Gee Lau

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Research Output

2020

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

McDaniel, C. T., Panmanee, W., Winsor, G. L., Gill, E., Bertelli, C., Schurr, M. J., Dongare, P., Paul, A. T., Ko, S. H. B., Lau, G. W., Dasgupta, N., Bogue, A. L., Miller, W. E., Mortensen, J. E., Haslam, D. B., Dexheimer, P., Muruve, D. A., Aronow, B. J., Forbes, M. D. E., Danilczuk, M. & 4 others, Brinkman, F. S. L., Hancock, R. E. W., Meyer, T. J. & Hassett, D. J., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4921-4930 10 p.

Research output: Contribution to journalArticle

Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae

Yang, Y., Lin, J., Harrington, A., Cornilescu, G., Lau, G. W. & Tal-Gan, Y., Jan 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1689-1699 11 p.

Research output: Contribution to journalArticle

Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling

Choi, W., Choe, S., Lin, J., Borchers, M. T., Kosmider, B., Vassallo, R., Limper, A. H. & Lau, G. W., Jul 1 2020, In : Mucosal Immunology. 13, 4, p. 637-651 15 p.

Research output: Contribution to journalArticle

Gram-Negative Antibiotic Active through Inhibition of an Essential Riboswitch

Motika, S. E., Ulrich, R. J., Geddes, E. J., Lee, H. Y., Lau, G. W. & Hergenrother, P. J., Jun 17 2020, In : Journal of the American Chemical Society. 142, 24, p. 10856-10862 7 p.

Research output: Contribution to journalArticle

Inactivation of FOXA2 by Respiratory Bacterial Pathogens and Dysregulation of Pulmonary Mucus Homeostasis

Choi, W., Choe, S. & Lau, G. W., Mar 25 2020, In : Frontiers in immunology. 11, 515.

Research output: Contribution to journalReview article

Open Access

Streptococcus pneumoniae elaborates persistent and prolonged competent state during pneumonia-derived sepsis

Lin, J., Park, P., Li, H., Oh, M. W., Dobrucki, I. T., Dobrucki, W. & Lau, G. W., Mar 1 2020, In : Infection and immunity. 88, 4, e00919-19.

Research output: Contribution to journalArticle

2019

Controlling chronic Pseudomonas aeruginosa infections by strategically interfering with the sensory function of SagS

Dingemans, J., Al-Feghali, R. E., Lau, G. W. & Sauer, K., May 2019, In : Molecular Microbiology. 111, 5, p. 1211-1228 18 p.

Research output: Contribution to journalArticle

DprA-dependent exit from the competent state regulates multifaceted streptococcus pneumoniae virulence

Lin, J. & Lau, G. W., Jan 1 2019, In : Infection and immunity. 87, 11, e00349-19.

Research output: Contribution to journalArticle

FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases

Choi, W., Yang, A. X., Waltenburg, M. A., Choe, S., Steiner, M., Radwan, A., Lin, J., Maddox, C. W., Stern, A. W., Fredrickson, R. L. & Lau, G. W., Jan 2019, In : Cellular Microbiology. 21, 1, e12957.

Research output: Contribution to journalArticle

Glutathione activates type III secretion system through Vfr in pseudomonas aeruginosa

Zhang, Y., Zhang, C., Du, X., Zhou, Y., Kong, W., Lau, G. W., Chen, G., Kohli, G. S., Yang, L., Wang, T. & Liang, H., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, MAY, 164.

Research output: Contribution to journalArticle

Open Access

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens

Parker, E. N., Drown, B. S., Geddes, E. J., Lee, H. Y., Ismail, N., Lau, G. W. & Hergenrother, P. J., Nov 18 2019, In : Nature Microbiology.

Research output: Contribution to journalLetter

The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. A ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection

Panmanee, W., Su, S., Schurr, M. J., Lau, G. W., Zhu, X., Ren, Z., McDaniel, C. T., Lu, L. J., Ohman, D. E., Muruve, D. A., Panos, R. J., Yu, H. D., Thompson, T. B., Tseng, B. S. & Hassett, D. J., Jun 2019, In : PloS one. 14, 6, e0216401.

Research output: Contribution to journalArticle

Open Access
2018

Development of a Dominant Negative Competence-Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia

Koirala, B., Lin, J., Lau, G. W. & Tal-Gan, Y., Nov 16 2018, In : ChemBioChem. 19, 22, p. 2380-2386 7 p.

Research output: Contribution to journalArticle

2016

Absence of TolC impairs biofilm formation in Actinobacillus pleuropneumoniae by reducing initial attachment

Li, Y., Cao, S., Zhang, L., Yuan, J., Lau, G. W., Wen, Y., Wu, R., Zhao, Q., Huang, X., Yan, Q., Huang, Y. & Wen, X., Sep 1 2016, In : PloS one. 11, 9, e0163364.

Research output: Contribution to journalArticle

A putative ABC transporter permease is necessary for resistance to acidified nitrite and EDTA in Pseudomonas aeruginosa under aerobic and anaerobic planktonic and biofilm conditions

McDaniel, C., Su, S., Panmanee, W., Lau, G. W., Browne, T., Cox, K., Paul, A. T., Ko, S. H. B., Mortensen, J. E., Lam, J. S., Muruve, D. A. & Hassett, D. J., Apr 1 2016, In : Frontiers in Microbiology. 7, APR, 291.

Research output: Contribution to journalArticle

A tolC-like protein of actinobacillus pleuropneumoniae is involved in antibiotic resistance and biofilm formation

Li, Y., Cao, S., Zhang, L., Lau, G. W., Wen, Y., Wu, R., Zhao, Q., Huang, X., Yan, Q., Huang, Y. & Wen, X., Oct 24 2016, In : Frontiers in Microbiology. 7, OCT, 1618.

Research output: Contribution to journalArticle

Disentangling competence for genetic transformation and virulence in Streptococcus pneumoniae

Lin, J., Zhu, L. & Lau, G. W., Feb 1 2016, In : Current Genetics. 62, 1, p. 97-103 7 p.

Research output: Contribution to journalReview article

Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014

Huang, L., Luo, X., Shao, J., Yan, H., Qiu, Y., Ke, P., Zheng, W., Xu, B., Li, W., Sun, D., Cao, D., Chen, C., Zhuo, F., Lin, X., Tang, F., Bao, B., Zhou, Y., Zhang, X., Li, H., Li, J. & 17 others, Wan, D., Yang, L., Chen, Y., Zhong, Q., Gu, X., Liu, J., Huang, L., Xie, R., Li, X., Xu, Y., Luo, Z., Liao, M., Wang, H., Sun, L., Li, H., Lau, G. W. & Duan, C., Feb 1 2016, In : European Journal of Clinical Microbiology and Infectious Diseases. 35, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

HtrA is important for stress resistance and virulence in haemophilus parasuis

Zhang, L., Li, Y., Wen, Y., Lau, G. W., Huang, X., Wu, R., Yan, Q., Huang, Y., Zhao, Q., Ma, X., Wen, X. & Caoa, S., 2016, In : Infection and immunity. 84, 8, p. 2209-2219 11 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis x to increase binding to airway epithelial cells

Jeffries, J. L., Jia, J., Choi, W., Choe, S., Miao, J., Xu, Y., Powell, R., Lin, J., Kuang, Z., Gaskins, H. R. & Lau, G. W., Jul 1 2016, In : Mucosal Immunology. 9, 4, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

2015

Deletion analysis of Streptococcus pneumoniae late competence genes distinguishes virulence determinants that are dependent or independent of competence induction

Zhu, L., Lin, J., Kuang, Z., Vidal, J. E. & Lau, G. W., Jul 1 2015, In : Molecular Microbiology. 97, 1, p. 151-165 15 p.

Research output: Contribution to journalArticle

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Parkinson, E. I., Bair, J. S., Nakamura, B. A., Lee, H. Y., Kuttab, H. I., Southgate, E. H., Lezmi, S., Lau, G. W. & Hergenrother, P. J., Apr 22 2015, In : Nature communications. 6, 6947.

Research output: Contribution to journalArticle

Regulation of nuclear-cytoplasmic shuttling and function of family with sequence similarity 13, member a (Fam13A), by B56-containing PP2As and Akt

Jin, Z., Chung, J. W., Mei, W., Strack, S., He, C., Lau, G. W. & Yang, J., Mar 15 2015, In : Molecular biology of the cell. 26, 6, p. 1160-1173 14 p.

Research output: Contribution to journalArticle

Type IV pilus glycosylation mediates resistance of Pseudomonas aeruginosa to opsonic activities of the pulmonary surfactant protein A

Tan, R. M., Kuang, Z., Hao, Y., Lee, F., Lee, T., Lee, R. J. & Lau, G. W., 2015, In : Infection and immunity. 83, 4, p. 1339-1346 8 p.

Research output: Contribution to journalArticle

2014

BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa

Li, Y., Petrova, O. E., Su, S., Lau, G. W., Panmanee, W., Na, R., Hassett, D. J., Davies, D. G. & Sauer, K., Jun 2014, In : PLoS pathogens. 10, 6, e1004168.

Research output: Contribution to journalArticle

Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins

Hao, Y., Kuang, Z., Jing, J., Miao, J., Mei, L. Y., Lee, R. J., Kim, S., Choe, S., Krause, D. C. & Lau, G., Jan 1 2014, In : Infection and immunity. 82, 12, p. 5246-5255 10 p.

Research output: Contribution to journalArticle

Perturbation of pulmonary immune functions by carbon nanotubes and susceptibility to microbial infection

Walling, B. E. & Lau, G. W., Mar 1 2014, In : Journal of Microbiology. 52, 3, p. 227-234 8 p.

Research output: Contribution to journalReview article

Type iv pilus of pseudomonasaeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-a

Tan, R. M., Kuang, Z., Hao, Y. & Lau, G. W., Feb 2014, In : Journal of Innate Immunity. 6, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

2013

Helical carbon nanotubes enhance the early immune response and inhibit macrophage-mediated phagocytosis of Pseudomonas aeruginosa

Walling, B. E., Kuang, Z., Hao, Y., Estrada, D., Wood, J. D., Lian, F., Miller, L. A., Shah, A. B., Jeffries, J. L., Haasch, R. T., Lyding, J. W., Pop, E. & Lau, G. W., Nov 18 2013, In : PloS one. 8, 11, e80283.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa Pyocyanin Activates NRF2-ARE-Mediated Transcriptional Response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP Kinase Signaling in Pulmonary Epithelial Cells

Xu, Y., Duan, C., Kuang, Z., Hao, Y., Jeffries, J. L. & Lau, G. W., Aug 27 2013, In : PloS one. 8, 8, e72528.

Research output: Contribution to journalArticle

Pyocyanin-induced mucin production is associated with redox modification of FOXA2

Hao, Y., Kuang, Z., Xu, Y., Walling, B. E. & Lau, G. W., Aug 5 2013, In : Respiratory Research. 14, 1, 82.

Research output: Contribution to journalArticle

Therapeutic potential of the Streptococcus pneumoniae competence regulon

Zhu, L. & Lau, G. W., Mar 11 2013, In : Expert Review of Anti-Infective Therapy. 11, 3, p. 227-229 3 p.

Research output: Contribution to journalReview article

2012

Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2

Hao, Y., Kuang, Z., Walling, B. E., Bhatia, S., Sivaguru, M., Chen, Y., Gaskins, H. R. & Lau, G., Mar 1 2012, In : Cellular Microbiology. 14, 3, p. 401-415 15 p.

Research output: Contribution to journalArticle

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Duan, C., Zhu, L., Xu, Y. & Lau, G. W., Sep 13 2012, In : PloS one. 7, 9, e44710.

Research output: Contribution to journalArticle

2011

Pseudomonas aeruginosa Elastase provides an Escape from phagocytosis by degrading the pulmonary surfactant protein-A

Kuang, Z., Hao, Y., Walling, B. E., Jeffries, J. L., Ohman, D. E. & Lau, G. W., Nov 1 2011, In : PloS one. 6, 11, e27091.

Research output: Contribution to journalArticle

The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing

Kuang, Z., Hao, Y., Hwang, S., Zhang, S., Kim, E., Akinbi, H. T., Schurr, M. J., Irvin, R. T., Hassett, D. J. & Lau, G. W., Mar 1 2011, In : Molecular Microbiology. 79, 5, p. 1220-1235 16 p.

Research output: Contribution to journalArticle

2010

Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells

Cheluvappa, R., Denning, G. M., Lau, G. W., Grimm, M. C., Hilmer, S. N. & Le Couteur, D. G., Oct 1 2010, In : International Journal of Infectious Diseases. 14, 10, p. e857-e867

Research output: Contribution to journalReview article

Pseudomonas aeruginosa biofilm infections in cystic fibrosis: Insights into pathogenic processes and treatment strategies

Hassett, D. J., Korfhagen, T. R., Irvin, R. T., Schurr, M. J., Sauer, K., Lau, G. W., Sutton, M. D., Yu, H. & Hoiby, N., Feb 1 2010, In : Expert Opinion on Therapeutic Targets. 14, 2, p. 117-130 14 p.

Research output: Contribution to journalReview article

2009

IscR modulates catalase a (KatA) activity, peroxide resistance, and full virulence of Pseudomonas aeruginosa PA14

Kim, S. H., Lee, B. Y., Lau, G. W. & Cho, Y. H., Dec 1 2009, In : Journal of Microbiology and Biotechnology. 19, 12, p. 1520-1526 7 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa and the hyperlipidaemia of sepsis

Cheluvappa, R., Denning, G. M., Lau, G., Grimm, M. C., Hilmer, S. N. & Le Couteur, D. G., Dec 2009, In : Pathology. 41, 7, p. 615-621 7 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis

Caldwell, C. C., Chen, Y., Goetzmann, H. S., Hao, Y., Borchers, M. T., Hassett, D. J., Young, L. R., Mavrodi, D., Thomashow, L. & Lau, G. W., Jan 1 2009, In : American Journal of Pathology. 175, 6, p. 2473-2488 16 p.

Research output: Contribution to journalArticle

2008

NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection

Wesselkamper, S. C., Eppert, B. L., Motz, G. T., Lau, G. W., Hassett, D. J. & Borchers, M. T., Jan 1 2008, In : Journal of Immunology. 181, 8, p. 5481-5489 9 p.

Research output: Contribution to journalArticle

Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions

Platt, M. D., Schurr, M. J., Sauer, K., Vazquez, G., Kukavica-Ibrulj, I., Potvin, E., Levesque, R. C., Fedynak, A., Brinkman, F. S. L., Schurr, J., Hwang, S. H., Lau, G. W., Limbach, P. A., Rowe, J. J., Lieberman, M. A., Barraud, N., Webb, J., Kjelleberg, S., Hunt, D. F. & Hassett, D. J., Apr 1 2008, In : Journal of bacteriology. 190, 8, p. 2739-2758 20 p.

Research output: Contribution to journalArticle

2007

Genome sequence comparison and superinfection between two related Pseudomonas aeruginosa phages, D3112 and MP22

Heo, Y. J., Chung, I. Y., Choi, K. B., Lau, G. W. & Cho, Y. H., Sep 1 2007, In : Microbiology. 153, 9, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A

Zhang, S., McCormack, F. X., Levesque, R. C., O'Toole, G. A. & Lau, G. W., Jun 27 2007, In : PloS one. 2, 6, e564.

Research output: Contribution to journalArticle

2006

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Sang, S. Y., Coakley, R., Lau, G. W., Lymar, S. V., Gaston, B., Karabulut, A. C., Hennigan, R. F., Hwang, S. H., Buettner, G., Schurr, M. J., Mortensen, J. E., Burns, J. L., Speert, D., Boucher, R. C. & Hassett, D. J., Feb 1 2006, In : Journal of Clinical Investigation. 116, 2, p. 436-446 11 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization

Kong, F., Young, L., Chen, Y., Ran, H., Meyers, M., Joseph, P., Cho, Y. H., Hassett, D. J. & Lau, G. W., Jul 1 2006, In : Cellular Microbiology. 8, 7, p. 1121-1133 13 p.

Research output: Contribution to journalArticle

The NKG2D-activating receptor mediates pulmonary clearance of Pseudomonas aeruginosa

Borchers, M. T., Harris, N. L., Wesselkamper, S. C., Zhang, S., Chen, Y., Young, L. & Lau, G. W., May 1 2006, In : Infection and immunity. 74, 5, p. 2578-2586 9 p.

Research output: Contribution to journalArticle