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Research Output

2020

Acute exposure to physiological doses of triiodothyronine does not induce gonadal caspase 3 activity in goldfish in vitro

Allan, E. R. O., Dores, C. B., Nelson, E. R. & Habibi, H. R., Apr 1 2020, In : General and Comparative Endocrinology. 289, 113382.

Research output: Contribution to journalArticle

2019

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Racioppi, L., Nelson, E. R., Huang, W., Mukherjee, D., Lawrence, S. A., Lento, W., Masci, A. M., Jiao, Y., Park, S., York, B., Liu, Y., Baek, A. E., Drewry, D. H., Zuercher, W. J., Bertani, F. R., Businaro, L., Geradts, J., Hall, A., Means, A. R., Chao, N. & 2 others, Chang, C. Y. & McDonnell, D. P., Dec 1 2019, In : Nature communications. 10, 1, 2450.

Research output: Contribution to journalArticle

Open Access

Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations

Yu, L., Wang, L., Mao, C., Duraki, D., Kim, J. E., Huang, R., Helferich, W. G., Nelson, E. R., Park, B. H. & Shapiro, D. J., Feb 1 2019, In : Cancer Letters. 442, p. 373-382 10 p.

Research output: Contribution to journalArticle

Host CYP27A1 expression is essential for ovarian cancer progression

He, S., Ma, L., Baek, A. E., Vardanyan, A., Vembar, V., Chen, J. J., Nelson, A. T., Burdette, J. E. & Nelson, E. R., Jan 1 2019, In : Endocrine-Related Cancer. 26, 7, p. 659-675 17 p.

Research output: Contribution to journalArticle

Nuclear receptors, cholesterol homeostasis and the immune system

Shahoei, S. H. & Nelson, E. R., Jul 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 191, 105364.

Research output: Contribution to journalReview article

Oxysterols and nuclear receptors

Ma, L. & Nelson, E. R., Mar 15 2019, In : Molecular and Cellular Endocrinology. 484, p. 42-51 10 p.

Research output: Contribution to journalReview article

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

Shahoei, S. H., Kim, Y. C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K. & Nelson, E. R., Jan 1 2019, In : Endocrinology. 160, 7, p. 1573-1589 17 p.

Research output: Contribution to journalArticle

2018

Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells

Pomatto, V., Cottone, E., Cocci, P., Mozzicafreddo, M., Mosconi, G., Nelson, E. R., Palermo, F. A. & Bovolin, P., Apr 2018, In : Journal of Steroid Biochemistry and Molecular Biology. 178, p. 322-332 11 p.

Research output: Contribution to journalArticle

Targeting multidrug-resistant ovarian cancer through estrogen receptor a dependent ATP depletion caused by hyperactivation of the unfolded protein response

Zheng, X., Andruska, N., Lambrecht, M. J., He, S., Parissenti, A., Hergenrother, P. J., Nelson, E. R. & Shapiro, D. J., Jan 1 2018, In : Oncotarget. 9, 19, p. 14741-14753 13 p.

Research output: Contribution to journalArticle

The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer

Nelson, E. R., May 5 2018, In : Molecular and Cellular Endocrinology. 466, p. 73-80 8 p.

Research output: Contribution to journalReview article

Vertical Integration of Cell-Laden Hydrogels with Bioinspired Photonic Crystal Membranes

Pei, Y., Shahoei, S. H., Li, Y., Reece, P. J., Nelson, E. R., Gooding, J. J. & Kilian, K. A., Dec 7 2018, In : Advanced Materials Interfaces. 5, 23, 1801233.

Research output: Contribution to journalArticle

2017

27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator

He, S. & Nelson, E. R., Oct 2017, In : Maturitas. 104, p. 29-35 7 p.

Research output: Contribution to journalReview article

CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer

Alfaqih, M. A., Nelson, E. R., Liu, W., Safi, R., Jasper, J. S., Macias, E., Geradts, J., Thompson, J. W., Dubois, L. G., Freeman, M. R., Chang, C. Y., Chi, J. T., McDonnell, D. P. & Freedland, S. J., Jan 1 2017, In : Cancer Research. 77, 7, p. 1662-1673 12 p.

Research output: Contribution to journalArticle

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, A. E., Yu, Y. R. A., He, S., Wardell, S. E., Chang, C. Y., Kwon, S., Pillai, R. V., McDowell, H. B., Thompson, J. W., Dubois, L. G., Sullivan, P. M., Kemper, J. K., Gunn, M. D., McDonnell, D. P. & Nelson, E. R., Dec 1 2017, In : Nature communications. 8, 1, 864.

Research output: Contribution to journalArticle

2016

A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues

Yu, Y. R. A., O'Koren, E. G., Hotten, D. F., Kan, M. J., Kopin, D., Nelson, E. R., Que, L. & Gunn, M. D., Mar 2016, In : PloS one. 11, 3, e0150606.

Research output: Contribution to journalArticle

Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface

Nelson, E. R., Li, S., Kennedy, M., Payne, S., Kilibarda, K., Groth, J., Bowie, M., Parilla-Castellar, E., de Ridder, G., Marcom, P. K., Lyes, M., Peterson, B. L., Cook, M., Pizzo, S. V., McDonnell, D. P. & Bachelder, R. E., Jan 1 2016, In : Oncotarget. 7, 51, p. 84030-84042 13 p.

Research output: Contribution to journalArticle

Detection of endogenous selective estrogen receptor modulators such as 27-hydroxycholesterol

Nelson, E. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 431-443 13 p. (Methods in Molecular Biology; vol. 1366).

Research output: Chapter in Book/Report/Conference proceedingChapter

Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers

Ma, L., Liu, T. W., Wallig, M. A., Dobrucki, I. T., Dobrucki, L. W., Nelson, E. R., Swanson, K. S. & Smith, A. M., Jul 26 2016, In : ACS Nano. 10, 7, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer

Baek, A. E. & Nelson, E. R., Aug 1 2016, In : Hormones and Cancer. 7, 4, p. 219-228 10 p.

Research output: Contribution to journalReview article

Thyroid hormone regulates vitellogenin by inducing estrogen receptor alpha in the goldfish liver

Nelson, E. R. & Habibi, H. R., Nov 15 2016, In : Molecular and Cellular Endocrinology. 436, p. 259-267 9 p.

Research output: Contribution to journalArticle

2015

Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study

Glass, O. K., Inman, B. A., Broadwater, G., Courneya, K. S., Mackey, J. R., Goruk, S., Nelson, E. R., Jasper, J., Field, C. J., Bain, J. R., Muehlbauer, M., Stevens, R. D., Hirschey, M. D. & Jones, L. W., Mar 3 2015, In : British Journal of Cancer. 112, 5, p. 825-831 7 p.

Research output: Contribution to journalArticle

Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader

Wardell, S. E., Nelson, E. R., Chao, C. A., Alley, H. M. & McDonnell, D. P., Oct 1 2015, In : Endocrine-Related Cancer. 22, 5, p. 713-724 12 p.

Research output: Contribution to journalArticle

2014

Cholesterol and breast cancer pathophysiology

Nelson, E. R., Chang, C. Y. & McDonnell, D. P., Dec 1 2014, In : Trends in Endocrinology and Metabolism. 25, 12, p. 649-655 7 p.

Research output: Contribution to journalReview article

Copper signaling axis as a target for prostate cancer therapeutics

Safi, R., Nelson, E. R., Chitneni, S. K., Franz, K. J., George, D. J., Zalutsky, M. R. & McDonnell, D. P., Oct 15 2014, In : Cancer Research. 74, 20, p. 5819-5831 13 p.

Research output: Contribution to journalArticle

Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer

Wright, T. M., Wardell, S. E., Jasper, J. S., Stice, J. P., Safi, R., Nelson, E. R. & McDonnell, D. P., Dec 1 2014, In : Molecular Cancer Research. 12, 12, p. 1829-1839 11 p.

Research output: Contribution to journalArticle

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

Wardell, S. E., Nelson, E. R. & McDonnell, D. P., Nov 15 2014, In : Steroids. 90, p. 30-38 9 p.

Research output: Contribution to journalArticle

Obesity, cholesterol metabolism, and breast cancer pathogenesis

McDonnell, D. P., Park, S., Goulet, M. T., Jasper, J., Wardell, S. E., Chang, C. Y., Norris, J. D., Guyton, J. R. & Nelson, E. R., Jul 24 2014, In : Cancer Research. 74, 18, p. 4976-4982 7 p.

Research output: Contribution to journalReview article

The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer

Mcdonnell, D. P., Chang, C. Y. & Nelson, E., Dec 1 2014, In : Climacteric. 17, p. 60-65 6 p.

Research output: Contribution to journalArticle

2013

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology

Nelson, E. R., Wardell, S. E., Jasper, J. S., Park, S., Suchindran, S., Howe, M. K., Carver, N. J., Pillai, R. V., Sullivan, P. M., Sondhi, V., Umetani, M., Geradts, J. & McDonnell, D. P., Jan 1 2013, In : Science. 342, 6162, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: Implications for treatment of advanced disease

Wardell, S. E., Nelson, E. R., Chao, C. A. & McDonnell, D. P., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2420-2431 12 p.

Research output: Contribution to journalArticle

Estrogen receptor function and regulation in fish and other vertebrates

Nelson, E. R. & Habibi, H. R., Oct 1 2013, In : General and Comparative Endocrinology. 192, p. 15-24 10 p.

Research output: Contribution to journalReview article

Regulation of Bone Cell Function by Estrogens

Wardell, S. E., McDonnell, D. P. & Nelson, E. R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 329-344 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Nelson, E. R., Wardell, S. E. & McDonnell, D. P., Mar 1 2013, In : Bone. 53, 1, p. 42-50 9 p.

Research output: Contribution to journalReview article

2012

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer

Jones, L. W., Antonelli, J., Masko, E. M., Broadwater, G., Lascola, C. D., Fels, D., Dewhirst, M. W., Dyck, J. R. B., Nagendran, J., Flores, C. T., Betof, A. S., Nelson, E. R., Pollak, M., Dash, R. C., Young, M. E. & Freedland, S. J., Jul 15 2012, In : Journal of Applied Physiology. 113, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

New insights into thyroid hormone function and modulation of reproduction in goldfish

Habibi, H. R., Nelson, E. R. & Allan, E. R. O., Jan 1 2012, In : General and Comparative Endocrinology. 175, 1, p. 19-26 8 p.

Research output: Contribution to journalReview article

The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis

Wang, X., Liao, S., Nelson, E. R., Schmalzigaug, R., Spurney, R. F., Guilak, F., Premont, R. T. & Gesty-Palmer, D., Aug 24 2012, In : Biochemical and Biophysical Research Communications. 425, 2, p. 407-412 6 p.

Research output: Contribution to journalArticle

2011

Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis

Nelson, E. R., Allan, E. R. O., Pang, F. Y. & Habibi, H. R., May 15 2011, In : General and Comparative Endocrinology. 172, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C. Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., Giguere, V., Zuercher, W. J., Powell, J. D., Shinohara, M. L., McDonnell, D. P. & Rathmell, J. C., Nov 8 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 45, p. 18348-18353 6 p.

Research output: Contribution to journalArticle

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors

Nelson, E. R., DuSell, C. D., Wang, X., Howe, M. K., Evans, G., Michalek, R. D., Umetani, M., Rathmell, J. C., Khosla, S., Gesty-Palmer, D. & McDonnell, D. P., Dec 1 2011, In : Endocrinology. 152, 12, p. 4691-4705 15 p.

Research output: Contribution to journalArticle

2010

Functional significance of nuclear estrogen receptor subtypes in the liver of goldfish

Nelson, E. R. & Habibi, H. R., Apr 1 2010, In : Endocrinology. 151, 4, p. 1668-1676 9 p.

Research output: Contribution to journalArticle

Gender-related expression of TRα and TRβ in the protandrous black porgy, Acanthopagrus schlegeli, during sex change processes

An, K. W., An, M. I., Nelson, E. R., Habibi, H. R. & Choi, C. Y., Jan 1 2010, In : General and Comparative Endocrinology. 165, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators

DuSell, C. D., Nelson, E., Wittmann, B. M., Fretz, J. A., Kazmin, D., Thomas, R. S., Pike, J. W. & McDonnell, D. P., Jan 1 2010, In : Molecular Endocrinology. 24, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis

DuSell, C. D., Nelson, E., Wang, X., Abdo, J., Mödder, U. I., Umetani, M., Gesty-Palmer, D., Javitt, N. B., Khosla, S. & McDonnell, D. P., Aug 1 2010, In : Endocrinology. 151, 8, p. 3675-3685 11 p.

Research output: Contribution to journalArticle

Thyroid hormone and reproduction: Regulation of estrogen receptors in goldfish gonads

Nelson, E. R., Allan, E. R. O., Pang, F. Y. & Habibi, H. R., Sep 1 2010, In : Molecular reproduction and development. 77, 9, p. 784-794 11 p.

Research output: Contribution to journalArticle

2009

Seasonal regulation of vitellogenin by growth hormone in the goldfish liver

Moussavi, M., Nelson, E. R. & Habibi, H. R., Mar 2009, In : General and Comparative Endocrinology. 161, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

Thyroid receptor subtypes: Structure and function in fish

Nelson, E. R. & Habibi, H. R., Mar 2009, In : General and Comparative Endocrinology. 161, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

2008

Basin-wide impacts of compounds with estrogen-like activity on longnose dace (Rhinichthys cataractae) in two prairie rivers of Alberta, Canada

Jeffries, K. M., Nelson, E. R., Jackson, L. J. & Habibi, H. R., Oct 1 2008, In : Environmental Toxicology and Chemistry. 27, 10, p. 2042-2052 11 p.

Research output: Contribution to journalArticle

Functional significance of a truncated thyroid receptor subtype lacking a hormone-binding domain in goldfish

Nelson, E. R. & Habibi, H. R., Sep 1 2008, In : Endocrinology. 149, 9, p. 4702-4709 8 p.

Research output: Contribution to journalArticle