James A Imlay

1986 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

2019
Open Access
Fumarate Hydratase
Hydrogen Peroxide
Enzymes
Bacteria
Oxidants

Evolutionary adaptations that enable enzymes to tolerate oxidative stress

Imlay, J. A., Sethu, R. & Rohaun, S. K., Jan 1 2019, In : Free Radical Biology and Medicine.

Research output: Contribution to journalReview article

Oxidative stress
Oxidative Stress
Iron
Oxygen
Enzymes

Where in the world do bacteria experience oxidative stress?

Imlay, J. A., Feb 1 2019, In : Environmental Microbiology. 21, 2, p. 521-530 10 p.

Research output: Contribution to journalReview article

Oxidative Stress
oxidative stress
Bacteria
bacterium
Ecosystem
2018

4-Hydroxybenzaldehyde sensitizes Acinetobacter baumannii to amphenicols

Shin, B., Park, C., Imlay, J. A. & Park, W., Mar 1 2018, In : Applied Microbiology and Biotechnology. 102, 5, p. 2323-2335 13 p.

Research output: Contribution to journalArticle

Acinetobacter baumannii
Chloramphenicol
4-hydroxybenzaldehyde
Thiamphenicol
Facilitated Diffusion
Superoxides
Oxygen
Enzymes
Escherichia coli
Fumarate Hydratase
Escherichia coli
Hydrogen Peroxide
Toxicity
Bacteria
Experiments
2017
Cytochrome-c Peroxidase
Hydrogen Peroxide
Oxidoreductases
Electrons
Escherichia coli

Lineage-specific SoxR-mediated regulation of an endoribonuclease protects non-enteric bacteria from redox-active compounds

Kim, J., Park, C., Imlay, J. A. & Park, W., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 121-133 13 p.

Research output: Contribution to journalArticle

Endoribonucleases
Oxidation-Reduction
Bacteria
Transcription Factors
Anti-Bacterial Agents
Succinate Dehydrogenase
Reactive Oxygen Species
Escherichia coli
Enzymes
Oxygen
2016

The cytochrome bd oxidase of Escherichia coli prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide

Korshunov, S., Imlay, K. R. C. & Imlay, J. A., Jul 1 2016, In : Molecular Microbiology. 101, 1, p. 62-77 16 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Sulfides
Electron Transport Complex IV
Escherichia coli
Cystine
2015

Diagnosing oxidative stress in bacteria: not as easy as you might think

Imlay, J. A., Apr 1 2015, In : Current Opinion in Microbiology. 24, p. 124-131 8 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Oxidative Stress
Bacteria
Poisons
Oxidation-Reduction

Physiological roles and adverse effects of the two cystine importers of Escherichia coli

Chonoles Imlay, K. R., Korshunov, S. & Imlay, J. A., Jan 1 2015, In : Journal of bacteriology. 197, 23, p. 3629-3644 16 p.

Research output: Contribution to journalArticle

Cystine
Escherichia coli
Cysteine
Sulfur
Allosteric Site

The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese

Martin, J. E., Waters, L. S., Storz, G. & Imlay, J. A., Mar 16 2015, In : PLoS Genetics. 11, 3, e1004977.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Manganese
manganese
Escherichia coli
protein
Heme
Catalase
Hydrogen Peroxide
Iron
Escherichia coli

Transcription Factors That Defend Bacteria Against Reactive Oxygen Species

Imlay, J. A., Oct 15 2015, In : Annual review of microbiology. 69, 1, p. 93-108 16 p.

Research output: Contribution to journalReview article

Superoxides
Oxidation-Reduction
Reactive Oxygen Species
Transcription Factors
Iron
2014
Poisons
Biosynthetic Pathways
Superoxides
Hydrogen Peroxide
Iron

The mismetallation of enzymes during oxidative stress

Imlay, J. A., Oct 10 2014, In : Journal of Biological Chemistry. 289, 41, p. 28121-28128 8 p.

Research output: Contribution to journalReview article

Oxidative stress
Oxidative Stress
Iron
Enzymes
Manganese
2013

An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide

Mishra, S. & Imlay, J. A., Dec 1 2013, In : Molecular Microbiology. 90, 6, p. 1356-1371 16 p.

Research output: Contribution to journalArticle

Anaerobic Bacteria
Catalase
Hydrogen Peroxide
NAD+ peroxidase
Enzymes

Cell death from antibiotics without the involvement of reactive oxygen species

Liu, Y. & Imlay, J. A., Mar 8 2013, In : Science. 339, 6124, p. 1210-1213 4 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cell Death
Anti-Bacterial Agents
DNA Replication
DNA Repair

Comparative study of SoxR activation by redox-active compounds

Singh, A. K., Shin, J. H., Lee, K. L., Imlay, J. A. & Roe, J. H., Dec 1 2013, In : Molecular Microbiology. 90, 5, p. 983-996 14 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Paraquat
Escherichia coli
Oxidants
Streptomyces coelicolor

How Escherichia coli tolerates profuse hydrogen peroxide formation by a catabolic pathway

Kumar, S. R. & Imlay, J. A., Oct 18 2013, In : Journal of bacteriology. 195, 20, p. 4569-4579 11 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Escherichia coli
Phenethylamines
Enzymes
NAD+ peroxidase

Superoxide poisons mononuclear iron enzymes by causing mismetallation

Gu, M. & Imlay, J. A., Jul 1 2013, In : Molecular Microbiology. 89, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

Poisons
Superoxides
Iron
Zinc
Enzymes

The molecular mechanisms and physiological consequences of oxidative stress: Lessons from a model bacterium

Imlay, J. A., Jul 1 2013, In : Nature Reviews Microbiology. 11, 7, p. 443-454 12 p.

Research output: Contribution to journalReview article

Oxidative Stress
Bacteria
Superoxides
Poisons
Peroxides
2012

Mononuclear iron enzymes are primary targets of hydrogen peroxide stress

Anjem, A. & Imlay, J. A., May 4 2012, In : Journal of Biological Chemistry. 287, 19, p. 15544-15556 13 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Cysteine
Iron
peptide deformylase
L-threonine 3-dehydrogenase
Hydro-Lyases
Mercury
Cadmium
Silver
Sulfur

Why do bacteria use so many enzymes to scavenge hydrogen peroxide?

Mishra, S. & Imlay, J. A., Sep 15 2012, In : Archives of Biochemistry and Biophysics. 525, 2, p. 145-160 16 p.

Research output: Contribution to journalReview article

Hydrogen Peroxide
Bacteria
Enzymes
NAD+ peroxidase
Chemical Phenomena
2011
Racemases and Epimerases
Manganese
Hydrogen Peroxide
Iron
Escherichia coli

Letter to the editor

Imlay, J. A. & Gu, M., Jun 15 2011, In : Free Radical Biology and Medicine. 50, 12, p. 1814-1815 2 p.

Research output: Contribution to journalLetter

Regulon
Trans-Activators
Bacterial Proteins
Escherichia coli Proteins
Superoxides

Oxidative and nitrosative stress defence systems in Escherichia Coli and pseudomonas aeruginosa: A model organism of study versus a human opportunistic pathogen

Imlay, J. A. & Hassett, D. J., Jun 27 2011, Advances in Molecular and Cellular Microbiology: Stress Response in Pathogenic Bacteria. CABI Publishing, p. 1-32 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pathogens
Pseudomonas aeruginosa
Escherichia coli
Oxidative Stress
pathogens

Rapid identification of bacteria with a disposable colorimetric sensing array

Carey, J. R., Suslick, K. S., Hulkower, K. I., Imlay, J. A., Imlay, K. R. C., Ingison, C. K., Ponder, J. B., Sen, A. & Wittrig, A. E., May 18 2011, In : Journal of the American Chemical Society. 133, 19, p. 7571-7576 6 p.

Research output: Contribution to journalArticle

Sensor arrays
Bacteria
sensor
bacterium
Enterococcus faecalis

Redox pioneer: professor Irwin Fridovich.

Imlay, J. A., Jan 1 2011, In : Antioxidants & redox signaling. 14, 3, p. 335-340 6 p.

Research output: Contribution to journalArticle

Superoxides
Superoxide Dismutase
Oxidation-Reduction
Oxidative stress
Oxidative Stress
Ribonucleotide Reductases
Manganese
Starvation
Iron
Escherichia coli

The escherichia coli btue protein functions as a resistance determinant against reactive oxygen species

Arenas, F. A., Covarrubias, P. C., Sandoval, J. M., Pérez-Donoso, J. M., Imlay, J. A. & Vásquez, C. C., Feb 1 2011, In : PloS one. 6, 1, e15979.

Research output: Contribution to journalArticle

Oxidative stress
Escherichia coli Proteins
Escherichia coli
reactive oxygen species
Reactive Oxygen Species

The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide

Gu, M. & Imlay, J. A., Mar 1 2011, In : Molecular Microbiology. 79, 5, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Superoxides
Oxidation-Reduction
Escherichia coli
Pharmaceutical Preparations
Superoxide Dismutase
Regulon
Escherichia coli Proteins
Hydrogen Peroxide
Iron
DNA Damage
2010

A small RNA promotes siderophore production through transcriptional and metabolic remodeling

Salvail, H., Lanthier-Bourbonnais, P., Sobota, J. M., Caza, M., Benjamin, J. A. M., Mendieta, M. E. S., Lépine, F., Dozois, C. M., Imlay, J. A. & Massé, E., Aug 24 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15223-15228 6 p.

Research output: Contribution to journalArticle

Siderophores
Enterobactin
RNA
Serine
Serine O-Acetyltransferase
Hydro-Lyases
Regulon
Sulfur
Oxidants
Hydrogen Peroxide

Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species

Yeom, J., Imlay, J. A. & Park, W., Jul 16 2010, In : Journal of Biological Chemistry. 285, 29, p. 22689-22695 7 p.

Research output: Contribution to journalArticle

Cell death
Pseudomonas
Homeostasis
Cell Death
Iron

Mechanism of Escherichia coli inactivation on palladium-modified nitrogen-doped titanium dioxide

Wu, P., Imlay, J. A. & Shang, J. K., Oct 1 2010, In : Biomaterials. 31, 29, p. 7526-7533 8 p.

Research output: Contribution to journalArticle

Palladium
Titanium dioxide
Escherichia coli
Nitrogen
Atomic Force Microscopy

The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions

Arenas, F. A., Díaz, W. A., Leal, C. A., Pérez-Donoso, J. M., Imlay, J. A. & Vásquez, C. C., Aug 1 2010, In : Biochemical and Biophysical Research Communications. 398, 4, p. 690-694 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Glutathione Peroxidase
Escherichia coli
Hydrogen Peroxide
Oxidative Stress

Two sources of endogenous hydrogen peroxide in Escherichia coli

Korshunov, S. & Imlay, J. A., Jan 1 2010, In : Molecular Microbiology. 75, 6, p. 1389-1401 13 p.

Research output: Contribution to journalArticle

Hydrogen Peroxide
Fumarates
Electron Transport Complex IV
Oxygen
Escherichia coli
2009

Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli

Anjem, A., Varghese, S. & Imlay, J. A., May 1 2009, In : Molecular Microbiology. 72, 4, p. 844-858 15 p.

Research output: Contribution to journalArticle

Response Elements
Manganese
Hydrogen Peroxide
Escherichia coli
Peroxides

Oxidative stress

Imlay, J. A., Jan 1 2009, In : EcoSal Plus. 3, 2

Research output: Contribution to journalArticle

Oxidative Stress
Escherichia coli
Salmonella
Oxygen
Superoxides
Hydro-Lyases
Sulfur
Copper
Iron
Enzymes

Visible-light-induced photocatalytic inactivation of bacteria by composite photocatalysts of palladium oxide and nitrogen-doped titanium oxide

Wu, P., Xie, R., Imlay, J. A. & Shang, J. K., May 20 2009, In : Applied Catalysis B: Environmental. 88, 3-4, p. 576-581 6 p.

Research output: Contribution to journalArticle

Titanium oxides
palladium
Photocatalysts
Palladium
titanium
2008

Cellular defenses against superoxide and hydrogen peroxide

Imlay, J. A., Sep 25 2008, In : Annual review of biochemistry. 77, p. 755-776 22 p.

Research output: Contribution to journalReview article

Superoxides
Hydrogen Peroxide
Oxygen
Metabolism
Photosystem II Protein Complex

How obligatory is anaerobiosis?

Imlay, J. A., May 1 2008, In : Molecular Microbiology. 68, 4, p. 801-804 4 p.

Research output: Contribution to journalComment/debate

Anaerobiosis
Clostridium acetobutylicum
Oxygen
Aerobic Bacteria
Microbiology
2007

Bactericidal antibiotics and oxidative stress: A radical proposal

Hassett, D. J. & Imlay, J. A., Nov 1 2007, In : ACS chemical biology. 2, 11, p. 708-710 3 p.

Research output: Contribution to journalArticle

Oxidative stress
Hydroxyl Radical
Oxidative Stress
Anti-Bacterial Agents

Intracellular copper does not catalyze the formation of oxidative DNA damage in Escherichia coli

Macomber, L., Rensing, C. & Imlay, J. A., Mar 1 2007, In : Journal of bacteriology. 189, 5, p. 1616-1626 11 p.

Research output: Contribution to journalArticle

DNA Damage
Copper
Escherichia coli
Hydroxyl Radical
Iron