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Research Output 1983 2019

Article

Phylogenomic analysis of the α proteasome gene family from early-diverging eukaryotes

Bouzatrid, J. L., McNeilrid, L. K., Robertson, H. M., Solter, L. F., Nixon, J. E., Beever, J. E., Gaskins, H. R., Olsen, G. J., Subramaniam, S., Sogin, M. L. & Lewinid, H. A., 2000, In : Journal of Molecular Evolution. 51, 6, p. 532-543 12 p.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
eukaryote
Proteasome Endopeptidase Complex
Eukaryota
eukaryotic cells

Phylomat: An automated protein motif analysis tool for phylogenomics

Graham, W. V., Tcheng, D. K., Shirk, A. L., Attene-Ramos, M. S., Welge, M. & Gaskins, H. R., Nov 1 2004, In : Journal of Proteome Research. 3, 6, p. 1289-1291 3 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Proteome
Proteins
History
Data Mining

Pig Lmp7 proteasome subunit cDNA cloning and expression analysis

Chun, T., Hermel, E., Aldrich, C. J. & Gaskins, H. R., Jan 26 1999, In : Immunogenetics. 49, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Cysteine Endopeptidases
Molecular Sequence Data
Multienzyme Complexes
Amino Acid Sequence Homology
Organ Specificity

Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints

Gomez, A., Sharma, A. K., Mallott, E. K., Petrzelkova, K. J., Jost Robinson, C. A., Yeoman, C. J., Carbonero, F., Pafco, B., Rothman, J. M., Ulanov, A., Vlckova, K., Amato, K. R., Schnorr, S. L., Dominy, N. J., Modry, D., Todd, A., Torralba, M., Nelson, K. E., Burns, M. B., Blekhman, R. & 8 others, Remis, M., Stumpf, R. M., Wilson, B. A., Gaskins, H. R., Garber, P. A., White, B. A., Leigh, S. R. & Mcmahon, K., Jul 31 2019, In : mSphere. 4, 4, 14 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Primates
Haplorhini
Cercopithecidae
Population

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic β-cells

Kitiphongspattana, K., Mathews, C. E., Leiter, E. H. & Gaskins, H. R., Apr 22 2005, In : Journal of Biological Chemistry. 280, 16, p. 15727-15734 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Insulin
Glucose
Tyrosine
Endoplasmic Reticulum

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic β-cells

Kitiphongspattana, K., Khan, T. A., Ishii-Schrade, K., Roe, M. W., Philipson, L. H. & Gaskins, H. R., Jun 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 6, p. E1543-E1554

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Protein folding
Nitric Oxide
Glutathione Disulfide
Genes

Protein-energy malnutrition (PEM) delays small-intestinal recovery in neonatal pigs infected with rota virus

Zijlstra, R. T., McCracken, B. A., Gaskins, H. R. & Donovan, S. M., 1996, In : FASEB Journal. 10, 3

Research output: Contribution to journalArticle

Protein-Energy Malnutrition
protein energy malnutrition
Viruses
Swine
Recovery

Protein-energy malnutrition delays small-intestinal recovery in neonatal pigs infected with rotavirus

Zijlstra, R. T., Donovan, S. M., Odle, J., Gelberg, H. B., Petschow, B. W. & Gaskins, H. R., Jun 20 1997, In : Journal of Nutrition. 127, 6, p. 1118-1127 10 p.

Research output: Contribution to journalArticle

Protein-Energy Malnutrition
Rotavirus
Swine
Diarrhea
Lactase

Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2

Hao, Y., Kuang, Z., Walling, B. E., Bhatia, S., Sivaguru, M., Chen, Y., Gaskins, H. R. & Lau, G., Mar 1 2012, In : Cellular Microbiology. 14, 3, p. 401-415 15 p.

Research output: Contribution to journalArticle

Pyocyanine
Goblet Cells
Metaplasia
Mucus
Pseudomonas aeruginosa

Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis x to increase binding to airway epithelial cells

Jeffries, J. L., Jia, J., Choi, W., Choe, S., Miao, J., Xu, Y., Powell, R., Lin, J., Kuang, Z., Gaskins, H. R. & Lau, G. W., Jul 1 2016, In : Mucosal Immunology. 9, 4, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

Pyocyanine
Mucins
Glycosylation
Pseudomonas aeruginosa
Epithelial Cells

Pyrosequencing-based analysis of the mucosal microbiota in healthy individuals reveals ubiquitous bacterial groups and micro-heterogeneity

Hong, P. Y., Croix, J. A., Greenberg, E., Gaskins, H. R. & Mackie, R. I., Sep 22 2011, In : PloS one. 6, 9, e25042.

Research output: Contribution to journalArticle

Biopsy
Microbiota
colon
microorganisms
Colon

Race-dependent association of sulfidogenic bacteria with colorectal cancer

Yazici, C., Wolf, P. G., Kim, H., Cross, T. W. L., Vermillion, K., Carroll, T., Augustus, G. J., Mutlu, E., Tussing-Humphreys, L., Braunschweig, C., Xicola, R. M., Jung, B., Llor, X., Ellis, N. A. & Gaskins, H. R., Nov 1 2017, In : Gut. 66, 11, p. 1983-1994 12 p.

Research output: Contribution to journalArticle

African Americans
Colorectal Neoplasms
Bacteria
Mucous Membrane
Bilophila

Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins

Gunawan, R. C., Choban, E. R., Conour, J. E., Silvestre, J., Schook, L. B., Gaskins, H. R., Leckband, D. E. & Kenis, P. J. A., Mar 29 2005, In : Langmuir. 21, 7, p. 3061-3068 8 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
cultured cells
counters
Cytology
Immobilized Proteins

Regulation of insulin-like growth factor-i ribonucleic acid expression, polypeptide secretion, and binding protein activity by growth hormone in porcine preadipocyte cultures

Gaskins, H. R., Kim, J. W., Wright, J. T., Rund, L. A., Hausman, G. J. & Hausman, G. J., Jan 1990, In : Endocrinology. 126, 1, p. 622-630 9 p.

Research output: Contribution to journalArticle

Somatomedins
Insulin-Like Growth Factor I
Swine
RNA
Peptides

Relationship between Microbiota of the Colonic Mucosa vs Feces and Symptoms, Colonic Transit, and Methane Production in Female Patients with Chronic Constipation

Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R. & Bharucha, A. E., Feb 1 2016, In : Gastroenterology. 150, 2, p. 367-379.e1

Research output: Contribution to journalArticle

Microbiota
Methane
Constipation
Feces
Mucous Membrane

Reproducibility of assessing fecal microbiota in chronic constipation

Parthasarathy, G., Chen, J., Chia, N., O'Connor, H. M., Gaskins, H. R. & Bharucha, A. E., Oct 2017, In : Neurogastroenterology and Motility. 29, 10, p. 1-10 10 p.

Research output: Contribution to journalArticle

Microbiota
Constipation
Healthy Volunteers
Laxatives
Energy Intake

Roles of Vibrio fischeri and nonsymbiotic bacteria in the dynamics of mucus secretion during symbiont colonization of the Euprymna scolopes light organ

Nyholm, S. V., Deplancke, B., Gaskins, H. R., Apicella, M. A. & McFall-Ngai, M. J., Oct 1 2002, In : Applied and environmental microbiology. 68, 10, p. 5113-5122 10 p.

Research output: Contribution to journalArticle

Aliivibrio fischeri
Vibrio fischeri
mucus
Mucus
symbiont

Selective growth of mucolytic bacteria including Clostridium perfringens in a neonatal piglet model of total parenteral nutrition

Deplancke, B., Vidal, O., Ganessunker, D., Donovan, S. M., Mackie, R. I. & Gaskins, H. R., Nov 1 2002, In : American Journal of Clinical Nutrition. 76, 5, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

expectorants
Expectorants
Clostridium perfringens
Total Parenteral Nutrition
total parenteral nutrition

Short-term metabolic responses do not differ between neonatal piglets fed formulas containing hydrolyzed or intact soy proteins

Zijlstra, R. T., Mies, A. M., Mccracken, B. A., Odle, J., Gaskins, H. R., Lien, E. L. & Donovan, S. M., Apr 1 1996, In : Journal of Nutrition. 126, 4, p. 913-923 11 p.

Research output: Contribution to journalArticle

Soybean Proteins
feed formulation
soy protein
piglets
protein hydrolysates

Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning

Spreeuwenberg, M. A. M., Verdonk, J. M. A. J., Gaskins, H. R. & Verstegen, M. W. A., May 21 2001, In : Journal of Nutrition. 131, 5, p. 1520-1527 8 p.

Research output: Contribution to journalArticle

Weaning
Small Intestine
small intestine
Lactose
weaning

Specific-Pathogen-Free Conditions Enhance Inflammatory Bowel Disease in T-Cell Receptor Knockout, but not C3H/HeJBir Mice

Gaskins, H. R., Vondrak-Juergens, G. L., McCracken, B. A. & Woolsey, J. H., Dec 1 1997, In : Laboratory Animal Science. 47, 6, p. 650-655 6 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Rodent Diseases
animal disease models
Specific Pathogen-Free Organisms
Animal Disease Models

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice

Baldwin, J., Collins, B., Wolf, P. G., Martinez, K., Shen, W., Chuang, C. C., Zhong, W., Cooney, P., Cockrell, C., Chang, E., Gaskins, H. R. & McIntosh, M. K., Jan 1 2016, In : Journal of Nutritional Biochemistry. 27, p. 123-135 13 p.

Research output: Contribution to journalArticle

Butter
Lipogenesis
Adiposity
Vitis
Fats

Temporal changes of multiple redox couples from proliferation to growth arrest in IEC-6 intestinal epithelial cells

Attene-Ramos, M. S., Kitiphongspattana, K., Ishii-Schrade, K. & Gaskins, H. R., Nov 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5, p. C1220-C1228

Research output: Contribution to journalArticle

Oxidation-Reduction
Epithelial Cells
Growth
NAD
Contact Inhibition

The nonobese diabetic scid mouse: Model for spontaneous thymomagenesis associated with immunodeficiency

Prochazka, M., Gaskins, H. R., Shultz, L. D. & Leiter, E. H., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 8, p. 3290-3294 5 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Proviruses
Retroviridae
Mink
Chromosomes, Human, Pair 11

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Ridlon, J. M., Devendran, S., Alves, J. M., Doden, H., Wolf, P. G., Pereira, G. V., Ly, L., Volland, A., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., Green, S. J., Hernandez, A. G., Fields, C. J., Wright, C. L., Kakiyama, G., Cann, I., Kashyap, P. & 2 others, McCracken, V. & Gaskins, H. R., Jan 1 2019, In : Gut Microbes.

Research output: Contribution to journalArticle

Germ-Free Life
Metabolomics
Genomics
Bile Acids and Salts
Life Style

Thiol-based antioxidants elicit mitochondrial oxidation via respiratory complex III

Kolossov, V. L., Beaudoin, J. N., Ponnuraj, N., Diliberto, S. J., Hanafin, W. P., Kenis, P. J. A. & Gaskins, H. R., Jul 15 2015, In : American Journal of Physiology - Cell Physiology. 309, 2, p. C81-C91

Research output: Contribution to journalArticle

Electron Transport Complex III
Sulfhydryl Compounds
Antioxidants
Acetylcysteine
Esters

TNF-α sensitizes HT-29 colonic epithelial cells to intestinal lactobacilli

McCracken, V. J., Chun, T., Baldeo, M. E., Ahrne, S., Molin, G., Mackie, R. I. & Gaskins, H. R., Sep 2002, In : Experimental Biology and Medicine. 227, 8, p. 665-670 6 p.

Research output: Contribution to journalArticle

Lactobacillus
Lactobacillus plantarum
Tumor Necrosis Factor-alpha
Epithelial Cells
HT29 Cells
Total Parenteral Nutrition
Colon
Goblet Cells
Lymphocyte Count
Inflammation

Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets

Chowdhury, S. R., King, D. E., Willing, B. P., Band, M. R., Beever, J. E., Lane, A. B., Loor, J. J., Marini, J. C., Rund, L. A., Schook, L. B., Van Kessel, A. G. & Gaskins, H. R., Jul 5 2007, In : BMC genomics. 8, 215.

Research output: Contribution to journalArticle

Gene Expression Profiling
T Cell Transcription Factor 1
Intestinal Mucosa
Microbiota
Inflammation

Transient light-induced intracellular oxidation revealed by redox biosensor

Kolossov, V. L., Beaudoin, J. N., Hanafin, W. P., DiLiberto, S. J., Kenis, P. J. A. & Gaskins, H. R., Oct 4 2013, In : Biochemical and Biophysical Research Communications. 439, 4, p. 517-521 5 p.

Research output: Contribution to journalArticle

Biosensing Techniques
Biosensors
Oxidation-Reduction
Cells
Glutaredoxins

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J Mice

Allen, J. M., Miller, M. E. B., Pence, B. D., Whitlock, K., Nehra, V., Gaskins, H. R., White, B. A., Fryer, J. D. & Woods, J. A., Apr 15 2015, In : Journal of Applied Physiology. 118, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Running
Gastrointestinal Microbiome
Colitis
Feces

Weaning anorexia may contribute to local inflammation in the piglet small intestine

McCracken, B. A., Spurlock, M. E., Roos, M. A., Zuckermann, F. A. & Gaskins, H. R., Mar 17 1999, In : Journal of Nutrition. 129, 3, p. 613-619 7 p.

Research output: Contribution to journalArticle

Anorexia
villi
Weaning
anorexia
Small Intestine

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells

Shao, Y., Wolf, P. G., Guo, S., Guo, Y., Gaskins, H. R. & Zhang, B., May 1 2017, In : Journal of Nutritional Biochemistry. 43, p. 18-26 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Caco-2 Cells
Sirolimus
Zinc
Tight Junctions
Chapter

Host and intestinal microbiota negotiations in the context of animal growth efficiency

Gaskins, H. R., Dec 1 2008, Gut Efficiency; The Key Ingredient in Pig and Poultry Production: Elevating Animal Performance and Health. Wageningen Academic Publishers, p. 29-37 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

animal growth
Negotiating
intestinal microorganisms
Animals
animal

Intestinal bacteria and their influence on swine growth

Gaskins, H. R., Jan 1 2000, Swine Nutrition, Second Edition. CRC Press, p. 585-608 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

intestinal microorganisms
Swine
Microbiota
Bacteria
swine

Prokaryote Diversity of Epithelial Mucosal Biofilms in the Human Digestive Tract

Krause, D. O., Gaskins, H. R. & Mackie, R. I., Nov 30 2007, Biofilms in the Food Environment. Blackwell Publishing Ltd, p. 127-152 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biofilms
Mucus
prokaryotic cells
mucus
digestive tract
Comment/debate

Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes-susceptible NOD mice

Gaskins, H. R., Monaco, J. J., Leiter, E. H., Wicker, L. S., Podolin, P. L., Fischer, P., Sirotina, A., Boltz, R. C., Peterson, L. B., Faustman, D., Li, X., Lin, H. Y., Huang, R. & Guo, J., Jan 1 1992, In : Science. 256, 5065, p. 1826-1831 6 p.

Research output: Contribution to journalComment/debate

T Lymphocyte Differentiation Antigens
CD27 Antigens
H-2 Antigens
Animal Disease Models
Histocompatibility Antigens Class I
Conference contribution

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Silvestre, J., Gunawan, R. C., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., 2006, 2006 AIChE Annual Meeting.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Extracellular Matrix Proteins
Proteins

Patient derived glioblastoma cells activate microglia in a three-dimensional gelatin hydrogel

Chen, J. W. E., Lumibao, J., Gaskins, H. R. & Harley, B. A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hydrogel
Microglia
Gelatin
Glioblastoma
Hydrogels

Preliminary results for GAMI: A genetic algorithms approach to motif inference

Congdon, C. B., Fizer, C. W., Smith, N. W., Gaskins, H. R., Aman, J., Nava, G. M. & Mattingly, C., Dec 1 2005, Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. 1594904. (Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genetic algorithms
Systems analysis
Nucleotides

Towards interactive visualization for exploring conserved motifs in noncoding DNA sequence

Congdon, C. B., Gaskins, H. R., Nava, G. M. & Mattingly, C., Dec 1 2007, Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. p. 234-237 4 p. 4524110. (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

DNA sequences
Visualization
Transcription factors
Binding sites
Computational methods
Editorial

Developmental ecology of the neonatal intestine: Introduction

Gaskins, H. R. & Lien, E. L., May 11 1999, In : American Journal of Clinical Nutrition. 69, 5

Research output: Contribution to journalEditorial

intestines
ecology

The art to science of cell and developmental biology in EBM

Gaskins, H. R., Feb 1 2008, In : Experimental Biology and Medicine. 233, 2, p. 107-108 2 p.

Research output: Contribution to journalEditorial

Cytology
Developmental Biology
Art
Cell Biology
Letter

Letter to the editor [2] (multiple letters)

Patterson, M. M., Schauer, D. B., Fox, J. G. & Gaskins, H. R., 1998, In : Laboratory Animal Science. 48, 5, p. 432-433 2 p.

Research output: Contribution to journalLetter

animal disease models
Helicobacter
Specific Pathogen-Free Organisms
Animal Disease Models
Bacterial DNA
Review article

Contributions of the microbial hydrogen economy to colonic homeostasis

Carbonero, F., Benefiel, A. C. & Gaskins, H. R., Sep 1 2012, In : Nature Reviews Gastroenterology and Hepatology. 9, 9, p. 504-518 15 p.

Research output: Contribution to journalReview article

Hydrogen
Homeostasis
Gases
Hydrogen Sulfide
Methane

Exercise and gut immune function: Evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training

Cook, M. D., Allen, J. M., Pence, B. D., Wallig, M. A., Gaskins, H. R., White, B. A. & Woods, J. A., Feb 1 2016, In : Immunology and Cell Biology. 94, 2, p. 158-163 6 p.

Research output: Contribution to journalReview article

Microbiota
Colon
Homeostasis
Dysbiosis
Exercise

Influence of dietary fat on intestinal microbes, inflammation, barrier function and metabolic outcomes

Shen, W., Gaskins, H. R. & McIntosh, M. K., Mar 1 2014, In : Journal of Nutritional Biochemistry. 25, 3, p. 270-280 11 p.

Research output: Contribution to journalReview article

Dietary Fats
Fermentation
Inflammation
Health
Germ-Free Life

Methods to study the tumor microenvironment under controlled oxygen conditions

Byrne, M. B., Leslie, M. T., Gaskins, H. R. & Kenis, P. J. A., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 556-563 8 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Tumors
Microfluidics
Oxygen
Epithelial-Mesenchymal Transition

Redox control of the transsulfuration and glutathione biosynthesis pathways.

Deplancke, B. & Gaskins, H. R., Jan 2002, In : Current opinion in clinical nutrition and metabolic care. 5, 1, p. 85-92 8 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Glutathione
Cysteine
Reactive Oxygen Species
Sulfur Amino Acids

Regulation of gene expression during adipocyte differentiation: a review.

Gaskins, H. R., Hausman, G. J. & Martin, R. J., Sep 1989, In : Journal of animal science. 67, 9, p. 2263-2272 10 p.

Research output: Contribution to journalReview article

gene expression regulation
Gene Expression Regulation
adipocytes
Adipocytes
Gene Expression