara, T. Y., He, W. S., Tang, C., Clarke, S. D. & Nakamura, M. T., Sep 20 2002, In : Biochemical and Biophysical Research Communications. 296, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Sterols
Unsaturated Fatty Acids
Genes
Phospholipids
2001

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription

Rufo, C., Teran-Garcia, M., Nakamura, M. T., Koo, S. H., Towle, H. C. & Clarke, S. D., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21969-21975 7 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Transcription
Liver
Rats
Genes

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

Xu, J., Teran-Garcia, M., Park, J. H. Y., Nakamura, M. T. & Clarke, S. D., Mar 30 2001, In : Journal of Biological Chemistry. 276, 13, p. 9800-9807 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Liver
Messenger RNA
Rats
2000

Regulation of hepatic Δ-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice

Nakamura, M. T., Cho, H. P. & Clarke, S. D., Jun 20 2000, In : Journal of Nutrition. 130, 6, p. 1561-1565 5 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Unsaturated Fatty Acids
Gene Expression
Acids
Liver
1999

Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase

Cho, H. P., Nakamura, M. & Clarke, S. D., Dec 24 1999, In : Journal of Biological Chemistry. 274, 52, p. 37335-37339 5 p.

Research output: Contribution to journalArticle

Cloning
Nutrition
Organism Cloning
Fatty Acids
Liver

Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase

Cho, H. P., Nakamura, M. T. & Clarke, S. D., Jan 1 1999, In : Journal of Biological Chemistry. 274, 1, p. 471-477 7 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Amino Acids
Peptides
Brain

Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition

Baillie, R. A., Takada, R., Nakamura, M. & Clarke, S. D., Jan 1 1999, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 60, 5-6, p. 351-356 6 p.

Research output: Contribution to journalArticle

Unsaturated Dietary Fats
Fish Oils
Adipose Tissue
Rats
Fats

Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene

Rufo, C., Gasperikova, D., Clarke, S. D., Teran-Garcia, M. & Nakamura, M. T., Aug 2 1999, In : Biochemical and Biophysical Research Communications. 261, 2, p. 400-405 6 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Rats
Genes
Hypersensitivity
Transcription
Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Genes
Fats
Fatty Acid Synthases
1998
Fatty Acid Synthases
Rats
Genes
Chloramphenicol
Acids

Mapping glucocorticoid response sequences (GRE) in the 5′-flanking region of rat Fatty Acid Synthase (FAS) gene

Rufo, C., Teran-Garcia, M., Nakamura, M. T. & Clarke, S. D., Mar 20 1998, In : FASEB Journal. 12, 5, p. A832

Research output: Contribution to journalArticle

Fatty Acid Synthases
5' Flanking Region
Glucocorticoids
Rats
Genes
1997

Fatty acid regulation of gene expression: Its role in fuel partitioning and insulin resistance

Clarke, S. D., Baillie, R., Jump, D. B. & Nakamura, M. T., Jan 1 1997, In : Annals of the New York Academy of Sciences. 827, p. 178-187 10 p.

Research output: Contribution to journalArticle

Fatty Acids
Insulin
Gene Expression

Mapping 5' flanking region of rat fatty acid synthase gene for hormone- and nutrient-response elements

Nakamura, M. T., Teran-Garcia, M., Kim, S. Y. & Clarke, S. D., Dec 1 1997, In : FASEB Journal. 11, 3, p. A139

Research output: Contribution to journalArticle

Fatty Acid Synthases
5' Flanking Region
Response Elements
Nutrients
Rats
1996

Effect of dietary fats and barley fiber on total cholesterol and upoprotein cholesterol distribution in plasma of hamsters

German, J. B., Xu, R., Walzem, R., Kinsella, J. E., Knuckles, B., Nakamura, M. & Yokoyama, W. H., Jul 1996, In : Nutrition Research. 16, 7, p. 1239-1249 11 p.

Research output: Contribution to journalArticle

Dietary Fats
Hordeum
Cricetinae
Cholesterol
Fish Oils