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Follicular mechanisms associated with 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats

Springer, L. N., Flaws, J. A., Sipes, I. G. & Hoyer, P. B., Jan 1 1996, In : Reproductive Toxicology. 10, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling

Madak-Erdogan, Z., Band, S., Zhao, Y. C., Smith, B. P., Kulkoyluoglu-Cotul, E., Zuo, Q., Casiano, A. S., Wrobel, K., Rossi, G., Smith, R. L., Kim, S. H., Katzenellenbogen, J. A., Johnson, M. L., Patel, M., Marino, N., Storniolo, A. M. V. & Flaws11, J. A., 2019, In : Cancer Research. 79, 10, p. 2494-2510 17 p.

Research output: Contribution to journalArticle

Genetically induced estrogen receptor α mRNA (Esr1) overexpression does not adversely affect fertility or penile development in male mice

Heath, J., Abdelmageed, Y., Braden, T. D., Williams, C. S., Williams, J. W., Paulose, T., Hernandez-Ochoa, I., Gupta, R., Flaws, J. A. & Goyal, H. O., May 2011, In : Journal of andrology. 32, 3, p. 282-294 13 p.

Research output: Contribution to journalArticle

Genetic polymorphisms, hormone levels, and hot flashes in midlife women

Schilling, C., Gallicchio, L., Miller, S. R., Langenberg, P., Zacur, H. & Flaws, J. A., Jun 20 2007, In : Maturitas. 57, 2, p. 120-131 12 p.

Research output: Contribution to journalArticle

Genetic polymorphisms in the aryl hydrocarbon receptor-signaling pathway and sleep disturbances in middle-aged women

Ziv-Gal, A., Flaws, J. A., Mahoney, M. M., Miller, S. R., Zacur, H. A. & Gallicchio, L., Sep 2013, In : Sleep Medicine. 14, 9, p. 883-887 5 p.

Research output: Contribution to journalArticle

Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes

Ziv-Gal, A., Gallicchio, L., Miller, S. R., Zacur, H. A. & Flaws, J. A., Sep 2012, In : American Journal of Obstetrics and Gynecology. 207, 3, p. 202.e9-202.e18

Research output: Contribution to journalArticle

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G., Mar 2014, In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331.

Research output: Contribution to journalArticle

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A., Feb 15 2016, In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations

Barakat, R., Lin, P. C., Park, C. J., Zeineldin, M., Zhou, S., Rattan, S., Brehm, E., Flaws, J. A. & Ko, C. M. J., Dec 1 2020, In : Scientific reports. 10, 1, 5705.

Research output: Contribution to journalArticle

Open Access

Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

Gupta, R. K. & Flaws, J. A., May 2005, In : Fertility and Sterility. 83, 5, p. 1339-1342 4 p.

Research output: Contribution to journalArticle

Health care construction. Which architect should you pick?

Flaws, J. A., Jul 1 1992, In : Health facilities management. 5, 7, p. 34, 36, 38 passim

Research output: Contribution to journalArticle

Health outcomes of children born to cosmetologists compared to children of women in other occupations

Gallicchio, L., Miller, S. R., Greene, T., Zacur, H. & Flaws, J. A., Jun 1 2010, In : Reproductive Toxicology. 29, 3, p. 361-365 5 p.

Research output: Contribution to journalArticle

Hormone variability and hot flash experience: Results from the midlife women's health study

Chiang, C., Gallicchio, L., Zacur, H., Miller, S., Flaws, J. A. & Smith, R. L., Jan 2019, In : Maturitas. 119, p. 1-7 7 p.

Research output: Contribution to journalArticle

Hot flashes and blood pressure in midlife women

Gallicchio, L., Miller, S. R., Zacur, H. & Flaws, J. A., Jan 2010, In : Maturitas. 65, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites

Paulose, T., Hernández-Ochoa, I., Basavarajappa, M. S., Peretz, J. & Flaws, J. A., 2011, In : Toxicological Sciences. 120, 2, p. 447-459 13 p., kfr011.

Research output: Contribution to journalArticle

Infertility among cosmetologists

Peretz, J., Gallicchio, L., Miller, S., Greene, T., Zacur, H. & Flaws, J. A., Nov 1 2009, In : Reproductive Toxicology. 28, 3, p. 359-364 6 p.

Research output: Contribution to journalArticle

Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test

Marty, M. S., Allen, B., Chapin, R. E., Cooper, R., Daston, G. P., Flaws, J. A., Foster, P. M. D., Makris, S. L., Mylchreest, E., Sandler, D. & Tyl, R. W., Dec 2009, In : Birth Defects Research Part B - Developmental and Reproductive Toxicology. 86, 6, p. 470-489 20 p.

Research output: Contribution to journalArticle

Interleukin-1 β-converting enzyme-related proteases (irps) and mammalian cell death: Dissociation of irp-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle

Flaws, J. A., Kugu, K., Trbovich, A. M., Desanti, A., Tilly, K. I., Hirshfield, A. N. & Tilly, J. L., Nov 1995, In : Endocrinology. 136, 11, p. 5042-5053 12 p.

Research output: Contribution to journalArticle

Introduction of Estrogen Receptor-α into the tTA/TAg Conditional Mouse Model Precipitates the Development of Estrogen-Responsive Mammary Adenocarcinoma

Tilli, M. T., Frech, M. S., Steed, M. E., Hruska, K. S., Johnson, M. D., Flaws, J. A. & Furth, P. A., Nov 2003, In : American Journal of Pathology. 163, 5, p. 1713-1719 7 p.

Research output: Contribution to journalArticle

In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) induces genital dysmorphogenesis in the female rat

Flaws, J. A., Sommer, R. J., Silbergeld, E. K., Peterson, R. E. & Hirshfield, A. N., Dec 1997, In : Toxicology and Applied Pharmacology. 147, 2, p. 351-362 12 p.

Research output: Contribution to journalArticle

In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat

Lewis, B. C., Hudgins, S., Lewis, A., Schorr, K., Sommer, R., Peterson, R. E., Flaws, J. A. & Furth, P. A., 2001, In : Toxicological Sciences. 62, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse

Wang, W., Hafner, K. S. & Flaws, J. A., Apr 15 2014, In : Toxicology and Applied Pharmacology. 276, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats

Springer, L. N., McAsey, M. E., Flaws, J. A., Tilly, J. L., Sipes, I. G. & Hoyer, P. B., Aug 1996, In : Toxicology and Applied Pharmacology. 139, 2, p. 394-401 8 p.

Research output: Contribution to journalArticle

Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice

Chiang, C., Lewis, L. R., Borkowski, G. & Flaws, J. A., Apr 2020, In : Reproductive Toxicology. 93, p. 28-42 15 p.

Research output: Contribution to journalArticle

Loss of the peroxisome proliferation-activated receptor gamma (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility

Cui, Y., Miyoshi, K., Claudio, E., Siebenlist, U. K., Gonzalez, F. J., Flaws, J., Wagner, K. U. & Hennighausen, L., May 17 2002, In : Journal of Biological Chemistry. 277, 20, p. 17830-17835 6 p.

Research output: Contribution to journalArticle

Low fibrinogen level: A predisposing factor for venous thromboembolic events with hormone replacement therapy

Whiteman, M. K., Cui, Y., Flaws, J. A., Espeland, M. & Bush, T. L., 1999, In : American Journal of Hematology. 61, 4, p. 271-273 3 p.

Research output: Contribution to journalArticle

Media coverage of women's health issues: Is there a bias in the reporting of an association between hormone replacement therapy and breast cancer?

Whiteman, M. K., Cui, Y., Flaws, J. A., Langenberg, P. & Bush, T. L., Sep 11 2001, In : Journal of Women's Health and Gender-Based Medicine. 10, 6, p. 571-577 7 p.

Research output: Contribution to journalArticle

Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Gallicchio, L., Tkaczuk, K., Lord, G., Danton, M., Lewis, L. M., Lim, C. K. & Flaws, J. A., Jul 28 2004, In : Cancer Letters. 211, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

Menstrual cycle abnormalities among cosmetologists: The Reproductive Outcomes in Salon Employees (ROSE) study

Gallicchio, L., Miller, S., Greene, T., Zacur, H. & Flaws, J. A., Jan 1 2010, In : Reproductive Sciences. 17, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Metallothionein expression in invasive and in situ breast carcinomas

Gallicchio, L. M., Flaws, J. A., Fowler, B. A. & Ioffe, O. B., Sep 16 2005, In : Cancer Detection and Prevention. 29, 4, p. 332-337 6 p.

Research output: Contribution to journalArticle

Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium

Symonds, D. A., Merchenthaler, I. & Flaws, J. A., 2008, In : Toxicological Sciences. 105, 1, p. 182-187 6 p.

Research output: Contribution to journalArticle

Methoxychlor and Its metabolites inhibit growth and induce atresia of baboon antral follicles

Gupta, R. K., Aberdeen, G., Babus, J. K., Albrecht, E. D. & Flaws, J. A., Aug 2007, In : Toxicologic Pathology. 35, 5, p. 649-656 8 p.

Research output: Contribution to journalArticle

Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary

Gupta, R. K., Schuh, R. A., Fiskum, G. & Flaws, J. A., Nov 1 2006, In : Toxicology and Applied Pharmacology. 216, 3, p. 436-445 10 p.

Research output: Contribution to journalArticle

Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and bax-mediated pathways

Miller, K. P., Gupta, R. K., Greenfeld, C. R., Babus, J. K. & Flaws, J. A., Nov 1 2005, In : Toxicological Sciences. 88, 1, p. 213-221 9 p.

Research output: Contribution to journalArticle

Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol

Borgeest, C., Miller, K. P., Gupta, R., Greenfeld, C., Hruska, K. S., Hoyer, P. & Flaws, J. A., Jun 1 2004, In : Biology of reproduction. 70, 6, p. 1828-1835 8 p.

Research output: Contribution to journalArticle

Methoxychlor-Induced Ovarian Follicle Toxicity in Mice: Dose and Exposure Duration-Dependent Effects

Paulose, T., Tannenbaum, L. V., Borgeest, C. & Flaws, J. A., Jun 2012, In : Birth Defects Research Part B - Developmental and Reproductive Toxicology. 95, 3, p. 219-224 6 p.

Research output: Contribution to journalArticle

Methoxychlor induces atresia by altering Bcl2 factors and inducing caspase activity in mouse ovarian antral follicles in vitro

Basavarajappa, M. S., Karman, B. N., Wang, W., Gupta, R. K. & Flaws, J. A., Dec 2012, In : Reproductive Toxicology. 34, 4, p. 545-551 7 p.

Research output: Contribution to journalArticle

Methoxychlor induces atresia of antral follicles in ERα-overexpressing mice

Tomic, D., Frech, M. S., Babus, J. K., Gupta, R. K., Furth, P. A., Koos, R. D. & Flaws, J. A., Sep 15 2006, In : Toxicological Sciences. 93, 1, p. 196-204 9 p.

Research output: Contribution to journalArticle

Methoxychlor induces proliferation of the mouse ovarian surface epithelium

Symonds, D. A., Tomic, D., Miller, K. P. & Flaws, J. A., Feb 1 2005, In : Toxicological Sciences. 83, 2, p. 355-362 8 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation

Schuh, R. A., Kristián, T., Gupta, R. K., Flaws, J. A. & Fiskum, G., Dec 1 2005, In : Toxicological Sciences. 88, 2, p. 495-504 10 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative Stress Pathway

Gupta, R. K., Miller, K. P., Babus, J. K. & Flaws, J. A., Oct 1 2006, In : Toxicological Sciences. 93, 2, p. 382-389 8 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits growth and induces atresia through the aryl hydrocarbon receptor pathway in mouse ovarian antral follicles

Basavarajappa, M. S., Hernández-Ochoa, I., Wang, W. & Flaws, J. A., Aug 2012, In : Reproductive Toxicology. 34, 1, p. 16-21 6 p.

Research output: Contribution to journalArticle

Methoxychlor inhibits growth of antral follicles by altering cell cycle regulators

Gupta, R. K., Meachum, S., Hernández-Ochoa, I., Peretz, J., Yao, H. H. & Flaws, J. A., Oct 1 2009, In : Toxicology and Applied Pharmacology. 240, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse

Borgeest, C., Symonds, D., Mayer, L. P., Hoyer, P. B. & Flaws, J. A., Aug 2002, In : Toxicological Sciences. 68, 2, p. 473-478 6 p.

Research output: Contribution to journalArticle

Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways

Miller, K. P., Gupta, R. K. & Flaws, J. A., Sep 15 2006, In : Toxicological Sciences. 93, 1, p. 180-188 9 p.

Research output: Contribution to journalArticle

Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro

Basavarajappa, M. S., Craig, Z. R., Hernández-Ochoa, I., Paulose, T., Leslie, T. C. & Flaws, J. A., Jun 15 2011, In : Toxicology and Applied Pharmacology. 253, 3, p. 161-169 9 p.

Research output: Contribution to journalArticle

Mono(2-ethylhexyl) phthalate accelerates early folliculogenesis and inhibits steroidogenesis in cultured mouse whole ovaries and antral follicles

Hannon, P. R., Brannick, K. E., Wang, W. & Flaws, J. A., May 1 2015, In : Biology of reproduction. 92, 5, 120.

Research output: Contribution to journalArticle