Erik Procko

20012019
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Research Output 2001 2019

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2019

Conformational engineering of HIV-1 Env based on mutational tolerance in the CD4 and PG16 bound states

Heredia, J. D., Park, J., Choi, H., Gill, K. S. & Procko, E., Jan 1 2019, In : Journal of virology. 93, 11, e0021919.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
engineering
mutation
Mutation

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

Park, J., Selvam, B., Sanematsu, K., Shigemura, N., Shukla, D. & Procko, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 4759-4774 16 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Dimerization
Dimers
Cysteine
Cells
2018

Mapping interaction sites on human chemokine receptors by deep mutational scanning

Heredia, J. D., Park, J., Brubaker, R. J., Szymanski, S. K., Gill, K. S. & Procko, E., Jun 1 2018, In : Journal of Immunology. 200, 11, p. 3825-3839 15 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Chemokines
HIV Envelope Protein gp120
Mutation
Ligands

Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy

Kim, E. C., Zhang, J., Pang, W., Wang, S., Lee, K. Y., Cavaretta, J. P., Walters, J., Procko, E., Tsai, N-P. & Chung, H. J., Oct 2018, In : Neurobiology of Disease. 118, p. 76-93 18 p.

Research output: Contribution to journalArticle

Brain Diseases
Phosphatidylinositols
Calmodulin
Mutation
Voltage-Gated Potassium Channels
2016

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry

Harris, DT., Singh, NK. K., Cai, Q., Smith, SN. N., Vander Kooi, CW. W., Procko, E., Kranz, D. M. & Baker, BM. M., Jul 6 2016, In : Structure. 24, 7, p. 1142-1154 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Major Histocompatibility Complex
Peptide Receptors
Molecular Evolution
Proteins

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Berger, S., Procko, E., Margineantu, D., Lee, E. F., Shen, B. W., Zelter, A., Silva, D. A., Chawla, K., Herold, M. J., Garnier, J. M., Johnson, R., Maccoss, M. J., Lessene, G., Davis, T. N., Stayton, P. S., Stoddard, B. L., Fairlie, W. D., Hockenbery, D. M. & Baker, D., Nov 2 2016, In : eLife. 5, NOVEMBER2016, e20352.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
Neoplasms
Proteins
Survival
Apoptosis

Deep mutational scans as a guide to engineering high affinity t cell receptor interactions with peptide-bound major histocompatibility complex

Harris, D. T., Wang, N., Riley, T. P., Anderson, S. D., Singh, N. K., Procko, E., Baker, B. M. & Kran, D. M., Nov 18 2016, In : Journal of Biological Chemistry. 291, 47, p. 24566-24578 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Cell Communication
Yeast
High-Throughput Nucleotide Sequencing
2015

Intracellular delivery system for antibody-peptide drug conjugates

Berguig, G. Y., Convertine, A. J., Frayo, S., Kern, H. B., Procko, E., Roy, D., Srinivasan, S., Margineantu, D. H., Booth, G., Palanca-Wessels, M. C., Baker, D., Hockenbery, D., Press, O. W. & Stayton, P. S., May 9 2015, In : Molecular Therapy. 23, 5, p. 907-917 11 p.

Research output: Contribution to journalArticle

Peptides
Antibodies
Pharmaceutical Preparations
Neoplasms
Biomarkers
2014

A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells

Procko, E., Berguig, G. Y., Shen, B. W., Song, Y., Frayo, S., Convertine, A. J., Margineantu, D., Booth, G., Correia, B. E., Cheng, Y., Schief, W. R., Hockenbery, D. M., Press, O. W., Stoddard, B. L., Stayton, P. S. & Baker, D., Jun 19 2014, In : Cell. 157, 7, p. 1644-1656 13 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Viruses
Apoptosis
Neoplasms
Proteins
2013

Computational design of a protein-based enzyme inhibitor

Procko, E., Hedman, R., Hamilton, K., Seetharaman, J., Fleishman, S. J., Su, M., Aramini, J., Kornhaber, G., Hunt, J. F., Tong, L., Montelione, G. T. & Baker, D., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3563-3575 13 p.

Research output: Contribution to journalArticle

Enzyme Inhibitors
Catalytic Domain
Proteins
Muramidase
Mutagenesis

Structural and energetic basis of folded-protein transport by the FimD usher

Geibel, S., Procko, E., Hultgren, S. J., Baker, D. & Waksman, G., Apr 11 2013, In : Nature. 496, 7444, p. 243-246 4 p.

Research output: Contribution to journalArticle

Uropathogenic Escherichia coli
Protein Transport
Polymerization
Polymers
Membranes
2012

Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

Lau, S. Y., Procko, E. & Gaudet, R., Dec 14 2012, In : Journal of General Physiology. 140, 5, p. 541-555 15 p.

Research output: Contribution to journalArticle

Nucleic Acid Regulatory Sequences
Calmodulin
Ankyrin Repeat
Binding Sites
trophoblastin

Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel

Inada, H., Procko, E., Sotomayor, M. & Gaudet, R., Aug 7 2012, In : Biochemistry. 51, 31, p. 6195-6206 12 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Adenosine Triphosphate
Mutation
Thermodynamic stability
Hot Temperature
2008

Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter

Procko, E. & Gaudet, R., May 27 2008, In : Biochemistry. 47, 21, p. 5699-5708 10 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Nucleotides
Adenosine Triphosphate
Peptides
Hydrolysis
2007

Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels.

Phelps, C. B., Procko, E., Lishko, P. V., Wang, R. R. & Gaudet, R., Jan 1 2007, In : Channels (Austin, Tex.). 1, 3, p. 148-151 4 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Ion Channels
Calcium
Binding Sites
Terminal Repeat Sequences

The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity

Lishko, P. V., Procko, E., Jin, X., Phelps, C. B. & Gaudet, R., Jun 21 2007, In : Neuron. 54, 6, p. 905-918 14 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Calmodulin
Tachyphylaxis
Binding Sites
Ligands
2006

Distinct Structural and Functional Properties of the ATPase Sites in an Asymmetric ABC Transporter

Procko, E., Ferrin-O'Connell, I., Ng, S. L. & Gaudet, R., Oct 6 2006, In : Molecular cell. 24, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Adenosine Triphosphatases
Adenosine Triphosphate
Dimerization
Hydrolysis
2005

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I

Procko, E., Raghuraman, G., Wiley, D. C., Raghavan, M. & Gaudet, R., Oct 1 2005, In : Immunology and Cell Biology. 83, 5, p. 475-482 8 p.

Research output: Contribution to journalArticle

Peptides
Molecules
ATP-Binding Cassette Transporters
Endoplasmic Reticulum
Insects
2001

Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene

Rao, S., Procko, E. & Shannon, M. F., Oct 15 2001, In : Journal of Immunology. 167, 8, p. 4494-4503 10 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Genetic Promoter Regions
Interleukin-2
Real-Time Polymerase Chain Reaction
T-Lymphocytes