Jefferson Kar Fai Chan

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2020

An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells

Yadav, A. K., Reinhardt, C. J., Arango, A. S., Huff, H. C., Dong, L., Malkowski, M. G., Das, A., Tajkhorshid, E. & Chan, J., Feb 17 2020, In : Angewandte Chemie - International Edition. 59, 8, p. 3307-3314 8 p.

Research output: Contribution to journalArticle

A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold to Arrest Cell Migration

Smaga, L. P., Pino, N. W., Ibarra, G. E., Krishnamurthy, V. & Chan, J., Jan 15 2020, In : Journal of the American Chemical Society. 142, 2, p. 680-684 5 p.

Research output: Contribution to journalArticle

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform

Reinhardt, C. J., Xu, R. & Chan, J., Feb 14 2020, In : Chemical Science. 11, 6, p. 1587-1592 6 p.

Research output: Contribution to journalArticle

Open Access

Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity

Bearrood, T. E., Aguirre-Figueroa, G. & Chan, J., Feb 19 2020, In : Bioconjugate Chemistry. 31, 2, p. 224-228 5 p.

Research output: Contribution to journalArticle

2019

A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties

Zhou, E. Y., Knox, H. J., Liu, C., Zhao, W. & Chan, J., Nov 6 2019, In : Journal of the American Chemical Society. 141, 44, p. 17601-17609 9 p.

Research output: Contribution to journalArticle

Biodegradable Biliverdin Nanoparticles for Efficient Photoacoustic Imaging

Fathi, P., Knox, H. J., Sar, D., Tripathi, I., Ostadhossein, F., Misra, S. K., Esch, M. B., Chan, J. & Pan, D., Jul 23 2019, In : ACS Nano. 13, 7, p. 7690-7704 15 p.

Research output: Contribution to journalArticle

Simultaneous photoacoustic imaging of intravascular and tissue oxygenation

Chen, M., Knox, H. J., Tang, Y., Liu, W., Nie, L., Chan, J. & Yao, J., Aug 1 2019, In : Optics Letters. 44, 15, p. 3773-3776 4 p.

Research output: Contribution to journalArticle

2018

Acoustogenic Probes: A New Frontier in Photoacoustic Imaging

Knox, H. J. & Chan, J., Nov 20 2018, In : Accounts of chemical research. 51, 11, p. 2897-2905 9 p.

Research output: Contribution to journalArticle

A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide

Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G. & Chan, J., Jan 24 2018, In : Journal of the American Chemical Society. 140, 3, p. 1011-1018 8 p.

Research output: Contribution to journalArticle

Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system

Xiao, T., Ackerman, C. M., Carroll, E. C., Jia, S., Hoagland, A., Chan, J., Thai, B., Liu, C. S., Isacoff, E. Y. & Chang, C. J., Jul 1 2018, In : Nature chemical biology. 14, 7, p. 655-663 9 p.

Research output: Contribution to journalArticle

Damage-Responsive Microcapsules for Amplified Photoacoustic Detection of Microcracks in Polymers

Geng, J. L., Li, W., Smaga, L. P., Sottos, N. R. & Chan, J., Apr 10 2018, In : Chemistry of Materials. 30, 7, p. 2198-2202 5 p.

Research output: Contribution to journalArticle

Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring

Zhou, E. Y., Knox, H. J., Reinhardt, C. J., Partipilo, G., Nilges, M. J. & Chan, J., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11686-11697 12 p.

Research output: Contribution to journalArticle

Photophysical Tuning of N-Oxide-Based Probes Enables Ratiometric Photoacoustic Imaging of Tumor Hypoxia

Knox, H. J., Kim, T. W., Zhu, Z. & Chan, J., Jul 20 2018, In : ACS chemical biology. 13, 7, p. 1838-1843 6 p.

Research output: Contribution to journalArticle

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

2017

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia

Knox, H. J., Hedhli, J., Kim, T. W., Khalili, K., Dobrucki, L. W. & Chan, J., Dec 1 2017, In : Nature communications. 8, 1, 1794.

Research output: Contribution to journalArticle

DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice

Zhang, J., Smaga, L. P., Satyavolu, N. S. R., Chan, J. & Lu, Y., Dec 6 2017, In : Journal of the American Chemical Society. 139, 48, p. 17225-17228 4 p.

Research output: Contribution to journalArticle

Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection

Ladomersky, E., Khan, A., Shanbhag, V., Cavet, J. S., Chan, J., Weisman, G. A. & Petris, M. J., Sep 1 2017, In : Infection and immunity. 85, 9, e00351-17.

Research output: Contribution to journalArticle

NitroxylFluor: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl

Pino, N. W., Davis, J., Yu, Z. & Chan, J., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18476-18479 4 p.

Research output: Contribution to journalArticle

The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans

Chun, H., Sharma, A. K., Lee, J., Chan, J., Jia, S. & Kim, B. E., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

2016

Copper regulates cyclic-AMP-dependent lipolysis

Krishnamoorthy, L., Cotruvo, J. A., Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V. S., Jia, S., Aron, A. T., Ackerman, C. M., Wal, M. N. V., Guan, T., Smaga, L. P., Farhi, S. L., New, E. J., Lutsenko, S. & Chang, C. J., Aug 1 2016, In : Nature chemical biology. 12, 8, p. 586-592 7 p.

Research output: Contribution to journalArticle

2015

A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells

Roth, A., Li, H., Anorma, C. & Chan, J., Sep 2 2015, In : Journal of the American Chemical Society. 137, 34, p. 10890-10893 4 p.

Research output: Contribution to journalArticle

Disease modeling and gene therapy of copper storage disease in canine hepatic organoids

Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., Van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., De Bruin, A., Rothuizen, J., Penning, L. C. & Schotanus, B. A., Nov 10 2015, In : Stem Cell Reports. 5, 5, p. 895-907 13 p.

Research output: Contribution to journalArticle

Photoacoustic Probes for Ratiometric Imaging of Copper(II)

Li, H., Zhang, P., Smaga, L. P., Hoffman, R. A. & Chan, J. K. F., Dec 23 2015, In : Journal of the American Chemical Society. 137, 50, p. 15628-15631 4 p.

Research output: Contribution to journalArticle

2014

Copper is an endogenous modulator of neural circuit spontaneous activity

Dodani, S. C., Firl, A., Chan, J., Nam, C. I., Aron, A. T., Onak, C. S., Ramos-Torres, K. M., Paek, J., Webster, C. M., Feller, M. B. & Chang, C. J., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16280-16285 6 p.

Research output: Contribution to journalArticle

Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin

Huang, C. P., Fofana, M., Chan, J. K. F., Chang, C. J. & Howell, S. B., Mar 1 2014, In : Metallomics. 6, 3, p. 654-661 8 p.

Research output: Contribution to journalArticle

Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress

Kashyap, D. R., Rompca, A., Gaballa, A., Helmann, J. D., Chan, J., Chang, C. J., Hozo, I., Gupta, D. & Dziarski, R., Jul 2014, In : PLoS pathogens. 10, 7, e1004280.

Research output: Contribution to journalArticle

Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas

Hong-Hermesdorf, A., Miethke, M., Gallaher, S. D., Kropat, J., Dodani, S. C., Chan, J., Barupala, D., Domaille, D. W., Shirasaki, D. I., Loo, J. A., Weber, P. K., Pett-Ridge, J., Stemmler, T. L., Chang, C. J. & Merchant, S. S., Dec 1 2014, In : Nature chemical biology. 10, 12, p. 1034-1042 9 p.

Research output: Contribution to journalArticle

The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli

Hao, Z., Lou, H., Zhu, R., Zhu, J., Zhang, D., Zhao, B. S., Zeng, S., Chen, X., Chan, J., He, C. & Chen, P. R., Jan 1 2014, In : Nature chemical biology. 10, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

Transition-state structure for the hydronium-ion-promoted hydrolysis of ±- d -glucopyranosyl fluoride

Chan, J. K. F., Tang, A. & Bennet, A. J., Jan 1 2014, In : Canadian Journal of Chemistry. 93, 4, p. 463-467 5 p.

Research output: Contribution to journalArticle

Transition-state structure for the quintessential SN2 reaction of a carbohydrate: Reaction of α-glucopyranosyl fluoride with azide ion in Water

Chan, J. K. F., Sannikova, N., Tang, A. & Bennet, A. J., Sep 3 2014, In : Journal of the American Chemical Society. 136, 35, p. 12225-12228 4 p.

Research output: Contribution to journalArticle

Wilson Disease Protein ATP7B Utilizes Lysosomal Exocytosis to Maintain Copper Homeostasis

Polishchuk, E. V., Concilli, M., Iacobacci, S., Chesi, G., Pastore, N., Piccolo, P., Paladino, S., Baldantoni, D., vanIJzendoorn, S. C. D., Chan, J., Chang, C. J., Amoresano, A., Pane, F., Pucci, P., Tarallo, A., Parenti, G., Brunetti-Pierri, N., Settembre, C., Ballabio, A. & Polishchuk, R. S., Jun 23 2014, In : Developmental cell. 29, 6, p. 686-700 15 p.

Research output: Contribution to journalArticle

2013

Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe

Au-Yeung, H. Y., Chan, J., Chantarojsiri, T. & Chang, C. J., Oct 21 2013, In : Journal of the American Chemical Society. 135, 40, p. 15165-15173 9 p.

Research output: Contribution to journalArticle

2012

A stepwise solvent-promoted S Ni reaction of α-d- glucopyranosyl fluoride: Mechanistic implications for retaining glycosyltransferases

Chan, J., Tang, A. & Bennet, A. J., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

Bacterial and viral sialidases: Contribution of the conserved active site glutamate to catalysis

Chan, J., Watson, J. N., Lu, A., Cerda, V. C., Borgford, T. J. & Bennet, A. J., Jan 10 2012, In : Biochemistry. 51, 1, p. 433-441 9 p.

Research output: Contribution to journalArticle

Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase

Macauley, M. S., Chan, J., Zandberg, W. F., He, Y., Whitworth, G. E., Stubbs, K. A., Yuzwa, S. A., Bennet, A. J., Varki, A., Davies, G. J. & Vocadlo, D. J., Aug 17 2012, In : Journal of Biological Chemistry. 287, 34, p. 28882-28897 16 p.

Research output: Contribution to journalArticle

Transition state analysis of Vibrio cholerae sialidase-catalyzed hydrolyses of natural substrate analogues

Chan, J., Lewis, A. R., Indurugalla, D., Schur, M., Wakarchuk, W. & Bennet, A. J., Feb 29 2012, In : Journal of the American Chemical Society. 134, 8, p. 3748-3757 10 p.

Research output: Contribution to journalArticle

2011

A mechanistic study of sialic acid mutarotation: Implications for mutarotase enzymes

Chan, J., Sandhu, G. & Bennet, A. J., Jul 7 2011, In : Organic and Biomolecular Chemistry. 9, 13, p. 4818-4822 5 p.

Research output: Contribution to journalArticle

The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2- nonulosonic acid hydrolase (KDNase): Structural and mechanistic insights

Telford, J. C., Yeung, J. H. F., Xu, G., Kiefel, M. J., Watts, A. G., Hader, S., Chan, J., Bennet, A. J., Moore, M. M. & Taylor, G. L., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 10783-10792 10 p.

Research output: Contribution to journalArticle

2010

A direct NMR method for the measurement of competitive kinetic isotope effects

Chan, J., Lewis, A. R., Gilbert, M., Karwaski, M. F. & Bennet, A. J., Jun 2010, In : Nature chemical biology. 6, 6, p. 405-407 3 p.

Research output: Contribution to journalArticle