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Article
2020

Stochastic simulation and statistical inference platform for visualization and estimation of transcriptional kinetics

Gorin, G., Wang, M., Golding, I. & Xu, H., Jan 1 2020, In : PloS one. 15, 3, e0230736.

Research output: Contribution to journalArticle

Open Access
2019

Cofilin-Mediated Actin Stress Response Is Maladaptive in Heat-Stressed Embryos

Figard, L., Zheng, L., Biel, N., Xue, Z., Seede, H., Coleman, S., Golding, I. & Sokac, A. M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3493-3501.e4

Research output: Contribution to journalArticle

Open Access
2017

The transcription fidelity factor GreA impedes DNA break repair

Sivaramakrishnan, P., Sepúlveda, L. A., Halliday, J. A., Liu, J., Núñez, M. A. B., Golding, I., Rosenberg, S. M. & Herman, C., Oct 12 2017, In : Nature. 550, 7675, p. 214-218 5 p.

Research output: Contribution to journalArticle

2016

Measurement of gene regulation in individual cells reveals rapid switching between promoter states

Sepúlveda, L. A., Xu, H., Zhang, J., Wang, M. & Golding, I., Mar 11 2016, In : Science. 351, 6278, p. 1218-1222 5 p.

Research output: Contribution to journalArticle

Open Access

Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir

Figard, L., Wang, M., Zheng, L., Golding, I. & Sokac, A. M., May 9 2016, In : Developmental cell. 37, 3, p. 267-278 12 p.

Research output: Contribution to journalArticle

Open Access

Single-cell analysis of transcription kinetics across the cell cycle

Skinner, S. O., Xu, H., Nagarkar-Jaiswal, S., Freire, P. R., Zwaka, T. P. & Golding, I., Jan 29 2016, In : eLife. 5, JANUARY2016, e12175.

Research output: Contribution to journalArticle

Open Access

Single-Cell Studies of Phage λ: Hidden Treasures under Occam's Rug

Golding, I., Sep 29 2016, In : Annual Review of Virology. 3, p. 453-472 20 p.

Research output: Contribution to journalArticle

Stochastic Kinetics of Nascent RNA

Xu, H., Skinner, S. O., Sokac, A. M. & Golding, I., Sep 13 2016, In : Physical review letters. 117, 12, 128101.

Research output: Contribution to journalArticle

Open Access
2015

Combining protein and mRNA quantification to decipher transcriptional regulation

Xu, H., Sepúlveda, L. A., Figard, L., Sokac, A. M. & Golding, I., Jul 30 2015, In : Nature Methods. 12, 8, p. 739-742 4 p.

Research output: Contribution to journalArticle

Determination of in vivo target search kinetics of regulatory noncoding RNA

Fei, J., Singh, D., Zhang, Q., Park, S., Balasubramanian, D., Golding, I., Vanderpool, C. & Ha, T., Mar 20 2015, In : Science. 347, 6228, p. 1371-1374 4 p.

Research output: Contribution to journalArticle

DksA involvement in transcription fidelity buffers stochastic epigenetic change

Satory, D., Gordon, A. J. E., Wang, M., Halliday, J. A., Golding, I. & Herman, C., Jan 1 2015, In : Nucleic acids research. 43, 21, p. 10190-10199 10 p.

Research output: Contribution to journalArticle

Open Access

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Hsu, T. Y. T., Simon, L. M., Neill, N. J., Marcotte, R., Sayad, A., Bland, C. S., Echeverria, G. V., Sun, T., Kurley, S. J., Tyagi, S., Karlin, K. L., Dominguez-Vidaña, R., Hartman, J. D., Renwick, A., Scorsone, K., Bernardi, R. J., Skinner, S. O., Jain, A., Orellana, M., Lagisetti, C. & 9 others, Golding, I., Jung, S. Y., Neilson, J. R., Zhang, X. H. F., Cooper, T. A., Webb, T. R., Neel, B. G., Shaw, C. A. & Westbrook, T. F., Sep 17 2015, In : Nature. 525, 7569, p. 384-388 5 p.

Research output: Contribution to journalArticle

2014

A nutrient-tunable bistable switch controls motility in Salmonella enterica serovar Typhimurium

Koirala, S., Mears, P., Sim, M., Golding, I., Chemla, Y. R., Aldridge, P. D. & Rao, C. V., Aug 26 2014, In : mBio. 5, 5, e01611-14.

Research output: Contribution to journalArticle

Escherichia coli swimming is robust against variations in flagellar number

Mears, P. J., Koirala, S., Rao, C. V., Golding, I. & Chemla, Y. R., Feb 11 2014, In : eLife. 2014, 3, e01916.

Research output: Contribution to journalArticle

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity

Gordon, A. J. E., Satory, D., Wang, M., Halliday, J. A., Golding, I. & Herman, C., Oct 29 2014, In : Nucleic acids research. 42, 19, p. 12015-12026 12 p.

Research output: Contribution to journalArticle

Open Access

Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda

Bednarz, M., Halliday, J. A., Herman, C. & Golding, I., Jun 25 2014, In : PloS one. 9, 6, e100876.

Research output: Contribution to journalArticle

Open Access
2013

Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization

Skinner, S. O., Sepúlveda, L. A., Xu, H. & Golding, I., Jun 1 2013, In : Nature Protocols. 8, 6, p. 1100-1113 14 p.

Research output: Contribution to journalArticle

The Maternal-to-Zygotic Transition Targets Actin to Promote Robustness during Morphogenesis

Zheng, L., Sepúlveda, L. A., Lua, R. C., Lichtarge, O., Golding, I. & Sokac, A. M., Nov 1 2013, In : PLoS genetics. 9, 11, e1003901.

Research output: Contribution to journalArticle

Open Access

The plasma membrane flattens out to fuel cell-surface growth during drosophila cellularization

Figard, L., Xu, H., Garcia, H. G., Golding, I. & Sokac, A. M., Dec 23 2013, In : Developmental cell. 27, 6, p. 648-655 8 p.

Research output: Contribution to journalArticle

Open Access
2012

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

Kessler, J. D., Kahle, K. T., Sun, T., Meerbrey, K. L., Schlabach, M. R., Schmitt, E. M., Skinner, S. O., Xu, Q., Li, M. Z., Hartman, Z. C., Rao, M., Yu, P., Dominguez-Vidana, R., Liang, A. C., Solimini, N. L., Bernardi, R. J., Yu, B., Hsu, T., Golding, I., Luo, J. & 7 others, Osborne, C. K., Creighton, C. J., Hilsenbeck, S. G., Schiff, R., Shaw, C. A., Elledge, S. J. & Westbrook, T. F., Jan 20 2012, In : Science. 335, 6066, p. 348-353 6 p.

Research output: Contribution to journalArticle

Chemotactic adaptation kinetics of individual Escherichia coli cells

Min, T. L., Mears, P. J., Golding, I. & Chemla, Y. R., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9869-9874 6 p.

Research output: Contribution to journalArticle

Visualizing Escherichia coli sub-cellular structure using sparse deconvolution spatial light interference tomography

Mir, M., Babacan, S. D., Bednarz, M., Do, M. N., Golding, I. & Popescu, G., Jun 28 2012, In : PloS one. 7, 6, e39816.

Research output: Contribution to journalArticle

2011

Decision making in living cells: Lessons from a simple system

Golding, I., Jun 9 2011, In : Annual Review of Biophysics. 40, 1, p. 63-80 18 p.

Research output: Contribution to journalArticle

Following cell-fate in E. coli after infection by phage lambda

Zeng, L. & Golding, I., Oct 2011, In : Journal of Visualized Experiments. 56, e3363.

Research output: Contribution to journalArticle

Open Access

General properties of transcriptional time series in Escherichia coli

So, L. H., Ghosh, A., Zong, C., Sepúlveda, L. A., Segev, R. & Golding, I., Jun 1 2011, In : Nature Genetics. 43, 6, p. 554-560 7 p.

Research output: Contribution to journalArticle

Optical measurement of cycle-dependent cell growth

Mir, M., Wang, Z., Shen, Z., Bednarz, M., Bashir, R., Golding, I., Prasanth, S. G. & Popescu, G., Aug 9 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 32, p. 13124-13129 6 p.

Research output: Contribution to journalArticle

Single-virus tracking reveals a spatial receptor-dependent search mechanism

Rothenberg, E., Sepúlveda, L. A., Skinner, S. O., Zeng, L., Selvin, P. R. & Golding, I., Jan 1 2011, In : Biophysical journal. 100, 12, p. 2875-2882 8 p.

Research output: Contribution to journalArticle

Two-photon 3D fiona of individual quantum dots in an aqueous environment

Zhang, R., Rothenberg, E., Fruhwirth, G., Simonson, P. D., Ye, F., Golding, I., Ng, T., Lopes, W. & Selvin, P. R., Oct 12 2011, In : Nano letters. 11, 10, p. 4074-4078 5 p.

Research output: Contribution to journalArticle

2010

Decision Making at a Subcellular Level Determines the Outcome of Bacteriophage Infection

Zeng, L., Skinner, S. O., Zong, C., Sippy, J., Feiss, M. & Golding, I., May 1 2010, In : Cell. 141, 4, p. 682-691 10 p.

Research output: Contribution to journalArticle

Open Access

FliZ induces a kinetic switch in flagellar gene expression

Saini, S., Koirala, S., Floess, E., Mears, P. J., Chemla, Y. R., Golding, I., Aldridge, C., Aldridge, P. D. & Rao, C. V., Dec 1 2010, In : Journal of bacteriology. 192, 24, p. 6477-6481 5 p.

Research output: Contribution to journalArticle

Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene

Zong, C., So, L. H., Sepúlveda, L. A., Skinner, S. O. & Golding, I., Dec 13 2010, In : Molecular Systems Biology. 6, 440.

Research output: Contribution to journalArticle

Open Access
2009

High-resolution, long-term characterization of bacterial motility using optical tweezers

Min, T. L., Mears, P. J., Chubiz, L. M., Rao, C. V., Golding, I. & Chemla, Y. R., Oct 1 2009, In : Nature Methods. 6, 11, p. 831-835 5 p.

Research output: Contribution to journalArticle

Quantitative transcription factor binding kinetics at the single-molecule level

Wang, Y., Guo, L., Golding, I., Cox, E. C. & Ong, N. P., Jan 21 2009, In : Biophysical journal. 96, 2, p. 609-620 12 p.

Research output: Contribution to journalArticle

Open Access
2006

Physical nature of bacterial cytoplasm

Golding, I. & Cox, E. C., Mar 20 2006, In : Physical review letters. 96, 9, 098102.

Research output: Contribution to journalArticle

2005

Population fitness and the regulation of Escherichia coli genes by bacterial viruses

Chen, Y., Golding, I., Sawai, S., Guo, L. & Cox, E. C., Jul 2005, In : PLoS biology. 3, 7, p. 1276-1282 7 p., e229.

Research output: Contribution to journalArticle

Open Access

Real-time kinetics of gene activity in individual bacteria

Golding, I., Paulsson, J., Zawilski, S. M. & Cox, E. C., Dec 16 2005, In : Cell. 123, 6, p. 1025-1036 12 p.

Research output: Contribution to journalArticle

Open Access

Single-molecule studies of repressor-DNA interactions show long-range interactions

Wang, Y. M., Tegenfeldt, J. O., Reisner, W., Riehn, R., Guan, X. J., Guo, L., Golding, I., Cox, E. C., Sturm, J. & Austin, R. H., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9796-9801 6 p.

Research output: Contribution to journalArticle

Open Access
2004

Autoimmunity as an immune defense against degenerative processes: A primary mathematical model illustrating the bright side of autoimmunity

Nevo, U., Golding, I., Neumann, A. U., Schwartz, M. & Akselrod, S., Apr 21 2004, In : Journal of Theoretical Biology. 227, 4, p. 583-592 10 p.

Research output: Contribution to journalArticle

RNA dynamics in live Escherichia coli cells

Golding, I. & Cox, E. C., Aug 3 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 31, p. 11310-11315 6 p.

Research output: Contribution to journalArticle

Open Access
2003

Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases

Ron, I. G., Golding, I., Lifsitz-Mercer, B. & Ben-Jacob, E., Mar 15 2003, In : Physica A: Statistical Mechanics and its Applications. 320, p. 485-496 12 p.

Research output: Contribution to journalArticle

2002

Morphological characterization of in vitro neuronal networks

Shefi, O., Golding, I., Segev, R., Ben-Jacob, E. & Ayali, A., Aug 14 2002, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 66, 2

Research output: Contribution to journalArticle

2001

A quantitative study of the dynamics of adaptive mutation appearance

Golding, I., Drossel, B., Shapira, Y. & Ben-Jacob, E., May 1 2001, In : Physica A: Statistical Mechanics and its Applications. 294, 1-2, p. 195-212 18 p.

Research output: Contribution to journalArticle

Biofluiddynamics of lubricating bacteria

Cohen, I., Golding, I., Ron, I. G. & Ben-Jacob, E., Nov 25 2001, In : Mathematical Methods in the Applied Sciences. 24, 17-18, p. 1429-1468 40 p.

Research output: Contribution to journalArticle

2000

Bacterial cooperative organization under antibiotic stress

Ben-Jacob, E., Cohen, I., Golding, I., Gutnick, D. L., Tcherpakov, M., Helbing, D. & Ron, I. G., Jul 1 2000, In : Physica A: Statistical Mechanics and its Applications. 282, 1, p. 247-282 36 p.

Research output: Contribution to journalArticle

1999

Continuous and discrete models of cooperation in complex bacterial colonies

Cohen, I., Golding, I., Kozlovsky, Y., Ben-Jacob, E. & Ron, I. G., Sep 1999, In : Fractals. 7, 3, p. 235-247 13 p.

Research output: Contribution to journalArticle

Lubricating bacteria model for branching growth of bacterial colonies

Kozlovsky, Y., Cohen, I., Golding, I. & Ben-Jacob, E., Jan 1 1999, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 59, 6, p. 7025-7035 11 p.

Research output: Contribution to journalArticle

Studies of sector formation in expanding bacterial colonies

Golding, I., Cohen, I. & Ben-Jacob, E., Dec 1 1999, In : Europhysics Letters. 48, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

1998

Studies of bacterial branching growth using reaction-diffusion models for colonial development

Golding, I., Kozlovsky, Y., Cohen, I. & Ben-Jacob, E., Nov 15 1998, In : Physica A: Statistical Mechanics and its Applications. 260, 3-4, p. 510-554 45 p.

Research output: Contribution to journalArticle

1997