Gee Lau

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Research Output

1993

Genetic analysis of mutations to increased virulence in Magnaporthe grisea

Lau, G. W. & Ellingboe, A. H., Jan 1 1993, In : Phytopathology. 83, 10, p. 1093-1096 4 p.

Research output: Contribution to journalArticle

1994

Morphogenesis and adhesion of Aureobasidium pullulans

Andrews, J. H., Harris, R. F., Spear, R. N., Lau, G. W. & Nordheim, E. V., Jan 1 1994, In : Canadian journal of microbiology. 40, 1, p. 6-17 12 p.

Research output: Contribution to journalArticle

1996

Regulatory genes controlling MPG1 expression and pathogenicity in the rice blast fungus magnaporthe grisea

Lau, G. & Hamer, J. E., May 1 1996, In : Plant Cell. 8, 5, p. 771-781 11 p.

Research output: Contribution to journalArticle

1998

Acropetal: A genetic locus required for conidiophore architecture and pathogenicity in the rice blast fungus

Lau, G. W. & Hamer, J. E., Jun 1998, In : Fungal Genetics and Biology. 24, 1-2, p. 228-239 12 p.

Research output: Contribution to journalArticle

2000

Insertion of the LINE retrotransposon MGL causes a conidiophore pattern mutation in Magnaporthe grisea

Nishimura, M., Hayashi, N., Jwa, N. S., Lau, G. W., Hamer, J. E. & Hasebe, A., Aug 2000, In : Molecular Plant-Microbe Interactions. 13, 8, p. 892-894 3 p.

Research output: Contribution to journalArticle

Plants and animals share functionally common bacterial virulence factors

Rahme, L. G., Ausubel, F. M., Cao, H., Drenkard, E., Goumnerov, B. C., Lau, G. W., Mahajan-Miklos, S., Plotnikova, J., Tan, M. W., Tsongalis, J., Walendziewicz, C. L. & Tompkins, R. G., Aug 1 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 16, p. 8815-8821 7 p.

Research output: Contribution to journalArticle

2001

A functional genomic analysis of type 3 streptococcus pneumoniae virulence

Lau, G. W., Haataja, S., Lonetto, M., Kensit, S. E., Marra, A., Bryant, A. P., McDevitt, D., Morrison, D. A. & Holden, D. W., May 29 2001, In : Molecular Microbiology. 40, 3, p. 555-571 17 p.

Research output: Contribution to journalArticle

2002

Use of plant and insect hosts to model bacterial pathogenesis

Baldini, R. L., Lau, G. W. & Rahme, L. G., Jan 1 2002, In : Methods in enzymology. 358, p. 3-13 11 p.

Research output: Contribution to journalArticle

2003

Human targets of Pseudomonas aeruginosa pyocyanin

Ran, H., Hassett, D. J. & Lau, G. W., Nov 25 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, SUPPL. 2, p. 14315-14320 6 p.

Research output: Contribution to journalArticle

In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets

Potvin, E., Lehoux, D. E., Kukavica-Ibrulj, I., Richard, K. L., Sanschagrin, F., Lau, G. W. & Levesque, R. C., Dec 1 2003, In : Environmental Microbiology. 5, 12, p. 1294-1308 15 p.

Research output: Contribution to journalArticle

The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa

Lau, G. W., Goumnerov, B. C., Walendziewicz, C. L., Hewitson, J., Xiao, W., Mahajan-Miklos, S., Tompkins, R. G., Perkins, L. A. & Rahme, L. G., Jul 1 2003, In : Infection and immunity. 71, 7, p. 4059-4066 8 p.

Research output: Contribution to journalArticle

2004

Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice

Lau, G. W., Ran, H., Kong, F., Hassett, D. J. & Mavrodi, D., Jul 1 2004, In : Infection and immunity. 72, 7, p. 4275-4278 4 p.

Research output: Contribution to journalArticle

The role of pyocyanin in Pseudomonas aeruginosa infection

Lau, G. W., Hassett, D. J., Ran, H. & Kong, F., Dec 1 2004, In : Trends in Molecular Medicine. 10, 12, p. 599-606 8 p.

Research output: Contribution to journalReview article

2005

Comparative signature-tagged mutagenesis identifies Pseudomonas factors conferring resistance to the pulmonary collectin SP-A

Zhang, S., Chen, Y., Potvin, E., Sanschagrin, F., Levesque, R. C., McCormack, F. X. & Lau, G. W., Dec 1 2005, In : PLoS pathogens. 1, 3, p. 259-268 10 p., e31.

Research output: Contribution to journalArticle

Modulation of lung epithelial functions by Pseudomonas aeruginosa

Lau, G. W., Hassett, D. J. & Britigan, B. E., Aug 1 2005, In : Trends in Microbiology. 13, 8, p. 389-397 9 p.

Research output: Contribution to journalReview article

Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression

Apidianakis, Y., Mindrinos, M. N., Xiao, W., Lau, G. W., Baldini, R. L., Davis, R. W. & Rahme, L. G., Feb 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 7, p. 2573-2578 6 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils

Lau, G. W., Britigan, B. E. & Hassett, D. J., Apr 1 2005, In : Infection and immunity. 73, 4, p. 2550-2553 4 p.

Research output: Contribution to journalArticle

2006

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Sang, S. Y., Coakley, R., Lau, G. W., Lymar, S. V., Gaston, B., Karabulut, A. C., Hennigan, R. F., Hwang, S. H., Buettner, G., Schurr, M. J., Mortensen, J. E., Burns, J. L., Speert, D., Boucher, R. C. & Hassett, D. J., Feb 1 2006, In : Journal of Clinical Investigation. 116, 2, p. 436-446 11 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vacuolar ATPase-dependent cystic fibrosis transmembrane conductance regulator expression and localization

Kong, F., Young, L., Chen, Y., Ran, H., Meyers, M., Joseph, P., Cho, Y. H., Hassett, D. J. & Lau, G. W., Jul 1 2006, In : Cellular Microbiology. 8, 7, p. 1121-1133 13 p.

Research output: Contribution to journalArticle

The NKG2D-activating receptor mediates pulmonary clearance of Pseudomonas aeruginosa

Borchers, M. T., Harris, N. L., Wesselkamper, S. C., Zhang, S., Chen, Y., Young, L. & Lau, G. W., May 1 2006, In : Infection and immunity. 74, 5, p. 2578-2586 9 p.

Research output: Contribution to journalArticle

2007

Genome sequence comparison and superinfection between two related Pseudomonas aeruginosa phages, D3112 and MP22

Heo, Y. J., Chung, I. Y., Choi, K. B., Lau, G. W. & Cho, Y. H., Sep 1 2007, In : Microbiology. 153, 9, p. 2885-2895 11 p.

Research output: Contribution to journalArticle

The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A

Zhang, S., McCormack, F. X., Levesque, R. C., O'Toole, G. A. & Lau, G. W., Jun 27 2007, In : PloS one. 2, 6, e564.

Research output: Contribution to journalArticle

2008

NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection

Wesselkamper, S. C., Eppert, B. L., Motz, G. T., Lau, G. W., Hassett, D. J. & Borchers, M. T., Jan 1 2008, In : Journal of Immunology. 181, 8, p. 5481-5489 9 p.

Research output: Contribution to journalArticle

Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions

Platt, M. D., Schurr, M. J., Sauer, K., Vazquez, G., Kukavica-Ibrulj, I., Potvin, E., Levesque, R. C., Fedynak, A., Brinkman, F. S. L., Schurr, J., Hwang, S. H., Lau, G. W., Limbach, P. A., Rowe, J. J., Lieberman, M. A., Barraud, N., Webb, J., Kjelleberg, S., Hunt, D. F. & Hassett, D. J., Apr 1 2008, In : Journal of bacteriology. 190, 8, p. 2739-2758 20 p.

Research output: Contribution to journalArticle

2009

IscR modulates catalase a (KatA) activity, peroxide resistance, and full virulence of Pseudomonas aeruginosa PA14

Kim, S. H., Lee, B. Y., Lau, G. W. & Cho, Y. H., Dec 1 2009, In : Journal of Microbiology and Biotechnology. 19, 12, p. 1520-1526 7 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa and the hyperlipidaemia of sepsis

Cheluvappa, R., Denning, G. M., Lau, G., Grimm, M. C., Hilmer, S. N. & Le Couteur, D. G., Dec 2009, In : Pathology. 41, 7, p. 615-621 7 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis

Caldwell, C. C., Chen, Y., Goetzmann, H. S., Hao, Y., Borchers, M. T., Hassett, D. J., Young, L. R., Mavrodi, D., Thomashow, L. & Lau, G. W., Jan 1 2009, In : American Journal of Pathology. 175, 6, p. 2473-2488 16 p.

Research output: Contribution to journalArticle

2010

Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells

Cheluvappa, R., Denning, G. M., Lau, G. W., Grimm, M. C., Hilmer, S. N. & Le Couteur, D. G., Oct 1 2010, In : International Journal of Infectious Diseases. 14, 10, p. e857-e867

Research output: Contribution to journalReview article

Pseudomonas aeruginosa biofilm infections in cystic fibrosis: Insights into pathogenic processes and treatment strategies

Hassett, D. J., Korfhagen, T. R., Irvin, R. T., Schurr, M. J., Sauer, K., Lau, G. W., Sutton, M. D., Yu, H. & Hoiby, N., Feb 1 2010, In : Expert Opinion on Therapeutic Targets. 14, 2, p. 117-130 14 p.

Research output: Contribution to journalReview article

2011

Pseudomonas aeruginosa Elastase provides an Escape from phagocytosis by degrading the pulmonary surfactant protein-A

Kuang, Z., Hao, Y., Walling, B. E., Jeffries, J. L., Ohman, D. E. & Lau, G. W., Nov 1 2011, In : PloS one. 6, 11, e27091.

Research output: Contribution to journalArticle

The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing

Kuang, Z., Hao, Y., Hwang, S., Zhang, S., Kim, E., Akinbi, H. T., Schurr, M. J., Irvin, R. T., Hassett, D. J. & Lau, G. W., Mar 1 2011, In : Molecular Microbiology. 79, 5, p. 1220-1235 16 p.

Research output: Contribution to journalArticle

2012

Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2

Hao, Y., Kuang, Z., Walling, B. E., Bhatia, S., Sivaguru, M., Chen, Y., Gaskins, H. R. & Lau, G., Mar 1 2012, In : Cellular Microbiology. 14, 3, p. 401-415 15 p.

Research output: Contribution to journalArticle

Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Duan, C., Zhu, L., Xu, Y. & Lau, G. W., Sep 13 2012, In : PloS one. 7, 9, e44710.

Research output: Contribution to journalArticle

2013

Helical carbon nanotubes enhance the early immune response and inhibit macrophage-mediated phagocytosis of Pseudomonas aeruginosa

Walling, B. E., Kuang, Z., Hao, Y., Estrada, D., Wood, J. D., Lian, F., Miller, L. A., Shah, A. B., Jeffries, J. L., Haasch, R. T., Lyding, J. W., Pop, E. & Lau, G. W., Nov 18 2013, In : PloS one. 8, 11, e80283.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa Pyocyanin Activates NRF2-ARE-Mediated Transcriptional Response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP Kinase Signaling in Pulmonary Epithelial Cells

Xu, Y., Duan, C., Kuang, Z., Hao, Y., Jeffries, J. L. & Lau, G. W., Aug 27 2013, In : PloS one. 8, 8, e72528.

Research output: Contribution to journalArticle

Pyocyanin-induced mucin production is associated with redox modification of FOXA2

Hao, Y., Kuang, Z., Xu, Y., Walling, B. E. & Lau, G. W., Aug 5 2013, In : Respiratory Research. 14, 1, 82.

Research output: Contribution to journalArticle

Therapeutic potential of the Streptococcus pneumoniae competence regulon

Zhu, L. & Lau, G. W., Mar 11 2013, In : Expert Review of Anti-Infective Therapy. 11, 3, p. 227-229 3 p.

Research output: Contribution to journalReview article

2014

BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa

Li, Y., Petrova, O. E., Su, S., Lau, G. W., Panmanee, W., Na, R., Hassett, D. J., Davies, D. G. & Sauer, K., Jun 2014, In : PLoS pathogens. 10, 6, e1004168.

Research output: Contribution to journalArticle

Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins

Hao, Y., Kuang, Z., Jing, J., Miao, J., Mei, L. Y., Lee, R. J., Kim, S., Choe, S., Krause, D. C. & Lau, G., Jan 1 2014, In : Infection and immunity. 82, 12, p. 5246-5255 10 p.

Research output: Contribution to journalArticle

Perturbation of pulmonary immune functions by carbon nanotubes and susceptibility to microbial infection

Walling, B. E. & Lau, G. W., Mar 1 2014, In : Journal of Microbiology. 52, 3, p. 227-234 8 p.

Research output: Contribution to journalReview article

Type iv pilus of pseudomonasaeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-a

Tan, R. M., Kuang, Z., Hao, Y. & Lau, G. W., Feb 2014, In : Journal of Innate Immunity. 6, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

2015

Deletion analysis of Streptococcus pneumoniae late competence genes distinguishes virulence determinants that are dependent or independent of competence induction

Zhu, L., Lin, J., Kuang, Z., Vidal, J. E. & Lau, G. W., Jul 1 2015, In : Molecular Microbiology. 97, 1, p. 151-165 15 p.

Research output: Contribution to journalArticle

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Parkinson, E. I., Bair, J. S., Nakamura, B. A., Lee, H. Y., Kuttab, H. I., Southgate, E. H., Lezmi, S., Lau, G. W. & Hergenrother, P. J., Apr 22 2015, In : Nature communications. 6, 6947.

Research output: Contribution to journalArticle

Regulation of nuclear-cytoplasmic shuttling and function of family with sequence similarity 13, member a (Fam13A), by B56-containing PP2As and Akt

Jin, Z., Chung, J. W., Mei, W., Strack, S., He, C., Lau, G. W. & Yang, J., Mar 15 2015, In : Molecular biology of the cell. 26, 6, p. 1160-1173 14 p.

Research output: Contribution to journalArticle

Type IV pilus glycosylation mediates resistance of Pseudomonas aeruginosa to opsonic activities of the pulmonary surfactant protein A

Tan, R. M., Kuang, Z., Hao, Y., Lee, F., Lee, T., Lee, R. J. & Lau, G. W., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1339-1346 8 p.

Research output: Contribution to journalArticle

2016

Absence of TolC impairs biofilm formation in Actinobacillus pleuropneumoniae by reducing initial attachment

Li, Y., Cao, S., Zhang, L., Yuan, J., Lau, G. W., Wen, Y., Wu, R., Zhao, Q., Huang, X., Yan, Q., Huang, Y. & Wen, X., Sep 1 2016, In : PloS one. 11, 9, e0163364.

Research output: Contribution to journalArticle

A putative ABC transporter permease is necessary for resistance to acidified nitrite and EDTA in Pseudomonas aeruginosa under aerobic and anaerobic planktonic and biofilm conditions

McDaniel, C., Su, S., Panmanee, W., Lau, G. W., Browne, T., Cox, K., Paul, A. T., Ko, S. H. B., Mortensen, J. E., Lam, J. S., Muruve, D. A. & Hassett, D. J., Apr 1 2016, In : Frontiers in Microbiology. 7, APR, 291.

Research output: Contribution to journalArticle

A tolC-like protein of actinobacillus pleuropneumoniae is involved in antibiotic resistance and biofilm formation

Li, Y., Cao, S., Zhang, L., Lau, G. W., Wen, Y., Wu, R., Zhao, Q., Huang, X., Yan, Q., Huang, Y. & Wen, X., Oct 24 2016, In : Frontiers in Microbiology. 7, OCT, 1618.

Research output: Contribution to journalArticle