Liviu Mihail Mirica

20022019
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Research Output 2002 2019

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2019

Aerobic C-C and C-O bond formation reactions mediated by high-valent nickel species

Smith, S. M., Planas, O., Gómez, L., Rath, N. P., Ribas, X. & Mirica, L. M., Jan 1 2019, In : Chemical Science. 10, 44, p. 10366-10372 7 p.

Research output: Contribution to journalArticle

Open Access
Nickel
Oxidants
Ligands
Oxygenases
Catalysis

Axial Donor Effects on Oxidatively Induced Ethane Formation from Nickel-Dimethyl Complexes

Smith, S. M., Rath, N. P. & Mirica, L. M., Oct 14 2019, In : Organometallics. 38, 19, p. 3602-3609 8 p.

Research output: Contribution to journalArticle

Ethane
Nickel
ethane
nickel
Ligands

Mononuclear Organometallic Pd(II), Pd(III), and Pd(IV) Complexes Stabilized by a Pyridinophane Ligand with a C-Donor Group

Ruhs, N. P., Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Oct 14 2019, In : Organometallics. 38, 19, p. 3834-3843 10 p.

Research output: Contribution to journalArticle

Organometallics
Bromotrichloromethane
Bearings (structural)
Chemical activation
Ligands
2018

Azo-dyes based small bifunctional molecules for metal chelation and controlling amyloid formation

Rana, M., Cho, H. J., Roy, T. K., Mirica, L. M. & Sharma, A. K., Feb 24 2018, In : Inorganica Chimica Acta. 471, p. 419-429 11 p.

Research output: Contribution to journalArticle

Azo Compounds
chelation
Azo dyes
Chelation
Amyloid

Electronic: Versus steric effects of pyridinophane ligands on Pd(III) complexes

Tang, F., Park, S. V., Rath, N. P. & Mirica, L. M., Jan 1 2018, In : Dalton Transactions. 47, 4, p. 1151-1158 8 p.

Research output: Contribution to journalArticle

Open Access
Ligands
Discrete Fourier transforms
Electronic properties
X ray crystallography
Molecular orbitals
2017

Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer's Disease

Sharma, A. K., Schultz, J. W., Prior, J. T., Rath, N. P. & Mirica, L. M., Nov 20 2017, In : Inorganic Chemistry. 56, 22, p. 13801-13814 14 p.

Research output: Contribution to journalArticle

Open Access
Positron emission tomography
positrons
tomography
chemistry
Imaging techniques

Engineered holocytochrome c synthases that biosynthesize new cytochromes c

Mendez, D. L., Babbitt, S. E., King, J. D., D'Alessandro, J., Watson, M. B., Blankenship, R. E., Mirica, L. M. & Kranz, R. G., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2235-2240 6 p.

Research output: Contribution to journalArticle

Open Access
Cytochromes c
Ligands
Heme
Sulfides
Circular Dichroism

Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer's Disease

Bandara, N., Sharma, A. K., Krieger, S., Schultz, J. W., Han, B. H., Rogers, B. E. & Mirica, L. M., Jan 1 2017, In : Journal of the American Chemical Society. 139, 36, p. 12550-12558 9 p.

Research output: Contribution to journalArticle

Open Access
Radiopharmaceuticals
peptide
Peptides
Alzheimer Disease
Imaging techniques

Improved synthesis of symmetrically & asymmetrically: N -substituted pyridinophane derivatives

Wessel, A. J., Schultz, J. W., Tang, F., Duan, H. & Mirica, L. M., Jan 1 2017, In : Organic and Biomolecular Chemistry. 15, 46, p. 9923-9931 9 p.

Research output: Contribution to journalArticle

Open Access
Ligands
Derivatives
ligands
synthesis
Column chromatography

Mononuclear Rhodium(II) and Iridium(II) Complexes Supported by Tetradentate Pyridinophane Ligands

Fuchigami, K., Rath, N. P. & Mirica, L. M., Aug 21 2017, In : Inorganic Chemistry. 56, 16, p. 9404-9408 5 p.

Research output: Contribution to journalArticle

Iridium
Rhodium
crack opening displacement
iridium
rhodium

Oxidative C-C bond formation reactivity of organometallic Ni(II), Ni(III), and Ni(IV) complexes

Watson, M. B., Rath, N. P. & Mirica, L. M., Jan 11 2017, In : Journal of the American Chemical Society. 139, 1, p. 35-38 4 p.

Research output: Contribution to journalArticle

Open Access
Organometallics
ligand
Ligands
oxidation
Oxidation

The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Cascella, B., Lee, S. G., Singh, S., Jez, J. M. & Mirica, L. M., Jan 1 2017, In : Chemical Communications. 53, 13, p. 2174-2177 4 p.

Research output: Contribution to journalArticle

Histone Demethylases
Assays
Crystal structure
X rays
Molecules
2016

Aromatic cyanoalkylation through double c-h activation mediated by Ni(III)

Zhou, W., Zheng, S., Schultz, J. W., Rath, N. P. & Mirica, L. M., May 11 2016, In : Journal of the American Chemical Society. 138, 18, p. 5777-5780 4 p.

Research output: Contribution to journalArticle

Nitriles
Chemical activation
substrate
economics
Economics

Evidence for a cysteine-mediated mechanism of excitation energy regulation in a photosynthetic antenna complex

Orf, G. S., Saer, R. G., Niedzwiedzki, D. M., Zhang, H., McIntosh, C. L., Schultz, J. W., Mirica, L. M. & Blankenship, R. E., Aug 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. E4486-E4493

Research output: Contribution to journalArticle

Open Access
Photosynthetic Reaction Center Complex Proteins
Bacteriochlorophylls
Cysteine
Carotenoids
Mutagenesis

Isolated Organometallic Nickel(III) and Nickel(IV) Complexes Relevant to Carbon-Carbon Bond Formation Reactions

Schultz, J. W., Fuchigami, K., Zheng, B., Rath, N. P. & Mirica, L. M., Oct 5 2016, In : Journal of the American Chemical Society. 138, 39, p. 12928-12934 7 p.

Research output: Contribution to journalArticle

Cross Reactions
Organometallics
Nickel
Oxidants
nickel

Ligand effects on the properties of Ni(III) complexes: Aerobically-induced aromatic cyanation at room temperature

Zhou, W., Watson, M. B., Zheng, S., Rath, N. P. & Mirica, L. M., Jan 1 2016, In : Dalton Transactions. 45, 40, p. 15886-15893 8 p.

Research output: Contribution to journalArticle

Ligands
X ray crystallography
Organometallics
Amines
Paramagnetic resonance

Oxidatively-induced aromatic cyanation mediated by Ni(III)

Zhou, W., Rath, N. P. & Mirica, L. M., Jan 1 2016, In : Dalton Transactions. 45, 21, p. 8693-8695 3 p.

Research output: Contribution to journalArticle

Ligands
Oxidants

Perturbation of the O-U-O Angle in Uranyl by Coordination to a 12-Membered Macrocycle

Pedrick, E. A., Schultz, J. W., Wu, G., Mirica, L. M. & Hayton, T. W., Jun 6 2016, In : Inorganic Chemistry. 55, 11, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

Powders
Ligands
perturbation
X ray crystallography
ligands
2015

Aromatic Methoxylation and Hydroxylation by Organometallic High-Valent Nickel Complexes

Zhou, W., Schultz, J. W., Rath, N. P. & Mirica, L. M., Jun 24 2015, In : Journal of the American Chemical Society. 137, 24, p. 7604-7607 4 p.

Research output: Contribution to journalArticle

Hydroxylation
Organometallics
Nickel
Oxidants
nickel

Stable bis(trifluoromethyl)nickel(III) complexes

Tang, F., Rath, N. P. & Mirica, L. M., Feb 21 2015, In : Chemical Communications. 51, 15, p. 3113-3116 4 p.

Research output: Contribution to journalArticle

Organometallics
Nickel
Ligands
Oxidation
2014

Dioxygen activation by an organometallic Pd(II) precursor: Formation of a Pd(IV)-OH complex and its C-O bond formation reactivity

Qu, F., Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Mar 21 2014, In : Chemical Communications. 50, 23, p. 3036-3039 4 p.

Research output: Contribution to journalArticle

Hydroxylation
Thermolysis
Organometallics
Chemical activation
Oxygen

Organometallic nickel(III) complexes relevant to cross-coupling and carbon-heteroatom bond formation reactions

Zheng, B., Tang, F., Luo, J., Schultz, J. W., Rath, N. P. & Mirica, L. M., Apr 30 2014, In : Journal of the American Chemical Society. 136, 17, p. 6499-6504 6 p.

Research output: Contribution to journalArticle

Cross Reactions
Organometallics
Nickel
nickel
Carbon

Small bifunctional chelators that do not disaggregate amyloid β fibrils exhibit reduced cellular toxicity

Sharma, A. K., Kim, J., Prior, J. T., Hawco, N. J., Rath, N. P., Kim, J. & Mirica, L. M., Nov 3 2014, In : Inorganic Chemistry. 53, 21, p. 11367-11376 10 p.

Research output: Contribution to journalArticle

Open Access
Chelating Agents
Amyloid
toxicity
Toxicity
Metals

The conformational flexibility of the tetradentate ligand tBuN4 is essential for the stabilization of (tBuN4)PdIII complexes

Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Dec 15 2014, In : Inorganic Chemistry. 53, 24, p. 13112-13129 18 p.

Research output: Contribution to journalArticle

flexibility
Stabilization
stabilization
Ligands
ligands
2013

Late first-row transition metal complexes of a tetradentate pyridinophane ligand: Electronic properties and reactivity implications

Khusnutdinova, J. R., Luo, J., Rath, N. P. & Mirica, L. M., Apr 1 2013, In : Inorganic Chemistry. 52, 7, p. 3920-3932 13 p.

Research output: Contribution to journalArticle

Coordination Complexes
Electronic properties
Transition metals
reactivity
transition metals

Oxidative reactivity of (N2S2)PdRX complexes (R = Me, Cl; X = Me, Cl, Br): Involvement of palladium(III) and palladium(IV) intermediates

Luo, J., Rath, N. P. & Mirica, L. M., Jun 10 2013, In : Organometallics. 32, 11, p. 3343-3353 11 p.

Research output: Contribution to journalArticle

Palladium
palladium
reactivity
Oxidation
oxidation

Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

Zhang, Y., Rempel, D. L., Zhang, J., Sharma, A. K., Mirica, L. M. & Gross, M. L., Sep 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. 14604-14609 6 p.

Research output: Contribution to journalArticle

Open Access
Deuterium
Amyloid beta-Peptides
Hydrogen
Mass Spectrometry
Amyloidogenic Proteins

The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

Sharma, A. K., Pavlova, S. T., Kim, J., Kim, J. & Mirica, L. M., Nov 1 2013, In : Metallomics. 5, 11, p. 1529-1536 8 p.

Research output: Contribution to journalArticle

Peptides
Metal ions
Toxicity
Oligomerization
Agglomeration
2012

Bifunctional compounds for controlling metal-mediated aggregation of the Aβ 42 peptide

Sharma, A. K., Pavlova, S. T., Kim, J., Finkelstein, D., Hawco, N. J., Rath, N. P., Kim, J. & Mirica, L. M., Apr 18 2012, In : Journal of the American Chemical Society. 134, 15, p. 6625-6636 12 p.

Research output: Contribution to journalArticle

peptide
Peptides
Agglomeration
Amyloid
Metals

Cycloaddition reactivity studies of first-row transition metal-azide complexes and alkynes: An inorganic click reaction for metalloenzyme inhibitor synthesis

Evangelio, E., Rath, N. P. & Mirica, L. M., Jul 14 2012, In : Dalton Transactions. 41, 26, p. 8010-8021 12 p.

Research output: Contribution to journalArticle

Alkynes
Azides
Cycloaddition
Metal complexes
Transition metals

Detection of Pd(III) and Pd(IV) intermediates during the aerobic oxidative C-C bond formation from a Pd(II) dimethyl complex

Tang, F., Zhang, Y., Rath, N. P. & Mirica, L. M., Sep 24 2012, In : Organometallics. 31, 18, p. 6690-6696 7 p.

Research output: Contribution to journalArticle

Ethane
ethane
elimination
Organometallics
Paramagnetic resonance

Formation of the palladium(IV) complex [(Me 3tacn)Pd IVMe 3] + through aerobic oxidation of (Me 3tacn)Pd IIMe 2 (Me 3tacn = N, N ′, N ″-trimethyl-1,4,7-triazacyclononane)

Khusnutdinova, J. R., Qu, F., Zhang, Y., Rath, N. P. & Mirica, L. M., Jul 9 2012, In : Organometallics. 31, 13, p. 4627-4630 4 p.

Research output: Contribution to journalArticle

Palladium
palladium
Oxidation
oxidation
Ethane
Histone Demethylases
Jumonji Domain-Containing Histone Demethylases
Histones
Assays
Iron

Structural and reactivity comparison of analogous organometallic Pd(iii) and Pd(iv) complexes

Tang, F., Qu, F., Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Dec 14 2012, In : Dalton Transactions. 41, 46, p. 14046-14050 5 p.

Research output: Contribution to journalArticle

Organometallics
Ligands
Oxidation
Geometry
Metals

The aerobic oxidation of a Pd(II) dimethyl complex leads to selective ethane elimination from a Pd(III) intermediate

Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Feb 1 2012, In : Journal of the American Chemical Society. 134, 4, p. 2414-2422 9 p.

Research output: Contribution to journalArticle

Ethane
ethane
Oxidative Coupling
oxidation
Oxidation

Unsupported d 8-d 8 interactions in cationic Pd II and Pt II complexes: Evidence for a significant metal-metal bonding character

Luo, J., Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Feb 1 2012, In : Chemical Communications. 48, 10, p. 1532-1534 3 p.

Research output: Contribution to journalArticle

Metals
Ligands
2011

Dinuclear Co(II)Co(III) mixed-valence and Co(III)Co(III) complexes with N- and O-donor ligands: Characterization and water oxidation studies

Luo, J., Rath, N. P. & Mirica, L. M., Jul 4 2011, In : Inorganic Chemistry. 50, 13, p. 6152-6157 6 p.

Research output: Contribution to journalArticle

Ligands
valence
Oxidation
ligands
oxidation
Palladium
Ligands
Oxidation
Alkenes
Olefins
2010

Stable mononuclear organometallic Pd(III) complexes and their C-C bond formation reactivity

Khusnutdinova, J. R., Rath, N. P. & Mirica, L. M., Jun 2 2010, In : Journal of the American Chemical Society. 132, 21, p. 7303-7305 3 p.

Research output: Contribution to journalArticle

Ethane
ethane
Organometallics
electron spin resonance
X-Ray Diffraction
2009

Galactose oxidase as a model for reactivity at a copper superoxide center

Humphreys, K. J., Mirica, L. M., Wang, Y. & Klinman, J. P., Apr 8 2009, In : Journal of the American Chemical Society. 131, 13, p. 4657-4663 7 p.

Research output: Contribution to journalArticle

Galactose Oxidase
Superoxides
Isotopes
Copper
Deuterium

Reaction coordinate of a functional model of tyrosinase: Spectroscopic and computational characterization

Holt, B. T. O. T., Vance, M. A., Mirica, L. M., Heppner, D. E., Stack, T. D. P. & Solomon, E. I., May 13 2009, In : Journal of the American Chemical Society. 131, 18, p. 6421-6438 18 p.

Research output: Contribution to journalArticle

ethylenediamine
Monophenol Monooxygenase
Copper
Oxygen
copper
2008

18O kinetic isotope effects in non-heme iron enzymes: Probing the nature of Fe/O2 intermediates

Mirica, L. M., McCusker, K. P., Munos, J. W., Liu, H. W. & Klinman, J. P., Jul 2 2008, In : Journal of the American Chemical Society. 130, 26, p. 8122-8123 2 p.

Research output: Contribution to journalArticle

Enzyme kinetics
Isotopes
Iron
Enzymes
isotope
Open Access
Isotopes
Iron
Oxygen Isotopes
Plant Growth Regulators
Plant Development
2007

Partial conversion of Hansenula polymorpha amine oxidase into a "plant" amine oxidase: Implications for copper chemistry and mechanism

Welford, R. W. D., Lam, A., Mirica, L. M. & Klinman, J. P., Sep 25 2007, In : Biochemistry. 46, 38, p. 10817-10827 11 p.

Research output: Contribution to journalArticle

Amine Oxidase (Copper-Containing)
Pichia
Amines
Oxidoreductases
Electrons
2006

Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates

Thrower, J., Mirica, L. M., McCusker, K. P. & Klinman, J. P., Oct 31 2006, In : Biochemistry. 45, 43, p. 13108-13117 10 p.

Research output: Contribution to journalArticle

Substrates
Decarboxylation
Glycine
Amines
Iron

μ-η22-peroxodicopper(II) complex with a secondary diamine ligand: A functional model of tyrosinase

Mirica, L. M., Rudd, D. J., Vance, M. A., Solomon, E. I., Hodgson, K. O., Hedman, B. & Stack, T. D. P., Mar 1 2006, In : Journal of the American Chemical Society. 128, 8, p. 2654-2665 12 p.

Research output: Contribution to journalArticle

ethylenediamine
Diamines
Monophenol Monooxygenase
ligand
Ligands
2005

A tris(μ-hydroxy)tricopper(II) complex as a model of the native intermediate in laccase and its relationship to a binuclear analogue

Mirica, L. M. & Stack, T. D. P., Apr 7 2005, In : Inorganic Chemistry. 44, 7, p. 2131-2133 3 p.

Research output: Contribution to journalArticle

Laccase
Diamines
Copper
Oxidoreductases
analogs

Bis(μ-oxo)dicopper(III) complexes of a homologous series of simple peralkylated 1,2-diamines: Steric modulation of structure, stability, and reactivity

Cole, A. P., Mahadevan, V., Mirica, L. M., Ottenwaelder, X. & Stack, T. D. P., Oct 17 2005, In : Inorganic Chemistry. 44, 21, p. 7345-7364 20 p.

Research output: Contribution to journalArticle

Diamines
diamines
reactivity
Modulation
Ligands

Chemistry: Tyrosinase reactivity in a model complex: An alternative hydroxylation mechanism

Mirica, L. M., Vance, M., Rudd, D. J., Hedman, B., Hodgson, K. O., Solomon, E. I. & Stack, T. D. P., Jun 24 2005, In : Science. 308, 5730, p. 1890-1892 3 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Hydroxylation
Catechols
Phenols
Phenol
Dichroism
Magnetic Fields
Circular Dichroism
Oxidoreductases
Metals