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Article
2020

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Byun, S., Seok, S., Kim, Y. C., Zhang, Y., Yau, P., Iwamori, N., Xu, H. E., Ma, J., Kemper, B. & Kemper, J. K., Dec 1 2020, In : Nature communications. 11, 1, 807.

Research output: Contribution to journalArticle

Open Access
2019

MicroRNA-210 Promotes Bile Acid–Induced Cholestatic Liver Injury by Targeting Mixed-Lineage Leukemia-4 Methyltransferase in Mice

Kim, Y. C., Jung, H., Seok, S., Zhang, Y., Ma, J., Li, T., Kemper, B. & Kemper, J. K., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis

Byun, S., Jung, H., Chen, J., Kim, Y. C., Kim, D. H., Kong, B., Guo, G., Kemper, B. & Kemper, J. K., May 31 2019, In : Journal of Biological Chemistry. 294, 22, p. 8732-8744 13 p.

Research output: Contribution to journalArticle

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

Kim, Y. C., Byun, S., Seok, S., Guo, G., Xu, H. E., Kemper, B. & Kemper, J. K., Mar 2019, In : Gastroenterology. 156, 4, p. 1052-1065 14 p.

Research output: Contribution to journalArticle

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

Shahoei, S. H., Kim, Y. C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K. & Nelson, E. R., Jan 1 2019, In : Endocrinology. 160, 7, p. 1573-1589 17 p.

Research output: Contribution to journalArticle

2018

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

Kim, Y. C., Seok, S., Byun, S., Kong, B., Zhang, Y., Guo, G., Xie, W., Ma, J., Kemper, B. & Kemper, J. K., Dec 1 2018, In : Nature communications. 9, 1, 540.

Research output: Contribution to journalArticle

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ß-oxidation

Seok, S., Kim, Y. C., Byun, S., Choi, S., Xiao, Z., Iwamori, N., Zhang, Y., Wang, C., Ma, J., Ge, K., Kemper, B. & Kemper, J. K., Jul 2 2018, In : Journal of Clinical Investigation. 128, 7, p. 3144-3159 16 p.

Research output: Contribution to journalArticle

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Byun, S., Kim, D. H., Ryerson, D., Kim, Y. C., Sun, H., Kong, B., Yau, P., Guo, G., Eric Xu, H., Kemper, B. & Kemper, J. K., Dec 1 2018, In : Nature communications. 9, 1, 2590.

Research output: Contribution to journalArticle

2017

A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy

Byun, S., Kim, Y. C., Zhang, Y., Kong, B., Guo, G., Sadoshima, J., Ma, J., Kemper, B. & Kemper, J. K., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1755-1769 15 p.

Research output: Contribution to journalArticle

Obesity-linked phosphorylation of SIRT1 by casein kinase 2 inhibits its nuclear localization and promotes fatty liver

Choi, S. E., Kwon, S., Seok, S., Xiao, Z., Lee, K. W., Kang, Y., Li, X., Shinoda, K., Kajimura, S., Kemper, B. & Kemper, J. K., Aug 1 2017, In : Molecular and cellular biology. 37, 15, e00006-17.

Research output: Contribution to journalArticle

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, A. E., Yu, Y. R. A., He, S., Wardell, S. E., Chang, C. Y., Kwon, S., Pillai, R. V., McDowell, H. B., Thompson, J. W., Dubois, L. G., Sullivan, P. M., Kemper, J. K., Gunn, M. D., McDonnell, D. P. & Nelson, E. R., Dec 1 2017, In : Nature communications. 8, 1, 864.

Research output: Contribution to journalArticle

2016

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Kim, D. H., Kwon, S., Byun, S., Xiao, Z., Park, S., Wu, S. Y., Chiang, C. M., Kemper, B. & Kemper, J. K., Jul 14 2016, In : Nature communications. 7, 12179.

Research output: Contribution to journalArticle

FXR primes the liver for intestinal FGF15 signaling by transient induction of β-Klotho

Fu, T., Kim, Y. C., Byun, S., Kim, D. H., Seok, S., Suino-Powell, K., Eric Xu, H., Kemper, B. & Kemper, J. K., Jan 2016, In : Molecular Endocrinology. 30, 1, p. 92-103 12 p.

Research output: Contribution to journalArticle

2015

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Kim, D. H., Xiao, Z., Kwon, S., Sun, X., Ryerson, D., Tkac, D., Ma, P., Wu, S. Y., Chiang, C. M., Zhou, E., Xu, H. E., Palvimo, J. J., Chen, L. F., Kemper, B. & Kemper, J. K., Jan 14 2015, In : EMBO Journal. 34, 2, p. 184-199 16 p.

Research output: Contribution to journalArticle

Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2

Kim, Y. C., Byun, S., Zhang, Y., Seok, S., Kemper, B., Ma, J. & Kemper, J. K., Dec 4 2015, In : Genome biology. 16, 1, 268.

Research output: Contribution to journalArticle

2014

MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function

Fu, T., Seok, S., Choi, S., Huang, Z., Suino-Powell, K., Eric Xu, H., Kemper, B. & Kemper, J. K., Jan 1 2014, In : Molecular and cellular biology. 34, 22, p. 4130-4142 13 p.

Research output: Contribution to journalArticle

Transcriptional regulation of autophagy by an FXR-CREB axis

Seok, S., Fu, T., Choi, S. E., Li, Y., Zhu, R., Kumar, S., Sun, X., Yoon, G., Kang, Y., Zhong, W., Ma, J., Kemper, B. & Kemper, J. K., Dec 4 2014, In : Nature. 516, 729, p. 108-111 4 p.

Research output: Contribution to journalArticle

2013

Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes

Seok, S., Kanamaluru, D., Xiao, Z., Ryerson, D., Choi, S. E., Suino-Powell, K., Xu, H. E., Veenstra, T. D. & Kemper, J. K., Aug 9 2013, In : Journal of Biological Chemistry. 288, 32, p. 23252-23263 12 p.

Research output: Contribution to journalArticle

Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT

Choi, S. E., Fu, T., Seok, S., Kim, D. H., Yu, E., Lee, K. W., Kang, Y., Li, X., Kemper, B. & Kemper, J. K., Dec 1 2013, In : Aging Cell. 12, 6, p. 1062-1072 11 p.

Research output: Contribution to journalArticle

2012

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

Fu, T., Choi, S. E., Kim, D. H., Seok, S., Suino-Powell, K. M., Xu, H. E. & Kemper, J. K., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16137-16142 6 p.

Research output: Contribution to journalArticle

Cross-regulation of protein stability by p53 and nuclear receptor SHP

Yang, Z., Zhang, Y., Kemper, J. K. & Wang, L., Jun 21 2012, In : PloS one. 7, 6, e39789.

Research output: Contribution to journalArticle

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice

Lee, J., Seok, S., Yu, P., Kim, K., Smith, Z., Rivas-Astroza, M., Zhong, S. & Kemper, J. K., Jul 1 2012, In : Hepatology. 56, 1, p. 108-117 10 p.

Research output: Contribution to journalArticle

Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice

Purushotham, A., Xu, Q., Lu, J., Foley, J. F., Yan, X., Kim, D. H., Kemper, J. K. & Li, X., Apr 1 2012, In : Molecular and cellular biology. 32, 7, p. 1226-1236 11 p.

Research output: Contribution to journalArticle

2011

Arginine methylation by PRMT5 at a naturally occurring mutation site Is critical for liver metabolic regulation by small heterodimer partner

Kanamaluru, D., Xiao, Z., Fang, S., Choi, S. E., Kim, D. H., Veenstra, T. D. & Kemper, J. K., Apr 1 2011, In : Molecular and cellular biology. 31, 7, p. 1540-1550 11 p.

Research output: Contribution to journalArticle

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes

Miao, J., Choi, S. E., Seok, S. M., Yang, L., Zuercher, W. J., Xu, Y., Willson, T. M., Eric Xu, H. & Kemper, J. K., Jul 1 2011, In : Molecular Endocrinology. 25, 7, p. 1159-1169 11 p.

Research output: Contribution to journalArticle

2010

A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via MicroRNA-34a inhibition

Lee, J., Padhye, A., Sharma, A., Song, G., Miao, J., Mo, Y. Y., Wang, L. & Kemper, J. K., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12604-12611 8 p.

Research output: Contribution to journalArticle

Controlling SIRT1 expression by microRNAs in health and metabolic disease

Lee, J. & Kemper, J. K., Aug 2010, In : Aging. 2, 8, p. 527-534 8 p.

Research output: Contribution to journalArticle

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

Ponugoti, B., Kim, D. H., Xiao, Z., Smith, Z., Miao, J., Zang, M., Wu, S. Y., Chiang, C. M., Veenstra, T. D. & Kemper, J. K., Oct 29 2010, In : Journal of Biological Chemistry. 285, 44, p. 33959-33970 12 p.

Research output: Contribution to journalArticle

2009

Bile acid signaling pathways increase stability of small heterodimer partner (SHP) by inhibiting ubiquitin-proteasomal degradation

Miao, J., Xiao, Z., Kanamaluru, D., Min, G., Yau, P. M., Veenstra, T. D., Ellis, E., Strom, S., Suino-Powell, K., Xu, H. E. & Kemper, J. K., Apr 15 2009, In : Genes and Development. 23, 8, p. 986-996 11 p.

Research output: Contribution to journalArticle

Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis

Miao, J., Fang, S., Lee, J., Comstock, C., Knudsen, K. E. & Kemper, J. K., Dec 1 2009, In : Molecular and cellular biology. 29, 23, p. 6170-6181 12 p.

Research output: Contribution to journalArticle

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

Kemper, J. K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S. Y., Chiang, C. M. & Veenstra, T. D., Nov 4 2009, In : Cell Metabolism. 10, 5, p. 392-404 13 p.

Research output: Contribution to journalArticle

2008

The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP

Fang, S., Tsang, S., Jones, R., Ponugoti, B., Yoon, H., Wu, S. Y., Chiang, C. M., Willson, T. M. & Kemper, J. K., Dec 12 2008, In : Journal of Biological Chemistry. 283, 50, p. 35086-35095 10 p.

Research output: Contribution to journalArticle

2007

Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism

Fang, S., Miao, J., Xiang, L., Ponugoti, B., Treuter, E. & Kemper, J. K., Feb 1 2007, In : Molecular and cellular biology. 27, 4, p. 1407-1424 18 p.

Research output: Contribution to journalArticle

2006

Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2

Zhang, Q., Bae, Y., Kemper, J. K. & Kemper, B., Jul 15 2006, In : Archives of Biochemistry and Biophysics. 451, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

Brd4 links chromatin targeting to HPV transcriptional silencing

Wu, S. Y., Lee, A. Y., Hou, S. Y., Kemper, J. K., Erdjument-Bromage, H., Tempst, P. & Chiang, C. M., Sep 1 2006, In : Genes and Development. 20, 17, p. 2383-2396 14 p.

Research output: Contribution to journalArticle

2004

Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites

Petz, L. N., Ziegler, Y. S., Schultz, J. R., Kim, H., Kemper, J. K. & Nardulli, A. M., Feb 1 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 88, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP

Kemper, J. K., Kim, H., Miao, J., Bhalla, S. & Bae, Y., Sep 1 2004, In : Molecular and cellular biology. 24, 17, p. 7707-7719 13 p.

Research output: Contribution to journalArticle

2003

Differential regulation of rat and human CYP7A 1 by the nuclear oxysterol receptor liver X receptor-α

Goodwin, B., Watson, M. A., Kim, H., Miao, J., Kemper, J. K. & Kliewer, S. A., Mar 1 2003, In : Molecular Endocrinology. 17, 3, p. 386-394 9 p.

Research output: Contribution to journalArticle

2002
2001
2000

Regulation of the estrogen-responsive pS2 gene in MCF-7 human breast cancer cells

Kim, J., Petz, L. N., Ziegler, Y. S., Wood, J. R., Potthoff, S. J. & Nardulli, A. M., Nov 15 2000, In : Journal of Steroid Biochemistry and Molecular Biology. 74, 4, p. 157-168 12 p.

Research output: Contribution to journalArticle