Karin Jeanne Jensen

20122019
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Research Output 2012 2019

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Article
2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition letter

Wong, G. S., Zhou, J., Liu, J. B., Wu, Z., Xu, X., Li, T., Xu, D., Schumacher, S. E., Puschhof, J., McFarland, J., Zou, C., Dulak, A., Henderson, L., Xu, P., O'Day, E., Rendak, R., Liao, W. L., Cecchi, F., Hembrough, T., Schwartz, S. & 18 others, Szeto, C., Rustgi, A. K., Wong, K. K., Diehl, J. A., Jensen, K., Graziano, F., Ruzzo, A., Fereshetian, S., Mertins, P., Carr, S. A., Beroukhim, R., Nakamura, K., Oki, E., Watanabe, M., Baba, H., Imamura, Y., Catenacci, D. & Bass, A. J., Jul 1 2018, In : Nature Medicine. 24, 7, p. 968-977 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Amplification
Chemical activation
Neoplasms
Mutation
2016

Network architecture predisposes an enzyme to either pharmacologic or genetic targeting

Jensen, K. J., Moyer, C. B. & Janes, K. A., Feb 24 2016, In : Cell Systems. 2, 2, p. 112-121 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Enzymes
Homeostasis
MAP Kinase Kinase Kinases
Pharmaceutical Preparations
2015

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

Wagenaar, T. R., Tolstykh, T., Shi, C., Jiang, L., Zhang, J., Li, Z., Yu, Q., Qu, H., Sun, F., Cao, H., Pollard, J., Dai, S., Gao, Q., Zhang, B., Arlt, H., Cindhuchao, M., Hoffmann, D., Light, M., Jensen, K., Hopke, J. & 5 others, Newcombe, R., Garcia-Echeverria, C., Winter, C., Zabludoff, S. & Wiederschain, D., Jan 30 2015, In : Nucleic acids research. 43, 2, p. 1204-1215 12 p.

Research output: Contribution to journalArticle

Open Access
Endosomal Sorting Complexes Required for Transport
Neoplasms
Cell Line
RNA Interference
MicroRNAs
2013

An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection

Jensen, K. J., Garmaroudi, F. S., Zhang, J., Lin, J., Boroomand, S., Zhang, M., Luo, Z., Yang, D., Luo, H., McManus, B. M. & Janes, K. A., Jan 16 2013, In : Cell Host and Microbe. 13, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Coxsackievirus Infections
Enterovirus
Necrosis
Apoptosis
Viruses

Simultaneous profiling of 194 distinct receptor transcripts in human cells

Kang, B. H., Jensen, K. J., Hatch, J. A. & Janes, K. A., Aug 6 2013, In : Science Signaling. 6, 287, rs13.

Research output: Contribution to journalArticle

Polymerase chain reaction
Transcription
Reverse Transcription
Cells
Polymerase Chain Reaction
2012

Modeling the latent dimensions of multivariate signaling datasets

Jensen, K. J. & Janes, K. A., Aug 1 2012, In : Physical Biology. 9, 4, 045004.

Research output: Contribution to journalArticle

Systems Biology
Principal Component Analysis
Least-Squares Analysis
Signal Transduction
Proteins

Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma

Roller, D. G., Axelrod, M., Capaldo, B. J., Jensen, K., Mackey, A., Weber, M. J. & Gioeli, D., Nov 1 2012, In : Molecular Cancer Therapeutics. 11, 11, p. 2505-2515 11 p.

Research output: Contribution to journalArticle

Diclofenac
Melanoma
Celecoxib
Drug Combinations
Drug Substitution