Hannah Diane Holscher

Assistant Professor of Nutrition and Human Microbiome

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Personal profile

Research Interests

Research in my laboratory, the Nutrition and Human Microbiome Laboratory, integrates the areas of nutrition, gastrointestinal physiology, and the microbiome. Our research focuses on the clinical application of nutritional sciences with an overarching goal of improving human health through dietary modulation of the gastrointestinal microbiome. The advances in sequencing technologies and bioinformatics have revolutionized our view of the microbiome and expanded our understanding of its role in host physiology and subsequent health and disease. However, the capability of diet to modulate health via changes in the microbiome remains under-investigated. My research laboratory aims to advance foundational knowledge in the field of nutrition and the human microbiome by characterizing the impact of diet and ingestive behaviors (e.g. eating frequency and timing) on the human gastrointestinal microbiome using machine learning and big data approaches. Other research interests include delineating the interrelationship of diet and the gastrointestinal microbiome on metabolic health and studying the physiological functions of fibers, prebiotics, and probiotics on the gut-microbiota-brain axis. The long-range goal of my research is to develop targeted dietary interventions for disease prevention and treatment by identifying key foods and/or nutrients that can be utilized for manipulation of the human gastrointestinal microbiome for health benefit.



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Research Output 2012 2019

Associations among diet, the gastrointestinal microbiota, and negative emotional states in adults

Taylor, A. M., Thompson, S. V., Edwards, C. G., Musaad, S. M. A., Khan, N. A. & Holscher, H. D., Jan 1 2019, In : Nutritional Neuroscience.

Research output: Contribution to journalArticle

Mood Disorders

Broccoli consumption affects the human gastrointestinal microbiota

Kaczmarek, J. L., Liu, X., Charron, C. S., Novotny, J. A., Jeffery, E. H., Seifried, H. E., Ross, S. A., Miller, M. J., Swanson, K. S. & Holscher, H. D., Jan 1 2019, In : Journal of Nutritional Biochemistry. 63, p. 27-34 8 p.

Research output: Contribution to journalArticle


Dietary choline is related to neural efficiency during a selective attention task among middle-aged adults with overweight and obesity

Edwards, C. G., Walk, A. M., Cannavale, C. N., Flemming, I. R., Thompson, S. V., Reeser, G. R., Holscher, H. D. & Khan, N. A., Jan 1 2019, In : Nutritional Neuroscience.

Research output: Contribution to journalArticle

Neuroprotective Agents
Reaction Time

Dietary fiber is independently related to blood triglycerides among adults with overweight and obesity

Hannon, B. A., Thompson, S. V., Edwards, C. G., Skinner, S. K., Niemiro, G. M., Burd, N. A., Holscher, H. D., Teran-Garcia, M. D. L. & Khan, N. A., Feb 1 2019, In : Current Developments in Nutrition. 3, 2, nzy094.

Research output: Contribution to journalArticle

metabolic syndrome
Dietary Fiber
dietary fiber

Relations between mode of birth delivery and timing of developmental milestones and adiposity in preadolescence: A retrospective study

Chojnacki, M. R., Holscher, H. D., Balbinot, A. R., Raine, L. B., Biggan, J. R., Walk, A. M., Kramer, A. F., Cohen, N. J., Hillman, C. H. & Khan, N. A., Feb 1 2019, In : Early Human Development. 129, p. 52-59 8 p.

Research output: Contribution to journalArticle

Retrospective Studies
Toilet Training