Research Output 1992 2017

2017

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets

Suitor, K., Payne, G. W., Sarr, O., Abdelmagid, S., Nakamura, M. T., Ma, D. W. L. & Mutch, D. M. Nov 1 2017 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 126, p. 84-91 8 p.

Research output: Research - peer-reviewArticle

Fatty Acid Desaturases
White Adipose Tissue
Fat-Restricted Diet
Linoleic Acid
Arachidonic Acid

The essentiality of arachidonic acid in addition to docosahexaenoic acid for brain growth and function

Harauma, A., Yasuda, H., Hatanaka, E., Nakamura, M. T., Salem, N. & Moriguchi, T. Jan 1 2017 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 116, p. 9-18 10 p.

Research output: Research - peer-reviewArticle

Docosahexaenoic Acids
Arachidonic Acid
Brain
Growth
Body Weight
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T. 2016 In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Research - peer-reviewArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Essentiality of arachidonic acid intake in murine early development

Hatanaka, E., Harauma, A., Yasuda, H., Watanabe, J., Nakamura, M. T., Salem, N. & Moriguchi, T. May 1 2016 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 108, p. 51-57 7 p.

Research output: Research - peer-reviewArticle

Arachidonic Acid
Docosahexaenoic Acids
Motor Activity
Growth
Linoleoyl-CoA Desaturase
Food
Meals
Proteins
Fats
Restaurants

The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion

Monk, J. M., Liddle, D. M., Cohen, D. J. A., Tsang, D. H., Hillyer, L. M., Abdelmagid, S. A., Nakamura, M. T., Power, K. A., Ma, D. W. L. & Robinson, L. E. Jun 1 2016 In : Journal of Nutritional Biochemistry. 32, p. 29-38 10 p.

Research output: Research - peer-reviewArticle

Linoleoyl-CoA Desaturase
Omega-3 Fatty Acids
Linoleic Acid
Knockout Mice
Fatty Acids
2014

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M. T., Yudell, B. E. & Loor, J. J. Jan 2014 In : Progress in Lipid Research. 53, 1, p. 124-144 21 p.

Research output: Research - peer-reviewReview article

Energy Metabolism
Fatty Acids
Skin
PPAR gamma
Genes
2013

Oils rich in Δ-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse1

Monteiro, J., Askarian, F., Nakamura, M. T., Moghadasian, M. H. & Ma, D. W. L. Jun 2013 In : Canadian Journal of Physiology and Pharmacology. 91, 6, p. 469-479 11 p.

Research output: Research - peer-reviewArticle

alpha-Linolenic Acid
Fatty Liver
Liver Diseases
Oils
Eicosapentaenoic Acid
2012

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Monteiro, J., Li, F. J., MacLennan, M., Rabalski, A., Moghadasian, M. H., Nakamura, M. T. & Ma, D. W. L. 2012 In : Lipids in Health and Disease. 11, 60

Research output: Research - peer-reviewArticle

Linoleoyl-CoA Desaturase
Safflower Oil
Soybean Oil
Unsaturated Fatty Acids
Fatty Acids
2011

Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice

Roqueta-Rivera, M., Abbott, T. L., Sivaguru, M., Hess, R. A. & Nakamura, M. T. Oct 1 2011 In : Biology of Reproduction. 85, 4, p. 721-732 12 p.

Research output: Research - peer-reviewArticle

Acrosome
Omega-3 Fatty Acids
Docosahexaenoic Acids
Acrosin
Spermatids
2010

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Roqueta-Rivera, M., Stroud, C. K., Haschek, W. M., Akare, S. J., Segre, M., Brush, R. S., Agbaga, M. P., Anderson, R. E., Hess, R. A. & Nakamura, M. T. Feb 1 2010 In : Journal of Lipid Research. 51, 2, p. 360-367 8 p.

Research output: Research - peer-reviewArticle

Linoleoyl-CoA Desaturase
Docosahexaenoic Acids
Spermatogenesis
Fertility
Arachidonic Acid

Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Δ6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid

Rosenblat, M., Volkova, N., Roqueta-Rivera, M., Nakamura, M. T. & Aviram, M. Jun 2010 In : Atherosclerosis. 210, 2, p. 414-421 8 p.

Research output: Research - peer-reviewArticle

Aryldialkylphosphatase
Arachidonic Acid
Macrophages
Cholesterol
oxynide

Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits

Simon Cho, B. H., Park, J. R., Nakamura, M. T., Odintsov, B. M., Wallig, M. A. & Chung, B. H. 2010 In : Experimental Biology and Medicine. 235, 10, p. 1194-1203 10 p.

Research output: Research - peer-reviewArticle

Dimyristoylphosphatidylcholine
HDL Lipoproteins
Liposomes
Cholesterol
Rabbits
2009

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Stroud, C. K., Nara, T. Y., Roqueta-Rivera, M., Radlowski, E. C., Lawrence, P., Zhang, Y., Cho, B. H., Segre, M., Hess, R. A., Brenna, J. T., Haschek, W. M. & Nakamura, M. T. 2009 In : Journal of Lipid Research. 50, 9, p. 1870-1880 11 p.

Research output: Research - peer-reviewArticle

Linoleoyl-CoA Desaturase
Reproduction
Skin
Genes
Linoleic Acid

Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus

Koo, H. Y., Miyashita, M., Simon Cho, B. H. & Nakamura, M. T. Dec 11 2009 In : Biochemical and Biophysical Research Communications. 390, 2, p. 285-289 5 p.

Research output: Research - peer-reviewArticle

Fructose
Liver
Rats
Glucose
Proteins
2008

Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver

Koo, H. Y., Wallig, M. A., Chung, B. H., Nara, T. Y., Cho, B. H. S. & Nakamura, M. T. May 2008 In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1782, 5, p. 341-348 8 p.

Research output: Research - peer-reviewArticle

Carbohydrate Metabolism
Fructose
Lipid Metabolism
Liver
Genes
2006

A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats

Baum, J. I., Layman, D. K., Freund, G. G., Rahn, K. A., Nakamura, M. T. & Yudell, B. E. 2006 In : Journal of Nutrition. 136, 7, p. 1855-1861 7 p.

Research output: Research - peer-reviewArticle

glycemic control
adipose tissue
dietary protein
carbohydrates
glucose

Dietary lycopene downregulates carotenoid 15,15′-monooxygenase and PPAR-γ in selected rat tissues

Zaripheh, S., Nara, T. Y., Nakamura, M. T. & Erdman, J. W. Apr 2006 In : Journal of Nutrition. 136, 4, p. 932-938 7 p.

Research output: Research - peer-reviewArticle

lycopene
carotenoids
receptors
rats
tissues

Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase

Adamson, A. W., Suchankova, G., Rufo, C., Nakamura, M. T., Teran-Garcia, M., Clarke, S. D. & Gettys, T. W. Oct 15 2006 In : Biochemical Journal. 399, 2, p. 285-295 11 p.

Research output: Research - peer-reviewArticle

Hepatocyte Nuclear Factors
Fatty Acid Synthases
Transcriptional Activation
Carbohydrates
Liver

Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats

Campbell, J. K., Stroud, C. K., Nakamura, M. T., Lila, M. A. & Erdman, J. W. Nov 2006 In : Journal of Nutrition. 136, 11, p. 2813-2819 7 p.

Research output: Research - peer-reviewArticle

Inbred F344 Rats
Lycopersicon esculentum
Powders
Testosterone
Serum
2005
Overlapping Genes
Peroxisome Proliferators
PPAR alpha
Fasting
Swine

Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis

Li, Y., Nara, T. Y. & Nakamura, M. T. Nov 2005 In : Journal of Lipid Research. 46, 11, p. 2432-2440 9 p.

Research output: Research - peer-reviewArticle

PPAR alpha
Unsaturated Fatty Acids
Feedback
Essential Fatty Acids
Genes
2004

Mechanisms of regulation of gene expression by fatty acids

Nakamura, M. T., Cheon, Y., Li, Y. & Nara, T. Y. Nov 2004 In : Lipids. 39, 11, p. 1077-1083 7 p.

Research output: Research - peer-reviewArticle

gene expression regulation
fatty acids
peroxisome proliferator-activated receptors
PPAR alpha
Gene Expression Regulation

Structure, function, and dietary regulation of Δ6, Δ5, and Δ9 desaturases

Nakamura, M. T. & Nara, T. Y. 2004 In : Annual Review of Nutrition. 24, p. 345-376 32 p.

Research output: Research - peer-reviewReview article

Unsaturated Fatty Acids
Phospholipids
Fatty Acids
Mammals
Triglycerides
2003

Essential fatty acid synthesis and its regulation in mammals

Nakamura, M. T. & Nara, T. Y. Feb 1 2003 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 68, 2, p. 145-150 6 p.

Research output: Research - peer-reviewReview article

Essential Fatty Acids
Unsaturated Fatty Acids
Mammals
Sterol Regulatory Element Binding Protein 1
Linoleoyl-CoA Desaturase

Regulation of human Δ-6 desaturase gene transcription: Identification of a functional direct repeat-1 element

Tang, C., Cho, H. P., Nakamura, M. T. & Clarke, S. D. Apr 2003 In : Journal of Lipid Research. 44, 4, p. 686-695 10 p.

Research output: Research - peer-reviewArticle

Nucleic Acid Repetitive Sequences
Genes
Transcription
pirinixic acid
Hep G2 Cells
2002

Delayed induction of Δ-6 and Δ-5 desaturases by a peroxisome proliferator

He, W. S., Nara, T. Y. & Nakamura, M. T. 2002 In : Biochemical and Biophysical Research Communications. 299, 5, p. 832-838 7 p.

Research output: Research - peer-reviewArticle

Peroxisome Proliferators
Unsaturated Fatty Acids
Fatty Acids
Enzymes
Genes

Gene regulation of mammalian desaturases

Nakamura, M. T. & Nara, T. Y. Nov 2002 In : Biochemical Society Transactions. 30, 6, p. 1076-1079 4 p.

Research output: Research - peer-reviewArticle

Peroxisome Proliferators
Genes
Gene expression
Unsaturated Fatty Acids
Stearoyl-CoA Desaturase

NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription

Teran-Garcia, M., Rufo, C., Nakamura, M. T., Clarke, S. D. & Osborne, T. F. 2002 In : Biochemical and Biophysical Research Communications. 290, 4, p. 1295-1299 5 p.

Research output: Research - peer-reviewArticle

Fatty Acid Synthases
Fats
Genes
Transcription
Stearoyl-CoA Desaturase

The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids

Nara, T. Y., He, W. S., Tang, C., Clarke, S. D. & Nakamura, M. T. 2002 In : Biochemical and Biophysical Research Communications. 296, 1, p. 111-117 7 p.

Research output: Research - peer-reviewArticle

Sterols
Unsaturated Fatty Acids
Genes
Sterol Regulatory Element Binding Protein 1
Phospholipids
2001

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription

Rufo, C., Teran-Garcia, M., Nakamura, M. T., Koo, S. H., Towle, H. C. & Clarke, S. D. Jun 15 2001 In : Journal of Biological Chemistry. 276, 24, p. 21969-21975 7 p.

Research output: Research - peer-reviewArticle

Fatty Acid Synthases
Transcription
Liver
Rats
Genes

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

Xu, J., Teran-Garcia, M., Park, J. H. Y., Nakamura, M. T. & Clarke, S. D. Mar 30 2001 In : Journal of Biological Chemistry. 276, 13, p. 9800-9807 8 p.

Research output: Research - peer-reviewArticle

Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Liver
Messenger RNA
Rats
2000
fatty-acid synthase
polyunsaturated fatty acids
gene expression
liver
acids
1999

Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase

Cho, H. P., Nakamura, M. & Clarke, S. D. Dec 24 1999 In : Journal of Biological Chemistry. 274, 52, p. 37335-37339 5 p.

Research output: Research - peer-reviewArticle

Organism Cloning
Fatty Acids
Messenger RNA
Liver
Cloning

Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase

Cho, H. P., Nakamura, M. T. & Clarke, S. D. Jan 1 1999 In : Journal of Biological Chemistry. 274, 1, p. 471-477 7 p.

Research output: Research - peer-reviewArticle

Cloning
Amino Acids
Peptides
Organism Cloning
Liver

Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition

Baillie, R. A., Takada, R., Nakamura, M. & Clarke, S. D. 1999 In : Prostaglandins Leukotrienes and Essential Fatty Acids. 60, 5-6, p. 351-356 6 p.

Research output: Research - peer-reviewArticle

Unsaturated Dietary Fats
Fish Oils
Adipose Tissue
acyl CoA oxidase 3
peroxisomal acyl-CoA oxidase

Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene

Rufo, C., Gasperikova, D., Clarke, S. D., Teran-Garcia, M. & Nakamura, M. T. Aug 2 1999 In : Biochemical and Biophysical Research Communications. 261, 2, p. 400-405 6 p.

Research output: Research - peer-reviewArticle

Fatty Acid Synthases
Genes
Rats
Hypersensitivity
Insulin
Sterol Regulatory Element Binding Protein 1
Unsaturated Fatty Acids
Fats
Genes
Fatty Acid Synthases
1998
fatty-acid synthase
acids
rats
genes
Fatty Acid Synthases
Fatty Acid Synthases
5' Flanking Region
Glucocorticoids
Rats
Genes
1997

Fatty acid regulation of gene expression: Its role in fuel partitioning and insulin resistance

Clarke, S. D., Baillie, R., Jump, D. B. & Nakamura, M. T. 1997 In : Annals of the New York Academy of Sciences. 827, p. 178-187 10 p.

Research output: Research - peer-reviewArticle

Mapping 5' flanking region of rat fatty acid synthase gene for hormone- and nutrient-response elements

Nakamura, M. T., Teran-Garcia, M., Kim, S. Y. & Clarke, S. D. 1997 In : FASEB Journal. 11, 3

Research output: Research - peer-reviewArticle

Fatty Acid Synthases
5' Flanking Region
Response Elements
Hormones
Food
1996

Effect of dietary fats and barley fiber on total cholesterol and upoprotein cholesterol distribution in plasma of hamsters

German, J. B., Xu, R., Walzem, R., Kinsella, J. E., Knuckles, B., Nakamura, M. & Yokoyama, W. H. Jul 1996 In : Nutrition Research. 16, 7, p. 1239-1249 11 p.

Research output: Research - peer-reviewArticle

Dietary Fats
Hordeum
Cricetinae
Cholesterol
Fish Oils

Increased hepatic Δ6-Desaturase activity with growth hormone expression in the MG101 transgenic mouse

Nakamura, M. T., Phinney, S. D., Tang, A. B., Oberbauer, A. M., German, J. B. & Murray, J. D. Feb 1996 In : Lipids. 31, 2, p. 139-143 5 p.

Research output: Research - peer-reviewArticle

somatotropin
gene expression
liver
mice
Transgenic Mice
1995

Another obese gene function

Nakamura, M. T. Mar 9 1995 In : Nature. 374, 6518, p. 124 1 p.

Research output: Research - peer-reviewArticle

Erratum: 'Another obese gene function' (Nature (1995) 374 (124))

Nakamura, M. T. 1995 In : Nature. 375, 6533, p. 638 1 p.

Research output: Research - peer-reviewComment/debate

1994

Effects of ethanol feeding on liver, kidney and jejunal membranes of micropigs

Villanueva, J., Chandler, C. J., Shimasaki, N., Tang, A. B., Nakamura, M., Phinney, S. D. & Halsted, C. H. 1994 In : Hepatology. 19, 5, p. 1229-1240 12 p.

Research output: Research - peer-reviewArticle

Ethanol
Kidney
Membranes
Liver
Anisotropy

Selective reduction of Δ6 and Δ5 desaturase activities but not Δ9 desaturase in micropigs chronically fed ethanol

Nakamura, M. T., Tang, A. B., Villanueva, J., Halsted, C. H. & Phinney, S. D. Jan 1994 In : Journal of Clinical Investigation. 93, 1, p. 450-454 5 p.

Research output: Research - peer-reviewArticle

Ethanol
Liver
Phospholipids
Swine
Coenzyme A
1993

Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by γ-linolenic acid administration

Phinney, S. D., Tang, A. B., Thurmond, D. C., Nakamura, M. T. & Stern, J. S. 1993 In : Metabolism. 42, 9, p. 1127-1140 14 p.

Research output: Research - peer-reviewArticle

gamma-Linolenic Acid
Zucker Rats
Lipid Metabolism
Liver
black currant oil

The body composition and lipid metabolic effects of long-term ethanol feeding during a high ω6 polyunsaturated fatty acid diet in micropigs

Nakamura, M. T., Tang, A. B., Villanueva, J., Halsted, C. H. & Phinney, S. D. 1993 In : Metabolism. 42, 10, p. 1340-1350 11 p.

Research output: Research - peer-reviewArticle

Body Composition
Unsaturated Fatty Acids
Ethanol
Diet
Lipids