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Research Output 2005 2019

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Article
2019

Clostridium scindens ATCC 35704: Integration of nutritional requirements, the complete genome sequence, and global transcriptional responses to bile acids

Devendran, S., Shrestha, R., Alves, J. M. P., Wolf, P. G., Ly, L., Hernandez, A. G., Méndez-García, C., Inboden, A., Wiley, J., Paul, O., Allen, A., Springer, E., Wright, C. L., Fields, C. J., Daniel, S. L. & Ridlon, J. M., Apr 1 2019, In : Applied and environmental microbiology. 85, 7, e00052-19.

Research output: Contribution to journalArticle

Clostridium scindens
nutritional requirement
Nutritional Requirements
Clostridium
bile acids

Structural and biochemical characterization of 20-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Doden, H. L., Pollet, R. M., Mythen, S. M., Wawrzak, Z., Devendran, S., Cann, I., Koropatkin, N. M. & Ridlon, J. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12040-12053 14 p.

Research output: Contribution to journalArticle

Open Access
20-Hydroxysteroid Dehydrogenases
Hydrocortisone
Androgens
Bacteria
Oxidoreductases

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Ridlon, J. M., Devendran, S., Alves, J. M., Doden, H., Wolf, P. G., Pereira, G. V., Ly, L., Volland, A., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., Green, S. J., Hernandez, A. G., Fields, C. J., Wright, C. L., Kakiyama, G., Cann, I., Kashyap, P. & 2 others, McCracken, V. & Gaskins, H. R., Jan 1 2019, In : Gut Microbes.

Research output: Contribution to journalArticle

Germ-Free Life
Metabolomics
Genomics
Bile Acids and Salts
Life Style
2018

Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243 T

Harris, S. C., Devendran, S., Méndez- García, C., Mythen, S. M., Wright, C. L., Fields, C. J., Hernandez, A. G., Cann, I., Hylemon, P. B. & Ridlon, J. M., Nov 2 2018, In : Gut Microbes. 9, 6, p. 523-539 17 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Hydroxysteroid Dehydrogenases
Atmosphere
Gases
Lithocholic Acid

Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

Hale, V. L., Jeraldo, P., Chen, J., Mundy, M., Yao, J., Priya, S., Keeney, G., Lyke, K., Ridlon, J., White, B. A., French, A. J., Thibodeau, S. N., Diener, C., Resendis-Antonio, O., Gransee, J., Dutta, T., Petterson, X. M., Sung, J., Blekhman, R., Boardman, L. & 3 others, Larson, D., Nelson, H. & Chia, N., Oct 31 2018, In : Genome medicine. 10, 1, 1 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Microbiota
Ecology
Colorectal Neoplasms
Microbial Interactions

Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus

Hernandez, J., Volland, A., Leyshon, B. J., Juda, M., Ridlon, J. M., Johnson, R. W. & Steelman, A. J., Dec 1 2018, In : Scientific reports. 8, 1, 11615.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Eating
Swine
Viral RNA
Nicotinic Receptors

Effects of prebiotic inulin-Type fructans on blood metabolite and hormone concentrations and faecal microbiota and metabolites in overweight dogs

Alexander, C., Cross, T. W. L., Devendran, S., Neumer, F., Theis, S., Ridlon, J. M., Suchodolski, J. S., De Godoy, M. R. C. & Swanson, K. S., Sep 1 2018, In : Clay Minerals. 120, 6, p. 711-720 10 p.

Research output: Contribution to journalArticle

Fructans
Prebiotics
Inulin
Metabolites
hormone

Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704

Harris, S. C., Devendran, S., Alves, J. M. P., Mythen, S. M., Hylemon, P. B. & Ridlon, J. M., Mar 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 3, p. 276-283 8 p.

Research output: Contribution to journalArticle

Flavoproteins
Clostridium
Bile Acids and Salts
Bacteria
Genes

Metabolism of oxo-bile acids and characterization of recombinant 12α- hydroxysteroid dehydrogenases from bile acid 7α-dehydroxylating human gut bacteria

Doden, H., Sallam, L. A., Devendran, S., Ly, L., Doden, G., Daniel, S. L., Alves, J. M. P. & Ridlon, J. M., May 1 2018, In : Applied and environmental microbiology. 84, 10, e00235-18.

Research output: Contribution to journalArticle

Keto Acids
hydroxysteroid dehydrogenases
Hydroxysteroid Dehydrogenases
bile acids
Bile Acids and Salts
Eggerthella
3-Hydroxysteroid Dehydrogenases
Metagenomics
hydroxysteroid dehydrogenases
Hydroxysteroid Dehydrogenases

The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase

Devendran, S., Mythen, S. M. & Ridlon, J. M., Jan 1 2018, In : Journal of Lipid Research. 59, 6, p. 1005-1014 10 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Clostridium
Hydrocortisone
Genes
Steroids
2017

Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058

Devendran, S., Méndez-García, C. & Ridlon, J. M., May 2017, In : Journal of Lipid Research. 58, 5, p. 916-925 10 p.

Research output: Contribution to journalArticle

20-Hydroxysteroid Dehydrogenases
Anaerobic Bacteria
Bacteria
Steroid 17-alpha-Hydroxylase
Hydrocortisone
2016

Structure and functional characterization of a bile acid 7α dehydratase BaiE in secondary bile acid synthesis

Bhowmik, S., Chiu, H. P., Jones, D. H., Chiu, H. J., Miller, M. D., Xu, Q., Farr, C. L., Ridlon, J. M., Wells, J. E., Elsliger, M. A., Wilson, I. A., Hylemon, P. B. & Lesley, S. A., Mar 1 2016, In : Proteins: Structure, Function and Bioinformatics. 84, 3, p. 316-331 16 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Bile Acids and Salts
Coenzyme A
Clostridium
Lithocholic Acid
2015

Gut microbiota, cirrhosis, and alcohol regulate bile acid metabolism in the gut

Ridlon, J. M., Kang, D. J., Hylemon, P. B. & Bajaj, J. S., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 338-345 8 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Fibrosis
Alcohols
Dysbiosis
Liver Diseases
2014

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

Kakiyama, G., Hylemon, P. B., Zhou, H., Pandak, W. M., Heuman, D. M., Kang, D. J., Takei, H., Nittono, H., Ridlon, J. M., Fuchs, M., Gurley, E. C., Wang, Y., Liu, R., Sanyal, A. J., Gillevet, P. M. & Bajaj, J. S., Jun 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 11, p. G929-G937

Research output: Contribution to journalArticle

Alcoholic Liver Cirrhosis
Bile Acids and Salts
Inflammation
Fibrosis
Alcohols
2013

Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship

Ridlon, J. M., Alves, J. M., Hylemon, P. B. & Bajaj, J. S., Sep 1 2013, In : Gut Microbes. 4, 5

Research output: Contribution to journalArticle

Bile Acids and Salts
Fibrosis
Microbiota
Deoxycholic Acid
Clostridium

Clostridium scindens: A human gut microbe with a high potential to convert glucocorticoids into androgens

Ridlon, J. M., Ikegawa, S., Alves, J. M. P., Zhou, B., Kobayashi, A., Iida, T., Mitamura, K., Tanabe, G., Serrano, M., De Guzman, A., Cooper, P., Buck, G. A. & Hylemon, P. B., Sep 1 2013, In : Journal of Lipid Research. 54, 9, p. 2437-2449 13 p.

Research output: Contribution to journalArticle

20-Hydroxysteroid Dehydrogenases
Clostridium
L-threonine 3-dehydrogenase
Operon
Bile Acids and Salts

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., White, M. B., Noble, N. A., Monteith, P., Fuchs, M., Thacker, L. R., Sikaroodi, M. & Bajaj, J. S., May 1 2013, In : Journal of Hepatology. 58, 5, p. 949-955 7 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Fibrosis
Deoxycholic Acid
rifaximin
Cholic Acid

Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy

Bajaj, J. S., Heuman, D. M., Sanyal, A. J., Hylemon, P. B., Sterling, R. K., Stravitz, R. T., Fuchs, M., Ridlon, J. M., Daita, K., Monteith, P., Noble, N. A., White, M. B., Fisher, A., Sikaroodi, M., Rangwala, H. & Gillevet, P. M., Apr 2 2013, In : PloS one. 8, 4, e60042.

Research output: Contribution to journalArticle

rifaximin
encephalopathy
Hepatic Encephalopathy
cognition
Fibrosis
2012

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

Bajaj, J. S., Gillevet, P. M., Patel, N. R., Ahluwalia, V., Ridlon, J. M., Kettenmann, B., Schubert, C. M., Sikaroodi, M., Heuman, D. M., Crossey, M. M. E., Bell, D. E., Hylemon, P. B., Fatouros, P. P. & Taylor-Robinson, S. D., Jun 1 2012, In : Metabolic Brain Disease. 27, 2, p. 205-215 11 p.

Research output: Contribution to journalArticle

Lactulose
Systems Biology
Hepatic Encephalopathy
Brain
Spectroscopy

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M. & Gillevet, P. M., Sep 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 6, p. G675-G685

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Microbiota
Cognition
Fibrosis
Inflammation
Coenzyme A-Transferases
Clostridium
Bile Acids and Salts
Bacteria
Coenzyme A

Linkage of gut microbiome with cognition in hepatic encephalopathy

Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M. & Gillevet, P. M., Jan 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 1, p. G168-G175

Research output: Contribution to journalArticle

Hepatic Encephalopathy
Cognition
Lactulose
Microbiota
Veillonellaceae
2010

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

Ridlon, J. M., Kang, D. J. & Hylemon, P. B., Apr 1 2010, In : Anaerobe. 16, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

Clostridium
Operon
Bile Acids and Salts
Cholic Acid
Genes
2008

Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductases

Kang, D. J., Ridlon, J. M., Moore, D. R., Barnes, S. & Hylemon, P. B., Jan 1 2008, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1781, 1-2, p. 16-25 10 p.

Research output: Contribution to journalArticle

Clostridium
Oxidoreductases
Acids
Bile Acids and Salts
Genes
2005
Methanobrevibacter
Desulfovibrio vulgaris
Lactobacillus plantarum
Clostridium
Feces