Jefferson Kar Fai Chan

20102019
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Research Output 2010 2019

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2019

Biodegradable Biliverdin Nanoparticles for Efficient Photoacoustic Imaging

Fathi, P., Knox, H. J., Sar, D., Tripathi, I., Ostadhossein, F., Misra, S. K., Esch, M. B., Chan, J. K. F. & Pan, D., Jul 23 2019, In : ACS Nano. 13, 7, p. 7690-7704 15 p.

Research output: Contribution to journalArticle

Biliverdine
Photoacoustic effect
Nanoparticles
Imaging techniques
nanoparticles
2018

Acoustogenic Probes: A New Frontier in Photoacoustic Imaging

Knox, H. J. & Chan, J. K. F., Nov 20 2018, In : Accounts of chemical research. 51, 11, p. 2897-2905 9 p.

Research output: Contribution to journalArticle

Photoacoustic effect
Polyamideimides
Imaging techniques
Tissue
Molecules

A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide

Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G. & Chan, J. K. F., Jan 24 2018, In : Journal of the American Chemical Society. 140, 3, p. 1011-1018 8 p.

Research output: Contribution to journalArticle

Photoacoustic effect
Nitric oxide
nitric oxide
Nitric Oxide
probe

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

Xiao, T., Ackerman, C. M., Carroll, E. C., Jia, S., Hoagland, A., Chan, J. K. F., Thai, B., Liu, C. S., Isacoff, E. Y. & Chang, C. J., Jul 1 2018, In : Nature chemical biology. 14, 7, p. 655-663 9 p.

Research output: Contribution to journalArticle

Activity Cycles
Locus Coeruleus
Copper
Norepinephrine
Arousal

Damage-Responsive Microcapsules for Amplified Photoacoustic Detection of Microcracks in Polymers

Geng, J. L., Li, W., Smaga, L. P., Sottos, N. R. & Chan, J. K. F., Apr 10 2018, In : Chemistry of Materials. 30, 7, p. 2198-2202 5 p.

Research output: Contribution to journalArticle

Photoacoustic effect
Microcracks
Capsules
Polymers

Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring

Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G., Nilges, M. J. & Chan, J. K. F., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11686-11697 12 p.

Research output: Contribution to journalArticle

Nitric Oxide Donors
Photoacoustic effect
Nitric oxide
nitric oxide
near infrared

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

Knox, H. J., Kim, T. W., Zhu, Z. & Chan, J. K. F., Jul 20 2018, In : ACS chemical biology. 13, 7, p. 1838-1843 6 p.

Research output: Contribution to journalArticle

Photoacoustic effect
Oxides
Tumors
Tuning
Imaging techniques

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, W., Fan, T. M. & Chan, J. K. F., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Stem cells
Aldehydes
Fluorescent Dyes
Plasticity
2017

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia

Knox, H. J., Hedhli, J., Kim, T. W., Khalili, K., Dobrucki, W. & Chan, J. K. F., Dec 1 2017, In : Nature communications. 8, 1, 1794.

Research output: Contribution to journalArticle

Photoacoustic effect
hypoxia
Oxides
Imaging techniques
oxides

DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice

Zhang, J., Smaga, L. P., Satyavolu, N. S. R., Chan, J. K. F. & Lu, Y., Dec 6 2017, In : Journal of the American Chemical Society. 139, 48, p. 17225-17228 4 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Photoacoustic effect
Thrombin
DNA
probe

Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection

Ladomersky, E., Khan, A., Shanbhag, V., Cavet, J. S., Chan, J. K. F., Weisman, G. A. & Petris, M. J., Sep 1 2017, In : Infection and immunity. 85, 9, e00351-17.

Research output: Contribution to journalArticle

Salmonella Infections
Copper
Macrophages
Infection
copper-transporting ATPases

NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl

Pino, N. W., Davis, J., Yu, Z. & Chan, J. K. F., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18476-18479 4 p.

Research output: Contribution to journalArticle

thiol
Fluorescent Dyes
Sulfhydryl Compounds
probe
Imaging techniques

The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans

Chun, H., Sharma, A. K., Lee, J., Chan, J. K. F., Jia, S. & Kim, B. E., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Copper
Homeostasis
Biochemical Phenomena
Menkes Kinky Hair Syndrome
2016

Copper regulates cyclic-AMP-dependent lipolysis

Krishnamoorthy, L., Cotruvo, J. A., Chan, J. K. F., Kaluarachchi, H., Muchenditsi, A., Pendyala, V. S., Jia, S., Aron, A. T., Ackerman, C. M., Wal, M. N. V., Guan, T., Smaga, L. P., Farhi, S. L., New, E. J., Lutsenko, S. & Chang, C. J., Aug 1 2016, In : Nature chemical biology. 12, 8, p. 586-592 7 p.

Research output: Contribution to journalArticle

Lipolysis
Cyclic AMP
Copper
Oxidation-Reduction
Metals
2015

A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells

Roth, A., Li, H., Anorma, C. & Chan, J. K. F., Sep 2 2015, In : Journal of the American Chemical Society. 137, 34, p. 10890-10893 4 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
formaldehyde
Formaldehyde
Cells
probe

Disease modeling and gene therapy of copper storage disease in canine hepatic organoids

Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., Van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., De Bruin, A., Rothuizen, J., Penning, L. C. & Schotanus, B. A., Nov 10 2015, In : Stem Cell Reports. 5, 5, p. 895-907 13 p.

Research output: Contribution to journalArticle

Organoids
Gene therapy
Hepatolenticular Degeneration
Genetic Therapy
Liver

Photoacoustic Probes for Ratiometric Imaging of Copper(II)

Li, H., Zhang, P., Smaga, L. P., Hoffman, R. A. & Chan, J. K. F., Dec 23 2015, In : Journal of the American Chemical Society. 137, 50, p. 15628-15631 4 p.

Research output: Contribution to journalArticle

Photoacoustic effect
ester
Copper
Esters
Metals
2014

Copper is an endogenous modulator of neural circuit spontaneous activity

Dodani, S. C., Firl, A., Chan, J. K. F., Nam, C. I., Aron, A. T., Onak, C. S., Ramos-Torres, K. M., Paek, J., Webster, C. M., Feller, M. B. & Chang, C. J., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16280-16285 6 p.

Research output: Contribution to journalArticle

Copper
Metals
Alkaline Earth Metals
Alkalies
Oxidative Stress

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin

Huang, C. P., Fofana, M., Chan, J. K. F., Chang, C. J. & Howell, S. B., Mar 1 2014, In : Metallomics. 6, 3, p. 654-661 8 p.

Research output: Contribution to journalArticle

Cisplatin
Copper
Cells
Fibroblasts
Multifetal Pregnancy Reduction

Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress

Kashyap, D. R., Rompca, A., Gaballa, A., Helmann, J. D., Chan, J. K. F., Chang, C. J., Hozo, I., Gupta, D. & Dziarski, R., Jul 2014, In : PLoS pathogens. 10, 7, e1004280.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Metals
Bacteria
Anti-Bacterial Agents
Reactive Oxygen Species

Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas

Hong-Hermesdorf, A., Miethke, M., Gallaher, S. D., Kropat, J., Dodani, S. C., Chan, J. K. F., Barupala, D., Domaille, D. W., Shirasaki, D. I., Loo, J. A., Weber, P. K., Pett-Ridge, J., Stemmler, T. L., Chang, C. J. & Merchant, S. S., Dec 1 2014, In : Nature chemical biology. 10, 12, p. 1034-1042 9 p.

Research output: Contribution to journalArticle

Chlamydomonas
Homeostasis
X-Ray Absorption Spectroscopy
Metals
Plastocyanin

The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli

Hao, Z., Lou, H., Zhu, R., Zhu, J., Zhang, D., Zhao, B. S., Zeng, S., Chen, X., Chan, J. K. F., He, C. & Chen, P. R., Jan 1 2014, In : Nature chemical biology. 10, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

Microbial Drug Resistance
Copper
Escherichia coli
Anti-Bacterial Agents
Bacterial Drug Resistance

Transition-state structure for the hydronium-ion-promoted hydrolysis of ±- d -glucopyranosyl fluoride

Chan, J. K. F., Tang, A. & Bennet, A. J., Jan 1 2014, In : Canadian Journal of Chemistry. 93, 4, p. 463-467 5 p.

Research output: Contribution to journalArticle

Deuterium
Fluorides
Hydrolysis
Isotopes
Ions

Transition-state structure for the quintessential SN2 reaction of a carbohydrate: Reaction of α-glucopyranosyl fluoride with azide ion in Water

Chan, J. K. F., Sannikova, N., Tang, A. & Bennet, A. J., Sep 3 2014, In : Journal of the American Chemical Society. 136, 35, p. 12225-12228 4 p.

Research output: Contribution to journalArticle

Azides
Carbohydrates
Fluorides
Isotopes
fluoride

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

Polishchuk, E. V., Concilli, M., Iacobacci, S., Chesi, G., Pastore, N., Piccolo, P., Paladino, S., Baldantoni, D., vanIJzendoorn, S. C. D., Chan, J. K. F., Chang, C. J., Amoresano, A., Pane, F., Pucci, P., Tarallo, A., Parenti, G., Brunetti-Pierri, N., Settembre, C., Ballabio, A. & Polishchuk, R. S., Jun 23 2014, In : Developmental cell. 29, 6, p. 686-700 15 p.

Research output: Contribution to journalArticle

Exocytosis
Copper
Homeostasis
Lysosomes
Hepatolenticular Degeneration
2013

Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe

Au-Yeung, H. Y., Chan, J., Chantarojsiri, T. & Chang, C. J., Oct 21 2013, In : Journal of the American Chemical Society. 135, 40, p. 15165-15173 9 p.

Research output: Contribution to journalArticle

Molecular imaging
Molecular Imaging
Fluorescent Dyes
Iron
Cells
2012

A stepwise solvent-promoted S Ni reaction of α-d- glucopyranosyl fluoride: Mechanistic implications for retaining glycosyltransferases

Chan, J., Tang, A. & Bennet, A. J., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

Glycosyltransferases
Deuterium
deuterium
Fluorides
fluoride

Bacterial and viral sialidases: Contribution of the conserved active site glutamate to catalysis

Chan, J., Watson, J. N., Lu, A., Cerda, V. C., Borgford, T. J. & Bennet, A. J., Jan 10 2012, In : Biochemistry. 51, 1, p. 433-441 9 p.

Research output: Contribution to journalArticle

Neuraminidase
Catalysis
Aspartic Acid
Glutamic Acid
Hydrolysis

Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase

Macauley, M. S., Chan, J. K. F., Zandberg, W. F., He, Y., Whitworth, G. E., Stubbs, K. A., Yuzwa, S. A., Bennet, A. J., Varki, A., Davies, G. J. & Vocadlo, D. J., Aug 17 2012, In : Journal of Biological Chemistry. 287, 34, p. 28882-28897 16 p.

Research output: Contribution to journalArticle

Amino Sugars
Acetylglucosaminidase
Uridine Diphosphate
Metabolism
Vertebrates

Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues

Chan, J., Lewis, A. R., Indurugalla, D., Schur, M., Wakarchuk, W. & Bennet, A. J., Feb 29 2012, In : Journal of the American Chemical Society. 134, 8, p. 3748-3757 10 p.

Research output: Contribution to journalArticle

cholera
Vibrio cholerae
Deuterium
Neuraminidase
deuterium
2011

A mechanistic study of sialic acid mutarotation: Implications for mutarotase enzymes

Chan, J. K. F., Sandhu, G. & Bennet, A. J., Jul 7 2011, In : Organic and Biomolecular Chemistry. 9, 13, p. 4818-4822 5 p.

Research output: Contribution to journalArticle

N-Acetylneuraminic Acid
Anions
enzymes
Isotopes
acids

The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2- nonulosonic acid hydrolase (KDNase): Structural and mechanistic insights

Telford, J. C., Yeung, J. H. F., Xu, G., Kiefel, M. J., Watts, A. G., Hader, S., Chan, J. K. F., Bennet, A. J., Moore, M. M. & Taylor, G. L., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 10783-10792 10 p.

Research output: Contribution to journalArticle

Aspergillus fumigatus
Aspergillus
Neuraminidase
Hydrolases
Acids
Micromonospora
Neuraminidase
Isotopes
Deuterium
deuterium
2010

A direct NMR method for the measurement of competitive kinetic isotope effects

Chan, J. K. F., Lewis, A. R., Gilbert, M., Karwaski, M. F. & Bennet, A. J., Jun 2010, In : Nature chemical biology. 6, 6, p. 405-407 3 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Neuraminidase
Isotopes
Cats
Hydrolysis