Research Output 1999 2017

2017

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

Park, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H. & Sze, S. K. Jan 12 2017 In : Scientific Reports. 7, 40569

Research output: Research - peer-reviewArticle

Phytochemicals
Epigenomics
Neoplasms
phenethyl isothiocyanate
Polycomb-Group Proteins
cognition
epigenetics
learning
Epigenomics
Cognition
2016

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S. Dec 15 2016 In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Spatial Learning
Spatial Memory
2015
High Fat Diet
Fats
Liver
Nutrition
Histones

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X. Oct 1 2015 In : Physiological Genomics. 47, 10, p. 514-523 10 p.

Research output: Research - peer-reviewArticle

High Fat Diet
Epigenomics
Liver
Genes
DNA Methylation
2014

A mechanically-induced colon cancer cell population shows increased metastatic potential

Tang, X., Kuhlenschmidt, T. B., Li, Q., Ali, S., Lezmi, S., Chen, H., Pires-Alves, M., Laegreid, W. W., Saif, T. A. & Kuhlenschmidt, M. S. May 29 2014 In : Molecular Cancer. 13, 1, 131

Research output: Research - peer-reviewArticle

Colonic Neoplasms
Population
Neoplasm Metastasis
Neoplasms
bovine corneal protein 54

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H. Feb 1 2014 Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: ResearchChapter

Epigenomics
Colonic Neoplasms
Neoplasms
Histone Code
Genetic Epigenesis

Fat accumulation in the liver of obese rats is alleviated by soy protein isolate through β-catenin signaling

Zhou, D., Lezmi, S., Wang, H., Davis, J., Banz, W. & Chen, H. Jan 2014 In : Obesity. 22, 1, p. 151-158 8 p.

Research output: Research - peer-reviewArticle

Soybean Proteins
beta Catenin
Fats
Liver
Caseins
2013

DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development

Zhang, Y., Li, Q. & Chen, H. Aug 2013 In : Carcinogenesis. 34, 8, p. 1756-1763 8 p.

Research output: Research - peer-reviewArticle

Histone Code
Genistein
DNA Methylation
Colonic Neoplasms
Genes

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

Zhang, Y., Li, Q., Zhou, D. & Chen, H. Jan 14 2013 In : British Journal of Nutrition. 109, 1, p. 33-42 10 p.

Research output: Research - peer-reviewArticle

Azoxymethane
Isoflavones
Genistein
beta Catenin
Colon
2012

Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line

Wang, H., Li, Q. & Chen, H. Jul 18 2012 In : PLoS ONE. 7, 7, e40955

Research output: Research - peer-reviewArticle

genistein
colorectal neoplasms
histones
cell lines
genes

Silencing of wnt5a during colon cancer metastasis involves histone modifications

Li, Q. & Chen, H. 2012 In : Epigenetics. 7, 6, p. 551-558 8 p.

Research output: Research - peer-reviewArticle

Histone Code
Colonic Neoplasms
Neoplasm Metastasis
Histone Deacetylase Inhibitors
Histones
2011
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Genes
RNA, Transfer, His

Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis

Li, Q. & Chen, H. 2011 In : Epigenetics. 6, 7, p. 849-852 4 p.

Research output: Research - peer-reviewArticle

Tumor Suppressor Genes
Epigenomics
Colonic Neoplasms
Neoplasm Metastasis
Neoplasms

Genistein, an epigenome modifier during cancer prevention

Zhang, Y. & Chen, H. 2011 In : Epigenetics. 6, 7, p. 888-891 4 p.

Research output: Research - peer-reviewArticle

Genistein
Neoplasms
DNA Methylation
Epigenomics
Carcinogenesis

Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line

Zhang, Y. & Chen, H. Jun 2011 In : Experimental Biology and Medicine. 236, 6, p. 714-722 9 p.

Research output: Research - peer-reviewArticle

Genistein
Colonic Neoplasms
Cell Line
Cells
beta Catenin
Colonic Neoplasms
Cell Line
Genes
Histones
Methylation
2010

Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116

Wang, Z. & Chen, H. Nov 2010 In : Anticancer Research. 30, 11, p. 4537-4545 9 p.

Research output: Research - peer-reviewArticle

Genistein
Colonic Neoplasms
Gene Expression
Cell Line
CpG Islands
Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Liver
2009

Amino acid limitation induces down-regulation of WNT5a at transcriptional level

Wang, Z. & Chen, H. Jan 23 2009 In : Biochemical and Biophysical Research Communications. 378, 4, p. 789-794 6 p.

Research output: Research - peer-reviewArticle

Down-Regulation
Amino Acids
Messenger RNA
Colonic Neoplasms
Cells
2007
Activating Transcription Factor 3
Genes
Chemical activation
Amino Acids
CCAAT-Enhancer-Binding Proteins
2006
Aspartate-Ammonia Ligase
Transcription Initiation Site
Hep G2 Cells
Human Activities
Amino Acids
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S. Nov 1 2005 In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Research - peer-reviewArticle

CCAAT-Enhancer-Binding Protein-beta
Transcription
Genes
Amino Acids
Proteins

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y., Wong, E. A. & Webb, K. E. Feb 2005 In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Research - peer-reviewArticle

peptide transporters
dietary protein
crude protein
chickens
Dietary Proteins
RNA-Binding Proteins
3' Untranslated Regions
Amino Acids
Messenger RNA
ELAV-Like Protein 1

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V. 2005 In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Research - peer-reviewReview article

Gene Expression
Amino Acids
Proteins
Messenger RNA
Activating Transcription Factor 4
2004
Aspartate-Ammonia Ligase
Leucine Zippers
Acetylation
Transcription
Histones

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

Leung-Pineda, V., Pan, Y., Chen, H. & Kilberg, M. S. Apr 1 2004 In : Biochemical Journal. 379, 1, p. 79-88 10 p.

Research output: Research - peer-reviewArticle

Hepatocellular Carcinoma
Amino Acids
Messenger RNA
Histidine
Proteins
Neutral Amino Acid Transport Systems
Sodium
Amino Acids
Genes
Response Elements
2003
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Endoplasmic Reticulum Stress
Hep G2 Cells
Amino Acids
2002

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Siu, F., Bain, P. J., Leblanc-Chaffin, R., Chen, H. & Kilberg, M. S. Jul 5 2002 In : Journal of Biological Chemistry. 277, 27, p. 24120-24127 8 p.

Research output: Research - peer-reviewArticle

Aspartate-Ammonia Ligase
Food
Genes
Nutrients
Response Elements

Characterization and regulation of a cloned ovine gastrointestinal peptide transporter (oPepT1) expressed in a mammalian cell line

Chen, H., Yuan Xiang Pan, X. P., Wong, E. A. & Webb K.E., J. 2002 In : Journal of Nutrition. 132, 1, p. 38-42 5 p.

Research output: Research - peer-reviewArticle

peptide transporters
cell lines
uptake mechanisms
sheep
Sheep

Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells

Chen, H., Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 387-393 7 p.

Research output: Research - peer-reviewArticle

Molecular Cloning
Xenopus
Cricetulus
Oocytes
Ovary

The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase

Bain, P. J., Leblanc-Chaffin, R., Chen, H., Palii, S. S., Leach, K. M. & Kilberg, M. S. Oct 1 2002 In : Journal of Nutrition. 132, 10, p. 3023-3029 7 p.

Research output: Research - peer-reviewArticle

aspartate-ammonia ligase
transcriptional activation
transporters
amino acids
genes
1999

Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens

Chen, H., Wong, E. A. & Webb, K. E. May 1999 In : Journal of Animal Science. 77, 5, p. 1277-1283 7 p.

Research output: Research - peer-reviewArticle

peptide transporters
tissue distribution
hybridization
dairy cows
chickens