John Alan Gerlt

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1989

Isotopic labeling with hydrogen-2 and carbon-13 to compare conformations of proteins and mutants generated by site-directed mutagenesis, II

Wilde, J. A., Bolton, P. H., Hibler, D. W., Harpold, L., Pourmotabbed, T., Dell'Acqua, M. & Gerlt, J. A., Jan 1 1989, In : Methods in enzymology. 177, C, p. 282-292 11 p.

Research output: Contribution to journalArticle

Kinetic and Magnetic Resonance Studies of the Glutamate-43 to Serine Mutant of Staphylococcal Nuclease

Serpersu, E. H., Hibler, D. W., Gerlt, J. A. & Mildvan, A. S., 1989, In : Biochemistry. 28, 4, p. 1539-1548 10 p.

Research output: Contribution to journalArticle

Observation and Sequence Assignment of a Cis Prolyl Peptide Bond in Unliganded Staphylococcal Nuclease

Stanczyk, S. M., Bolton, P. H., Dell'Acqua, M. & Gerlt, J. A., Oct 1 1989, In : Journal of the American Chemical Society. 111, 21, p. 8317-8318 2 p.

Research output: Contribution to journalArticle

Selection and Characterization of a Mutant of the Cloned Gene for Mandelate Racemase That Confers Resistance to an Affinity Label by Greatly Enhanced Production of Enzyme

Tsou, A. Y., Ransom, S. C., Gerlt, J. A., Powers, V. M. & Kenyon, G. L., 1989, In : Biochemistry. 28, 3, p. 969-975 7 p.

Research output: Contribution to journalArticle

Site-specific 13C labeling of DNA to deduce DNA repair mechanisms of uracil-DNA glycosylase and UV endonuclease V

Manoharan, M., Mazumder, A. & Gerlt, J. A., Jan 1 1989, In : Nucleosides and Nucleotides. 8, 5-6, p. 879-883 5 p.

Research output: Contribution to journalArticle

UV Endonuclease V from Bacteriophage T4 Catalyzes DNA Strand Cleavage at Aldehydic Abasic Sites by a Syn β-Elimination Reaction

Mazumder, A., Gerlt, J. A., Rabow, L., Absalon, M. J., Stubbe, J. A. & Bolton, P. H., Sep 1 1989, In : Journal of the American Chemical Society. 111, 20, p. 8029-8030 2 p.

Research output: Contribution to journalArticle

1988

Cloning, DNA Sequence Analysis, and Expression in Escherichia coli of the Gene for Mandelate Racemase from Pseudomonas putida

Ransom, S. C., Gerlt, J. A., Powers, V. M. & Kenyon, G. L., Jan 1 1988, In : Biochemistry. 27, 2, p. 540-545 6 p.

Research output: Contribution to journalArticle

Direct observation of multiple environments for the Hδ but not the Hε proton of a histidine residue in staphylococcal nuclease

Stanczyk, S. M., Bolton, P. H., Dell'Acqua, M., Pourmotabbed, T. & Gerlt, J. A., Nov 1988, In : Journal of the American Chemical Society. 110, 23, p. 7908-7910 3 p.

Research output: Contribution to journalArticle

Isolation and characterization of a small catalytic domain released from the adenylate cyclase from Escherichia coli by digestion with trypsin

Holland, M. M., Leib, T. K. & Gerlt, J. A., 1988, In : Journal of Biological Chemistry. 263, 29, p. 14661-14668 8 p.

Research output: Contribution to journalArticle

Mechanism of UV endonuclease V cleavage of abasic sites in DNA determined by 13C labeling

Manoharan, M., Mazumder, A., Ransom, S. C., Gerlt, J. A. & Bolton, P. H., Apr 1988, In : Journal of the American Chemical Society. 110, 8, p. 2690-2691 2 p.

Research output: Contribution to journalArticle

Preliminary x-ray data on crystals of mandelate racemase.

Neidhart, D. J., Powers, V. M., Kenyon, G. L., Tsou, A. Y., Ransom, S. C., Gerlt, J. A. & Petsko, G. A., Jul 5 1988, In : The Journal of biological chemistry. 263, 19, p. 9268-9270 3 p.

Research output: Contribution to journalArticle

The Characterization of Abasic Sites in DNA Heteroduplexes by Site Specific Labeling with 13C

Manoharan, M., Ransom, S. C., Mazumder, A., Gerlt, J. A., Wilde, J. A., Withka, J. A. & Bolton, P. H., Mar 1988, In : Journal of the American Chemical Society. 110, 5, p. 1620-1622 3 p.

Research output: Contribution to journalArticle

1987

Coexistence of Conformations in a DNA Heteroduplex Revealed by Site Specific Labeling with 13C-Labeled Nucleotides

Manoharan, M., Gerlt, J. A., Wilde, J. A., Withka, J. M. & Bolton, P. H., Nov 1 1987, In : Journal of the American Chemical Society. 109, 23, p. 7217-7219 3 p.

Research output: Contribution to journalArticle

Site-Directed Mutants of Staphylococcal Nuclease. Detection and Localization by 1H NMR Spectroscopy of Conformational Changes Accompanying Substitutions for Glutamic Acid-43

Gerlt, J. A., Bolton, P. H., Hibler, D. W., Stolowich, N. J., Reynolds, M. A. & Wilde, J. A., 1987, In : Biochemistry. 26, 19, p. 6278-6286 9 p.

Research output: Contribution to journalArticle

1986

A method for the observation of selected proton NMR resonances of proteins

Wilde, J. A., Bolton, P. H., Stolowich, N. J. & Gerlt, J. A., Jun 1 1986, In : Journal of Magnetic Resonance (1969). 68, 1, p. 168-171 4 p.

Research output: Contribution to journalArticle

Identification of the Alkaline-Labile Product Accompanying Cytosine Release during Bleomycin-Mediated Degradation of d(CGCGCG)

Rabow, L., Stubbe, J., Kozarich, J. W. & Gerlt, J. A., Jan 1 1986, In : Journal of the American Chemical Society. 108, 22, p. 7130-7131 2 p.

Research output: Contribution to journalArticle

1985

The ompA signal peptide directed secretion of staphylococcal nuclease A by Escherichia coli

Takahara, M., Hibler, D. W., Barr, P. J., Gerlt, J. A. & Inouye, M., 1985, In : Journal of Biological Chemistry. 260, 5, p. 2670-2674 5 p.

Research output: Contribution to journalArticle

Thermal Denaturation of Staphylococcal Nuclease

Calderon, R. O., Stolowich, N. J., Gerlt, J. A. & Sturtevant, J. M., Oct 1 1985, In : Biochemistry. 24, 22, p. 6044-6049 6 p.

Research output: Contribution to journalArticle

1984

A General Procedure for Assigning the 31P Spectra of Nucleic Acids

Petersheim, M., Mehdi, S. & Gerlt, J. A., Jan 1 1984, In : Journal of the American Chemical Society. 106, 2, p. 439-440 2 p.

Research output: Contribution to journalArticle

1983

15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl Imidodiphosphate

Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In : Journal of the American Chemical Society. 105, 21, p. 6475-6481 7 p.

Research output: Contribution to journalArticle

17O NMR as a Probe of Nucleic Acid Dynamics

Petersheim, M., Miner, V. W., Gerlt, J. A. & Prestegard, J. H., Sep 1983, In : Journal of the American Chemical Society. 105, 20, p. 6357-6358 2 p.

Research output: Contribution to journalArticle

17O NMR Spectral Properties of Pyrophosphate, Simple Phosphonates, and Thiophosphate and Phosphonate Analogues of ATP

Gerlt, J. A., Reynolds, M. A., Demou, P. C. & Kenyon, G. L., Oct 1983, In : Journal of the American Chemical Society. 105, 21, p. 6469-6475 7 p.

Research output: Contribution to journalArticle

Evidence for a small catalytic domain in the adenylate cyclase from Salmonella typhimurium.

Leib, T. K. & Gerlt, J. A., Nov 10 1983, In : Journal of Biological Chemistry. 258, 21, p. 12982-12987 6 p.

Research output: Contribution to journalArticle

Oxygen chiral phosphodiesters-8. Stereochemical course of the base-catalyzed hydrolysis of cyclic 2'-deoxyadenosine 3',5'-[17O, 18O]monophosphate

Mehdi, S., Coderre, J. A. & Gerlt, J. A., 1983, In : Tetrahedron. 39, 21, p. 3483-3492 10 p.

Research output: Contribution to journalArticle

1982

17O NMR Spectral Properties of Simple Phosphate Esters and Adenine Nucleotides

Gerlt, J. A., Demou, P. C. & Mehdi, S., Jan 1 1982, In : Journal of the American Chemical Society. 104, 10, p. 2848-2856 9 p.

Research output: Contribution to journalArticle

Oxygen Chiral Phosphodiesters. 7. Stereochemical Course of a Reaction Catalyzed by Staphylococcal Nuclease

Mehdi, S. & Gerlt, J. A., Jan 1 1982, In : Journal of the American Chemical Society. 104, 11, p. 3223-3225 3 p.

Research output: Contribution to journalArticle

1981

Oxygen Chiral Phosphodiesters. 3. Use of 170 NMR Spectroscopy To Demonstrate Configurational Differences in the Diastereomers of Cyclic 2'-Deoxyadenosine 3’,5'-[17O,18O]Monophosphate

Coderre, J. A., Mehdi, S., Demou, P. C., Weber, R., Traficante, D. D. & Gerlt, J. A., Apr 1981, In : Journal of the American Chemical Society. 103, 7, p. 1870-1872 3 p.

Research output: Contribution to journalArticle

1980

Conformational Properties of 5-Alkoxy and 5-Alkyl Substituted Trimethylene Phosphates in Solution

Gerlt, J. A., Gutterson, N. I., Drews, R. E. & Sokolow, J. A., Feb 1980, In : Journal of the American Chemical Society. 102, 5, p. 1665-1670 6 p.

Research output: Contribution to journalArticle

Crystal and Molecular Structure of 5-Ethoxytrimethylenephosphoric Acid

Gerlt, J. A., Chodosh, D. F., Drews, R. E. & Adams, R. D., Mar 1980, In : Journal of Organic Chemistry. 45, 7, p. 1282-1286 5 p.

Research output: Contribution to journalArticle

Mechanism of the adenylate cyclase reaction. Stereochemistry of the reaction catalyzed by the enzyme from Brevibacterium liquefaciens

Gerlt, J. A., Coderre, J. A. & Wolin, M. S., Jan 1 1980, In : Journal of Biological Chemistry. 255, 2, p. 331-334 4 p.

Research output: Contribution to journalArticle

Theoretical Calculations on the Geometric Destabilization of 3’,5'- and 2’,3'-Cyclic Nucleotides

Marsh, F. J., Weiner, P., KoIlman, P. A., Kenyon, G. L., Douglas, J. E. & Gerlt, J. A., Feb 1980, In : Journal of the American Chemical Society. 102, 5, p. 1660-1665 6 p.

Research output: Contribution to journalArticle

Thermochemical Identification of the Structural Factors Responsible for the Thermodynamic Instability of 3’,5'-Cyclic Nucleotides

Gerlt, J. A., Gutterson, N. I., Datta, P., Belleau, B. & Penney, C. L., Feb 1980, In : Journal of the American Chemical Society. 102, 5, p. 1655-1660 6 p.

Research output: Contribution to journalArticle

The Solution Conformational Preferences of the Sugar and Sugar Phosphate Constituents of RNA and DNA

Gerlt, J. A. & Virginia Youngblood, A., Dec 1980, In : Journal of the American Chemical Society. 102, 25, p. 7433-7438 6 p.

Research output: Contribution to journalArticle

1979
1975

Purification and properties of a phosphohydrolase from Enterobacter aerogenes

Gerlt, J. A. & Whitman, G. J. R., Dec 1 1975, In : Journal of Biological Chemistry. 250, 13, p. 5053-5058 6 p.

Research output: Contribution to journalArticle

The enthalpies of hydrolysis of acyclic, monocyclic, and glycoside cyclic phosphate diesters

Gerlt, J. A., Westheimer, F. H. & Sturtevant, J. M., Dec 1 1975, In : Journal of Biological Chemistry. 250, 13, p. 5059-5067 9 p.

Research output: Contribution to journalArticle

1973

The mechanism of action of 5' adenylic acid activated threonine dehydrase. IV. Characterization of kinetic effect of adenosine monophosphate

Dunne, C. P., Gerlt, J. A., Rabinowitz, K. W. & Wood, W. A., 1973, In : Journal of Biological Chemistry. 248, 23, p. 8189-8199 11 p.

Research output: Contribution to journalArticle