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2020

Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells

Ly, L. K., Rowles, J. L., Paul, H. M., Alves, J. M. P., Yemm, C., Wolf, P. M., Devendran, S., Hudson, M. E., Morris, D. J., Erdman, J. W. & Ridlon, J. M., May 2020, In : Journal of Steroid Biochemistry and Molecular Biology. 199, 105567.

Research output: Contribution to journalArticle

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Ridlon, J. M., Devendran, S., Alves, J. M., Doden, H., Wolf, P. G., Pereira, G. V., Ly, L., Volland, A., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., Green, S. J., Hernandez, A. G., Fields, C. J., Wright, C. L., Kakiyama, G., Cann, I., Kashyap, P. & 2 others, McCracken, V. & Gaskins, H. R., May 3 2020, In : Gut Microbes. 11, 3, p. 381-404 24 p.

Research output: Contribution to journalArticle

2019

Clostridium scindens ATCC 35704: Integration of nutritional requirements, the complete genome sequence, and global transcriptional responses to bile acids

Devendran, S., Shrestha, R., Alves, J. M. P., Wolf, P. G., Ly, L., Hernandez, A. G., Méndez-García, C., Inboden, A., Wiley, J., Paul, O., Allen, A., Springer, E., Wright, C. L., Fields, C. J., Daniel, S. L. & Ridlon, J. M., Apr 1 2019, In : Applied and environmental microbiology. 85, 7, e00052-19.

Research output: Contribution to journalArticle

Structural and biochemical characterization of 20-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Doden, H. L., Pollet, R. M., Mythen, S. M., Wawrzak, Z., Devendran, S., Cann, I., Koropatkin, N. M. & Ridlon, J. M., Aug 9 2019, In : Journal of Biological Chemistry. 294, 32, p. 12040-12053 14 p.

Research output: Contribution to journalArticle

Open Access
2018

Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243 T

Harris, S. C., Devendran, S., Méndez- García, C., Mythen, S. M., Wright, C. L., Fields, C. J., Hernandez, A. G., Cann, I., Hylemon, P. B. & Ridlon, J. M., Nov 2 2018, In : Gut Microbes. 9, 6, p. 523-539 17 p.

Research output: Contribution to journalArticle

Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

Hale, V. L., Jeraldo, P., Chen, J., Mundy, M., Yao, J., Priya, S., Keeney, G., Lyke, K., Ridlon, J., White, B. A., French, A. J., Thibodeau, S. N., Diener, C., Resendis-Antonio, O., Gransee, J., Dutta, T., Petterson, X. M., Sung, J., Blekhman, R., Boardman, L. & 3 others, Larson, D., Nelson, H. & Chia, N., Oct 31 2018, In : Genome medicine. 10, 1, 78.

Research output: Contribution to journalArticle

Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus

Hernandez, J., Volland, A., Leyshon, B. J., Juda, M., Ridlon, J. M., Johnson, R. W. & Steelman, A. J., Dec 1 2018, In : Scientific reports. 8, 1, 11615.

Research output: Contribution to journalArticle

Effects of prebiotic inulin-Type fructans on blood metabolite and hormone concentrations and faecal microbiota and metabolites in overweight dogs

Alexander, C., Cross, T. W. L., Devendran, S., Neumer, F., Theis, S., Ridlon, J. M., Suchodolski, J. S., De Godoy, M. R. C. & Swanson, K. S., Sep 1 2018, In : Clay Minerals. 120, 6, p. 711-720 10 p.

Research output: Contribution to journalArticle

Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704

Harris, S. C., Devendran, S., Alves, J. M. P., Mythen, S. M., Hylemon, P. B. & Ridlon, J. M., Mar 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 3, p. 276-283 8 p.

Research output: Contribution to journalArticle

Metabolism of oxo-bile acids and characterization of recombinant 12α- hydroxysteroid dehydrogenases from bile acid 7α-dehydroxylating human gut bacteria

Doden, H., Sallam, L. A., Devendran, S., Ly, L., Doden, G., Daniel, S. L., Alves, J. M. P. & Ridlon, J. M., May 1 2018, In : Applied and environmental microbiology. 84, 10, e00235-18.

Research output: Contribution to journalArticle

The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase

Devendran, S., Mythen, S. M. & Ridlon, J. M., 2018, In : Journal of Lipid Research. 59, 6, p. 1005-1014 10 p.

Research output: Contribution to journalArticle

2017

Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058

Devendran, S., Méndez-García, C. & Ridlon, J. M., May 2017, In : Journal of Lipid Research. 58, 5, p. 916-925 10 p.

Research output: Contribution to journalArticle

2016

Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis

Bhowmik, S., Chiu, H. P., Jones, D. H., Chiu, H. J., Miller, M. D., Xu, Q., Farr, C. L., Ridlon, J. M., Wells, J. E., Elsliger, M. A., Wilson, I. A., Hylemon, P. B. & Lesley, S. A., Mar 1 2016, In : Proteins: Structure, Function and Bioinformatics. 84, 3, p. 316-331 16 p.

Research output: Contribution to journalArticle

2015

Gut microbiota, cirrhosis, and alcohol regulate bile acid metabolism in the gut

Ridlon, J. M., Kang, D. J., Hylemon, P. B. & Bajaj, J. S., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 338-345 8 p.

Research output: Contribution to journalArticle

2014

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

Kakiyama, G., Hylemon, P. B., Zhou, H., Pandak, W. M., Heuman, D. M., Kang, D. J., Takei, H., Nittono, H., Ridlon, J. M., Fuchs, M., Gurley, E. C., Wang, Y., Liu, R., Sanyal, A. J., Gillevet, P. M. & Bajaj, J. S., Jun 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 11, p. G929-G937

Research output: Contribution to journalArticle

2013

Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship

Ridlon, J. M., Alves, J. M., Hylemon, P. B. & Bajaj, J. S., Sep 1 2013, In : Gut Microbes. 4, 5

Research output: Contribution to journalArticle

Clostridium scindens: A human gut microbe with a high potential to convert glucocorticoids into androgens

Ridlon, J. M., Ikegawa, S., Alves, J. M. P., Zhou, B., Kobayashi, A., Iida, T., Mitamura, K., Tanabe, G., Serrano, M., De Guzman, A., Cooper, P., Buck, G. A. & Hylemon, P. B., Sep 1 2013, In : Journal of Lipid Research. 54, 9, p. 2437-2449 13 p.

Research output: Contribution to journalArticle

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., White, M. B., Noble, N. A., Monteith, P., Fuchs, M., Thacker, L. R., Sikaroodi, M. & Bajaj, J. S., May 1 2013, In : Journal of Hepatology. 58, 5, p. 949-955 7 p.

Research output: Contribution to journalArticle

Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy

Bajaj, J. S., Heuman, D. M., Sanyal, A. J., Hylemon, P. B., Sterling, R. K., Stravitz, R. T., Fuchs, M., Ridlon, J. M., Daita, K., Monteith, P., Noble, N. A., White, M. B., Fisher, A., Sikaroodi, M., Rangwala, H. & Gillevet, P. M., Apr 2 2013, In : PloS one. 8, 4, e60042.

Research output: Contribution to journalArticle

2012

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

Bajaj, J. S., Gillevet, P. M., Patel, N. R., Ahluwalia, V., Ridlon, J. M., Kettenmann, B., Schubert, C. M., Sikaroodi, M., Heuman, D. M., Crossey, M. M. E., Bell, D. E., Hylemon, P. B., Fatouros, P. P. & Taylor-Robinson, S. D., Jun 1 2012, In : Metabolic Brain Disease. 27, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M. & Gillevet, P. M., Sep 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 6, p. G675-G685

Research output: Contribution to journalArticle

Linkage of gut microbiome with cognition in hepatic encephalopathy

Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M. & Gillevet, P. M., Jan 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1, p. G168-G175

Research output: Contribution to journalArticle

2010

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

Ridlon, J. M., Kang, D. J. & Hylemon, P. B., Apr 1 2010, In : Anaerobe. 16, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

2008

Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductases

Kang, D. J., Ridlon, J. M., Moore, D. R., Barnes, S. & Hylemon, P. B., Jan 1 2008, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1781, 1-2, p. 16-25 10 p.

Research output: Contribution to journalArticle

2005