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2020

Biodegradable Polyanhydrides as Encapsulation Layers for Transient Electronics

Choi, Y. S., Koo, J., Lee, Y. J., Lee, G., Avila, R., Ying, H., Reeder, J., Hambitzer, L., Im, K., Kim, J., Lee, K. M., Cheng, J., Huang, Y., Kang, S. K. & Rogers, J. A., Jan 1 2020, (Accepted/In press) In : Advanced Functional Materials.

Research output: Contribution to journalArticle

Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering

Shen, L., Shen, L., Cai, K., Yu, J. & Cheng, J., Jun 16 2020, In : ACS Omega. 5, 23, p. 14111-14115 5 p.

Research output: Contribution to journalArticle

Open Access

Manipulating the helix-coil transition profile of synthetic polypeptides by leveraging side-chain molecular interactions

Song, Z., Tan, Z., Zheng, X., Fu, Z., Ponnusamy, E. & Cheng, J., Feb 28 2020, In : Polymer Chemistry. 11, 8, p. 1445-1449 5 p.

Research output: Contribution to journalArticle

Targeting infected host cells in vivo via responsive azido-sugar mediated metabolic cell labeling followed by click reaction

Bo, Y., Jiang, Y., Chen, K., Cai, K., Li, W., Roy, J., Bao, Y. & Cheng, J., Apr 2020, In : Biomaterials. 238, 119843.

Research output: Contribution to journalArticle

2019

Azido-galactose outperforms azido-mannose for metabolic labeling and targeting of hepatocellular carcinoma

Wang, H., Liu, Y., Xu, M. & Cheng, J., Oct 2019, In : Biomaterials Science. 7, 10, p. 4166-4173 8 p.

Research output: Contribution to journalArticle

Enzyme-mimetic self-catalyzed polymerization of polypeptide helices

Song, Z., Fu, H., Baumgartner, R., Zhu, L., Shih, K. C., Xia, Y., Zheng, X., Yin, L., Chipot, C., Lin, Y. & Cheng, J., Dec 1 2019, In : Nature communications. 10, 1, 5470.

Research output: Contribution to journalArticle

Open Access

Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N-Carboxyanhydrides

Wang, X., Song, Z., Tan, Z., Zhu, L., Xue, T., Lv, S., Fu, Z., Zheng, X., Ren, J. & Cheng, J., Nov 19 2019, In : ACS Macro Letters. 8, 11, p. 1517-1521 5 p.

Research output: Contribution to journalArticle

Hindered urea bond: A bilaterally responsive chemistry to hydrogen peroxide

Ying, H., Yang, Y., Cai, K. & Cheng, J., Jan 1 2019, In : European Journal of Organic Chemistry. 2019, 4, p. 728-731 4 p.

Research output: Contribution to journalArticle

In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction

Wang, H., Bo, Y., Liu, Y., Xu, M., Cai, K., Wang, R. & Cheng, J., Oct 2019, In : Biomaterials. 218, 119305.

Research output: Contribution to journalArticle

Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labeling and Imaging via Cu-Free Click Chemistry

Shen, L., Cai, K., Yu, J. & Cheng, J., Sep 18 2019, In : Bioconjugate Chemistry. 30, 9, p. 2317-2322 6 p.

Research output: Contribution to journalArticle

Proximity-Induced Cooperative Polymerization in "hinged" Helical Polypeptides

Chen, C., Fu, H., Baumgartner, R., Song, Z., Lin, Y. & Cheng, J., Jun 5 2019, In : Journal of the American Chemical Society. 141, 22, p. 8680-8683 4 p.

Research output: Contribution to journalArticle

Reconfigurable Poly(urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-Shape-Memory Performance

Jia, Y., Ying, H., Zhang, Y., He, H. & Cheng, J., Jun 2019, In : Macromolecular Chemistry and Physics. 220, 12, 1900148.

Research output: Contribution to journalArticle

Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides

Song, Z., Fu, H., Wang, J., Hui, J., Xue, T., Pacheco, L. A., Yan, H., Baumgartner, R., Wang, Z., Xia, Y., Wang, X., Yin, L., Chen, C., Rodríguez-López, J., Ferguson, A. L., Lin, Y. & Cheng, J., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10658-10663 6 p.

Research output: Contribution to journalArticle

2018

A caged metabolic precursor for DT-diaphorase-responsive cell labeling

Wang, R., Cai, K., Wang, H., Yin, C. & Cheng, J., Jan 1 2018, In : Chemical Communications. 54, 38, p. 4878-4881 4 p.

Research output: Contribution to journalArticle

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy

He, X., Cai, K., Zhang, Y., Lu, Y., Guo, Q., Zhang, Y., Liu, L., Ruan, C., Chen, Q., Chen, X., Li, C., Sun, T., Cheng, J. & Jiang, C., Nov 21 2018, In : ACS Applied Materials and Interfaces. 10, 46, p. 39455-39467 13 p.

Research output: Contribution to journalArticle

Dynamic Ureas with Fast and pH-Independent Hydrolytic Kinetics

Cai, K., Ying, H. & Cheng, J., May 23 2018, In : Chemistry - A European Journal. 24, 29, p. 7345-7348 4 p.

Research output: Contribution to journalArticle

Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

He, H., Chen, Y., Li, Y., Song, Z., Zhong, Y., Zhu, R., Cheng, J. & Yin, L., Apr 5 2018, In : Advanced Functional Materials. 28, 14, 1706710.

Research output: Contribution to journalArticle

Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy

He, X., Zhang, J., Li, C., Zhang, Y., Lu, Y., Zhang, Y., Liu, L., Ruan, C., Chen, Q., Chen, X., Guo, Q., Sun, T., Cheng, J. & Jiang, C., Jan 1 2018, In : Theranostics. 8, 18, p. 4884-4897 14 p.

Research output: Contribution to journalArticle

Open Access

High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions

Lv, S., Wu, Y., Cai, K., He, H., Li, Y., Lan, M., Chen, X., Cheng, J. & Yin, L., Jan 31 2018, In : Journal of the American Chemical Society. 140, 4, p. 1235-1238 4 p.

Research output: Contribution to journalArticle

Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Liu, L., Wang, R., Wang, C., Wang, J., Chen, L. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 997-1001 5 p.

Research output: Contribution to journalArticle

Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

Zhang, Y., Cai, K., Li, C., Guo, Q., Chen, Q., He, X., Liu, L., Zhang, Y., Lu, Y., Chen, X., Sun, T., Huang, Y., Cheng, J. & Jiang, C., Mar 14 2018, In : Nano letters. 18, 3, p. 1908-1915 8 p.

Research output: Contribution to journalArticle

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Wang, H. X., Song, Z., Lao, Y. H., Xu, X., Gong, J., Cheng, D., Chakraborty, S., Park, J. S., Li, M., Huang, D., Yin, L., Cheng, J. & Leong, K. W., May 8 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. 4903-4908 6 p.

Research output: Contribution to journalArticle

Synthesis of indocyanine green functionalized comblike poly(aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum

Wan, J., Sun, L., Wu, P., Wang, F., Guo, J., Cheng, J. & Wang, C., Mar 14 2018, In : Polymer Chemistry. 9, 10, p. 1206-1215 10 p.

Research output: Contribution to journalArticle

Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles

Liu, Y., Song, Z., Zheng, N., Nagasaka, K., Yin, L. & Cheng, J., Aug 28 2018, In : Nanoscale. 10, 32, p. 15339-15349 11 p.

Research output: Contribution to journalArticle

2017

Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition

Xiong, M., Han, Z., Song, Z., Yu, J., Ying, H., Yin, L. & Cheng, J., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 36, p. 10826-10829 4 p.

Research output: Contribution to journalArticle

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα

Bao, Y., Wu, X., Chen, J., Hu, X., Zeng, F., Cheng, J., Jin, H., Lin, X. & Chen, L. F., May 16 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 20, p. E3993-E4001

Research output: Contribution to journalArticle

Cooperative polymerization of α-helices induced by macromolecular architecture

Baumgartner, R., Fu, H., Song, Z., Lin, Y. & Cheng, J., Jul 1 2017, In : Nature Chemistry. 9, 7, p. 614-622 9 p.

Research output: Contribution to journalArticle

Degradable and biocompatible hydrogels bearing a hindered urea bond

Ying, H., Yen, J., Wang, R., Lai, Y., Hsu, J. L. A., Hu, Y. & Cheng, J., Dec 2017, In : Biomaterials Science. 5, 12, p. 2398-2402 5 p.

Research output: Contribution to journalArticle

Folding Cooperativity of Synthetic Polypeptides with or without "tertiary" Interactions

Ren, Y., Fu, H., Baumgartner, R., Zhang, Y., Cheng, J. & Lin, Y., Jul 18 2017, In : ACS Macro Letters. 6, 7, p. 733-737 5 p.

Research output: Contribution to journalArticle

Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide

Zheng, N., Song, Z., Liu, Y., Yin, L. & Cheng, J., Dec 1 2017, In : Frontiers of Chemical Science and Engineering. 11, 4, p. 521-528 8 p.

Research output: Contribution to journalArticle

Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine

Lv, S., Tang, Z., Song, W., Zhang, D., Li, M., Liu, H., Cheng, J., Zhong, W. & Chen, X., Mar 28 2017, In : Small. 13, 12, 1600954.

Research output: Contribution to journalArticle

Interactions between Membranes and "metaphilic" Polypeptide Architectures with Diverse Side-Chain Populations

Lee, M. W., Han, M., Bossa, G. V., Snell, C., Song, Z., Tang, H., Yin, L., Cheng, J., May, S., Luijten, E. & Wong, G. C. L., Mar 28 2017, In : ACS Nano. 11, 3, p. 2858-2871 14 p.

Research output: Contribution to journalArticle

Investigation on the controlled synthesis and post-modification of poly-[( N-2-hydroxyethyl)-aspartamide]-based polymers

Lv, S., Wu, Y., Dang, J., Tang, Z., Song, Z., Ma, S., Wang, X., Chen, X., Cheng, J. & Yin, L., Mar 28 2017, In : Polymer Chemistry. 8, 12, p. 1872-1877 6 p.

Research output: Contribution to journalArticle

Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery

Zheng, N., Song, Z., Yang, J., Liu, Y., Li, F., Cheng, J. & Yin, L., Aug 2017, In : Acta Biomaterialia. 58, p. 146-157 12 p.

Research output: Contribution to journalArticle

Modulation of polypeptide conformation through donor-acceptor transformation of side-chain hydrogen bonding ligands

Song, Z., Mansbach, R. A., He, H., Shih, K. C., Baumgartner, R., Zheng, N., Ba, X., Huang, Y., Mani, D., Liu, Y., Lin, Y., Nieh, M. P., Ferguson, A. L., Yin, L. & Cheng, J., Dec 1 2017, In : Nature communications. 8, 1, 92.

Research output: Contribution to journalArticle

Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer

Tian, J., Min, Y., Rodgers, Z., Wan, X., Qiu, H., Mi, Y., Tian, X., Wagner, K. T., Caster, J. M., Qi, Y., Roche, K., Zhang, T., Cheng, J. & Wang, A. Z., Apr 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 3, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution

Ren, Y., Baumgartner, R., Fu, H., Van Der Schoot, P., Cheng, J. & Lin, Y., Aug 14 2017, In : Biomacromolecules. 18, 8, p. 2324-2332 9 p.

Research output: Contribution to journalArticle

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, Cheng, J., Apr 1 2017, In : Nature chemical biology. 13, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides

Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L. F. & Cheng, J., Nov 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. 12675-12680 6 p.

Research output: Contribution to journalArticle

Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors

Chen, J., Ding, J., Wang, Y., Cheng, J., Ji, S., Zhuang, X. & Chen, X., Aug 25 2017, In : Advanced Materials. 29, 32, 1701170.

Research output: Contribution to journalArticle

Singlet oxygen-responsive micelles for enhanced photodynamic therapy

Li, X., Gao, M., Xin, K., Zhang, L., Ding, D., Kong, D., Wang, Z., Shi, Y., Kiessling, F., Lammers, T., Cheng, J. & Zhao, Y., Aug 28 2017, In : Journal of Controlled Release. 260, p. 12-21 10 p.

Research output: Contribution to journalArticle

Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in Situ

Xia, H., Fu, H., Zhang, Y., Shih, K. C., Ren, Y., Anuganti, M., Nieh, M. P., Cheng, J. & Lin, Y., Aug 16 2017, In : Journal of the American Chemical Society. 139, 32, p. 11106-11116 11 p.

Research output: Contribution to journalArticle

Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers

Baumgartner, R., Kuai, D. & Cheng, J., Sep 2017, In : Biomaterials Science. 5, 9, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

2016

A delayed curing ROMP based thermosetting resin

Baumgartner, R., Ryba, K., Song, Z., Wang, R., Harris, K., Katz, J. S. & Cheng, J., Aug 28 2016, In : Polymer Chemistry. 7, 32, p. 5093-5098 6 p.

Research output: Contribution to journalArticle

Bioresorbable silicon electronic sensors for the brain

Kang, S. K., Murphy, R. K. J., Hwang, S. W., Lee, S. M., Harburg, D. V., Krueger, N. A., Shin, J., Gamble, P., Cheng, H., Yu, S., Liu, Z., McCall, J. G., Stephen, M., Ying, H., Kim, J., Park, G., Webb, R. C., Lee, C. H., Chung, S., Wie, D. S. & 10 others, Gujar, A. D., Vemulapalli, B., Kim, A. H., Lee, K. M., Cheng, J., Huang, Y., Lee, S. H., Braun, P. V., Ray, W. Z. & Rogers, J. A., Feb 4 2016, In : Nature. 530, 7588, p. 71-76 6 p.

Research output: Contribution to journalArticle

CD44 Mediated Nonviral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic-Acid-Coated Nanoparticles

Yen, J., Ying, H., Wang, H., Yin, L., Uckun, F. & Cheng, J., Mar 14 2016, In : ACS Biomaterials Science and Engineering. 2, 3, p. 326-335 10 p.

Research output: Contribution to journalArticle

Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using a β-Diiminate Zinc Catalyst

Wang, R., Zhang, J., Yin, Q., Xu, Y., Cheng, J. & Tong, R., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 42, p. 13010-13014 5 p.

Research output: Contribution to journalArticle

Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores

Li, Y., Bai, Y., Zheng, N., Liu, Y., Vincil, G. A., Pedretti, B. J., Cheng, J. & Zimmerman, S. C., Jan 1 2016, In : Chemical Communications. 52, 19, p. 3781-3784 4 p.

Research output: Contribution to journalArticle

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

Bai, Y., Nguyen, L., Song, Z., Peng, S., Lee, J., Zheng, N., Kapoor, I., Hagler, L. D., Cai, K., Cheng, J., Chan, H. Y. E. & Zimmerman, S. C., Aug 3 2016, In : Journal of the American Chemical Society. 138, 30, p. 9498-9507 10 p.

Research output: Contribution to journalArticle