John Alan Gerlt

1973 …2019
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Research Output 1973 2019

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Short survey
2012

Divergent evolution in enolase superfamily: Strategies for assigning functions

Gerlt, J. A., Babbitt, P. C., Jacobson, M. P. & Almo, S. C., Jan 2 2012, In : Journal of Biological Chemistry. 287, 1, p. 29-34 6 p.

Research output: Contribution to journalShort survey

Protein Databases
Phosphopyruvate Hydratase
Proteins
Databases
2009

Acetoacetate decarboxylase: Hydrophobics, not electrostatics

Gerlt, J. A., Jul 2009, In : Nature chemical biology. 5, 7, p. 454-455 2 p.

Research output: Contribution to journalShort survey

acetoacetate decarboxylase
X Ray Crystallography
Static Electricity
Catalytic Domain
2002

"Fishing" for the functional proteome

Gerlt, J. A., Jan 1 2002, In : Nature Biotechnology. 20, 8, p. 786-787 2 p.

Research output: Contribution to journalShort survey

Biological Phenomena
Proteome
Proteins
2001

Barrels in pieces?

Gerlt, J. A. & Babbitt, P. C., Jan 19 2001, In : Nature Structural Biology. 8, 1, p. 5-7 3 p.

Research output: Contribution to journalShort survey

Gene encoding
Gene Duplication
Fusion reactions
imidazole glycerol phosphate synthase
2000

New wine from old barrels

Gerlt, J. A., Mar 1 2000, In : Nature Structural Biology. 7, 3, p. 171-173 3 p.

Research output: Contribution to journalShort survey

Indole-3-Glycerol-Phosphate Synthase
Wine
DNA Shuffling
Mutagenesis
Biosynthesis
1997

Understanding enzyme superfamilies. Chemistry as the fundamental determinant in the evolution of new catalytic activities

Babbitt, P. C. & Gerlt, J. A., Dec 5 1997, In : Journal of Biological Chemistry. 272, 49, p. 30591-30594 4 p.

Research output: Contribution to journalShort survey

Catalyst activity
Enzymes
Scaffolds
Gene Duplication
Substrates