If you made any changes in Pure, your changes will be visible here soon.

Research Output 2006 2019

2019

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Racioppi, L., Nelson, E., Huang, W., Mukherjee, D., Lawrence, S. A., Lento, W., Masci, A. M., Jiao, Y., Park, S., York, B., Liu, Y., Baek, A. E., Drewry, D. H., Zuercher, W. J., Bertani, F. R., Businaro, L., Geradts, J., Hall, A., Means, A. R., Chao, N. & 2 others, Chang, C. Y. & McDonnell, D. P., Dec 1 2019, In : Nature communications. 10, 1, 2450.

Research output: Contribution to journalArticle

Open Access
T-cells
regulators
Myeloid Cells
breast
Tumors

Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations

Yu, L., Wang, L., Mao, C., Duraki, D., Kim, J. E., Huang, R., Helferich, W. G., Nelson, E., Park, B. H. & Shapiro, D. J., Feb 1 2019, In : Cancer Letters. 442, p. 373-382 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Mutation
Neoplasm Metastasis

Host CYP27A1 expression is essential for ovarian cancer progression

He, S., Ma, L., Baek, A. E., Vardanyan, A., Vembar, V., Chen, J. J., Nelson, A. T., Burdette, J. E. & Nelson, E., Jan 1 2019, In : Endocrine-Related Cancer. 26, 7, p. 659-675 17 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Disease-Free Survival
Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Liver

Nuclear receptors, cholesterol homeostasis and the immune system

Shahoei, S. H. & Nelson, E. R., Jul 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 191, 105364.

Research output: Contribution to journalReview article

Immune system
Cytoplasmic and Nuclear Receptors
Immune System
Homeostasis
Cholesterol

Oxysterols and nuclear receptors

Ma, L. & Nelson, E., Mar 15 2019, In : Molecular and Cellular Endocrinology. 484, p. 42-51 10 p.

Research output: Contribution to journalReview article

Cytoplasmic and Nuclear Receptors
T-cells
Liver
Cholesterol
Ligands

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

Shahoei, S. H., Kim, Y. C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K. & Nelson, E. R., Jan 1 2019, In : Endocrinology. 160, 7, p. 1573-1589 17 p.

Research output: Contribution to journalArticle

Macrophages
T-Lymphocytes
Down-Regulation
Interleukin-2
Adoptive Transfer
2018

Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells

Pomatto, V., Cottone, E., Cocci, P., Mozzicafreddo, M., Mosconi, G., Nelson, E. R., Palermo, F. A. & Bovolin, P., Apr 2018, In : Journal of Steroid Biochemistry and Molecular Biology. 178, p. 322-332 11 p.

Research output: Contribution to journalArticle

3T3-L1 Cells
Plasticizers
Adipogenesis
Food
rosiglitazone

Targeting multidrug-resistant ovarian cancer through estrogen receptor a dependent ATP depletion caused by hyperactivation of the unfolded protein response

Zheng, X., Andruska, N., Lambrecht, M. J., He, S., Parissenti, A., Hergenrother, P., Nelson, E. & Shapiro, D. J., Jan 1 2018, In : Oncotarget. 9, 19, p. 14741-14753 13 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Estrogen Receptors
Ovarian Neoplasms
Paclitaxel
Adenosine Triphosphate

The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer

Nelson, E., May 5 2018, In : Molecular and Cellular Endocrinology. 466, p. 73-80 8 p.

Research output: Contribution to journalReview article

Metabolites
Cholesterol
Breast Neoplasms
Life Style
Selective Estrogen Receptor Modulators

Vertical Integration of Cell-Laden Hydrogels with Bioinspired Photonic Crystal Membranes

Pei, Y., Shahoei, S. H., Li, Y., Reece, P. J., Nelson, E. R., Gooding, J. J. & Kilian, K. A., Dec 7 2018, In : Advanced Materials Interfaces. 5, 23, 1801233.

Research output: Contribution to journalArticle

Porous silicon
Photonic crystals
Hydrogels
Membranes
Biopolymers
2017

27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator

He, S. & Nelson, E., Oct 2017, In : Maturitas. 104, p. 29-35 7 p.

Research output: Contribution to journalReview article

Selective Estrogen Receptor Modulators
Estrogen Receptors
Cholesterol
Physiology
Cardiovascular Physiological Phenomena

CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer

Alfaqih, M. A., Nelson, E. R., Liu, W., Safi, R., Jasper, J. S., Macias, E., Geradts, J., Thompson, J. W., Dubois, L. G., Freeman, M. R., Chang, C. Y., Chi, J. T., McDonnell, D. P. & Freedland, S. J., Jan 1 2017, In : Cancer Research. 77, 7, p. 1662-1673 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Homeostasis
Cholesterol
Sterol Regulatory Element Binding Protein 2
Down-Regulation

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, A. E., Yu, Y. R. A., He, S., Wardell, S. E., Chang, C. Y., Kwon, S., Pillai, R. V., McDowell, H. B., Thompson, J. W., Dubois, L. G., Sullivan, P. M., Kemper, K. J., Gunn, M. D., McDonnell, D. P. & Nelson, E., Dec 1 2017, In : Nature communications. 8, 1, 864.

Research output: Contribution to journalArticle

neutrophils
metabolites
cholesterol
metastasis
Metabolites
2016

A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues

Yu, Y. R. A., O'Koren, E. G., Hotten, D. F., Kan, M. J., Kopin, D., Nelson, E. R., Que, L. & Gunn, M. D., Mar 2016, In : PloS one. 11, 3, e0150606.

Research output: Contribution to journalArticle

Macrophages
Tissue
mice
dendritic cells
Tumors

Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface

Nelson, E. R., Li, S., Kennedy, M., Payne, S., Kilibarda, K., Groth, J., Bowie, M., Parilla-Castellar, E., de Ridder, G., Marcom, P. K., Lyes, M., Peterson, B. L., Cook, M., Pizzo, S. V., McDonnell, D. P. & Bachelder, R. E., Jan 1 2016, In : Oncotarget. 7, 51, p. 84030-84042 13 p.

Research output: Contribution to journalArticle

Cadherins
Triple Negative Breast Neoplasms
Breast Neoplasms
Drug Therapy
Neoplasms

Detection of endogenous selective estrogen receptor modulators such as 27-hydroxycholesterol

Nelson, E. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 431-443 13 p. (Methods in Molecular Biology; vol. 1366).

Research output: Chapter in Book/Report/Conference proceedingChapter

Selective Estrogen Receptor Modulators
Ligands
Estrogen Receptors
Estrogens
Tamoxifen

Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers

Ma, L., Liu, T. W., Wallig, M. A., Dobrucki, I. T., Dobrucki, L. W., Nelson, E. R., Swanson, K. S. & Smith, A. M., Jul 26 2016, In : ACS Nano. 10, 7, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

obesity
adipose tissues
macrophages
Macrophages
polysaccharides

The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer

Baek, A. E. & Nelson, E., Aug 1 2016, In : Hormones and Cancer. 7, 4, p. 219-228 10 p.

Research output: Contribution to journalReview article

Cholesterol
Breast Neoplasms
Obesity
Tumor Microenvironment
Hypercholesterolemia

Thyroid hormone regulates vitellogenin by inducing estrogen receptor alpha in the goldfish liver

Nelson, E. & Habibi, H. R., Nov 15 2016, In : Molecular and Cellular Endocrinology. 436, p. 259-267 9 p.

Research output: Contribution to journalArticle

Vitellogenins
Goldfish
Estrogen Receptor alpha
Thyroid Hormones
Liver
2015

Effect of aerobic training on the host systemic milieu in patients with solid tumours: An exploratory correlative study

Glass, O. K., Inman, B. A., Broadwater, G., Courneya, K. S., Mackey, J. R., Goruk, S., Nelson, E., Jasper, J., Field, C. J., Bain, J. R., Muehlbauer, M., Stevens, R. D., Hirschey, M. D. & Jones, L. W., Mar 3 2015, In : British Journal of Cancer. 112, 5, p. 825-831 7 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Neoplasms
Cytokines
Macrophage Inflammatory Proteins
Ergometry

Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader

Wardell, S. E., Nelson, E. R., Chao, C. A., Alley, H. M. & McDonnell, D. P., Oct 1 2015, In : Endocrine-Related Cancer. 22, 5, p. 713-724 12 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Estrogen Receptors
Pharmacology
Breast Neoplasms
Selective Estrogen Receptor Modulators
2014

Cholesterol and breast cancer pathophysiology

Nelson, E., Chang, C. Y. & McDonnell, D. P., Dec 1 2014, In : Trends in Endocrinology and Metabolism. 25, 12, p. 649-655 7 p.

Research output: Contribution to journalReview article

Cholesterol
Breast Neoplasms
Estrogen Receptors
Membrane Fluidity
Dyslipidemias

Copper signaling axis as a target for prostate cancer therapeutics

Safi, R., Nelson, E. R., Chitneni, S. K., Franz, K. J., George, D. J., Zalutsky, M. R. & McDonnell, D. P., Oct 15 2014, In : Cancer Research. 74, 20, p. 5819-5831 13 p.

Research output: Contribution to journalArticle

Copper
Prostatic Neoplasms
Disulfiram
Androgen Receptors
Therapeutics

Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer

Wright, T. M., Wardell, S. E., Jasper, J. S., Stice, J. P., Safi, R., Nelson, E. R. & McDonnell, D. P., Dec 1 2014, In : Molecular Cancer Research. 12, 12, p. 1829-1839 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Tamoxifen
Selective Estrogen Receptor Modulators
Drug Resistance

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

Wardell, S. E., Nelson, E. & McDonnell, D. P., Nov 15 2014, In : Steroids. 90, p. 30-38 9 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Ligands
Estrogen Receptors
Estrogens
Pharmaceutical Preparations

Obesity, cholesterol metabolism, and breast cancer pathogenesis

McDonnell, D. P., Park, S., Goulet, M. T., Jasper, J., Wardell, S. E., Chang, C. Y., Norris, J. D., Guyton, J. R. & Nelson, E. R., Jul 24 2014, In : Cancer Research. 74, 18, p. 4976-4982 7 p.

Research output: Contribution to journalReview article

Obesity
Cholesterol
Breast Neoplasms
Lipid Metabolism
Macrophages

The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer

Mcdonnell, D. P., Chang, C. Y. & Nelson, E., Dec 1 2014, In : Climacteric. 17, p. 60-65 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Cholesterol
Breast Neoplasms
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Obesity
2013

27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology

Nelson, E., Wardell, S. E., Jasper, J. S., Park, S., Suchindran, S., Howe, M. K., Carver, N. J., Pillai, R. V., Sullivan, P. M., Sondhi, V., Umetani, M., Geradts, J. & McDonnell, D. P., Jan 1 2013, In : Science. 342, 6162, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

Hypercholesterolemia
Breast Neoplasms
Estrogen Receptors
Neoplasms
Cholesterol

Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: Implications for treatment of advanced disease

Wardell, S. E., Nelson, E. R., Chao, C. A. & McDonnell, D. P., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2420-2431 12 p.

Research output: Contribution to journalArticle

Tamoxifen
Animal Models
Selective Estrogen Receptor Modulators
Breast Neoplasms
Estrogen Receptors

Estrogen receptor function and regulation in fish and other vertebrates

Nelson, E. & Habibi, H. R., Oct 1 2013, In : General and Comparative Endocrinology. 192, p. 15-24 10 p.

Research output: Contribution to journalReview article

Estrogen Receptors
Vertebrates
Fishes
vertebrates
autoregulation

Regulation of Bone Cell Function by Estrogens

Wardell, S. E., McDonnell, D. P. & Nelson, E., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 329-344 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Estrogens
Bone and Bones
Estrogen Receptors
Selective Estrogen Receptor Modulators
Hormones

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Nelson, E. R., Wardell, S. E. & McDonnell, D. P., Mar 1 2013, In : Bone. 53, 1, p. 42-50 9 p.

Research output: Contribution to journalReview article

Molecular Mechanisms of Pharmacological Action
Selective Estrogen Receptor Modulators
Osteoporosis
Estrogens
Pharmacology
2012

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer

Jones, L. W., Antonelli, J., Masko, E. M., Broadwater, G., Lascola, C. D., Fels, D., Dewhirst, M. W., Dyck, J. R. B., Nagendran, J., Flores, C. T., Betof, A. S., Nelson, E. R., Pollak, M., Dash, R. C., Young, M. E. & Freedland, S. J., Jul 15 2012, In : Journal of Applied Physiology. 113, 2, p. 263-272 10 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasms
Neoplasm Metastasis
Vascular Endothelial Growth Factor A
Mitogen-Activated Protein Kinase Kinases

New insights into thyroid hormone function and modulation of reproduction in goldfish

Habibi, H. R., Nelson, E. & Allan, E. R. O., Jan 1 2012, In : General and Comparative Endocrinology. 175, 1, p. 19-26 8 p.

Research output: Contribution to journalReview article

Goldfish
goldfish
thyroid hormones
Thyroid Hormones
Reproduction

The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis

Wang, X., Liao, S., Nelson, E., Schmalzigaug, R., Spurney, R. F., Guilak, F., Premont, R. T. & Gesty-Palmer, D., Aug 24 2012, In : Biochemical and Biophysical Research Communications. 425, 2, p. 407-412 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Stem cells
Osteoblasts
Mesenchymal Stromal Cells
Scaffolds
2011

Auto-regulation of thyroid hormone receptors in the goldfish ovary and testis

Nelson, E., Allan, E. R. O., Pang, F. Y. & Habibi, H. R., May 15 2011, In : General and Comparative Endocrinology. 172, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

autoregulation
Thyroid Hormone Receptors
Goldfish
goldfish
Testis

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C. Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., Giguere, V., Zuercher, W. J., Powell, J. D., Shinohara, M. L., McDonnell, D. P. & Rathmell, J. C., Nov 8 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 45, p. 18348-18353 6 p.

Research output: Contribution to journalArticle

Eragrostis
Estrogen Receptors
Cell Differentiation
T-Lymphocytes
Glucose

The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors

Nelson, E. R., DuSell, C. D., Wang, X., Howe, M. K., Evans, G., Michalek, R. D., Umetani, M., Rathmell, J. C., Khosla, S., Gesty-Palmer, D. & McDonnell, D. P., Dec 1 2011, In : Endocrinology. 152, 12, p. 4691-4705 15 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Homeostasis
Osteoblasts
Cholesterol
2010

Functional significance of nuclear estrogen receptor subtypes in the liver of goldfish

Nelson, E. R. & Habibi, H. R., Apr 1 2010, In : Endocrinology. 151, 4, p. 1668-1676 9 p.

Research output: Contribution to journalArticle

Goldfish
Estrogen Receptors
Liver
Estradiol
Fishes

Gender-related expression of TRα and TRβ in the protandrous black porgy, Acanthopagrus schlegeli, during sex change processes

An, K. W., An, M. I., Nelson, E., Habibi, H. R. & Choi, C. Y., Jan 1 2010, In : General and Comparative Endocrinology. 165, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

porgy
Acanthopagrus schlegelii schlegelii
Thyroid Hormone Receptors
sex reversal
gender

Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators

DuSell, C. D., Nelson, E., Wittmann, B. M., Fretz, J. A., Kazmin, D., Thomas, R. S., Pike, J. W. & McDonnell, D. P., Jan 1 2010, In : Molecular Endocrinology. 24, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Aryl Hydrocarbon Receptors
Estrogen Receptors
Tamoxifen
Pharmacology

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis

DuSell, C. D., Nelson, E., Wang, X., Abdo, J., Mödder, U. I., Umetani, M., Gesty-Palmer, D., Javitt, N. B., Khosla, S. & McDonnell, D. P., Aug 1 2010, In : Endocrinology. 151, 8, p. 3675-3685 11 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Homeostasis
Bone and Bones
Estrogens
Cholesterol

Thyroid hormone and reproduction: Regulation of estrogen receptors in goldfish gonads

Nelson, E. R., Allan, E. R. O., Pang, F. Y. & Habibi, H. R., Sep 1 2010, In : Molecular reproduction and development. 77, 9, p. 784-794 11 p.

Research output: Contribution to journalArticle

Goldfish
Gonads
Thyroid Hormones
Estrogen Receptors
Reproduction
2009

Seasonal regulation of vitellogenin by growth hormone in the goldfish liver

Moussavi, M., Nelson, E. & Habibi, H. R., Mar 2009, In : General and Comparative Endocrinology. 161, 1, p. 79-82 4 p.

Research output: Contribution to journalArticle

Vitellogenins
Goldfish
goldfish
vitellogenin
somatotropin

Thyroid receptor subtypes: Structure and function in fish

Nelson, E. & Habibi, H. R., Mar 2009, In : General and Comparative Endocrinology. 161, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

Thyroid Gland
Fishes
receptors
vertebrates
Vertebrates
2008

Basin-wide impacts of compounds with estrogen-like activity on longnose dace (Rhinichthys cataractae) in two prairie rivers of Alberta, Canada

Jeffries, K. M., Nelson, E. R., Jackson, L. J. & Habibi, H. R., Oct 1 2008, In : Environmental Toxicology and Chemistry. 27, 10, p. 2042-2052 11 p.

Research output: Contribution to journalArticle

Cyprinidae
Alberta
Rivers
Vitellogenins
prairie
Estrogen Receptor beta
Estrogen Receptor alpha
Estrogen Receptors
Gonads
Testis

Functional significance of a truncated thyroid receptor subtype lacking a hormone-binding domain in goldfish

Nelson, E. R. & Habibi, H. R., Sep 1 2008, In : Endocrinology. 149, 9, p. 4702-4709 8 p.

Research output: Contribution to journalArticle

Goldfish
Thyroid Gland
Hormones
Iodide Peroxidase
Thyroid Hormones
porgy
Acanthopagrus schlegelii schlegelii
sex reversal
Gonads
gonadotropin-releasing hormone

Seasonal-related homologous regulation of goldfish liver Estrogen receptor subtypes

Nelson, E. & Habibi, H. R., Jul 31 2008, In : Cybium. 32, 2 SUPPL., p. 248-249 2 p.

Research output: Contribution to journalArticle

goldfish
liver
estrogens
gonads
estrogen receptors