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2006

Effect of bcl-2 overexpression in mice on ovotoxicity caused by 4-vinylcyclohexene

Flaws, J. A., Marion, S. L., Miller, K. P., Christian, P. J., Babus, J. K. & Hoyer, P. B., Aug 15 2006, In : Toxicology and Applied Pharmacology. 215, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Effect of methoxychlor and estradiol on cytochrome P450 enzymes in the mouse ovarian surface epithelium

Symonds, D. A., Miller, K. P., Tomic, D. & Flaws, J. A., Feb 2006, In : Toxicological Sciences. 89, 2, p. 510-514 5 p.

Research output: Contribution to journalArticle

Factors associated with determinants of sexual functioning in midlife women

Tomic, D., Gallicchio, L., Whiteman, M. K., Lewis, L. M., Langenberg, P. & Flaws, J. A., Jan 20 2006, In : Maturitas. 53, 2, p. 144-157 14 p.

Research output: Contribution to journalArticle

Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary

Gupta, R. K., Schuh, R. A., Fiskum, G. & Flaws, J. A., Nov 1 2006, In : Toxicology and Applied Pharmacology. 216, 3, p. 436-445 10 p.

Research output: Contribution to journalArticle

Methoxychlor induces atresia of antral follicles in ERα-overexpressing mice

Tomic, D., Frech, M. S., Babus, J. K., Gupta, R. K., Furth, P. A., Koos, R. D. & Flaws, J. A., Sep 15 2006, In : Toxicological Sciences. 93, 1, p. 196-204 9 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative Stress Pathway

Gupta, R. K., Miller, K. P., Babus, J. K. & Flaws, J. A., Oct 1 2006, In : Toxicological Sciences. 93, 2, p. 382-389 8 p.

Research output: Contribution to journalArticle

Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways

Miller, K. P., Gupta, R. K. & Flaws, J. A., Sep 15 2006, In : Toxicological Sciences. 93, 1, p. 180-188 9 p.

Research output: Contribution to journalArticle

The association between menopausal symptoms and quality of life in midlife women

Bankowski, B. J., Gallicchio, L. M., Whiteman, M. K., Lewis, L. M., Zacur, H. A. & Flaws, J. A., Oct 1 2006, In : Fertility and Sterility. 86, 4, p. 1006-1008 3 p.

Research output: Contribution to journalArticle

Type of menopause, patterns of hormone therapy use, and hot flashes

Gallicchio, L., Whiteman, M. K., Tomic, D., Miller, K. P., Langenberg, P. & Flaws, J. A., May 1 2006, In : Fertility and Sterility. 85, 5, p. 1432-1440 9 p.

Research output: Contribution to journalArticle

2005

Age of menopause and menopausal symptoms in HIV-infected women

Fantry, L. E., Zhan, M., Taylor, G. H., Sill, A. M. & Flaws, J. A., Nov 1 2005, In : AIDS Patient Care and STDs. 19, 11, p. 703-711 9 p.

Research output: Contribution to journalArticle

Body mass, estrogen levels, and hot flashes in midlife women

Gallicchio, L., Visvanathan, K., Miller, S. R., Babus, J., Lewis, L. M., Zacur, H. & Flaws, J. A., Oct 1 2005, In : American Journal of Obstetrics and Gynecology. 193, 4, p. 1353-1360 8 p.

Research output: Contribution to journalArticle

Current alcohol use is associated with a reduced risk of hot flashes in midlife women

Schiling, C., Gallicchio, L., Miller, S. R., Babus, J. K., Lewis, L. M., Zacur, H. & Flaws, J. A., Nov 1 2005, In : Alcohol and Alcoholism. 40, 6, p. 563-568 6 p.

Research output: Contribution to journalArticle

Cytochrome gene polymorphisms, serum estrogens, and hot flushes in midlife women

Visvanathan, K., Gallicchio, L., Schilling, C., Babus, J. K., Lewis, L. M., Miller, S. R., Zacur, H. & Flaws, J. A., Dec 2005, In : Obstetrics and Gynecology. 106, 6, p. 1372-1381 10 p.

Research output: Contribution to journalArticle

Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma In situ

Frech, M. S., Halama, E. D., Tilli, M. T., Singh, B., Gunther, E. J., Chodosh, L. A., Flaws, J. A. & Furth, P. A., Feb 1 2005, In : Cancer Research. 65, 3, p. 681-685 5 p.

Research output: Contribution to journalArticle

Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss

Thompson, K. E., Bourguet, S. M., Christian, P. J., Benedict, J. C., Sipes, I. G., Flaws, J. A. & Hoyer, P. B., Mar 1 2005, In : Toxicology and Applied Pharmacology. 203, 2, p. 114-123 10 p.

Research output: Contribution to journalArticle

Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

Gupta, R. K. & Flaws, J. A., May 2005, In : Fertility and Sterility. 83, 5, p. 1339-1342 4 p.

Research output: Contribution to journalArticle

Metallothionein expression in invasive and in situ breast carcinomas

Gallicchio, L. M., Flaws, J. A., Fowler, B. A. & Ioffe, O. B., Sep 16 2005, In : Cancer Detection and Prevention. 29, 4, p. 332-337 6 p.

Research output: Contribution to journalArticle

Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and bax-mediated pathways

Miller, K. P., Gupta, R. K., Greenfeld, C. R., Babus, J. K. & Flaws, J. A., Nov 1 2005, In : Toxicological Sciences. 88, 1, p. 213-221 9 p.

Research output: Contribution to journalArticle

Methoxychlor induces proliferation of the mouse ovarian surface epithelium

Symonds, D. A., Tomic, D., Miller, K. P. & Flaws, J. A., Feb 1 2005, In : Toxicological Sciences. 83, 2, p. 355-362 8 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation

Schuh, R. A., Kristián, T., Gupta, R. K., Flaws, J. A. & Fiskum, G., Dec 1 2005, In : Toxicological Sciences. 88, 2, p. 495-504 10 p.

Research output: Contribution to journalArticle

Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients

Badros, A. Z., Goloubeva, O., Rapoport, A. P., Ratterree, B., Gahres, N., Meisenberg, B., Takebe, N., Heyman, M., Zwiebel, J., Streicher, H., Gocke, C. D., Tomic, D., Flaws, J. A., Zhang, B. & Fenton, R. G., Dec 1 2005, In : Journal of Clinical Oncology. 23, 18, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients

Tucker, A. N., Tkaczuk, K. A., Lewis, L. M., Tomic, D., Lim, C. K. & Flaws, J. A., Jan 10 2005, In : Cancer Letters. 217, 1, p. 61-72 12 p.

Research output: Contribution to journalArticle

2004

Association of tamoxifen (TAM) and TAM metabolite concentrations with self-reported side effects of TAM in women with breast cancer

Gallicchio, L., Lord, G., Tkaczuk, K., Danton, M., Lewis, L. M., Lim, C. K. & Flaws, J. A., May 1 2004, In : Breast Cancer Research and Treatment. 85, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

Cigarette smoking and metallothionein expression in invasive breast carcinomas

Gallicchio, L., Flaws, J. A., Sexton, M. & Ioffe, O. B., Sep 25 2004, In : Toxicology Letters. 152, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Gallicchio, L., Tkaczuk, K., Lord, G., Danton, M., Lewis, L. M., Lim, C. K. & Flaws, J. A., Jul 28 2004, In : Cancer Letters. 211, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol

Borgeest, C., Miller, K. P., Gupta, R., Greenfeld, C., Hruska, K. S., Hoyer, P. & Flaws, J. A., Jun 1 2004, In : Biology of reproduction. 70, 6, p. 1828-1835 8 p.

Research output: Contribution to journalArticle

Ovarian follicle development requires Smad3

Tomic, D., Miller, K. P., Kenny, H. A., Woodruff, T. K., Hoyer, P. & Flaws, J. A., Sep 2004, In : Molecular Endocrinology. 18, 9, p. 2224-2240 17 p.

Research output: Contribution to journalArticle

Tubal sterilization and hot flashes

Whiteman, M. K., Miller, K. P., Tomic, D., Langenberg, P. & Flaws, J. A., Aug 1 2004, In : Fertility and Sterility. 82, 2, p. 502-504 3 p.

Research output: Contribution to journalArticle

2003

Ability of Exercise Testing to Predict Cardiovascular and All-Cause Death in Asymptomatic Women: A 20-Year Follow-up of the Lipid Research Clinics Prevalence Study

Mora, S., Redberg, R. F., Cui, Y., Whiteman, M. K., Flaws, J. A., Sharrett, A. R. & Blumenthal, R. S., Sep 25 2003, In : Journal of the American Medical Association. 290, 12, p. 1600-1607 8 p.

Research output: Contribution to journalArticle

Aging may be associated with concentrations of tamoxifen and its metabolites in breast cancer patients

Sheth, H. R., Lord, G., Tkaczuk, K., Danton, M., Lewis, L. M., Langenberg, P., Lim, C. K. & Flaws, J. A., Oct 2003, In : Journal of Women's Health. 12, 8, p. 799-808 10 p.

Research output: Contribution to journalArticle

A randomized trial of incentives to improve response rates to a mailed women's health questionnaire

Whiteman, M. K., Langenberg, P., Kjerulff, K., McCarter, R. & Flaws, J. A., Oct 2003, In : Journal of Women's Health. 12, 8, p. 821-828 8 p.

Research output: Contribution to journalArticle

Aryl hydrocarbon receptor regulates growth, but not atresia, of mouse preantral and antral follicles

Benedict, J. C., Miller, K. P., Lin, T. M., Greenfeld, C., Babus, J. K., Peterson, R. E. & Flaws, J. A., May 1 2003, In : Biology of reproduction. 68, 5, p. 1511-1517 7 p.

Research output: Contribution to journalArticle

Chemoprevention of mammary carcinogenesis in a transgenic mouse model by α-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity

Li, M., Ren, S., Tilli, M. T., Flaws, J. A., Lubet, R., Grubbs, C. J. & Furth, P. A., May 1 2003, In : Oncogene. 22, 17, p. 2568-2572 5 p.

Research output: Contribution to journalArticle

Introduction of Estrogen Receptor-α into the tTA/TAg Conditional Mouse Model Precipitates the Development of Estrogen-Responsive Mammary Adenocarcinoma

Tilli, M. T., Frech, M. S., Steed, M. E., Hruska, K. S., Johnson, M. D., Flaws, J. A. & Furth, P. A., Nov 2003, In : American Journal of Pathology. 163, 5, p. 1713-1719 7 p.

Research output: Contribution to journalArticle

Smad 3 regulates proliferation of the mouse ovarian surface epithelium

Symonds, D., Tomic, D., Borgeest, C., McGee, E. & Flaws, J. A., Aug 1 2003, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 273, 2, p. 681-686 6 p.

Research output: Contribution to journalArticle

Smoking, body mass, and hot flashes in midlife women

Whiteman, M. K., Staropoli, C. A., Langenberg, P. W., McCarter, R. J., Kjerulff, K. H. & Flaws, J. A., Feb 1 2003, In : Obstetrics and Gynecology. 101, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

2002

Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats

Hu, X., Flaws, J. A., Sipes, I. G. & Hoyer, P. B., Sep 1 2002, In : Biology of reproduction. 67, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary

Riedlinger, G., Okagaki, R., Wagner, K. U., Rucker, E. B., Oka, T., Miyoshi, K., Flaws, J. A. & Hennighausen, L., 2002, In : Biology of reproduction. 66, 2, p. 438-444 7 p.

Research output: Contribution to journalArticle

Body mass and stage of breast cancer at diagnosis

Cui, Y., Whiteman, M. K., Flaws, J. A., Langenberg, P., Tkaczuk, K. H. & Bush, T. L., Mar 10 2002, In : International Journal of Cancer. 98, 2, p. 279-283 5 p.

Research output: Contribution to journalArticle

Can obesity explain the racial difference in stage of breast cancer at diagnosis between black and white women?

Cui, Y., Whiteman, M. K., Langenberg, P., Sexton, M., Tkaczuk, K. H., Flaws, J. A. & Bush, T. L., Jul 1 2002, In : Journal of Women's Health and Gender-Based Medicine. 11, 6, p. 527-536 10 p.

Research output: Contribution to journalArticle

Conditional over-expression of estrogen receptor alpha in a transgenic mouse model

Hruska, K. S., Tilli, M. T., Ren, S., Cotarla, I., Kwong, T., Li, M., Fondell, J. D., Hewitt, J. A., Koos, R. D., Furth, P. A. & Flaws, J. A., Aug 1 2002, In : Transgenic Research. 11, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Loss of the peroxisome proliferation-activated receptor gamma (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility

Cui, Y., Miyoshi, K., Claudio, E., Siebenlist, U. K., Gonzalez, F. J., Flaws, J., Wagner, K. U. & Hennighausen, L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17830-17835 6 p.

Research output: Contribution to journalArticle

Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse

Borgeest, C., Symonds, D., Mayer, L. P., Hoyer, P. B. & Flaws, J. A., Aug 2002, In : Toxicological Sciences. 68, 2, p. 473-478 6 p.

Research output: Contribution to journalArticle

Smad 3 may regulate follicular growth in the mouse ovary

Tomic, D., Brodie, S. G., Deng, C., Hickey, R. J., Babus, J. K., Malkas, L. H. & Flaws, J. A., 2002, In : Biology of reproduction. 66, 4, p. 917-923 7 p.

Research output: Contribution to journalArticle

The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility

Le Provost, F., Riedlinger, G., Yim, S. H., Benedict, J., Gonzalez, F. J., Flaws, J. & Hennighausen, L., 2002, In : Genesis. 32, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

2001

Effect of Bcl-2 on the primordial follicle endowment in the mouse ovary

Flaws, J. A., Hirshfield, A. N., Hewitt, J. A., Babus, J. K. & Furth, P. A., 2001, In : Biology of reproduction. 64, 4, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

Ethnic differences in cancer mortality trends in the US, 1950-1992

Piffath, T. A., Whiteman, M. K., Flaws, J. A., Fix, A. D. & Bush, T. L., Jul 28 2001, In : Ethnicity and Health. 6, 2, p. 105-119 15 p.

Research output: Contribution to journalArticle

In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat

Lewis, B. C., Hudgins, S., Lewis, A., Schorr, K., Sommer, R., Peterson, R. E., Flaws, J. A. & Furth, P. A., 2001, In : Toxicological Sciences. 62, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Media coverage of women's health issues: Is there a bias in the reporting of an association between hormone replacement therapy and breast cancer?

Whiteman, M. K., Cui, Y., Flaws, J. A., Langenberg, P. & Bush, T. L., Sep 11 2001, In : Journal of Women's Health and Gender-Based Medicine. 10, 6, p. 571-577 7 p.

Research output: Contribution to journalArticle