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Research Output 1992 2019

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2019

An interview with Dr Karen Schindler

Flaws, J. A., Mar 1 2019, In : Biology of reproduction. 100, 3, p. 573-574 2 p.

Research output: Contribution to journalArticle

Open Access
Interviews

Chronic Exposure of Mice to Bisphenol-A Alters Uterine Fibroblast Growth Factor Signaling and Leads to Aberrant Epithelial Proliferation

Neff, A. M., Blanco, S. C., Flaws, J. A., Bagchi, I. C. & Bagchi, M. K., Jan 1 2019, In : Endocrinology. 160, 5, p. 1234-1246 13 p.

Research output: Contribution to journalArticle

Open Access
Fibroblast Growth Factors
Uterus
Endometrial Hyperplasia
Neural Crest
Steroids

Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice

Hatcher, K. M., Willing, J., Chiang, C., Rattan, S., Flaws, J. A. & Mahoney, M. M., Aug 1 2019, In : Physiology and Behavior. 207, p. 7-14 8 p.

Research output: Contribution to journalArticle

Amygdala
Anxiety
Gene Expression
Dopamine Receptors
Food Packaging

Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling

Madak-Erdogan, Z., Band, S., Zhao, Y. C., Smith, B. P., Kulkoyluoglu-Cotul, E., Zuo, Q., Casiano, A. S., Wrobel, K., Rossi, G., Smith, R. L., Kim, S. H., Katzenellenbogen, J. A., Johnson, M. L., Patel, M., Marino, N., Storniolo, A. M. V. & Flaws, J. A., Jan 1 2019, In : Cancer Research. 79, 10, p. 2494-2510 17 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Nonesterified Fatty Acids
Estrogen Receptors
Obesity
Breast Neoplasms

Hormone variability and hot flash experience: Results from the midlife women's health study

Chiang, C., Gallicchio, L., Zacur, H., Miller, S., Flaws, J. A. & Smith, R. L., Jan 2019, In : Maturitas. 119, p. 1-7 7 p.

Research output: Contribution to journalArticle

Hot Flashes
Women's Health
Progesterone
Hormones
Estradiol
methoxychlor
ovarian follicles
mammal
sperm
mammals

Ovarian metabolism of an environmentally relevant phthalate mixture

Warner, G. R., Li, Z. L., Houde, M. L., Atkinson, C. E., Meling, D. D., Chiang, C. & Flaws, J. A., Jan 1 2019, In : Toxicological Sciences. 169, 1, p. 246-259 14 p.

Research output: Contribution to journalArticle

Open Access
Metabolism
Dibutyl Phthalate
Ovary
Metabolites
Culture Media

Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries

Rattan, S., Beers, H. K., Kannan, A., Ramakrishnan, A., Brehm, E., Bagchi, I. C., Irudayaraj, J. M. K. & Flaws, J. A., Sep 15 2019, In : Toxicology and Applied Pharmacology. 379, 114629.

Research output: Contribution to journalArticle

DNA Methylation
Gene expression
Ovary
Gene Expression
Cytosine

Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis

Damdimopoulou, P., Chiang, C. & Flaws, J. A., Aug 2019, In : Reproductive Toxicology. 87, p. 32-41 10 p.

Research output: Contribution to journalArticle

Tretinoin
Retinoids
Ovary
Retinoic Acid Receptors
Physiology

Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products

Park, C. J., Barakat, R., Ulanov, A., Li, Z. L., Lin, P. C., Chiu, K., Zhou, S., Perez, P., Lee, J., Flaws, J. A. & Ko, C., Mar 2019, In : Reproductive Toxicology. 84, p. 114-121 8 p.

Research output: Contribution to journalArticle

Plastic products
Volatile Organic Compounds
Plastics
Diethylhexyl Phthalate
Xylenes
Reproduction
Periodicity
phthalic acid
diisononyl phthalate
Endocrine Disruptors

Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice

Wolstenholme, J. T., Drobná, Z., Henriksen, A. D., Goldsby, J. A., Stevenson, R., Irvin, J. W., Flaws, J. A. & Rissman, E. F., Jul 4 2019, In : Endocrinology. 160, 8, p. 1854-1867 14 p., 201900196.

Research output: Contribution to journalArticle

Post-Synaptic Density
Genes
Brain
Paternal Exposure
Guanylate Kinases
2018

Association between polycystic ovary syndrome and hot flash presentation during the midlife period

Yin, O., Zacur, H. A., Flaws, J. A. & Christianson, M. S., Jun 1 2018, In : Menopause. 25, 6, p. 691-696 6 p.

Research output: Contribution to journalArticle

Hot Flashes
Polycystic Ovary Syndrome
Nonparametric Statistics
Logistic Models
Follicle Stimulating Hormone

Bisphenol A and phthalates: How environmental chemicals are reshaping toxicology

Warner, G. R. & Flaws, J. A., Jan 1 2018, In : Toxicological Sciences. 166, 2, p. 246-249 4 p.

Research output: Contribution to journalArticle

Toxicology
phthalic acid
bisphenol A
Peritoneal Macrophages
Epigenomics
Histone Code
Gene Expression
Scavenger Receptors

Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice

Richardson, K. A., Hannon, P. R., Johnson-Walker, Y. J., Myint, M. S., Flaws, J. A. & Nowak, R. A., Apr 2018, In : Reproductive Toxicology. 77, p. 70-79 10 p.

Research output: Contribution to journalArticle

Uterus
phthalic acid
Endocrine Disruptors
Environmental Exposure
Blood vessels

Di(2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice

Rattan, S., Brehm, E., Gao, L. & Flaws, J. A., Jun 1 2018, In : Toxicological Sciences. 163, 2, p. 420-429 10 p.

Research output: Contribution to journalArticle

Fertility
Periodicity
Puberty
Parturition
Endocrine Disruptors

Dynamic and Sex-Specific Changes in Gonadotropin-Releasing Hormone Neuron Activity and Excitability in a Mouse Model of Temporal Lobe Epilepsy

Li, J., Robare, J. A., Gao, L., Ghane, M. A., Flaws, J. A., Nelson, M. E. & Christian, C. A., Sep 27 2018, In : eNeuro. 5, 5

Research output: Contribution to journalArticle

Temporal Lobe Epilepsy
Kainic Acid
Gonadotropin-Releasing Hormone
Neurons
Diestrus

Effects of exposure to the endocrine-Disrupting chemical bisphenol a during critical windows of murine pituitary development

Eckstrum, K. S., Edwards, W., Banerjee, A., Wang, W., Flaws, J. A., Katzenellenbogen, J. A., Kim, S. H. & Raetzman, L. T., Jan 1 2018, In : Endocrinology. 159, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Estrogen Receptors
Messenger RNA
Embryonic Development
Gene Expression
Women's Health
Menopause
Sleep
Perimenopause
Premenopause

Prenatal exposure to DEHP induces neuronal degeneration and neurobehavioral abnormalities in adult male mice

Barakat, R., Lin, P. C., Park, C. J., Best, C., Bakry, H. H., Abosalem, M. E., Abdelaleem, N. M., Flaws, J. A. & Ko, C., Jan 1 2018, In : Toxicological Sciences. 164, 2, p. 439-452 14 p.

Research output: Contribution to journalArticle

Neurons
Data storage equipment
Hippocampus
Androgen Receptors
phthalic acid

Prenatal exposure to Di(2-ethylhexyl) phthalate causes long-term transgenerational effects on female reproduction in mice

Brehm, E., Rattan, S., Gao, L. & Flaws, J. A., Feb 2018, In : Endocrinology. 159, 2, p. 795-809 15 p.

Research output: Contribution to journalArticle

Reproduction
Periodicity
Hormones
Endocrine Disruptors
Plasticizers

Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice

Rattan, S., Brehm, E., Gao, L., Niermann, S. & Flaws, J. A., Jan 1 2018, In : Biology of reproduction. 98, 1, p. 130-145 16 p., iox154.

Research output: Contribution to journalArticle

Organ Size
Progesterone
Ovary
Estradiol
Serum

The effects of dietary levels of genistein on ovarian follicle number and gene expression

Kundu, P., Patel, S., Meling, D. D., Deal, K., Gao, L., Helferich, W. G. & Flaws, J. A., Oct 2018, In : Reproductive Toxicology. 81, p. 132-139 8 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Genistein
Gene expression
Gene Expression
Ovary

Transgenerational effects of bisphenol a on gene expression and DNA methylation of imprinted genes in brain

Drobná, Z., Henriksen, A. D., Wolstenholme, J. T., Montiel, C., Lambeth, P. S., Shang, S., Harris, E. P., Zhou, C., Flaws, J. A., Adli, M. & Rissman, E. F., Jan 1 2018, In : Endocrinology. 159, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

DNA Methylation
Gene Expression
Brain
Genes
RNA Sequence Analysis

Understanding the complex relationships underlying hot flashes: A Bayesian network approach

Smith, R. L., Gallicchio, L. M. & Flaws, J. A., Feb 1 2018, In : Menopause. 25, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

Hot Flashes
Bayes Theorem
Smoking
Hormones
Body Mass Index
2017

An interview with Dr John Kerr (Jock) Findlay

Flaws, J. A., Oct 1 2017, In : Biology of reproduction. 97, 4, p. 515-516 2 p.

Research output: Contribution to journalArticle

Interviews

Bisphenol a exposure, ovarian follicle numbers, and female sex steroid hormone levels: Results from a CLARITY-BPA study

Patel, S., Brehm, E., Gao, L., Rattan, S., Ziv-Gal, A. & Flaws, J. A., Jun 1 2017, In : Endocrinology. 158, 6, p. 1727-1738 12 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Gonadal Steroid Hormones
Ovary
Ethinyl Estradiol
Steroids

Bisphenol A impairs decidualization of human uterine stromal fibroblasts

Olson, M. R., Su, R., Flaws, J. A. & Fazleabas, A. T., Oct 2017, In : Reproductive Toxicology. 73, p. 339-344 6 p.

Research output: Contribution to journalArticle

Fibroblasts
Steroid hormones
Steroid Receptors
Cells
Cell Proliferation

Effects of an environmentally relevant phthalate mixture on cultured mouse antral follicles

Zhou, C. & Flaws, J. A., Mar 1 2017, In : Toxicological Sciences. 156, 1, p. 217-229 13 p.

Research output: Contribution to journalArticle

Growth
Oocytes
Cell Cycle
phthalic acid
Antral

Environmental Contaminants Affecting Fertility and Somatic Health

Chiang, C., Mahalingam, S. & Flaws, J. A., May 1 2017, In : Seminars in Reproductive Medicine. 35, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

Fertility
Health
Spermatozoa
Parabens
Triclosan

Exposure to an environmentally relevant phthalate mixture causes transgenerational effects on female reproduction in mice

Zhou, C., Gao, L. & Flaws, J. A., Jun 1 2017, In : Endocrinology. 158, 6, p. 1739-1754 16 p.

Research output: Contribution to journalArticle

Reproduction
Fertility
phthalic acid
Dibutyl Phthalate
Endocrine Disruptors

Factors affecting sexual activity in midlife women: Results from the midlife health study

Smith, R. L., Gallicchio, L. & Flaws, J. A., Feb 2017, In : Journal of Women's Health. 26, 2, p. 103-108 6 p.

Research output: Contribution to journalArticle

Sexual Behavior
Health
Logistic Models
Hot Flashes
Sexual Partners

Factors Affecting Sexual Function in Midlife Women: Results from the Midlife Women's Health Study

Smith, R. L., Gallicchio, L. & Flaws, J. A., Sep 1 2017, In : Journal of women's health (2002). 26, 9, p. 923-932 10 p.

Research output: Contribution to journalArticle

Women's Health
Sexual Behavior
Logistic Models
Orgasm
Lubrication

Preconception exposure to dietary levels of genistein affects female reproductive outcomes

Patel, S., Hartman, J. A., Helferich, W. G. & Flaws, J. A., Dec 2017, In : Reproductive Toxicology. 74, p. 174-180 7 p.

Research output: Contribution to journalArticle

Genistein
Litter Size
Birth Rate
Fertility
Estradiol

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

Zhou, C., Gao, L. & Flaws, J. A., Mar 1 2017, In : Toxicology and Applied Pharmacology. 318, p. 49-57 9 p.

Research output: Contribution to journalArticle

Reproduction
Dams
Fertility
phthalic acid
Dibutyl Phthalate

Prenatal exposure to DEHP induces premature reproductive senescence in male mice

Barakat, R., Lin, P. C. P., Rattan, S., Brehm, E., Canisso, I. F., Abosalum, M. E., Flaws, J. A., Hess, R. & Ko, C. M., Mar 1 2017, In : Toxicological Sciences. 156, 1, p. 96-108 13 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Asthenozoospermia
Corn Oil
Tocopherols
phthalic acid

The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice

Mahalingam, S., Ther, L., Gao, L., Wang, W., Ziv-Gal, A. & Flaws, J. A., Dec 2017, In : Reproductive Toxicology. 74, p. 150-157 8 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Cytochrome P-450 Enzyme System
Aromatase
Ovary
3-Hydroxysteroid Dehydrogenases
2016
Aging of materials
Periodicity
phthalic acid
Metestrus
Diestrus

Age at menarche, androgen concentrations, and midlife obesity: Findings from the Midlife Women's Health Study

Gallicchio, L., Flaws, J. A. & Smith, R. L., Nov 1 2016, In : Menopause. 23, 11, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

Menarche
Women's Health
Androgens
Obesity
Testosterone

Chronic exposure to bisphenol a affects uterine function during early pregnancy in mice

Li, Q., Davila, J., Kannan, A., Flaws, J. A., Bagchi, M. K. & Bagchi, I. C., May 2016, In : Endocrinology. 157, 5, p. 1764-1774 11 p.

Research output: Contribution to journalArticle

Pregnancy
Progesterone Receptors
polycarbonate
Fibroblast Growth Factors
Environmental Exposure

Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis

Mahalingam, S., Gao, L., Eisner, J., Helferich, W. G. & Flaws, J. A., Dec 1 2016, In : Reproductive Toxicology. 66, p. 107-114 8 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Growth
Dimethyl Sulfoxide
Estradiol
Estrogens

Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

Mahalingam, S., Gao, L., Gonnering, M., Helferich, W. & Flaws, J. A., Mar 15 2016, In : Toxicology and Applied Pharmacology. 295, p. 47-55 9 p.

Research output: Contribution to journalArticle

Equol
Growth
Isoflavones
Ovarian Follicle
Metabolites
Aryl Hydrocarbon Receptors
Estrogen Receptors
Estrogens
Gene expression
Crosstalk

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y-X., Helferich, W. G. & Flaws, J. A., Feb 15 2016, In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Growth
Phytoestrogens
Cell Cycle
Cells

Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro

Jeong, C. H., Gao, L., Dettro, T., Wagner, E. D., Ricke, W. A., Plewa, M. J. & Flaws, J. A., Jul 1 2016, In : Reproductive Toxicology. 62, p. 71-76 6 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Disinfection
Drinking Water
Byproducts
Acids

Phthalate metabolite levels and menopausal hot flashes in midlife women

Ziv-Gal, A., Gallicchio, L., Chiang, C., Ther, S. N., Miller, S. R., Zacur, H. A., Dills, R. L. & Flaws, J. A., Apr 1 2016, In : Reproductive Toxicology. 60, p. 76-81 6 p.

Research output: Contribution to journalArticle

Hot Flashes
Metabolites
Odds Ratio
Confidence Intervals
phthalic acid

Risk Factors for Extended Duration and Timing of Peak Severity of Hot Flashes

Smith, R. L., Gallicchio, L., Miller, S. R., Zacur, H. A. & Flaws, J. A., Jan 1 2016, In : PloS one. 11, 5, p. e0155079

Research output: Contribution to journalArticle

Hot Flashes
Progesterone
risk factors
Alcohols
duration

The associations between body mass index, smoking, and alcohol intake with ovarian volume in midlife women

Gallicchio, L., Miller, S. R., Kiefer, J., Greene, T., Zacur, H. A. & Flaws, J. A., Apr 1 2016, In : Journal of Women's Health. 25, 4, p. 409-415 7 p.

Research output: Contribution to journalArticle

Body Mass Index
Smoking
Alcohols
Women's Health
Ambulatory Care

The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice

Berger, A., Ziv-Gal, A., Cudiamat, J., Wang, W., Zhou, C. & Flaws, J. A., Apr 1 2016, In : Reproductive Toxicology. 60, p. 39-52 14 p.

Research output: Contribution to journalArticle

Germ Cells
Ovary
Cells
Gene expression
Epoxy Resins