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Research Output 1983 2019

2011

Pyrosequencing-based analysis of the mucosal microbiota in healthy individuals reveals ubiquitous bacterial groups and micro-heterogeneity

Hong, P. Y., Croix, J. A., Greenberg, E., Gaskins, H. R. & Mackie, R. I., Sep 22 2011, In : PloS one. 6, 9, e25042.

Research output: Contribution to journalArticle

Biopsy
Microbiota
colon
microorganisms
Colon
2010

DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 int cells

Attene-Ramos, M. S., Nava, G. M., Muellner, M. G., Wagner, E. D., Plewa, M. J. & Gaskins, H. R., May 1 2010, In : Environmental and Molecular Mutagenesis. 51, 4, p. 304-314 11 p.

Research output: Contribution to journalArticle

Toxicogenetics
Hydrogen Sulfide
DNA Damage
Comet Assay
Gene Expression

Mechanisms of microbial hydrogen disposal in the human colon and implications for health and disease

Nakamura, N., Lin, H. C., McSweeney, C. S., Mackie, R. I. & Gaskins, H. R., Apr 1 2010, In : Annual Review of Food Science and Technology. 1, 1, p. 363-395 33 p.

Research output: Contribution to journalArticle

hydrogen
colon
Hydrogen
Colon
Health
2009

Arsenic (+ 3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis

Thomas, D. J., Nava, G. M., Cai, S. Y., Boyer, J. L., Hernández-Zavala, A. & Gaskins, H. R., Oct 15 2009, In : Toxicological Sciences. 113, 1, p. 70-76 7 p., kfp250.

Research output: Contribution to journalArticle

Nonvertebrate Chordata
Ciona intestinalis
Arsenicals
Methylation
Methyltransferases
environmental stress
corals
coral
surface temperature
irradiance

Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis

Nava, G. M., Lee, D. Y., Ospina, J. H., Cai, S. Y. & Gaskins, H. R., Nov 1 2009, In : Physiological genomics. 39, 3, p. 183-194 12 p.

Research output: Contribution to journalArticle

Nonvertebrate Chordata
Ciona intestinalis
Glutathione
Homeostasis
Oxidation-Reduction

Heterogeneity of vaginal microbial communities within individuals

Kim, T. K., Thomas, S. M., Ho, M., Sharma, S., Reich, C. I., Frank, J. A., Yeater, K. M., Biggs, D. R., Nakamura, N., Stumpf, R., Leigh, S. R., Tapping, R. I., Blanke, S. R., Slauch, J. M., Gaskins, H. R., Weisbaum, J. S., Olsen, G. J., Hoyer, L. L. & Wilson, B. A., Apr 1 2009, In : Journal of Clinical Microbiology. 47, 4, p. 1181-1189 9 p.

Research output: Contribution to journalArticle

Microbiota
Ecosystem
Gene Library
rRNA Genes
Cervix Uteri

Microbial community analysis of rectal methanogens and sulfate reducing bacteria in two non-human primate species

Nakamura, N., Leigh, S. R., Mackie, R. I. & Gaskins, H. R., Sep 17 2009, In : Journal of Medical Primatology. 38, 5, p. 360-370 11 p.

Research output: Contribution to journalArticle

sulfate-reducing bacteria
methanogens
Archaea
Primates
Sulfates

Molecular analysis of microbial community structure in the chicken ileum following organic acid supplementation

Nava, G. M., Attene-Ramos, M. S., Gaskins, H. R. & Richards, J. D., Jun 12 2009, In : Veterinary Microbiology. 137, 3-4, p. 345-353 9 p.

Research output: Contribution to journalArticle

formic acid
Ileum
ileum
organic acids and salts
microbial communities

Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics

Nakamura, N., Gaskins, H. R., Collier, C. T., Nava, G. M., Rai, D., Petschow, B., Russell, W. M., Harris, C., Mackie, R. I., Wampler, J. L. & Walker, D. C., Feb 1 2009, In : Applied and environmental microbiology. 75, 4, p. 1121-1128 8 p.

Research output: Contribution to journalArticle

polydextrose
galactooligosaccharides
Prebiotics
Infant Formula
infant formulas
2008
DNA sequences
Information Content
Nucleotides
DNA Sequence
Genetic algorithms

Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth

Collier, C. T., Hofacre, C. L., Payne, A. M., Anderson, D. B., Kaiser, P., Mackie, R. I. & Gaskins, H. R., Mar 15 2008, In : Veterinary Immunology and Immunopathology. 122, 1-2, p. 104-115 12 p.

Research output: Contribution to journalArticle

Coccidia
necrotic enteritis
Clostridium perfringens
Enteritis
Eimeria acervulina

Engineering redox-sensitive linkers for genetically encoded FRET-based biosensors

Kolossov, V. L., Spring, B. Q., Sokolowski, A., Conour, J. E., Clegg, R. M., Kenis, P. J. A. & Gaskins, H. R., Feb 1 2008, In : Experimental Biology and Medicine. 233, 2, p. 238-248 11 p.

Research output: Contribution to journalArticle

Energy Transfer
Biosensing Techniques
Biosensors
Energy transfer
Oxidation-Reduction

Host and intestinal microbiota negotiations in the context of animal growth efficiency

Gaskins, H. R., Dec 1 2008, Gut Efficiency; The Key Ingredient in Pig and Poultry Production: Elevating Animal Performance and Health. Wageningen Academic Publishers, p. 29-37 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

animal growth
Negotiating
intestinal microorganisms
Animals
animal

Impact of the intestinal microbiota on the development of mucosal defense

Gaskins, H. R., Croix, J. A., Nakamura, N. & Nava, G. M., Feb 1 2008, In : Clinical Infectious Diseases. 46, SUPPL. 2

Research output: Contribution to journalArticle

Microbiota
Ecosystem
Immune System
Eukaryotic Cells
Gastrointestinal Tract

The art to science of cell and developmental biology in EBM

Gaskins, H. R., Feb 2008, In : Experimental Biology and Medicine. 233, 2, p. 107-108 2 p.

Research output: Contribution to journalEditorial

Cytology
Developmental Biology
Art
Cell Biology
2007

Cross-talk between probiotic bacteria and the host immune system

Corthésy, B., Gaskins, H. R. & Mercenier, A., Mar 1 2007, In : Journal of Nutrition. 137, 3

Research output: Contribution to journalArticle

Probiotics
Immune System
Insurance Benefits
Bacteria
Secretory Immunoglobulin A

Hydrogen sulfide induces direct radical-associated DNA damage

Attene-Ramos, M. S., Wagner, E. D., Gaskins, H. R. & Plewa, M. J., May 1 2007, In : Molecular Cancer Research. 5, 5, p. 455-459 5 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Sulfides
DNA Damage
Sulfates
Free Radicals

Prokaryote Diversity of Epithelial Mucosal Biofilms in the Human Digestive Tract

Krause, D. O., Gaskins, H. R. & Mackie, R. I., Nov 30 2007, Biofilms in the Food Environment. Blackwell Publishing Ltd, p. 127-152 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biofilms
Mucus
prokaryotic cells
mucus
digestive tract

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic β-cells

Kitiphongspattana, K., Khan, T. A., Ishii-Schrade, K., Roe, M. W., Philipson, L. H. & Gaskins, H. R., Jun 1 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 6

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Protein folding
Nitric Oxide
Glutathione Disulfide
Genes

Towards interactive visualization for exploring conserved motifs in noncoding DNA sequence

Congdon, C. B., Gaskins, H. R., Nava, G. M. & Mattingly, C., Dec 1 2007, Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. p. 234-237 4 p. 4524110. (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

DNA sequences
Visualization
Transcription factors
Binding sites
Computational methods

Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets

Chowdhury, S. R., King, D. E., Willing, B. P., Band, M. R., Beever, J. E., Lane, A. B., Loor, J. J., Marini, J. C., Rund, L. A., Schook, L. B., Van Kessel, A. G. & Gaskins, H. R., Jul 5 2007, In : BMC genomics. 8, 215.

Research output: Contribution to journalArticle

Gene Expression Profiling
T Cell Transcription Factor 1
Intestinal Mucosa
Microbiota
Inflammation
2006

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Gunawan, R. C., Silvestre, J., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4250-4258 9 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Laminin
polarity
proteins
Proteins

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Silvestre, J., Gunawan, R. C., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., 2006, 2006 AIChE Annual Meeting.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Extracellular Matrix Proteins
Proteins

Evidence that hydrogen sulfide is a genotoxic agent

Attene-Ramos, M. S., Wagner, E. D., Plewa, M. J. & Gaskins, H. R., Jan 1 2006, In : Molecular Cancer Research. 4, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Sulfides
Cricetulus
DNA Repair
Colorectal Neoplasms
2005

Preliminary results for GAMI: A genetic algorithms approach to motif inference

Congdon, C. B., Fizer, C. W., Smith, N. W., Gaskins, H. R., Aman, J., Nava, G. M. & Mattingly, C., Dec 1 2005, Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. 1594904. (Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genetic algorithms
Systems analysis
Nucleotides

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic β-cells

Kitiphongspattana, K., Mathews, C. E., Leiter, E. H. & Gaskins, H. R., Apr 22 2005, In : Journal of Biological Chemistry. 280, 16, p. 15727-15734 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Insulin
Glucose
Tyrosine
Endoplasmic Reticulum

Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins

Gunawan, R. C., Choban, E. R., Conour, J. E., Silvestre, J., Schook, L. B., Gaskins, H. R., Leckband, D. E. & Kenis, P. J. A., Mar 29 2005, In : Langmuir. 21, 7, p. 3061-3068 8 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
cultured cells
counters
Cytology
Immobilized Proteins

Temporal changes of multiple redox couples from proliferation to growth arrest in IEC-6 intestinal epithelial cells

Attene-Ramos, M. S., Kitiphongspattana, K., Ishii-Schrade, K. & Gaskins, H. R., Nov 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5, p. C1220-C1228

Research output: Contribution to journalArticle

Oxidation-Reduction
Epithelial Cells
Growth
NAD
Contact Inhibition
Heparan Sulfate Proteoglycans
Critical Pathways
Mesoderm
Intestinal Mucosa
Small Intestine
2004

A combined in vitro/bioinformatic investigation of redox regulatory mechanisms governing cell cycle progression

Conour, J. E., Graham, W. V. & Gaskins, H. R., Oct 1 2004, In : Physiological genomics. 18, p. 196-205 10 p.

Research output: Contribution to journalArticle

Computational Biology
Cell Cycle
Cell Cycle Proteins
G2 Phase
G1 Phase

Commensal bacteria, redox stress, and colorectal cancer: Mechanisms and models

Huycke, M. M. & Gaskins, H. R., Jul 2004, In : Experimental Biology and Medicine. 229, 7, p. 586-597 12 p.

Research output: Contribution to journalShort survey

Oxidation-Reduction
Colorectal Neoplasms
Bacteria
DNA
Sulfates

Molecular Ecological Analysis of the Gastrointestinal Microbiota: A Review

Zoetendal, E. G., Collier, C. T., Koike, S., Mackie, R. I. & Gaskins, H. R., Feb 1 2004, In : Journal of Nutrition. 134, 2, p. 465-472 8 p.

Research output: Contribution to journalArticle

Microbiota
Physiological Phenomena
Bacteria
Nutritional Requirements
Population Density

Phylomat: An automated protein motif analysis tool for phylogenomics

Graham, W. V., Tcheng, D. K., Shirk, A. L., Attene-Ramos, M. S., Welge, M. & Gaskins, H. R., Nov 1 2004, In : Journal of Proteome Research. 3, 6, p. 1289-1291 3 p.

Research output: Contribution to journalArticle

Amino Acid Motifs
Proteome
Proteins
History
Data Mining
2003

Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis

Collier, C. T., Van der Klis, J. D., Deplancke, B., Anderson, D. B. & Gaskins, H. R., Oct 1 2003, In : Antimicrobial Agents and Chemotherapy. 47, 10, p. 3311-3317 7 p.

Research output: Contribution to journalArticle

Tylosin
Clostridium perfringens
Enteritis
Expectorants
Anti-Bacterial Agents

Fermentable fiber reduces recovery time and improves intestinal function in piglets following Salmonella typhimurium infection

Correa-Matos, N. J., Donovan, S. M., Isaacson, R. E., Gaskins, H. R., White, B. A. & Tappenden, K. A., Jun 1 2003, In : Journal of Nutrition. 133, 6, p. 1845-1852 8 p.

Research output: Contribution to journalArticle

Salmonella Infections
Salmonella typhimurium
Methylcellulose
Polysaccharides
Infection

Gastrointestinal and microbial responses to sulfate-supplemented drinking water in mice

Deplancke, B., Finster, K., Graham, W. V., Collier, C. T., Thurmond, J. E. & Gaskins, H. R., Apr 2003, In : Experimental Biology and Medicine. 228, 4, p. 424-433 10 p.

Research output: Contribution to journalArticle

Drinking Water
Sulfates
Bacteria
Goblet Cells
Cecum
Hydrogen Sulfide
Rats
Cell Cycle
Epithelial Cells
Cells

Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters

Collier, C. T., Smiricky-Tjardes, M. R., Albin, D. M., Wubben, J. E., Gabert, V. M., Deplancke, B., Bane, D., Anderson, D. B. & Gaskins, H. R., Dec 1 2003, In : Journal of animal science. 81, 12, p. 3035-3045 11 p.

Research output: Contribution to journalArticle

Microbiota
Tylosin
tylosin
Swine
anti-infective agents

New scientific paradigms for probiotics and prebiotics

Reid, G., Sanders, M. E., Gaskins, H. R., Gibson, G. R., Mercenier, A., Rastall, R., Roberfroid, M., Rowland, I., Cherbut, C. & Klaenhammer, T. R., Aug 1 2003, In : Journal of Clinical Gastroenterology. 37, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Prebiotics
Probiotics
Nonprofit Organizations
Intestinal Neoplasms
Intestinal Diseases
2002

Acidomucin goblet cell expansion induced by parenteral nutrition in the small intestine of piglets

Conour, J. E., Ganessunker, D., Tappenden, K. A., Donovan, S. M. & Gaskins, H. R., Nov 1 2002, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 283, 5 46-5

Research output: Contribution to journalArticle

Goblet Cells
Total Parenteral Nutrition
Parenteral Nutrition
Enteral Nutrition
Small Intestine

Antibiotics as growth promotants: Mode of action

Gaskins, H. R., Collier, C. T. & Anderson, D. B., May 1 2002, In : Animal Biotechnology. 13, 1, p. 29-42 14 p.

Research output: Contribution to journalArticle

Antibiotics
mechanism of action
antibiotics
Anti-Bacterial Agents
gastrointestinal system

Intestinal transport of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg through a Caco-2 Bbe monolayer

Vermeirssen, V., Deplancke, B., Tappenden, K. A., Van Camp, J., Gaskins, H. R. & Verstraete, W., 2002, In : Journal of Peptide Science. 8, 3, p. 95-100 6 p.

Research output: Contribution to journalArticle

lactokinins
Monolayers
Peptides
Pressure regulation
Lactoglobulins

Redox control of the transsulfuration and glutathione biosynthesis pathways.

Deplancke, B. & Gaskins, H. R., Jan 2002, In : Current opinion in clinical nutrition and metabolic care. 5, 1, p. 85-92 8 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Glutathione
Cysteine
Reactive Oxygen Species
Sulfur Amino Acids

Roles of Vibrio fischeri and nonsymbiotic bacteria in the dynamics of mucus secretion during symbiont colonization of the Euprymna scolopes light organ

Nyholm, S. V., Deplancke, B., Gaskins, H. R., Apicella, M. A. & McFall-Ngai, M. J., Oct 1 2002, In : Applied and environmental microbiology. 68, 10, p. 5113-5122 10 p.

Research output: Contribution to journalArticle

Aliivibrio fischeri
Vibrio fischeri
mucus
Mucus
symbiont

Selective growth of mucolytic bacteria including Clostridium perfringens in a neonatal piglet model of total parenteral nutrition

Deplancke, B., Vidal, O., Ganessunker, D., Donovan, S. M., Mackie, R. I. & Gaskins, H. R., Nov 1 2002, In : American Journal of Clinical Nutrition. 76, 5, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

expectorants
Expectorants
Clostridium perfringens
Total Parenteral Nutrition
total parenteral nutrition

TNF-α sensitizes HT-29 colonic epithelial cells to intestinal lactobacilli

McCracken, V. J., Chun, T., Baldeo, M. E., Ahrne, S., Molin, G., Mackie, R. I. & Gaskins, H. R., Sep 2002, In : Experimental Biology and Medicine. 227, 8, p. 665-670 6 p.

Research output: Contribution to journalArticle

Lactobacillus
Lactobacillus plantarum
Tumor Necrosis Factor-alpha
Epithelial Cells
HT29 Cells
2001

Cytotoxic t lymphocyte and cdna sequence analyses of the mhc class ib molecule qa1 in nonobese diabetic mice

Chun, T., Hermel, E., Gaskins, H. R. & Aldrich, C. J., Jan 1 2001, In : Immunogenetics. 53, 6, p. 506-510 5 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity Tests
Proinsulin
Histocompatibility Antigens Class I
Inbred NOD Mouse
Protein Precursors

Microbial modulation of innate defense: Goblet cells and the intestinal mucus layer

Deplancke, B. & Gaskins, H. R., Jun 12 2001, In : American Journal of Clinical Nutrition. 73, 6

Research output: Contribution to journalArticle

Goblet Cells
goblet cells
Mucus
mucus
mucins

Molecular ecological analysis of dietary and antibiotic-induced alterations of the mouse intestinal microbiota

McCracken, V. J., Simpson, J. M., Mackie, R. I. & Gaskins, H. R., 2001, In : Journal of Nutrition. 131, 6, p. 1862-1870 9 p.

Research output: Contribution to journalArticle

intestinal microorganisms
antibiotics
Anti-Bacterial Agents
Diet
mice