Manabu T Nakamura

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Research Output

2020
Open Access

Changes in behavior and fatty acid composition induced by long-term reduction in murine Δ6-desaturation activity

Harauma, A., Sueyasu, T., Tokuda, H., Yasuda, H., Hoshi, Y., Kaneda, Y., Rogi, T., Shibata, H., Nakamura, M. T. & Moriguchi, T., Apr 2020, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 155, 102079.

Research output: Contribution to journalArticle

Hydrolyzed Fat Formula Increases Brain White Matter in Small for Gestational Age and Appropriate for Gestational Age Neonatal Piglets

Caputo, M. P., Williams, J. N., Drnevich, J., Radlowski, E. C., Larsen, R. J., Sutton, B. P., Leyshon, B. J., Hussain, J., Nakamura, M. T., Kuchan, M. J., Das, T. & Johnson, R. W., Feb 12 2020, In : Frontiers in Pediatrics. 8, 32.

Research output: Contribution to journalArticle

Open Access
2019

Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency

Sarr, O., Payne, G. W., Hucik, B., Abdelmagid, S., Nakamura, M. T., Ma, D. W. L. & Mutch, D. M., Jan 2019, In : Journal of Nutritional Biochemistry. 63, p. 140-149 10 p.

Research output: Contribution to journalArticle

Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance

Hucik, B., Sarr, O., Nakamura, M. T., Dyck, D. J. & Mutch, D. M., May 2019, In : Journal of Nutritional Biochemistry. 67, p. 173-181 9 p.

Research output: Contribution to journalArticle

2018

Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

Burns, J. L., Nakamura, M. T. & Ma, D. W. L., Aug 2018, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 135, p. 1-4 4 p.

Research output: Contribution to journalReview article

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Vazquez-vidal, I., Voruganti, V. ., Hannon, B., Andrade, F., Aradillas-garcía, C., Nakamura, M. & Terán-garcía, M., Jan 1 2018, In : Lifestyle Genomics. 11, 1, p. 40-48

Research output: Contribution to journalArticle

2017

Effects of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid on brain development using artificial rearing of delta-6-desaturase knockout mice

Harauma, A., Hatanaka, E., Yasuda, H., Nakamura, M. T., Salem, N. & Moriguchi, T., Dec 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 127, p. 32-39 8 p.

Research output: Contribution to journalArticle

Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets

Suitor, K., Payne, G. W., Sarr, O., Abdelmagid, S., Nakamura, M. T., Ma, D. WL. & Mutch, D. M., Nov 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 126, p. 84-91 8 p.

Research output: Contribution to journalArticle

The essentiality of arachidonic acid in addition to docosahexaenoic acid for brain growth and function

Harauma, A., Yasuda, H., Hatanaka, E., Nakamura, M. T., Salem, N. & Moriguchi, T., Jan 1 2017, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 116, p. 9-18 10 p.

Research output: Contribution to journalArticle

2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T., Jan 1 2016, In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Essentiality of arachidonic acid intake in murine early development

Hatanaka, E., Harauma, A., Yasuda, H., Watanabe, J., Nakamura, M. T., Salem, N. & Moriguchi, T., May 1 2016, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 108, p. 51-57 7 p.

Research output: Contribution to journalArticle

The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion

Monk, J. M., Liddle, D. M., Cohen, D. J. A., Tsang, D. H., Hillyer, L. M., Abdelmagid, S. A., Nakamura, M. T., Power, K. A., Ma, D. W. L. & Robinson, L. E., Jun 1 2016, In : Journal of Nutritional Biochemistry. 32, p. 29-38 10 p.

Research output: Contribution to journalArticle

2014

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M. T., Yudell, B. E. & Loor, J. J., Jan 1 2014, In : Progress in Lipid Research. 53, 1, p. 124-144 21 p.

Research output: Contribution to journalReview article

2013

Fatty Acid Structure and Synthesis

Clarke, S. D. & Nakamura, M. T., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 285-289 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oils rich in Δ-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse1

Monteiro, J., Askarian, F., Nakamura, M. T., Moghadasian, M. H. & Ma, D. W. L., Jun 1 2013, In : Canadian Journal of Physiology and Pharmacology. 91, 6, p. 469-479 11 p.

Research output: Contribution to journalArticle

2012

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Monteiro, J., Li, F. J., MacLennan, M., Rabalski, A., Moghadasian, M. H., Nakamura, M. T. & Ma, D. W. L., May 30 2012, In : Lipids in Health and Disease. 11, 60.

Research output: Contribution to journalArticle

2011

Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice

Roqueta-Rivera, M., Abbott, T. L., Sivaguru, M., Hess, R. A. & Nakamura, M. T., Oct 1 2011, In : Biology of reproduction. 85, 4, p. 721-732 12 p.

Research output: Contribution to journalArticle

2010

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Roqueta-Rivera, M., Stroud, C. K., Haschek, W. M., Akare, S. J., Segre, M., Brush, R. S., Agbaga, M. P., Anderson, R. E., Hess, R. A. & Nakamura, M. T., Feb 1 2010, In : Journal of Lipid Research. 51, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Δ6-desaturase knockout (6-DS KO) mice: Beneficial effects of arachidonic acid

Rosenblat, M., Volkova, N., Roqueta-Rivera, M., Nakamura, M. T. & Aviram, M., Jun 1 2010, In : Atherosclerosis. 210, 2, p. 414-421 8 p.

Research output: Contribution to journalArticle

Synthetic dimyristoylphosphatidylcholine liposomes assimilating into high-density lipoprotein promote regression of atherosclerotic lesions in cholesterol-fed rabbits

Simon Cho, B. H., Park, J. R., Nakamura, M. T., Odintsov, B. M., Wallig, M. A. & Chung, B. H., Oct 2010, In : Experimental Biology and Medicine. 235, 10, p. 1194-1203 10 p.

Research output: Contribution to journalArticle

2009

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration

Stroud, C. K., Nara, T. Y., Roqueta-Rivera, M., Radlowski, E. C., Lawrence, P., Zhang, Y., Cho, B. H., Segre, M., Hess, R. A., Brenna, J. T., Haschek, W. M. & Nakamura, M. T., 2009, In : Journal of Lipid Research. 50, 9, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus

Koo, H. Y., Miyashita, M., Simon Cho, B. H. & Nakamura, M. T., Dec 11 2009, In : Biochemical and Biophysical Research Communications. 390, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

2008

Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver

Koo, H. Y., Wallig, M. A., Chung, B. H., Nara, T. Y., Cho, B. H. S. & Nakamura, M. T., May 2008, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1782, 5, p. 341-348 8 p.

Research output: Contribution to journalArticle

2006

A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats

Baum, J. I., Layman, D. K., Freund, G. G., Rahn, K. A., Nakamura, M. T. & Yudell, B. E., Jul 6 2006, In : Journal of Nutrition. 136, 7, p. 1855-1861 7 p.

Research output: Contribution to journalArticle

Dietary lycopene downregulates carotenoid 15,15′-monooxygenase and PPAR-γ in selected rat tissues

Zaripheh, S., Nara, T. Y., Nakamura, M. T. & Erdman, J. W., Apr 2006, In : Journal of Nutrition. 136, 4, p. 932-938 7 p.

Research output: Contribution to journalArticle

Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase

Adamson, A. W., Suchankova, G., Rufo, C., Nakamura, M. T., Teran-Garcia, M., Clarke, S. D. & Gettys, T. W., Oct 15 2006, In : Biochemical Journal. 399, 2, p. 285-295 11 p.

Research output: Contribution to journalArticle

Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats

Campbell, J. K., Stroud, C. K., Nakamura, M. T., Lila, M. A. & Erdman, J. W., Nov 1 2006, In : Journal of Nutrition. 136, 11, p. 2813-2819 7 p.

Research output: Contribution to journalArticle

2005

Peroxisome proliferator-activated receptor α is required for feedback regulation of highly unsaturated fatty acid synthesis

Li, Y., Nara, T. Y. & Nakamura, M. T., Nov 2005, In : Journal of Lipid Research. 46, 11, p. 2432-2440 9 p.

Research output: Contribution to journalArticle

2004

Mechanisms of regulation of gene expression by fatty acids

Nakamura, M. T., Cheon, Y., Li, Y. & Nara, T. Y., Nov 2004, In : Lipids. 39, 11, p. 1077-1083 7 p.

Research output: Contribution to journalArticle

Structure, function, and dietary regulation of Δ6, Δ5, and Δ9 desaturases

Nakamura, M. T. & Nara, T. Y., 2004, In : Annual Review of Nutrition. 24, p. 345-376 32 p.

Research output: Contribution to journalReview article

2003

Essential fatty acid synthesis and its regulation in mammals

Nakamura, M. T. & Nara, T. Y., Feb 1 2003, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 68, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

Regulation of human Δ-6 desaturase gene transcription: Identification of a functional direct repeat-1 element

Tang, C., Cho, H. P., Nakamura, M. T. & Clarke, S. D., Apr 1 2003, In : Journal of Lipid Research. 44, 4, p. 686-695 10 p.

Research output: Contribution to journalArticle

2002

Delayed induction of Δ-6 and Δ-5 desaturases by a peroxisome proliferator

He, W. S., Nara, T. Y. & Nakamura, M. T., 2002, In : Biochemical and Biophysical Research Communications. 299, 5, p. 832-838 7 p.

Research output: Contribution to journalArticle

Gene regulation of mammalian desaturases

Nakamura, M. T. & Nara, T. Y., Nov 2002, In : Biochemical Society transactions. 30, 6, p. 1076-1079 4 p.

Research output: Contribution to journalArticle

NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription

Teran-Garcia, M. D. L., Rufo, C., Nakamura, M. T., Clarke, S. D. & Osborne, T. F., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 290, 4, p. 1295-1299 5 p.

Research output: Contribution to journalArticle

The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids

Nara, T. Y., He, W. S., Tang, C., Clarke, S. D. & Nakamura, M. T., 2002, In : Biochemical and Biophysical Research Communications. 296, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

2001

Involvement of a Unique Carbohydrate-responsive Factor in the Glucose Regulation of Rat Liver Fatty-acid Synthase Gene Transcription

Rufo, C., Teran-Garcia, M., Nakamura, M. T., Koo, S. H., Towle, H. C. & Clarke, S. D., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21969-21975 7 p.

Research output: Contribution to journalArticle

Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay

Xu, J., Teran-Garcia, M., Park, J. H. Y., Nakamura, M. T. & Clarke, S. D., Mar 30 2001, In : Journal of Biological Chemistry. 276, 13, p. 9800-9807 8 p.

Research output: Contribution to journalArticle

2000

Regulation of hepatic Δ-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice

Nakamura, M. T., Cho, H. P. & Clarke, S. D., Jun 20 2000, In : Journal of Nutrition. 130, 6, p. 1561-1565 5 p.

Research output: Contribution to journalArticle

1999

Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase

Cho, H. P., Nakamura, M. & Clarke, S. D., Dec 24 1999, In : Journal of Biological Chemistry. 274, 52, p. 37335-37339 5 p.

Research output: Contribution to journalArticle

Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase

Cho, H. P., Nakamura, M. T. & Clarke, S. D., Jan 1 1999, In : Journal of Biological Chemistry. 274, 1, p. 471-477 7 p.

Research output: Contribution to journalArticle

Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition

Baillie, R. A., Takada, R., Nakamura, M. & Clarke, S. D., Jan 1 1999, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 60, 5-6, p. 351-356 6 p.

Research output: Contribution to journalArticle

Identification of a novel enhancer sequence in the distal promoter of the rat fatty acid synthase gene

Rufo, C., Gasperikova, D., Clarke, S. D., Teran-Garcia, M. & Nakamura, M. T., Aug 2 1999, In : Biochemical and Biophysical Research Communications. 261, 2, p. 400-405 6 p.

Research output: Contribution to journalArticle

1998

Mapping glucocorticoid response sequences (GRE) in the 5′-flanking region of rat Fatty Acid Synthase (FAS) gene

Rufo, C., Teran-Garcia, M., Nakamura, M. T. & Clarke, S. D., Mar 20 1998, In : FASEB Journal. 12, 5, p. A832

Research output: Contribution to journalArticle

1997

Fatty acid regulation of gene expression: Its role in fuel partitioning and insulin resistance

Clarke, S. D., Baillie, R., Jump, D. B. & Nakamura, M. T., Jan 1 1997, In : Annals of the New York Academy of Sciences. 827, p. 178-187 10 p.

Research output: Contribution to journalArticle