Research Output 1999 2017

2017

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

Park, J. E., Sun, Y., Lim, S. K., Tam, J. P., Dekker, M., Chen, H. & Sze, S. K. Jan 12 2017 In : Scientific Reports. 7, 40569

Research output: Contribution to journalArticle

Phytochemicals
Epigenomics
Polycomb-Group Proteins
Neoplasms
Histone Deacetylases
Epigenomics
cognition
epigenetics
Cognition
learning

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Wang, H., Wu, X., Lezmi, S., Li, Q., Helferich, W. G., Xu, Y. & Chen, H. Dec 2 2017 In : BMC Complementary and Alternative Medicine. 17, 1, 516

Research output: Contribution to journalArticle

Ginkgo biloba
Heterografts
Colonic Neoplasms
Neoplasm Metastasis
Liver

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y. X. Nov 1 2017 In : Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journalArticle

High Fat Diet
DNA Methylation
Metabolic Networks and Pathways
Mothers
Diet
2016

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S. Dec 15 2016 In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Bromodeoxyuridine
Cognition
2015

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X. May 1 2015 In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Histones
Rats
Histone Code

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X. Jan 1 2015 In : Physiological Genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Epigenomics
DNA Methylation
Liver
Genes
2014

A mechanically-induced colon cancer cell population shows increased metastatic potential

Tang, X., Kuhlenschmidt, T. B., Li, Q., Ali, S., Lezmi, S., Chen, H., Pires-Alves, M., Laegreid, W. W., Saif, T. A. & Kuhlenschmidt, M. S. May 29 2014 In : Molecular Cancer. 13, 1, 131

Research output: Contribution to journalArticle

Colonic Neoplasms
Population
Neoplasm Metastasis
Anoikis
Tumor Microenvironment

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H. Feb 1 2014 Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Colonic Neoplasms
Neoplasms
Histone Code
Genetic Epigenesis

Fat accumulation in the liver of obese rats is alleviated by soy protein isolate through β-catenin signaling

Zhou, D., Lezmi, S., Wang, H., Davis, J., Banz, W. & Chen, H. Jan 2014 In : Obesity. 22, 1, p. 151-158 8 p.

Research output: Contribution to journalArticle

Soybean Proteins
beta Catenin
Fats
Liver
Caseins
2013

DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development

Zhang, Y., Li, Q. & Chen, H. Aug 1 2013 In : Carcinogenesis. 34, 8, p. 1756-1763 8 p.

Research output: Contribution to journalArticle

Histone Code
Genistein
DNA Methylation
Colonic Neoplasms
Soybean Proteins

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

Zhang, Y., Li, Q., Zhou, D. & Chen, H. Jan 14 2013 In : British Journal of Nutrition. 109, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

Azoxymethane
Isoflavones
Genistein
beta Catenin
Colon
2012

Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line

Wang, H., Li, Q. & Chen, H. Jul 18 2012 In : PLoS ONE. 7, 7, e40955

Research output: Contribution to journalArticle

Histone Code
Genistein
genistein
colorectal neoplasms
histones

Silencing of wnt5a during colon cancer metastasis involves histone modifications

Li, Q. & Chen, H. 2012 In : Epigenetics. 7, 6, p. 551-558 8 p.

Research output: Contribution to journalArticle

Histone Code
Colonic Neoplasms
Neoplasm Metastasis
Histone Deacetylase Inhibitors
Histones
2011
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Assays
RNA, Transfer, His

Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis

Li, Q. & Chen, H. Jan 1 2011 In : Epigenetics. 6, 7, p. 849-852 4 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Epigenomics
Colonic Neoplasms
Neoplasm Metastasis
Colorectal Neoplasms

Genistein, an epigenome modifier during cancer prevention

Zhang, Y. & Chen, H. 2011 In : Epigenetics. 6, 7, p. 888-891 4 p.

Research output: Contribution to journalArticle

Genistein
DNA Methylation
Epigenomics
Neoplasms
Carcinogenesis

Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line

Zhang, Y. & Chen, H. Jun 1 2011 In : Experimental Biology and Medicine. 236, 6, p. 714-722 9 p.

Research output: Contribution to journalArticle

Genistein
Colonic Neoplasms
Cells
Cell Line
beta Catenin
Colonic Neoplasms
Cell Line
Genes
Histones
Methylation
2010

Genistein increases gene expression by demethylation of WNT5a promoter in colon cancer cell line SW1116

Wang, Z. & Chen, H. Nov 1 2010 In : Anticancer Research. 30, 11, p. 4537-4545 9 p.

Research output: Contribution to journalArticle

Genistein
Colonic Neoplasms
Gene Expression
Cell Line
CpG Islands

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y. X. & Chen, H. Jan 1 2010 In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Folic Acid
2009

Amino acid limitation induces down-regulation of WNT5a at transcriptional level

Wang, Z. & Chen, H. Jan 23 2009 In : Biochemical and Biophysical Research Communications. 378, 4, p. 789-794 6 p.

Research output: Contribution to journalArticle

Down-Regulation
Amino Acids
Colonic Neoplasms
Messenger RNA
Phosphorylation
2007
Activating Transcription Factor 3
Genes
Chemical activation
Amino Acids
CCAAT-Enhancer-Binding Proteins
2006
Aspartate-Ammonia Ligase
aspartate-ammonia ligase
Transcription Initiation Site
Hep G2 Cells
Human Activities
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S. Nov 1 2005 In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Transcription
Genes
Amino Acids
Proteins

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y., Wong, E. A. & Webb, K. E. Feb 2005 In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

peptide transporters
Dietary Proteins
dietary protein
Chickens
crude protein
RNA-Binding Proteins
3' Untranslated Regions
Stabilization
Amino Acids
Messenger RNA

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V. 2005 In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Contribution to journalReview article

Gene Expression
Amino Acids
Activating Transcription Factor 4
Basic-Leucine Zipper Transcription Factors
RNA Splicing
2004
Aspartate-Ammonia Ligase
Basic-Leucine Zipper Transcription Factors
Leucine Zippers
Acetylation
Transcription

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

Leung-Pineda, V., Pan, Y., Chen, H. & Kilberg, M. S. Apr 1 2004 In : Biochemical Journal. 379, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Stabilization
Amino Acids
Messenger RNA
Histidine
Neutral Amino Acid Transport Systems
Genes
Sodium
Availability
Amino Acids
2003
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Endoplasmic Reticulum Stress
Hep G2 Cells
Transcription
2002

ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene

Siu, F., Bain, P. J., Leblanc-Chaffin, R., Chen, H. & Kilberg, M. S. Jul 5 2002 In : Journal of Biological Chemistry. 277, 27, p. 24120-24127 8 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Response Elements
Nutrients
Genes
Food

Characterization and regulation of a cloned ovine gastrointestinal peptide transporter (oPepT1) expressed in a mammalian cell line

Chen, H., Yuan Xiang Pan, X. P., Wong, E. A. & Webb K.E., J. 2002 In : Journal of Nutrition. 132, 1, p. 38-42 5 p.

Research output: Contribution to journalArticle

peptide transporters
Sheep
cell lines
uptake mechanisms
protein kinase C

Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells

Chen, H., Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

peptide transporters
Chinese hamsters
Xenopus
Molecular Cloning
Cricetulus

The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase

Bain, P. J., Leblanc-Chaffin, R., Chen, H., Palii, S. S., Leach, K. M. & Kilberg, M. S. Oct 1 2002 In : Journal of Nutrition. 132, 10, p. 3023-3029 7 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
aspartate-ammonia ligase
Amino Acid Transport Systems
transcriptional activation
Transcriptional Activation
1999

Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens

Chen, H., Wong, E. A. & Webb, K. E. Jan 1 1999 In : Journal of animal science. 77, 5, p. 1277-1283 7 p.

Research output: Contribution to journalArticle

peptide transporters
tissue distribution
Tissue Distribution
Chickens
Sheep