John Alan Gerlt

1973 …2019
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Research Output 1973 2019

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Review article
2018

‘Democratized’ genomic enzymology web tools for functional assignment

Zallot, R., Oberg, N. O. & Gerlt, J. A., Dec 1 2018, In : Current Opinion in Chemical Biology. 47, p. 77-85 9 p.

Research output: Contribution to journalReview article

Protein Databases
Genome
Genes
Proteins
Costs and Cost Analysis
2015

Enzyme function initiative-enzyme similarity tool (EFI-EST): A web tool for generating protein sequence similarity networks

Gerlt, J. A., Bouvier, J. T., Davidson, D. B., Imker, H. J., Sadkhin, B., Slater, D. R. & Whalen, K. L., Aug 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 8, p. 1019-1037 19 p.

Research output: Contribution to journalReview article

Enzymes
Proteins
National Institute of General Medical Sciences (U.S.)
Orotidine-5'-Phosphate Decarboxylase
Biota
2011

The enzyme function initiative

Gerlt, J. A., Allen, K. N., Almo, S. C., Armstrong, R. N., Babbitt, P. C., Cronan, J. E., Dunaway-Mariano, D., Imker, H. J., Jacobson, M. P., Minor, W., Poulter, C. D., Raushel, F. M., Sali, A., Shoichet, B. K. & Sweedler, J. V., Nov 22 2011, In : Biochemistry. 50, 46, p. 9950-9962 13 p.

Research output: Contribution to journalReview article

Enzymes
Microbiology
Genes
Amidohydrolases
Genome
2009

Enzyme (re)design: lessons from natural evolution and computation

Gerlt, J. A. & Babbitt, P. C., Feb 1 2009, In : Current Opinion in Chemical Biology. 13, 1, p. 10-18 9 p.

Research output: Contribution to journalReview article

Mutagenesis
Enzymes
Screening
2006

Evolution of enzyme superfamilies

Glasner, M. E., Gerlt, J. A. & Babbitt, P. C., Oct 1 2006, In : Current Opinion in Chemical Biology. 10, 5, p. 492-497 6 p.

Research output: Contribution to journalReview article

Catalysis
Amidohydrolases
Molecular Sequence Annotation
Protein Engineering
Phosphopyruvate Hydratase
2003

Evolution of function in (β/α)8-barrel enzymes

Gerlt, J. A. & Raushel, F. M., Jan 1 2003, In : Current Opinion in Chemical Biology. 7, 2, p. 252-264 13 p.

Research output: Contribution to journalReview article

Enzymes
Databases

How to Find "missing" Genes

Gerlt, J. A., Jan 1 2003, In : Chemistry and Biology. 10, 12, p. 1141-1142 2 p.

Research output: Contribution to journalReview article

Microbial Genome
Metabolic Networks and Pathways
Genes
Proteins
2001

Divergent evolution of enzymatic function: Mechanistically diverse superfamilies and functionally distinct suprafamilies

Gerlt, J. A. & Babbitt, P. C., 2001, In : Annual Review of Biochemistry. 70, p. 209-246 38 p.

Research output: Contribution to journalReview article

Protein Databases
Enzymes
Enoyl-CoA Hydratase
Amidohydrolases
Reaction intermediates
1998

The low barrier hydrogen bond in enzymatic catalysis

Cleland, W. W., Frey, P. A. & Gerlt, J. A., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 25529-25532 4 p.

Research output: Contribution to journalReview article

Serine Endopeptidases
Steroid Isomerases
Triose-Phosphate Isomerase
Racemases and Epimerases
Citrate (si)-Synthase
1997

Understanding enzymic catalysis: The importance of short, strong hydrogen bonds

Gerlt, J. A., Kreevoy, M. M., Cleland, W. W. & Frey, P. A., Jan 1 1997, In : Chemistry and Biology. 4, 4, p. 259-267 9 p.

Research output: Contribution to journalReview article

Catalysis
Hydrogen
Hydrogen bonds
Catalytic Domain
Enzymes
1983

Oxygen chiral phosphate esters.

Gerlt, J. A., Coderre, J. A. & Mehdi, S., Jan 1 1983, In : Advances in enzymology and related areas of molecular biology. 55, p. 291-380 90 p.

Research output: Contribution to journalReview article

Catalysis
Esters
Oxygen Isotopes
Phosphates
Oxygen