Research Output 1992 2017

2017

Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on brain development using artificial rearing of delta-6-desaturase knockout mice

Harauma, A., Hatanaka, E., Yasuda, H., Nakamura, M. T., Salem, N. & Moriguchi, T. Dec 1 2017 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 127, p. 32-39 8 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Knockout Mice

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets

Suitor, K., Payne, G. W., Sarr, O., Abdelmagid, S., Nakamura, M. T., Ma, D. W. L. & Mutch, D. M. Nov 1 2017 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 126, p. 84-91 8 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
White Adipose Tissue
Fat-Restricted Diet
Linoleic Acid
Nutrition

The essentiality of arachidonic acid in addition to docosahexaenoic acid for brain growth and function

Harauma, A., Yasuda, H., Hatanaka, E., Nakamura, M. T., Salem, N. & Moriguchi, T. Jan 1 2017 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 116, p. 9-18 10 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Arachidonic Acid
Brain
Growth
Linoleoyl-CoA Desaturase
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T. Jan 1 2016 In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Essentiality of arachidonic acid intake in murine early development

Hatanaka, E., Harauma, A., Yasuda, H., Watanabe, J., Nakamura, M. T., Salem, N. & Moriguchi, T. May 1 2016 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 108, p. 51-57 7 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Docosahexaenoic Acids
Linoleoyl-CoA Desaturase
Motor Activity
Nutrition
Meals
Food
Fats
Restaurants
Proteins

The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion

Monk, J. M., Liddle, D. M., Cohen, D. J. A., Tsang, D. H., Hillyer, L. M., Abdelmagid, S. A., Nakamura, M. T., Power, K. A., Ma, D. W. L. & Robinson, L. E. Jun 1 2016 In : Journal of Nutritional Biochemistry. 32, p. 29-38 10 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Omega-3 Fatty Acids
Linoleic Acid
Knockout Mice
Arachidonic Acid
2014

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M. T., Yudell, B. E. & Loor, J. J. Jan 1 2014 In : Progress in Lipid Research. 53, 1, p. 124-144 21 p.

Research output: Contribution to journalReview article

Energy Metabolism
Fatty Acids
Skin
PPAR gamma
PPAR delta
2013

Fatty Acid Structure and Synthesis

Clarke, S. D. & Nakamura, M. T. Feb 15 2013 Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 285-289 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stearoyl-CoA Desaturase
Acetyl-CoA Carboxylase
Fatty Acid Synthases
Omega-3 Fatty Acids
Unsaturated Fatty Acids

Oils rich in Δ-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse1

Monteiro, J., Askarian, F., Nakamura, M. T., Moghadasian, M. H. & Ma, D. W. L. Jun 2013 In : Canadian Journal of Physiology and Pharmacology. 91, 6, p. 469-479 11 p.

Research output: Contribution to journalArticle

alpha-Linolenic Acid
Fatty Liver
Liver Diseases
Oils
Eicosapentaenoic Acid
2012

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Monteiro, J., Li, F. J., MacLennan, M., Rabalski, A., Moghadasian, M. H., Nakamura, M. T. & Ma, D. W. L. 2012 In : Lipids in Health and Disease. 11, 60

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Safflower Oil
Soybean Oil
Unsaturated Fatty Acids
Fatty Acids
2011

Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice

Roqueta-Rivera, M., Abbott, T. L., Sivaguru, M., Hess, R. A. & Nakamura, M. T. Oct 1 2011 In : Biology of Reproduction. 85, 4, p. 721-732 12 p.

Research output: Contribution to journalArticle

Acrosome
Omega-3 Fatty Acids
Docosahexaenoic Acids
Acrosin
Syntaxin 1
2010

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Roqueta-Rivera, M., Stroud, C. K., Haschek, W. M., Akare, S. J., Segre, M., Brush, R. S., Agbaga, M. P., Anderson, R. E., Hess, R. A. & Nakamura, M. T. Feb 1 2010 In : Journal of Lipid Research. 51, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Docosahexaenoic Acids
Spermatogenesis
Fertility
Arachidonic Acid

Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Δ6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid

Rosenblat, M., Volkova, N., Roqueta-Rivera, M., Nakamura, M. T. & Aviram, M. Jun 1 2010 In : Atherosclerosis. 210, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Arachidonic Acid
Macrophages
Cholesterol
Messenger RNA

Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits

Simon Cho, B. H., Park, J. R., Nakamura, M. T., Odintsov, B. M., Wallig, M. A. & Chung, B. H. Jan 1 2010 In : Experimental Biology and Medicine. 235, 10, p. 1194-1203 10 p.

Research output: Contribution to journalArticle

Dimyristoylphosphatidylcholine
HDL Lipoproteins
Liposomes
Cholesterol
Rabbits
2009

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Stroud, C. K., Nara, T. Y., Roqueta-Rivera, M., Radlowski, E. C., Lawrence, P., Zhang, Y., Cho, B. H., Segre, M., Hess, R. A., Brenna, J. T., Haschek, W. M. & Nakamura, M. T. 2009 In : Journal of Lipid Research. 50, 9, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Linoleoyl-CoA Desaturase
Reproduction
Genes
Skin
Linoleic Acid

Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus

Koo, H. Y., Miyashita, M., Simon Cho, B. H. & Nakamura, M. T. Dec 11 2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Fructose
Liver
Rats
Glucose
2008

Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver

Koo, H. Y., Wallig, M. A., Chung, B. H., Nara, T. Y., Cho, B. H. S. & Nakamura, M. T. May 1 2008 In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1782, 5, p. 341-348 8 p.

Research output: Contribution to journalArticle

Carbohydrate Metabolism
Fructose
Lipid Metabolism
Liver
Genes
2006

A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats

Baum, J. I., Layman, D. K., Freund, G. G., Rahn, K. A., Nakamura, M. T. & Yudell, B. E. 2006 In : Journal of Nutrition. 136, 7, p. 1855-1861 7 p.

Research output: Contribution to journalArticle

glycemic control
adipose tissue
dietary protein
Adipose Tissue
Carbohydrates

Dietary lycopene downregulates carotenoid 15,15′-monooxygenase and PPAR-γ in selected rat tissues

Zaripheh, S., Nara, T. Y., Nakamura, M. T. & Erdman, J. W. Apr 2006 In : Journal of Nutrition. 136, 4, p. 932-938 7 p.

Research output: Contribution to journalArticle

Carotenoids
lycopene
Mixed Function Oxygenases
carotenoids
Down-Regulation

Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase

Adamson, A. W., Suchankova, G., Rufo, C., Nakamura, M. T., Teran-Garcia, M., Clarke, S. D. & Gettys, T. W. Oct 15 2006 In : Biochemical Journal. 399, 2, p. 285-295 11 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factors
Fatty Acid Synthases
Transcriptional Activation
Chemical activation
Carbohydrates

Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats

Campbell, J. K., Stroud, C. K., Nakamura, M. T., Lila, M. A. & Erdman, J. W. Nov 2006 In : Journal of Nutrition. 136, 11, p. 2813-2819 7 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Lycopersicon esculentum
lycopene
Powders
testosterone
2005
Overlapping Genes
Peroxisome Proliferators
PPAR alpha
Clofibric Acid
Fasting

Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis

Li, Y., Nara, T. Y. & Nakamura, M. T. Nov 2005 In : Journal of Lipid Research. 46, 11, p. 2432-2440 9 p.

Research output: Contribution to journalArticle

PPAR alpha
Unsaturated Fatty Acids
Essential Fatty Acids
Feedback
Sterol Regulatory Element Binding Protein 1
2004

Mechanisms of regulation of gene expression by fatty acids

Nakamura, M. T., Cheon, Y., Li, Y. & Nara, T. Y. Nov 1 2004 In : Lipids. 39, 11, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

PPAR alpha
gene expression regulation
Gene Expression Regulation
Unsaturated Fatty Acids
Gene expression

Structure, function, and dietary regulation of Δ6, Δ5, and Δ9 desaturases

Nakamura, M. T. & Nara, T. Y. 2004 In : Annual Review of Nutrition. 24, p. 345-376 32 p.

Research output: Contribution to journalReview article

Unsaturated Fatty Acids
Phospholipids
Fatty Acids
Mammals
Linoleoyl-CoA Desaturase
2003

Essential fatty acid synthesis and its regulation in mammals

Nakamura, M. T. & Nara, T. Y. Feb 1 2003 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 68, 2, p. 145-150 6 p.

Research output: Contribution to journalReview article

Essential Fatty Acids
Mammals
Linoleoyl-CoA Desaturase
Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids

Regulation of human Δ-6 desaturase gene transcription: Identification of a functional direct repeat-1 element

Tang, C., Cho, H. P., Nakamura, M. T. & Clarke, S. D. Apr 2003 In : Journal of Lipid Research. 44, 4, p. 686-695 10 p.

Research output: Contribution to journalArticle

Nucleic Acid Repetitive Sequences
Transcription
Genes
Hep G2 Cells
Response Elements
2002

Delayed induction of Δ-6 and Δ-5 desaturases by a peroxisome proliferator

He, W. S., Nara, T. Y. & Nakamura, M. T. 2002 In : Biochemical and Biophysical Research Communications. 299, 5, p. 832-838 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
Unsaturated Fatty Acids
Fatty Acids
Genes
Liver

Gene regulation of mammalian desaturases

Nakamura, M. T. & Nara, T. Y. Nov 2002 In : Biochemical Society Transactions. 30, 6, p. 1076-1079 4 p.

Research output: Contribution to journalArticle

Peroxisome Proliferators
Gene expression
Unsaturated Fatty Acids
Stearoyl-CoA Desaturase
Sterol Regulatory Element Binding Protein 1

NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription

Teran-Garcia, M., Rufo, C., Nakamura, M. T., Clarke, S. D. & Osborne, T. F. Jan 1 2002 In : Biochemical and Biophysical Research Communications. 290, 4, p. 1295-1299 5 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Transcription
Genes
Fats
Stearoyl-CoA Desaturase

The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids

Nara, T. Y., He, W. S., Tang, C., Clarke, S. D. & Nakamura, M. T. Sep 20 2002 In : Biochemical and Biophysical Research Communications. 296, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Sterols
Unsaturated Fatty Acids
Genes
Phospholipids
2001

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription

Rufo, C., Teran-Garcia, M., Nakamura, M. T., Koo, S. H., Towle, H. C. & Clarke, S. D. Jun 15 2001 In : Journal of Biological Chemistry. 276, 24, p. 21969-21975 7 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Transcription
Liver
Rats
Genes

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

Xu, J., Teran-Garcia, M., Park, J. H. Y., Nakamura, M. T. & Clarke, S. D. Mar 30 2001 In : Journal of Biological Chemistry. 276, 13, p. 9800-9807 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Liver
Messenger RNA
Rats
2000
Fatty Acid Synthases
fatty-acid synthase
Unsaturated Fatty Acids
polyunsaturated fatty acids
Gene Expression
1999

Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase

Cho, H. P., Nakamura, M. & Clarke, S. D. Dec 24 1999 In : Journal of Biological Chemistry. 274, 52, p. 37335-37339 5 p.

Research output: Contribution to journalArticle

Cloning
Nutrition
Organism Cloning
Fatty Acids
Liver

Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase

Cho, H. P., Nakamura, M. T. & Clarke, S. D. Jan 1 1999 In : Journal of Biological Chemistry. 274, 1, p. 471-477 7 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Amino Acids
Peptides
Brain

Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition

Baillie, R. A., Takada, R., Nakamura, M. & Clarke, S. D. Jan 1 1999 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 60, 5-6, p. 351-356 6 p.

Research output: Contribution to journalArticle

Unsaturated Dietary Fats
Fish Oils
Adipose Tissue
Rats
Fats

Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene

Rufo, C., Gasperikova, D., Clarke, S. D., Teran-Garcia, M. & Nakamura, M. T. Aug 2 1999 In : Biochemical and Biophysical Research Communications. 261, 2, p. 400-405 6 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Rats
Genes
Hypersensitivity
Transcription
Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Genes
Fats
Fatty Acid Synthases
1998
Fatty Acid Synthases
fatty-acid synthase
Rats
chloramphenicol acetyltransferase
Genes
Fatty Acid Synthases
fatty-acid synthase
5' Flanking Region
glucocorticoids
Glucocorticoids
1997

Fatty acid regulation of gene expression: Its role in fuel partitioning and insulin resistance

Clarke, S. D., Baillie, R., Jump, D. B. & Nakamura, M. T. Jan 1 1997 In : Annals of the New York Academy of Sciences. 827, p. 178-187 10 p.

Research output: Contribution to journalArticle

Fatty Acids
Insulin
Gene Expression

Mapping 5' flanking region of rat fatty acid synthase gene for hormone- and nutrient-response elements

Nakamura, M. T., Teran-Garcia, M., Kim, S. Y. & Clarke, S. D. 1997 In : FASEB Journal. 11, 3

Research output: Contribution to journalArticle

Fatty Acid Synthases
5' Flanking Region
Response Elements
Nutrients
Rats
1996

Effect of dietary fats and barley fiber on total cholesterol and upoprotein cholesterol distribution in plasma of hamsters

German, J. B., Xu, R., Walzem, R., Kinsella, J. E., Knuckles, B., Nakamura, M. & Yokoyama, W. H. Jul 1 1996 In : Nutrition Research. 16, 7, p. 1239-1249 11 p.

Research output: Contribution to journalArticle

Dietary Fats
Hordeum
Cricetinae
Cholesterol
Fish Oils

Increased hepatic Δ6-Desaturase activity with growth hormone expression in the MG101 transgenic mouse

Nakamura, M. T., Phinney, S. D., Tang, A. B., Oberbauer, A. M., German, J. B. & Murray, J. D. Feb 1 1996 In : Lipids. 31, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

somatotropin
Transgenic Mice
Growth Hormone
Liver
gene expression
1995

Another obese gene function

Nakamura, M. T. Mar 9 1995 In : Nature. 374, 6518, 1 p.

Research output: Contribution to journalArticle

Body Composition
Obesity
Fats
Genes

Erratum: 'Another obese gene function' (Nature (1995) 374 (124))

Nakamura, M. T. 1995 In : Nature. 375, 6533, p. 638 1 p.

Research output: Contribution to journalComment/debate

1994

Effects of ethanol feeding on liver, kidney and jejunal membranes of micropigs

Villanueva, J., Chandler, C. J., Shimasaki, N., Tang, A. B., Nakamura, M., Phinney, S. D. & Halsted, C. H. 1994 In : Hepatology. 19, 5, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Ethanol
Kidney
Membranes
Liver
Anisotropy

Selective reduction of Δ6 and Δ5 desaturase activities but not Δ9 desaturase in micropigs chronically fed ethanol

Nakamura, M. T., Tang, A. B., Villanueva, J., Halsted, C. H. & Phinney, S. D. Jan 1 1994 In : Journal of Clinical Investigation. 93, 1, p. 450-454 5 p.

Research output: Contribution to journalArticle

Ethanol
Liver
Phospholipids
Swine
Coenzyme A