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Research Output

Article
Open Access

A mechanically-induced colon cancer cell population shows increased metastatic potential

Tang, X., Kuhlenschmidt, T. B., Li, Q., Ali, S., Lezmi, S., Chen, H., Pires-Alves, M., Laegreid, W. W., Saif, T. A. & Kuhlenschmidt, M. S., May 29 2014, In : Molecular Cancer. 13, 1, 131.

Research output: Contribution to journalArticle

Amino acid limitation induces down-regulation of WNT5a at transcriptional level

Wang, Z. & Chen, H., Jan 23 2009, In : Biochemical and Biophysical Research Communications. 378, 4, p. 789-794 6 p.

Research output: Contribution to journalArticle

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S., Nov 1 2005, In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus.) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis

Ma, L., Xu, G. B., Tang, X., Zhang, C., Zhao, W., Wang, J. & Chen, H., Jan 2020, In : Journal of Functional Foods. 64, 103677.

Research output: Contribution to journalArticle

Open Access

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Siu, F., Bain, P. J., Leblanc-Chaffin, R., Chen, H. & Kilberg, M. S., Jul 5 2002, In : Journal of Biological Chemistry. 277, 27, p. 24120-24127 8 p.

Research output: Contribution to journalArticle

Characterization and regulation of a cloned ovine gastrointestinal peptide transporter (oPepT1) expressed in a mammalian cell line

Chen, H., Yuan Xiang Pan, X. P., Wong, E. A. & Webb, J., Jan 16 2002, In : Journal of Nutrition. 132, 1, p. 38-42 5 p.

Research output: Contribution to journalArticle

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

Park, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H. & Sze, S. K., Jan 12 2017, In : Scientific reports. 7, 40569.

Research output: Contribution to journalArticle

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y. X., Wong, E. A. & Webb, K. E., Feb 2005, In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

Open Access

DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development

Zhang, Y., Li, Q. & Chen, H., Aug 1 2013, In : Carcinogenesis. 34, 8, p. 1756-1763 8 p.

Research output: Contribution to journalArticle

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X., May 1 2015, In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

Effects of Obesity and Exercise on Bone Marrow Progenitor Cells after Radiation

Emmons, R., Ngu, M., Xu, G., Hernández-Saavedra, D., Chen, H. & De Lisio, M., Jun 1 2019, In : Medicine and Science in Sports and Exercise. 51, 6, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice

Emmons, R., Xu, G., Hernández-Saavedra, D., Kriska, A., Pan, Y. X., Chen, H. & De Lisio, M., Feb 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 2, p. E210-E220

Research output: Contribution to journalArticle

Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis

Li, Q. & Chen, H., Jul 2011, In : Epigenetics. 6, 7, p. 849-852 4 p.

Research output: Contribution to journalArticle

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

Moody, L., Xu, G. B., Chen, H. & Pan, Y. X., Feb 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 2, p. 141-152 12 p.

Research output: Contribution to journalArticle

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Wang, H., Wu, X., Lezmi, S., Li, Q., Helferich, W. G., Xu, Y. & Chen, H., Dec 2 2017, In : BMC Complementary and Alternative Medicine. 17, 1, 516.

Research output: Contribution to journalArticle

Fat accumulation in the liver of obese rats is alleviated by soy protein isolate through β-catenin signaling

Zhou, D., Lezmi, S., Wang, H., Davis, J., Banz, W. & Chen, H., Jan 1 2014, In : Obesity. 22, 1, p. 151-158 8 p.

Research output: Contribution to journalArticle

Genistein, an epigenome modifier during cancer prevention

Zhang, Y. & Chen, H., Jul 2011, In : Epigenetics. 6, 7, p. 888-891 4 p.

Research output: Contribution to journalArticle

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

Zhang, Y., Li, Q., Zhou, D. & Chen, H., Jan 14 2013, In : British Journal of Nutrition. 109, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line

Wang, H., Li, Q. & Chen, H., Jul 18 2012, In : PloS one. 7, 7, e40955.

Research output: Contribution to journalArticle

Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line

Zhang, Y. & Chen, H., Jun 1 2011, In : Experimental Biology and Medicine. 236, 6, p. 714-722 9 p.

Research output: Contribution to journalArticle

Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116

Wang, Z. & Chen, H., Nov 1 2010, In : Anticancer Research. 30, 11, p. 4537-4545 9 p.

Research output: Contribution to journalArticle

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y-X. & Chen, H., Oct 2010, In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y-X., Oct 1 2015, In : Physiological genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

Leung-Pineda, V., Pan, Y. X., Chen, H. & Kilberg, M. S., Apr 1 2004, In : Biochemical Journal. 379, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S., Dec 15 2016, In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

Open Access

Maternal Low-Fat Diet Programs the Hepatic Epigenome despite Exposure to an Obesogenic Postnatal Diet

Moody, L., Shao, J., Chen, H. & Pan, Y-X., Sep 3 2019, In : Nutrients. 11, 9, 2075.

Research output: Contribution to journalArticle

Open Access

Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells

Chen, H., Pan, Y. X., Wong, E. A., Bloomquist, J. R. & Webb, K. E., 2002, In : Journal of Nutrition. 132, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

Open Access

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

Moody, L., Kougias, D., Jung, P. M., Digan, I., Hong, A., Gorski, A., Chen, H., Juraska, J. & Pan, Y. X., Mar 2019, In : Journal of Nutritional Biochemistry. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y. X., Nov 2017, In : Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journalArticle

Silencing of wnt5a during colon cancer metastasis involves histone modifications

Li, Q. & Chen, H., Jun 2012, In : Epigenetics. 7, 6, p. 551-558 8 p.

Research output: Contribution to journalArticle

The Late Effects of Radiation Therapy on Skeletal Muscle Morphology and Progenitor Cell Content are Influenced by Diet-Induced Obesity and Exercise Training in Male Mice

D’Souza, D., Roubos, S., Larkin, J., Lloyd, J., Emmons, R., Chen, H. & De Lisio, M., Dec 1 2019, In : Scientific reports. 9, 1, 6691.

Research output: Contribution to journalArticle

Open Access

The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase

Bain, P. J., Leblanc-Chaffin, R., Chen, H., Palii, S. S., Leach, K. M. & Kilberg, M. S., Oct 1 2002, In : Journal of Nutrition. 132, 10, p. 3023-3029 7 p.

Research output: Contribution to journalArticle

Open Access

Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens

Chen, H., Wong, E. A. & Webb, K. E., May 1999, In : Journal of animal science. 77, 5, p. 1277-1283 7 p.

Research output: Contribution to journalArticle

Chapter

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H., Feb 1 2014, Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenetic Regulation in Cancer Metastasis

Wang, H., Zhang, Y., Kriska, A. & Chen, H., Jul 1 2016, Medical Epigenetics. Elsevier Inc., p. 499-514 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Review article

Computational methods to identify bimodal gene expression and facilitate personalized treatment in cancer patients

Moody, L., Mantha, S., Chen, H. & Pan, Y. X., Mar 2019, In : Journal of Biomedical Informatics: X. 1, 100001.

Research output: Contribution to journalReview article

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

Hernández-Saavedra, D., Moody, L., Xu, G. B., Chen, H. & Pan, Y. X., May 1 2019, In : Advances in Nutrition. 10, 3, p. 520-536 17 p.

Research output: Contribution to journalReview article

Methods and novel technology for microRNA quantification in colorectal cancer screening

Moody, L., He, H., Pan, Y. X. & Chen, H., Jan 1 2017, In : Clinical epigenetics. 9, 1 p.

Research output: Contribution to journalReview article

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V., Sep 5 2005, In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Contribution to journalReview article