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Research Output 1997 2019

2019

Azido-galactose outperforms azido-mannose for metabolic labeling and targeting of hepatocellular carcinoma

Wang, H., Liu, Y., Xu, M. & Cheng, J., Oct 2019, In : Biomaterials Science. 7, 10, p. 4166-4173 8 p.

Research output: Contribution to journalArticle

Mannose
Galactose
Labeling
Monosaccharides
Tumors

Facile Synthesis of Helical Multiblock Copolypeptides: Minimal Side Reactions with Accelerated Polymerization of N-Carboxyanhydrides

Wang, X., Song, Z., Tan, Z., Zhu, L., Xue, T., Lv, S., Fu, Z., Zheng, X., Ren, J. & Cheng, J., Nov 19 2019, In : ACS Macro Letters. 8, 11, p. 1517-1521 5 p.

Research output: Contribution to journalArticle

Polymerization
Polypeptides
Chloroform
Chlorine compounds
Emulsions

Hindered urea bond: A bilaterally responsive chemistry to hydrogen peroxide

Ying, H., Yang, Y., Cai, K. & Cheng, J., Jan 1 2019, In : European Journal of Organic Chemistry. 2019, 4, p. 728-731 4 p.

Research output: Contribution to journalArticle

hydrogen peroxide
ureas
Isocyanates
Hydrogen Peroxide
isocyanates

In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction

Wang, H., Bo, Y., Liu, Y., Xu, M., Cai, K., Wang, R. & Cheng, J., Oct 2019, In : Biomaterials. 218, 119305.

Research output: Contribution to journalArticle

Nanoparticles
Labeling
Tumors
Sugars
Neoplasms

Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labeling and Imaging via Cu-Free Click Chemistry

Shen, L., Cai, K., Yu, J. & Cheng, J., Sep 18 2019, In : Bioconjugate Chemistry. 30, 9, p. 2317-2322 6 p.

Research output: Contribution to journalArticle

Click Chemistry
Labeling
Lipids
Imaging techniques
Triazoles

Proximity-Induced Cooperative Polymerization in "hinged" Helical Polypeptides

Chen, C., Fu, H., Baumgartner, R., Song, Z., Lin, Y. & Cheng, J., Jun 5 2019, In : Journal of the American Chemical Society. 141, 22, p. 8680-8683 4 p.

Research output: Contribution to journalArticle

Polypeptides
polymerization
Polymerization
Peptides
Diamines

Recent Advances and Future Perspectives of Synthetic Polypeptides from N-Carboxyanhydrides

Song, Z., Tan, Z. & Cheng, J., Jan 1 2019, (Accepted/In press) In : Macromolecules.

Research output: Contribution to journalArticle

Polypeptides
Peptides
Ring opening polymerization
Biocompatible Materials
Biomaterials

Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy

Mei, Y., Wang, R., Jiang, W., Bo, Y., Zhang, T., Yu, J., Cheng, M., Wu, Y., Cheng, J. & Ma, W., Jul 2019, In : Biomaterials Science. 7, 7, p. 2640-2651 12 p.

Research output: Contribution to journalReview article

Nucleic acids
RNA
Nanostructured materials
Nucleic Acids
Small Interfering RNA

Reconfigurable Poly(urea-urethane) Thermoset Based on Hindered Urea Bonds with Triple-Shape-Memory Performance

Jia, Y., Ying, H., Zhang, Y., He, H. & Cheng, J., Jun 2019, In : Macromolecular Chemistry and Physics. 220, 12, 1900148.

Research output: Contribution to journalArticle

urethanes
Urethane
Thermosets
Shape memory effect
ureas

Supramolecular nanotheranostics

Chen, X., Zheng, G., Cheng, J. & Yang, Y. Y., Jan 1 2019, In : Theranostics. 9, 11, p. 3014-3016 3 p.

Research output: Contribution to journalReview article

Open Access
Research

Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides

Song, Z., Fu, H., Wang, J., Hui, J., Xue, T., Pacheco, L. A., Yan, H., Baumgartner, R., Wang, Z., Xia, Y., Wang, X., Yin, L., Chen, C., Rodríguez-López, J., Ferguson, A. L., Lin, Y. & Cheng, J., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10658-10663 6 p.

Research output: Contribution to journalArticle

Polymerization
Peptides
Water
Catalytic RNA
Methylene Chloride
2018

A caged metabolic precursor for DT-diaphorase-responsive cell labeling

Wang, R., Cai, K., Wang, H., Yin, C. & Cheng, J., Jan 1 2018, In : Chemical Communications. 54, 38, p. 4878-4881 4 p.

Research output: Contribution to journalArticle

NAD(P)H Dehydrogenase (Quinone)
Metabolites
Sugars
Labeling
Cells

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Nanoconjugates
Tumors
Albumins
Bearings (structural)
Medical nanotechnology

Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy

He, X., Cai, K., Zhang, Y., Lu, Y., Guo, Q., Zhang, Y., Liu, L., Ruan, C., Chen, Q., Chen, X., Li, C., Sun, T., Cheng, J. & Jiang, C., Nov 21 2018, In : ACS Applied Materials and Interfaces. 10, 46, p. 39455-39467 13 p.

Research output: Contribution to journalArticle

Prodrugs
Camptothecin
Nanoparticles
Pharmaceutical Preparations
Polyethylene glycols

Dynamic Ureas with Fast and pH-Independent Hydrolytic Kinetics

Cai, K., Ying, H. & Cheng, J., May 23 2018, In : Chemistry - A European Journal. 24, 29, p. 7345-7348 4 p.

Research output: Contribution to journalArticle

Urea
Hydrolysis
Kinetics
Polymers
Biocompatible Materials

Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering

He, H., Chen, Y., Li, Y., Song, Z., Zhong, Y., Zhu, R., Cheng, J. & Yin, L., Apr 5 2018, In : Advanced Functional Materials. 28, 14, 1706710.

Research output: Contribution to journalArticle

delivery
cancer
engineering
proteins
Proteins

Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy

He, X., Zhang, J., Li, C., Zhang, Y., Lu, Y., Zhang, Y., Liu, L., Ruan, C., Chen, Q., Chen, X., Guo, Q., Sun, T., Cheng, J. & Jiang, C., Jan 1 2018, In : Theranostics. 8, 18, p. 4884-4897 14 p.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Prodrugs
Nanoparticles
Oxidation-Reduction
Pharmaceutical Preparations

High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions

Lv, S., Wu, Y., Cai, K., He, H., Li, Y., Lan, M., Chen, X., Cheng, J. & Yin, L., Jan 31 2018, In : Journal of the American Chemical Society. 140, 4, p. 1235-1238 4 p.

Research output: Contribution to journalArticle

Micelles
drug
Pharmaceutical Preparations
irinotecan
Electrons

Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Liu, L., Wang, R., Wang, C., Wang, J., Chen, L. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 997-1001 5 p.

Research output: Contribution to journalArticle

Photodynamic therapy
Chemotherapy
Porphyrins
Pharmaceutical Preparations

Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

Zhang, Y., Cai, K., Li, C., Guo, Q., Chen, Q., He, X., Liu, L., Zhang, Y., Lu, Y., Chen, X., Sun, T., Huang, Y., Cheng, J. & Jiang, C., Mar 14 2018, In : Nano letters. 18, 3, p. 1908-1915 8 p.

Research output: Contribution to journalArticle

macrophages
Chemotherapy
Macrophages
chemotherapy
Tumors

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Wang, H. X., Song, Z., Lao, Y. H., Xu, X., Gong, J., Cheng, D., Chakraborty, S., Park, J. S., Li, M., Huang, D., Yin, L., Cheng, J. & Leong, K. W., May 8 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. 4903-4908 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Peptides
Plasmids
Membranes
Gene Knock-In Techniques

Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications

Song, Z., Fu, H., Wang, R., Pacheco, L. A., Wang, X., Lin, Y. & Cheng, J., Oct 7 2018, In : Chemical Society Reviews. 47, 19, p. 7401-7425 25 p.

Research output: Contribution to journalReview article

Modulation
Association reactions
Peptides
Conformations
Polymers

Synthesis of indocyanine green functionalized comblike poly(aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum

Wan, J., Sun, L., Wu, P., Wang, F., Guo, J., Cheng, J. & Wang, C., Mar 14 2018, In : Polymer Chemistry. 9, 10, p. 1206-1215 10 p.

Research output: Contribution to journalArticle

Indocyanine Green
Ablation
Aspartic Acid
Endoplasmic Reticulum
Polyethylene glycols

Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanoparticles

Liu, Y., Song, Z., Zheng, N., Nagasaka, K., Yin, L. & Cheng, J., Aug 28 2018, In : Nanoscale. 10, 32, p. 15339-15349 11 p.

Research output: Contribution to journalArticle

Polypeptides
Small Interfering RNA
Tumors
Nanoparticles
Peptides
2017

Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition

Xiong, M., Han, Z., Song, Z., Yu, J., Ying, H., Yin, L. & Cheng, J., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 36, p. 10826-10829 4 p.

Research output: Contribution to journalArticle

Polypeptides
Peptides
Bacteria
Chemical activation
Toxicity

Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties

Cai, K., Wang, A. Z., Yin, L. & Cheng, J., Oct 10 2017, In : Journal of Controlled Release. 263, p. 211-222 12 p.

Research output: Contribution to journalReview article

Nanomedicine
Nanostructures
Medicine

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα

Bao, Y., Wu, X., Chen, J., Hu, X., Zeng, F., Cheng, J., Jin, H., Lin, X. & Chen, L. F., May 16 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 20, p. E3993-E4001

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Innate Immunity
Gene Expression
Macrophages

Cooperative polymerization of α-helices induced by macromolecular architecture

Baumgartner, R., Fu, H., Song, Z., Lin, Y. & Cheng, J., Jul 1 2017, In : Nature Chemistry. 9, 7, p. 614-622 9 p.

Research output: Contribution to journalArticle

Polypeptides
Polymerization
Macromolecules
Peptides
Proteins

Degradable and biocompatible hydrogels bearing a hindered urea bond

Ying, H., Yen, J., Wang, R., Lai, Y., Hsu, J. L. A., Hu, Y. & Cheng, J., Dec 2017, In : Biomaterials Science. 5, 12, p. 2398-2402 5 p.

Research output: Contribution to journalArticle

Bearings (structural)
Hydrogels
Hydrogel
Urea
Degradation

Folding Cooperativity of Synthetic Polypeptides with or without "tertiary" Interactions

Ren, Y., Fu, H., Baumgartner, R., Zhang, Y., Cheng, J. & Lin, Y., Jul 18 2017, In : ACS Macro Letters. 6, 7, p. 733-737 5 p.

Research output: Contribution to journalArticle

Polypeptides
Macromolecules
Peptides
Lysine
Protein folding

Gene delivery into isolated Arabidopsis thaliana protoplasts and intact leaves using cationic, α-helical polypeptide

Zheng, N., Song, Z., Liu, Y., Yin, L. & Cheng, J., Dec 1 2017, In : Frontiers of Chemical Science and Engineering. 11, 4, p. 521-528 8 p.

Research output: Contribution to journalArticle

Polypeptides
DNA
Genes
Peptides
Cells

Inhibiting Solid Tumor Growth In Vivo by Non-Tumor-Penetrating Nanomedicine

Lv, S., Tang, Z., Song, W., Zhang, D., Li, M., Liu, H., Cheng, J., Zhong, W. & Chen, X., Mar 28 2017, In : Small. 13, 12, 1600954.

Research output: Contribution to journalArticle

Nanomedicine
Medical nanotechnology
Tumors
Growth
Neoplasms

Interactions between Membranes and "metaphilic" Polypeptide Architectures with Diverse Side-Chain Populations

Lee, M. W., Han, M., Bossa, G. V., Snell, C., Song, Z., Tang, H., Yin, L., Cheng, J., May, S., Luijten, E. & Wong, G. C. L., Mar 28 2017, In : ACS Nano. 11, 3, p. 2858-2871 14 p.

Research output: Contribution to journalArticle

Polypeptides
polypeptides
Peptides
peptides
membranes

Investigation on the controlled synthesis and post-modification of poly-[( N-2-hydroxyethyl)-aspartamide]-based polymers

Lv, S., Wu, Y., Dang, J., Tang, Z., Song, Z., Ma, S., Wang, X., Chen, X., Cheng, J. & Yin, L., Mar 28 2017, In : Polymer Chemistry. 8, 12, p. 1872-1877 6 p.

Research output: Contribution to journalArticle

Polymers
Amphiphiles
Polypeptides
Biomaterials
Hydrogen bonds

Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery

Zheng, N., Song, Z., Yang, J., Liu, Y., Li, F., Cheng, J. & Yin, L., Aug 2017, In : Acta Biomaterialia. 58, p. 146-157 12 p.

Research output: Contribution to journalArticle

Polypeptides
Genes
Endocytosis
Membranes
Peptides

Modulation of polypeptide conformation through donor-acceptor transformation of side-chain hydrogen bonding ligands

Song, Z., Mansbach, R. A., He, H., Shih, K. C., Baumgartner, R., Zheng, N., Ba, X., Huang, Y., Mani, D., Liu, Y., Lin, Y., Nieh, M. P., Ferguson, A., Yin, L. & Cheng, J., Dec 1 2017, In : Nature communications. 8, 1, 92.

Research output: Contribution to journalArticle

polypeptides
Hydrogen Bonding
Conformations
Hydrogen bonds
Modulation

Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer

Tian, J., Min, Y., Rodgers, Z., Wan, X., Qiu, H., Mi, Y., Tian, X., Wagner, K. T., Caster, J. M., Qi, Y., Roche, K., Zhang, T., Cheng, J. & Wang, A. Z., Apr 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 3, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

docetaxel
Chemotherapy
Prodrugs
Cytotoxicity
Combination Drug Therapy

Revisiting the Helical Cooperativity of Synthetic Polypeptides in Solution

Ren, Y., Baumgartner, R., Fu, H., Van Der Schoot, P., Cheng, J. & Lin, Y., Aug 14 2017, In : Biomacromolecules. 18, 8, p. 2324-2332 9 p.

Research output: Contribution to journalArticle

Polypeptides
Peptides
Chain length

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, Cheng, J., Apr 1 2017, In : Nature chemical biology. 13, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

Neoplasms
Cell Surface Receptors
Click Chemistry
Triple Negative Breast Neoplasms
Cathepsin L

Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides

Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L. F. & Cheng, J., Nov 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. 12675-12680 6 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Bacteria
Stomach
Peptides
Glutamic Acid

Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors

Chen, J., Ding, J., Wang, Y., Cheng, J., Ji, S., Zhuang, X. & Chen, X., Aug 25 2017, In : Advanced Materials. 29, 32, 1701170.

Research output: Contribution to journalArticle

Tumors
Nanoparticles
Medical nanotechnology
Surface charge
Tissue

Singlet oxygen-responsive micelles for enhanced photodynamic therapy

Li, X., Gao, M., Xin, K., Zhang, L., Ding, D., Kong, D., Wang, Z., Shi, Y., Kiessling, F., Lammers, T., Cheng, J. & Zhao, Y., Aug 28 2017, In : Journal of Controlled Release. 260, p. 12-21 10 p.

Research output: Contribution to journalArticle

Singlet Oxygen
Photochemotherapy
Micelles
Photosensitizing Agents
Light

Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in Situ

Xia, H., Fu, H., Zhang, Y., Shih, K. C., Ren, Y., Anuganti, M., Nieh, M. P., Cheng, J. & Lin, Y., Aug 16 2017, In : Journal of the American Chemical Society. 139, 32, p. 11106-11116 11 p.

Research output: Contribution to journalArticle

Comb and Wattles
Static Electricity
Macromolecules
Polymerization
chemical reaction

Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers

Baumgartner, R., Kuai, D. & Cheng, J., Sep 2017, In : Biomaterials Science. 5, 9, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

Brushes
Glutamic Acid
Polymers
Molecular weight
Acids

Synthetic polypeptides: From polymer design to supramolecular assembly and biomedical application

Song, Z., Han, Z., Lv, S., Chen, C., Chen, L., Yin, L. & Cheng, J., Nov 7 2017, In : Chemical Society Reviews. 46, 21, p. 6570-6599 30 p.

Research output: Contribution to journalReview article

Polymers
Peptides
Hydrogels
Ring opening polymerization
Micelles
2016

A delayed curing ROMP based thermosetting resin

Baumgartner, R., Ryba, K., Song, Z., Wang, R., Harris, K., Katz, J. S. & Cheng, J., Aug 28 2016, In : Polymer Chemistry. 7, 32, p. 5093-5098 6 p.

Research output: Contribution to journalArticle

Thermosets
Curing
Thermodynamic properties
Hot Temperature
Temperature

Bioresorbable silicon electronic sensors for the brain

Kang, S. K., Murphy, R. K. J., Hwang, S. W., Lee, S. M., Harburg, D. V., Krueger, N. A., Shin, J., Gamble, P., Cheng, H., Yu, S., Liu, Z., McCall, J. G., Stephen, M., Ying, H., Kim, J., Park, G., Webb, R. C., Lee, C. H., Chung, S., Wie, D. S. & 10 others, Gujar, A. D., Vemulapalli, B., Kim, A. H., Lee, K. M., Cheng, J., Huang, Y., Lee, S. H., Braun, P. V., Ray, W. Z. & Rogers, J. A., Feb 4 2016, In : Nature. 530, 7588, p. 71-76 6 p.

Research output: Contribution to journalArticle

Silicon
Clinical Medicine
Equipment and Supplies
Brain
Modern 1601-history

CD44 Mediated Nonviral Gene Delivery into Human Embryonic Stem Cells via Hyaluronic-Acid-Coated Nanoparticles

Yen, J., Ying, H., Wang, H., Yin, L., Uckun, F. & Cheng, J., Mar 14 2016, In : ACS Biomaterials Science and Engineering. 2, 3, p. 326-335 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Hyaluronic Acid
Stem cells
Genes
Nanoparticles

Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using a β-Diiminate Zinc Catalyst

Wang, R., Zhang, J., Yin, Q., Xu, Y., Cheng, J. & Tong, R., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 42, p. 13010-13014 5 p.

Research output: Contribution to journalArticle

Ring opening polymerization
Zinc
Catalysts
Block copolymers
Monomers

Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores

Li, Y., Bai, Y., Zheng, N., Liu, Y., Vincil, G. A., Pedretti, B. J., Cheng, J. & Zimmerman, S. C., Jan 1 2016, In : Chemical Communications. 52, 19, p. 3781-3784 4 p.

Research output: Contribution to journalArticle

Fluorophores
Polyols
Ring opening polymerization
Quantum yield
Luminance