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Research Output 1992 2019

2019

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis

Zhang, Q., Duplany, A., Moncollin, V., Mouradian, S., Goillot, E., Mazelin, L., Gauthier, K., Streichenberger, N., Angleraux, C., Chen, J., Ding, S., Schaeffer, L. & Gangloff, Y. G., Feb 1 2019, In : Journal of Cachexia, Sarcopenia and Muscle. 10, 1, p. 35-53 19 p.

Research output: Contribution to journalArticle

Muscular Diseases
Sirolimus
Homeostasis
Phosphotransferases
Muscles

Lentivirus-mediated RNAi in skeletal myogenesis

Kim, D., Reyes-Ordoñez, A. & Chen, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 1889).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lentivirus
Muscle Development
RNA Interference
Small Interfering RNA
Muscle Cells

Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

Son, K., You, J. S., Yoon, M. S., Dai, C., Kim, J. H., Khanna, N., Banerjee, A., Martinis, S. A., Han, G., Han, J. M., Kim, S. & Chen, J., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

Open Access
Amino Acyl-tRNA Synthetases
Regeneration
Skeletal Muscle
Muscle Development
Transfer RNA Aminoacylation
2018

Effects of rapamycin on growth hormone receptor knockout mice

Fang, Y., Hill, C. M., Darcy, J., Reyes-Ordoñez, A., Arauz, E., McFadden, S., Zhang, C., Osland, J., Gao, J., Zhang, T., Frank, S. J., Javors, M. A., Yuan, R., Kopchick, J. J., Sun, L. Y., Chen, J. & Bartke, A., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. E1495-E1503

Research output: Contribution to journalArticle

Somatotropin Receptors
Sirolimus
Knockout Mice
Raptors
Homeostasis

Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

Kim, I. J., Lee, J., Oh, S. J., Yoon, M. S., Jang, S. S., Holland, R. L., Reno, M. L., Hamad, M. N., Maeda, T., Chung, H. J., Chen, J. & Blanke, S. R., May 9 2018, In : Cell Host and Microbe. 23, 5, p. 583-593.e8

Research output: Contribution to journalArticle

Helicobacter Infections
Helicobacter pylori
Autophagy
Amino Acids
Mitochondria

Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation

Dutta, D., Lai, K. Y., Reyes-Ordoñez, A., Chen, J. & van der Donk, W. A., Jan 1 2018, In : Journal of Lipid Research. 59, 8, p. 1433-1445 13 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Ligases
Protein C
CCAAT-Enhancer-Binding Proteins
Proteins

Mutually inhibitory Ras-PI(3,4)P 2 feedback loops mediate cell migration

Li, X., Edwards, M., Swaney, K. F., Singh, N., Bhattacharya, S., Borleis, J., Long, Y., Iglesias, P. A., Chen, J. & Devreotes, P. N., Sep 25 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9125-E9134

Research output: Contribution to journalArticle

Cell Movement
Phosphoric Monoester Hydrolases
Physiological Phenomena
Chemotactic Factors
Cytoskeleton

To Grow or Not to Grow: TOR and SnRK2 Coordinate Growth and Stress Response in Arabidopsis

Rosenberger, C. L. & Chen, J., Jan 4 2018, In : Molecular cell. 69, 1, p. 3-4 2 p.

Research output: Contribution to journalShort survey

Arabidopsis
Growth
2017

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

Arif, A., Terenzi, F., Potdar, A. A., Jia, J., Sacks, J., China, A., Halawani, D., Vasu, K., Li, X., Brown, J. M., Chen, J., Kozma, S. C., Thomas, G. & Fox, P. L., Feb 16 2017, In : Nature. 542, 7641, p. 357-361 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Adiposity
Fatty Acid Transport Proteins
Phosphorylation
Adipocytes

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals

He, C., Zeng, M., Dutta, D., Koh, T. H., Chen, J. & Van Der Donk, W. A., Jan 20 2017, In : Scientific Reports. 7, 40980.

Research output: Contribution to journalArticle

mammals
synthesis
biosynthesis
brain
proteins

α7β1 integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise

Mahmassani, Z. S., Son, K., Pincu, Y., Munroe, M., Drnevich, J., Chen, J. & Boppart, M., May 11 2017, In : American Journal of Physiology - Cell Physiology. 312, 5, p. 638-650 13 p.

Research output: Contribution to journalArticle

Integrins
Skeletal Muscle
Genes
Muscles
Costameres
2016

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

Yoon, M. S., Son, K., Arauz, E., Han, J. M., Kim, S. & Chen, J., Aug 9 2016, In : Cell Reports. 16, 6, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Amino Acids
Chemical activation
Leucine
Transfer RNA Aminoacylation

Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates

Arauz, E., Aggarwal, V., Jain, A., Ha, T. & Chen, J., May 3 2016, In : Analytical chemistry. 88, 8, p. 4269-4276 8 p.

Research output: Contribution to journalArticle

Lipids
Molecules
Proteins
Assays
Phospholipids
2015

Erratum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax (Nature Communications (2015) 5 (3966) DOI: 10.1038/ncomms4966)

Fang, X., Nevo, E., Han, L., Levanon, E. Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., Fishman, A., Feng, Y., Sher, N., Xiong, Z., Hankeln, T., Huang, Z., Gorbunova, V., Zhang, L., Zhao, W., Wildman, D. & 33 othersXiong, Y., Gudkov, A., Zheng, Q., Rechavi, G., Liu, S., Bazak, L., Chen, J., Knisbacher, B. A., Lu, Y., Shams, I., Gajda, K., Farré, M., Kim, J., Lewin, H. A., Ma, J., Band, M. R., Bicker, A., Kranz, A., Mattheus, T., Schmidt, H., Seluanov, A., Azpurua, J., McGowen, M. R., Ben Jacob, E., Li, K., Peng, S., Zhu, X., Liao, X., Li, S., Krogh, A., Zhou, X., Brodsky, L. & Wang, J., Aug 12 2015, In : Nature communications. 6, 8051.

Research output: Contribution to journalComment/debate

Rats
Genes
Communication

Rapid mitogenic regulation of the mTORC1 Inhibitor, DEPTOR, by phosphatidic acid

Yoon, M. S., Rosenberger, C. L., Wu, C., Truong, N., Sweedler, J. V. & Chen, J., May 7 2015, In : Molecular cell. 58, 3, p. 549-556 8 p.

Research output: Contribution to journalArticle

Phosphatidic Acids
Phospholipase D
Unsaturated Fatty Acids
Mitogens
mechanistic target of rapamycin complex 1
2014

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

Fang, X., Nevo, E., Han, L., Levanon, E. Y., Zhao, J., Avivi, A., Larkin, D., Jiang, X., Feranchuk, S., Zhu, Y., Fishman, A., Feng, Y., Sher, N., Xiong, Z., Hankeln, T., Huang, Z., Gorbunova, V., Zhang, L., Zhao, W., Wildman, D. & 33 othersXiong, Y., Gudkov, A., Zheng, Q., Rechavi, G., Liu, S., Bazak, L., Chen, J., Knisbacher, B. A., Lu, Y., Shams, I., Gajda, K., Farré, M., Kim, J., Lewin, H. A., Ma, J., Band, M. R., Bicker, A., Kranz, A., Mattheus, T., Schmidt, H., Seluanov, A., Azpurua, J., McGowen, M. R., Ben Jacob, E., Li, K., Peng, S., Zhu, X., Liao, X., Li, S., Krogh, A., Zhou, X., Brodsky, L. & Wang, J., Jun 3 2014, In : Nature communications. 5, 3966.

Research output: Contribution to journalArticle

Spalax
Mole Rats
genome
rats
Rats

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt

Zeng, M., Van Der Donk, W. A. & Chen, J., Dec 1 2014, In : Molecular biology of the cell. 25, 24, p. 3954-3961 8 p.

Research output: Contribution to journalArticle

Ligases
Protein C
Phosphorylation
Phosphotransferases
lanthionine

MicroRNA-146b promotes myogenic differentiation and modulates multiple gene targets in muscle cells

Khanna, N., Ge, Y. & Chen, J., Jun 23 2014, In : PloS one. 9, 6, e100657.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
myocytes
Muscle Cells
Muscle

Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown

Jain, A., Arauz, E., Aggarwal, V., Ikon, N., Chen, J. & Ha, T., Dec 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17833-17838 6 p.

Research output: Contribution to journalArticle

Sirolimus
Raptors
Dimerization
Fluorescence Microscopy
Phosphotransferases
2013

Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis

Yoon, M. S. & Chen, J., Dec 1 2013, In : Molecular biology of the cell. 24, 23, p. 3754-3763 10 p.

Research output: Contribution to journalArticle

Muscle Development
Sirolimus
Amino Acids
1-Phosphatidylinositol 4-Kinase
Aminoacylation

Duration of rapamycin treatment has differential effects on metabolism in mice

Fang, Y., Westbrook, R., Hill, C., Boparai, R. K., Arum, O., Spong, A., Wang, F., Javors, M. A., Chen, J., Sun, L. Y. & Bartke, A., Mar 5 2013, In : Cell Metabolism. 17, 3, p. 456-462 7 p.

Research output: Contribution to journalArticle

Sirolimus
Life Expectancy
Metabolome
Oxygen Consumption
Insulin Resistance

Flt3L is a novel regulator of skeletal myogenesis

Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., Sep 9 2013, In : Journal of Cell Science. 126, 15, p. 3370-3379 10 p.

Research output: Contribution to journalArticle

Muscle Development
Phosphotransferases
Ligands
Myoblasts
p120 GTPase Activating Protein

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

He, Y., Li, D., Cook, S. L., Yoon, M. S., Kapoor, A., Rao, C. V., Kenis, P. J. A., Chen, J. & Wang, F., Nov 1 2013, In : Molecular biology of the cell. 24, 21, p. 3369-3380 12 p.

Research output: Contribution to journalArticle

Chemotaxis
Sirolimus
Actin Cytoskeleton
Neutrophils
Actins

Mechanistic target of rapamycin controls homeostasis of adipogenesis

Yoon, M. S., Zhang, C., Sun, Y., Schoenherr, C. J. & Chen, J., Aug 1 2013, In : Journal of Lipid Research. 54, 8, p. 2166-2173 8 p.

Research output: Contribution to journalArticle

Adipogenesis
Sirolimus
Homeostasis
Peroxisome Proliferator-Activated Receptors
CCAAT-Enhancer-Binding Proteins

RNAi Screen Reveals Potentially Novel Roles of Cytokines in Myoblast Differentiation

Ge, Y., Waldemer, R. J., Nalluri, R., Nuzzi, P. D. & Chen, J., Jul 2 2013, In : PloS one. 8, 7, e68068.

Research output: Contribution to journalArticle

myoblasts
Myoblasts
RNA Interference
cytokines
Cytokines

XPLN is an endogenous inhibitor of mTORC2

Khanna, N., Fang, Y., Yoon, M. S. & Chen, J., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 15979-15984 6 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Phosphotransferases
TOR complex 2
rho GTP-Binding Proteins
Muscle Proteins
2012

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Zhang, C., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J. & Coleman, R. A., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1667-1672 6 p.

Research output: Contribution to journalArticle

Acyltransferases
Phosphatidic Acids
Insulin
Hepatocytes
Diglycerides

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., Sztalryd, C., Bennett, M. J., Ahima, R. S., Birnbaum, M. J. & Lazar, M. A., Jun 1 2012, In : Nature Medicine. 18, 6, p. 934-942 9 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Lipids
Liver
Insulin
Insulin Resistance

Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis

Ge, Y. & Chen, J., Dec 21 2012, In : Journal of Biological Chemistry. 287, 52, p. 43928-43935 8 p.

Research output: Contribution to journalShort survey

Muscle Development
Sirolimus
Mitogens
Muscle Cells
Nutrients
2011

Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway

Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A. & Chen, J., Oct 31 2011, In : Journal of Cell Biology. 195, 3, p. 435-447 13 p.

Research output: Contribution to journalArticle

Phospholipase D
Phosphatidylinositol 3-Kinases
Amino Acids
Aminoacylation
Sirolimus

IGF-II is regulated by microRNA-125b in skeletal myogenesis

Ge, Y., Sun, Y. & Chen, J., Jan 10 2011, In : Journal of Cell Biology. 192, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Muscle Development
MicroRNAs
Sirolimus
Muscles

MicroRNAs in skeletal myogenesis

Ge, Y. & Chen, J., Feb 1 2011, In : Cell Cycle. 10, 3, p. 441-448 8 p.

Research output: Contribution to journalReview article

Muscle Development
MicroRNAs
Skeletal Muscle
Naphazoline
Biological Phenomena

Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect

Yoon, M. S., Sun, Y., Arauz, E., Jiang, Y. & Chen, J., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29568-29574 7 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Phosphatidic Acids
Phosphotransferases
Tacrolimus Binding Protein 1A
Chemical activation

Probing cellular protein complexes using single-molecule pull-down

Jain, A., Liu, R., Ramani, B., Arauz, E., Ishitsuka, Y., Ragunathan, K., Park, J., Chen, J., Xiang, Y. K. & Ha, T., May 26 2011, In : Nature. 473, 7348, p. 484-488 5 p.

Research output: Contribution to journalArticle

Proteins
Macromolecular Substances
Tissue Extracts
Cyclic AMP-Dependent Protein Kinases
Fluorescence Microscopy

Raptor and rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1)

Ge, Y., Yoon, M. S. & Chen, J., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35675-35682 8 p.

Research output: Contribution to journalArticle

Raptors
Insulin Receptor Substrate Proteins
Muscle Development
Sirolimus
Phosphorylation
2010

A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy

Goodman, C. A., Miu, M. H., Frey, J. W., Mabrey, D. M., Lincoln, H. C., Ge, Y., Chen, J. & Hornberger, T. A., Sep 15 2010, In : Molecular biology of the cell. 21, 18, p. 3258-3268 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Sirolimus
Hypertrophy
Skeletal Muscle

Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis

Sun, Y., Ge, Y., Drnevich, J., Zhao, Y., Band, M. & Chen, J., Jun 28 2010, In : Journal of Cell Biology. 189, 7, p. 1157-1169 13 p.

Research output: Contribution to journalArticle

Follistatin
Muscle Development
Sirolimus
MicroRNAs
Histone Deacetylase 1
2009
Lipolysis
Sirolimus
Adipocytes
Insulin
Amino Acids

Chapter 21 Interleukin-6 and Insulin Resistance

Kim, J. H., Bachmann, R. A. & Chen, J., Mar 5 2009, Vitamins and Hormones. C ed. p. 613-633 21 p. (Vitamins and Hormones; vol. 80, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

Insulin Resistance
Interleukin-6
Insulin
Adipose Tissue
Liver

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization

Simons, M., Gault, W. J., Gotthardt, D., Rohatgi, R., Klein, T. J., Shao, Y., Lee, H. J., Wu, A. L., Fang, Y., Satlin, L. M., Dow, J. T., Chen, J., Zheng, J., Boutros, M. & Mlodzik, M., Feb 24 2009, In : Nature Cell Biology. 11, 3, p. 286-294 9 p.

Research output: Contribution to journalArticle

Cues
Phospholipids
Cell Membrane
Basic Amino Acids
Cell Polarity
Cues
Cell Biology
Cell Membrane

Erratum: Electrochemical cues regulate assembly of the Frizzled/ Dishevelled complex at the plasma membrane during planar epithelial polarization (Nature Cell Biology (2009) vol. 11 (286-294))

Simons, M., Gault, W. J., Gotthardt, D., Rohatgi, R., Klein, T. J., Shao, Y., Lee, H. J., Wu, A. L., Fang, Y., Satlin, L. M., Dow, J. T., Chen, J., Zheng, J., Boutros, M. & Mlodzik, M., Apr 14 2009, In : Nature Cell Biology. 11, 4, 1 p.

Research output: Contribution to journalComment/debate

Cues
Cell Biology
Cell Membrane

mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms

Ge, Y., Wu, A. L., Warnes, C., Liu, J., Zhang, C., Kawasome, H., Terada, N., Boppart, M. D., Schoenherr, C. J. & Chen, J., Dec 1 2009, In : American Journal of Physiology - Cell Physiology. 297, 6

Research output: Contribution to journalArticle

Sirolimus
Regeneration
Skeletal Muscle
Phosphotransferases
Muscles

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

Zhou, J., Su, P., Wang, L., Chen, J., Zimmermann, M., Genbacev, O., Afonja, O., Horne, M. C., Tanaka, T., Duan, E., Fisher, S. J., Liao, J., Chen, J. & Wang, F., May 12 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 19, p. 7840-7845 6 p.

Research output: Contribution to journalArticle

Endoderm
Mesoderm
Sirolimus
Developmental Genes
Protein-Serine-Threonine Kinases

Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin ignaling through serine 727 phosphorylation

Kim, J. H., Yoon, M. S. & Chen, J., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35425-35432 8 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Phosphorylation
Serine
Insulin
Amino Acids
2008

Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components

Wu, A. L., Kim, J. H., Zhang, C., Unterman, T. G. & Chen, J., Mar 1 2008, In : Endocrinology. 149, 3, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Sirolimus
Insulin-Like Growth Factor II
Muscle Development
Phosphatidylinositol 3-Kinase

mTOR signaling: PLD takes center stage

Sun, Y. & Chen, J., Oct 15 2008, In : Cell Cycle. 7, 20, p. 3118-3123 6 p.

Research output: Contribution to journalReview article

Phospholipase D
Sirolimus
Phosphatidic Acids
Biological Phenomena
Food

Phospholipase D1 is an effector of Rheb in the mTOR pathway

Sun, Y., Fang, Y., Yoon, M. S., Zhang, C., Roccio, M., Zwartkruis, F. J., Armstrong, M., Brown, H. A. & Chen, J., Jun 17 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8286-8291 6 p.

Research output: Contribution to journalArticle

Phospholipase D
Sirolimus
Phosphatidic Acids
AMP-Activated Protein Kinases
Monomeric GTP-Binding Proteins

PLD regulates myoblast differentiation through the mTOR-IGF2 pathway

Yoon, M. S. & Chen, J., Feb 1 2008, In : Journal of Cell Science. 121, 3, p. 282-289 8 p.

Research output: Contribution to journalArticle

Phospholipase D
Myoblasts
Sirolimus
Muscle Development
Skeletal Myoblasts

Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway

Kim, J. H., Jae, E. K., Liu, H. Y., Cao, W. & Chen, J., Jan 11 2008, In : Journal of Biological Chemistry. 283, 2, p. 708-715 8 p.

Research output: Contribution to journalArticle

Sirolimus
Insulin Resistance
Interleukin-6
Insulin
Ribosomal Protein S6 Kinases