James A Imlay

1986 …2019
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Research Output 1986 2019

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Article
2019
Open Access
Fumarate Hydratase
Hydrogen Peroxide
Enzymes
Bacteria
Oxidants
2018

4-Hydroxybenzaldehyde sensitizes Acinetobacter baumannii to amphenicols

Shin, B., Park, C., Imlay, J. A. & Park, W., Mar 1 2018, In : Applied Microbiology and Biotechnology. 102, 5, p. 2323-2335 13 p.

Research output: Contribution to journalArticle

Acinetobacter baumannii
Chloramphenicol
4-hydroxybenzaldehyde
Thiamphenicol
Facilitated Diffusion
Superoxides
Oxygen
Enzymes
Escherichia coli
Fumarate Hydratase
Escherichia coli
Hydrogen Peroxide
Toxicity
Bacteria
Experiments
2017
Cytochrome-c Peroxidase
Hydrogen Peroxide
Oxidoreductases
Electrons
Escherichia coli

Lineage-specific SoxR-mediated regulation of an endoribonuclease protects non-enteric bacteria from redox-active compounds

Kim, J., Park, C., Imlay, J. A. & Park, W., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

Endoribonucleases
Oxidation-Reduction
Bacteria
Transcription Factors
Anti-Bacterial Agents
Succinate Dehydrogenase
Reactive Oxygen Species
Escherichia coli
Enzymes
Oxygen
2016

The cytochrome bd oxidase of Escherichia coli prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide

Korshunov, S., Imlay, K. R. C. & Imlay, J. A., Jul 1 2016, In : Molecular Microbiology. 101, 1, p. 62-77 16 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Sulfides
Electron Transport Complex IV
Escherichia coli
Cystine
2015

Physiological roles and adverse effects of the two cystine importers of Escherichia coli

Chonoles Imlay, K. R., Korshunov, S. & Imlay, J. A., Jan 1 2015, In : Journal of bacteriology. 197, 23, p. 3629-3644 16 p.

Research output: Contribution to journalArticle

Cystine
Escherichia coli
Cysteine
Sulfur
Allosteric Site

The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese

Martin, J. E., Waters, L. S., Storz, G. & Imlay, J. A., Mar 16 2015, In : PLoS Genetics. 11, 3, e1004977.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Manganese
manganese
Escherichia coli
protein
Heme
Catalase
Hydrogen Peroxide
Iron
Escherichia coli
2014
Poisons
Biosynthetic Pathways
Superoxides
Hydrogen Peroxide
Iron
2013

An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide

Mishra, S. & Imlay, J. A., Dec 1 2013, In : Molecular Microbiology. 90, 6, p. 1356-1371 16 p.

Research output: Contribution to journalArticle

Anaerobic Bacteria
Catalase
Hydrogen Peroxide
NAD+ peroxidase
Enzymes

Cell death from antibiotics without the involvement of reactive oxygen species

Liu, Y. & Imlay, J. A., Mar 8 2013, In : Science. 339, 6124, p. 1210-1213 4 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cell Death
Anti-Bacterial Agents
DNA Replication
DNA Repair

Comparative study of SoxR activation by redox-active compounds

Singh, A. K., Shin, J. H., Lee, K. L., Imlay, J. A. & Roe, J. H., Dec 1 2013, In : Molecular Microbiology. 90, 5, p. 983-996 14 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Paraquat
Escherichia coli
Oxidants
Streptomyces coelicolor

How Escherichia coli tolerates profuse hydrogen peroxide formation by a catabolic pathway

Kumar, S. R. & Imlay, J. A., Oct 18 2013, In : Journal of bacteriology. 195, 20, p. 4569-4579 11 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Escherichia coli
Phenethylamines
Enzymes
NAD+ peroxidase

Superoxide poisons mononuclear iron enzymes by causing mismetallation

Gu, M. & Imlay, J. A., Jul 1 2013, In : Molecular Microbiology. 89, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

Poisons
Superoxides
Iron
Zinc
Enzymes
2012

Mononuclear iron enzymes are primary targets of hydrogen peroxide stress

Anjem, A. & Imlay, J. A., May 4 2012, In : Journal of Biological Chemistry. 287, 19, p. 15544-15556 13 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Cysteine
Iron
peptide deformylase
L-threonine 3-dehydrogenase
Hydro-Lyases
Mercury
Cadmium
Silver
Sulfur
2011
Racemases and Epimerases
Manganese
Hydrogen Peroxide
Iron
Escherichia coli

Rapid identification of bacteria with a disposable colorimetric sensing array

Carey, J. R., Suslick, K. S., Hulkower, K. I., Imlay, J. A., Imlay, K. R. C., Ingison, C. K., Ponder, J. B., Sen, A. & Wittrig, A. E., May 18 2011, In : Journal of the American Chemical Society. 133, 19, p. 7571-7576 6 p.

Research output: Contribution to journalArticle

Sensor arrays
Bacteria
sensor
bacterium
Enterococcus faecalis

Redox pioneer: professor Irwin Fridovich.

Imlay, J. A., Feb 1 2011, In : Antioxidants & redox signaling. 14, 3, p. 335-340 6 p.

Research output: Contribution to journalArticle

Superoxides
Superoxide Dismutase
Oxidation-Reduction
Oxidative stress
Oxidative Stress
Ribonucleotide Reductases
Manganese
Starvation
Iron
Escherichia coli

The escherichia coli btue protein functions as a resistance determinant against reactive oxygen species

Arenas, F. A., Covarrubias, P. C., Sandoval, J. M., Pérez-Donoso, J. M., Imlay, J. A. & Vásquez, C. C., Feb 1 2011, In : PloS one. 6, 1, e15979.

Research output: Contribution to journalArticle

Oxidative stress
Escherichia coli Proteins
Escherichia coli
reactive oxygen species
Reactive Oxygen Species

The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide

Gu, M. & Imlay, J. A., Mar 1 2011, In : Molecular Microbiology. 79, 5, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Superoxides
Oxidation-Reduction
Escherichia coli
Pharmaceutical Preparations
Superoxide Dismutase
Regulon
Escherichia coli Proteins
Hydrogen Peroxide
Iron
DNA Damage
2010

A small RNA promotes siderophore production through transcriptional and metabolic remodeling

Salvail, H., Lanthier-Bourbonnais, P., Sobota, J. M., Caza, M., Benjamin, J. A. M., Mendieta, M. E. S., Lépine, F., Dozois, C. M., Imlay, J. A. & Massé, E., Aug 24 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15223-15228 6 p.

Research output: Contribution to journalArticle

Siderophores
Enterobactin
RNA
Serine
Serine O-Acetyltransferase
Hydro-Lyases
Regulon
Sulfur
Oxidants
Hydrogen Peroxide

Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species

Yeom, J., Imlay, J. A. & Park, W., Jul 16 2010, In : Journal of Biological Chemistry. 285, 29, p. 22689-22695 7 p.

Research output: Contribution to journalArticle

Cell death
Pseudomonas
Homeostasis
Cell Death
Iron

Mechanism of Escherichia coli inactivation on palladium-modified nitrogen-doped titanium dioxide

Wu, P., Imlay, J. A. & Shang, J. K., Oct 1 2010, In : Biomaterials. 31, 29, p. 7526-7533 8 p.

Research output: Contribution to journalArticle

Palladium
Titanium dioxide
Escherichia coli
Nitrogen
Atomic Force Microscopy

The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions

Arenas, F. A., Díaz, W. A., Leal, C. A., Pérez-Donoso, J. M., Imlay, J. A. & Vásquez, C. C., Aug 1 2010, In : Biochemical and Biophysical Research Communications. 398, 4, p. 690-694 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Glutathione Peroxidase
Escherichia coli
Hydrogen Peroxide
Oxidative Stress

Two sources of endogenous hydrogen peroxide in Escherichia coli

Korshunov, S. & Imlay, J. A., Mar 2010, In : Molecular Microbiology. 75, 6, p. 1389-1401 13 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Fumarates
Electron Transport Complex IV
Oxygen
Escherichia coli
2009

Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli

Anjem, A., Varghese, S. & Imlay, J. A., May 1 2009, In : Molecular Microbiology. 72, 4, p. 844-858 15 p.

Research output: Contribution to journalArticle

Response Elements
Manganese
Hydrogen Peroxide
Escherichia coli
Peroxides

Oxidative stress

Imlay, J. A., Jan 1 2009, In : EcoSal Plus. 3, 2

Research output: Contribution to journalArticle

Oxidative Stress
Escherichia coli
Salmonella
Oxygen
Superoxides
Hydro-Lyases
Sulfur
Copper
Iron
Enzymes

Visible-light-induced photocatalytic inactivation of bacteria by composite photocatalysts of palladium oxide and nitrogen-doped titanium oxide

Wu, P., Xie, R., Imlay, J. A. & Shang, J. K., May 20 2009, In : Applied Catalysis B: Environmental. 88, 3-4, p. 576-581 6 p.

Research output: Contribution to journalArticle

Titanium oxides
palladium
Photocatalysts
Palladium
titanium
2007

Bactericidal antibiotics and oxidative stress: A radical proposal

Hassett, D. J. & Imlay, J. A., Nov 1 2007, In : ACS chemical biology. 2, 11, p. 708-710 3 p.

Research output: Contribution to journalArticle

Oxidative stress
Hydroxyl Radical
Oxidative Stress
Anti-Bacterial Agents

Intracellular copper does not catalyze the formation of oxidative DNA damage in Escherichia coli

Macomber, L., Rensing, C. & Imlay, J. A., Mar 1 2007, In : Journal of bacteriology. 189, 5, p. 1616-1626 11 p.

Research output: Contribution to journalArticle

DNA Damage
Copper
Escherichia coli
Hydroxyl Radical
Iron

Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes

Jang, S. & Imlay, J. A., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 929-937 9 p.

Research output: Contribution to journalArticle

Sulfur
Metabolism
Hydrogen Peroxide
Iron
Enzymes

Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes

Munroe, W., Kingsley, C., Durazo, A., Butler Gralla, E., Imlay, J. A., Srinivasan, C. & Selverstone Valentine, J., Nov 1 2007, In : Journal of Inorganic Biochemistry. 101, 11-12, p. 1875-1882 8 p.

Research output: Contribution to journalArticle

Manganese
Yeast
Escherichia coli
Superoxide Dismutase
Saccharomyces cerevisiae

Structural properties of periplasmic SodCI that correlate with virulence in Salmonella enterica serovar Typhimurium

Krishnakumar, R., Kim, B., Mollo, E. A., Imlay, J. A. & Slauch, J. M., Jun 1 2007, In : Journal of bacteriology. 189, 12, p. 4343-4352 10 p.

Research output: Contribution to journalArticle

Salmonella enterica
Virulence
Peptide Hydrolases
Phagosomes
Osmotic Pressure

Submicromolar hydrogen peroxide disrupts the ability of fur protein to control free-iron levels in Escherichia coli

Varghese, S., Wu, A., Park, S., Imlay, K. R. C. & Imlay, J. A., May 1 2007, In : Molecular Microbiology. 64, 3, p. 822-830 9 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Iron
Escherichia coli
Proteins
Regulon
2006

Detection and quantification of superoxide formed within the periplasm of Escherichia coli

Korshunov, S. & Imlay, J. A., Sep 1 2006, In : Journal of bacteriology. 188, 17, p. 6326-6334 9 p.

Research output: Contribution to journalArticle

Periplasm
Superoxides
Escherichia coli
Vitamin K 2
Bacteria

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Gakh, O., Park, S., Liu, G., Macomber, L., Imlay, J. A., Ferreira, G. C. & Isaya, G., Feb 1 2006, In : Human molecular genetics. 15, 3, p. 467-479 13 p.

Research output: Contribution to journalArticle

Iron
Oxidants
Insulin-Secreting Cells
Heme
Sulfur

RyhB small RNA modulates the free intracellular iron pool and is essential for normal growth during iron limitation in Escherichia coli

Jacques, J. F., Jang, S., Prévost, K., Desnoyers, G., Desmarais, M., Imlay, J. A. & Massé, E., Nov 1 2006, In : Molecular Microbiology. 62, 4, p. 1181-1190 10 p.

Research output: Contribution to journalArticle

Iron
RNA
Escherichia coli
Growth
Metals
2005
Hydrogen Peroxide
DNA Damage
Iron
Escherichia coli
Oxidants
2004

Are respiratory enzymes the primary sources of intracellular hydrogen peroxide?

Seaver, L. C. & Imlay, J. A., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 48742-48750 9 p.

Research output: Contribution to journalArticle

Electron Transport
Hydrogen Peroxide
Enzymes
Chemical Phenomena
Oxygen

Differences in enzymatic properties allow SodCI but not SodCII to contribute to virulence in Salmonella enterica serovar typhimurium strain 14028

Krishnakumar, R., Craig, M., Imlay, J. A. & Slauch, J. M., Aug 1 2004, In : Journal of bacteriology. 186, 16, p. 5230-5238 9 p.

Research output: Contribution to journalArticle

Salmonella enterica
Virulence
Copper
Phenotype
Enzymes

Repair of oxidized iron-sulfur clusters in Escherichia coli

Djaman, O., Outten, F. W. & Imlay, J. A., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44590-44599 10 p.

Research output: Contribution to journalArticle

Sulfur
Escherichia coli
Hydrogen Peroxide
Repair
Iron
2003

A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli

Woodmansee, A. N. & Imlay, J. A., Jul 1 2003, In : Molecular Microbiology. 49, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

DNA Damage
Nitric Oxide
Escherichia coli
Iron
Flavins