Eric Oldfield

1971 …2019
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Research Output 1971 2019

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2019

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Song, J., Shang, N., Baig, N., Yao, J., Shin, C., Kim, B. K., Li, Q., Malwal, S. R., Oldfield, E., Feng, X. & Guo, R. T., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 517-523 7 p.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Aspergillus flavus
Aspergillus
Ergosterol
Aspergillosis

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

Yang, Y., Li, L., Yuan, L., Zhou, X., Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y. & 3 others, Oldfield, E., Guo, R. T. & Zhang, Y., Apr 16 2019, In : Immunity. 50, 4, p. 1043-1053.e5

Research output: Contribution to journalArticle

T-Lymphocytes
Diphosphates
Atomic Force Microscopy
Drug Design
Molecular Dynamics Simulation

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Zhang, L., Ko, T. P., Malwal, S. R., Liu, W., Zhou, S., Yu, X., Oldfield, E., Guo, R. T. & Chen, C. C., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 800-805 6 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Branched-Chain Oligosaccharides
Substrates
Crystal structure
Derivatives

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
trans-hexaprenyltranstransferase
Diphosphonates
Bacillus subtilis
Cell Wall
2018

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle

Methicillin
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Metabolism
undecaprenyl pyrophosphate synthetase

Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways

Malwal, S. R., O'Dowd, B., Feng, X., Turhanen, P., Shin, C., Yao, J., Kim, B. K., Baig, N., Zhou, T., Bansal, S., Khade, R. L., Zhang, Y. & Oldfield, E., Jun 20 2018, In : Journal of the American Chemical Society. 140, 24, p. 7568-7578 11 p.

Research output: Contribution to journalArticle

Cell signaling
Adenosinetriphosphate
Diphosphonates
drug
Adenosine Triphosphate

Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes

Malwal, S. R., Gao, J., Hu, X., Yang, Y., Liu, W., Huang, J. W., Ko, T. P., Li, L., Chen, C. C., O'Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., May 4 2018, In : ACS Catalysis. 8, 5, p. 4299-4312 14 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Diphosphates
Asparagine
Biosynthesis
Terpenes

Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors

Kang, L., Gao, X. H., Liu, H. R., Men, X., Wu, H. N., Cui, P. W., Oldfield, E. & Yan, J. Y., Nov 1 2018, In : Molecular Diversity. 22, 4, p. 893-906 14 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cholinesterase Inhibitors
Acetylcholinesterase
inhibitors
Amines

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

Xia, Y., Xie, Y., Yu, Z., Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X. & 3 others, Liu, W., Shi, Y. & Zhang, Y., Nov 1 2018, In : Cell. 175, 4, p. 1059-1073.e21

Research output: Contribution to journalArticle

Mevalonic Acid
Vaccines
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diphosphonates
CD27 Antigens

“Head-to-Middle” and “Head-to-Tail” cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase

Gao, J., Ko, T. P., Chen, L., Malwal, S. R., Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E. & Guo, R. T., Jan 15 2018, In : Angewandte Chemie - International Edition. 57, 3, p. 683-687 5 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Diphosphates
Antibiotics
Tunnels
Dimethylallyltranstransferase
2017

Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, in Vitro and in Vivo Results

Boulmier, A., Feng, X., Oms, O., Mialane, P., Rivière, E., Shin, C. J., Yao, J., Kubo, T., Furuta, T., Oldfield, E. & Dolbecq, A., Jul 3 2017, In : Inorganic Chemistry. 56, 13, p. 7558-7565 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Diphosphonates
tumors
cancer
mice

Combining Vγ9Vδ2 T cells with a lipophilic bisphosphonate efficiently kills activated hepatic stellate cells

Zhou, X., Gu, Y., Xiao, H., Kang, N., Xie, Y., Zhang, G., Shi, Y., Hu, X., Oldfield, E., Zhang, X. & Zhang, Y., Oct 24 2017, In : Frontiers in immunology. 8, OCT, 1381.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Diphosphonates
T-Lymphocytes
Fibrosis
Hepatocellular Carcinoma

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

Neisseria
Pathogens
Staphylococcus aureus
Bacteria
Farnesyl-Diphosphate Farnesyltransferase

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Mohammad, H., Younis, W., Chen, L., Peters, C. E., Pogliano, J., Pogliano, K., Cooper, B., Zhang, J., Mayhoub, A., Oldfield, E., Cushman, M. & Seleem, M. N., Mar 23 2017, In : Journal of Medicinal Chemistry. 60, 6, p. 2425-2438 14 p.

Research output: Contribution to journalArticle

Cell Wall
undecaprenyl pyrophosphate synthetase
Diphosphates
Anti-Bacterial Agents
Phosphoric Monoester Hydrolases

Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase

Rao, G., Bansal, S., Law, W. X., O'Dowd, B., Dikanov, S. & Oldfield, E., Jul 25 2017, In : Biochemistry. 56, 29, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Electron Spin Resonance Spectroscopy
Drosophila
Paramagnetic resonance
Copper

Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors

O'Dowd, B., Williams, S., Wang, H., No, J. H., Rao, G., Wang, W., McCammon, J. A., Cramer, S. P. & Oldfield, E., May 18 2017, In : ChemBioChem. 18, 10, p. 914-920 7 p.

Research output: Contribution to journalArticle

Terpenes
Ligands
Biosynthesis
Pharmaceutical Preparations
Computer Simulation
2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle

Metal Nanoparticles
Alkynes
Azides
Click Chemistry
Metals

Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase

Wang, Y., Desai, J., Zhang, Y., Malwal, S. R., Shin, C. J., Feng, X., Sun, H., Liu, G., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. 11, 20, p. 2311-2319 9 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Growth Inhibitors
Diphosphates
Biosynthesis
Phosphoric Monoester Hydrolases

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI

Li, J., Feng, X., Zhu, W., Oskolkov, N., Zhou, T., Kim, B. K., Baig, N., McMahon, M. T. & Oldfield, E., Jan 4 2016, In : Chemistry - A European Journal. 22, 1, p. 264-271 8 p.

Research output: Contribution to journalArticle

Quantum chemistry
Magnetic resonance imaging
Contrast Media
Toxicity
Protons

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Ricci, C. G., Liu, Y. L., Zhang, Y., Wang, Y., Zhu, W., Oldfield, E. & McCammon, J. A., Sep 13 2016, In : Biochemistry. 55, 36, p. 5180-5190 11 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
zoledronic acid
Malaria
Molecular Dynamics Simulation
Pharmaceutical Preparations

Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109

García-García, V., Oldfield, E. & Benaim, G., Oct 2016, In : Antimicrobial Agents and Chemotherapy. 60, 10, p. 6386-6389 4 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Inhibitory Concentration 50
Tuberculosis
ethylenediamine
Growth

In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei

Yang, G., Zhu, W., Wang, Y., Huang, G., Byun, S. Y., Choi, G., Li, K., Huang, Z., Docampo, R., Oldfield, E. & No, J. H., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 388-398 11 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Geranyltranstransferase
Kinetoplast DNA
Parasites
Amidines

Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth

Desai, J., Wang, Y., Wang, K., Malwal, S. R. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 2205-2215 11 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Geranyltranstransferase
Biosynthesis
Terpenes
Cell growth

Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5

Zhang, L., Chen, C. C., Ko, T. P., Huang, J. W., Zheng, Y., Liu, W., Wang, I., Malwal, S. R., Feng, X., Wang, K., Huang, C. H., Hsu, S. T. D., Wang, A. H. J., Oldfield, E. & Guo, R. T., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4716-4720 5 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Biosynthesis
Antibiotics
Anti-Bacterial Agents
Glycosides

Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T. & Oldfield, E., Jan 1 2016, In : ChemMedChem. p. 1915-1923 9 p.

Research output: Contribution to journalArticle

trans-hexaprenyltranstransferase
Vitamin K 2
zoledronic acid
Cell growth
Staphylococcus aureus

Structure and Function of a "head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase

Liu, M., Chen, C. C., Chen, L., Xiao, X., Zheng, Y., Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E., Guo, R. T. & Ma, Y., Apr 4 2016, In : Angewandte Chemie - International Edition. 55, 15, p. 4721-4724 4 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Monoterpenes
Fragrances
Nucleophiles
Diphosphates

Structure and Function of Four Classes of the 4Fe-4S Protein, IspH

Rao, G. & Oldfield, E., Jul 26 2016, In : Biochemistry. 55, 29, p. 4119-4129 11 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Mutagenesis
Enzymes
4 alpha-glucanotransferase

Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets

Yang, Y., Ko, T. P., Chen, C. C., Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M. R., Hsu, S. T. D., O'Dowd, B., Huff, H. C., Huang, C. H., Docampo, R., Oldfield, E. & Guo, R. T., May 20 2016, In : ACS chemical biology. 11, 5, p. 1362-1371 10 p.

Research output: Contribution to journalArticle

Neglected Diseases
Pyrophosphatases
Antiparasitic Agents
Trypanosomiasis
Trypanosoma cruzi
2015

A molecular dynamics investigation of Mycobacterium tuberculosis prenyl synthases: Conformational flexibility and implications for computer-aided drug discovery

Kim, M. O., Feng, X., Feixas, F., Zhu, W., Lindert, S., Bogue, S., Sinko, W., De Oliveira, C., Rao, G., Oldfield, E. & McCammon, J. A., Jun 1 2015, In : Chemical Biology and Drug Design. 85, 6, p. 756-769 14 p.

Research output: Contribution to journalArticle

Drug Discovery
Molecular Dynamics Simulation
Mycobacterium tuberculosis
undecaprenyl pyrophosphate synthetase
Geranyltranstransferase

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

Farha, M. A., Czarny, T. L., Myers, C. L., Worrall, L. J., French, S., Conrady, D. G., Wang, Y., Oldfield, E., Strynadka, N. C. J. & Brown, E. D., Sep 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. 11048-11053 6 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Teichoic Acids
Clomiphene
Cell Wall
Staphylococcus aureus

Antibacterial drug leads: DNA and enzyme multitargeting

Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R. T. & Oldfield, E., Feb 12 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
Inhibitory Concentration 50
Staphylococcus aureus
DNA
Enzymes

Antiinfectives targeting enzymes and the proton motive force

Feng, X., Zhu, W., Schurig-Briccio, L. A., Lindert, S., Shoen, C., Hitchings, R., Li, J., Wang, Y., Baig, N., Zhou, T., Kim, B. K., Crick, D. C., Cynamon, M., McCammon, J. A., Gennis, R. B. & Oldfield, E., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. E7073-E7082

Research output: Contribution to journalArticle

Proton-Motive Force
Mycobacterium tuberculosis
undecaprenyl pyrophosphate synthetase
Membranes
Staphylococcus aureus

Atomic-resolution structures of discrete stages on the reaction coordinate of the [Fe4S4] enzyme IspG (GcpE)

Quitterer, F., Frank, A., Wang, K., Rao, G., O'Dowd, B., Li, J., Guerra, F., Abdel-Azeim, S., Bacher, A., Eppinger, J., Oldfield, E. & Groll, M., Jun 19 2015, In : Journal of Molecular Biology. 427, 12, p. 2220-2228 9 p.

Research output: Contribution to journalArticle

Erythritol
Diphosphates
Drug Design
Epoxy Compounds
Reducing Agents

Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms

Han, X., Chen, C. C., Kuo, C. J., Huang, C. H., Zheng, Y., Ko, T. P., Zhu, Z., Feng, X., Wang, K., Oldfield, E., Wang, A. H. J., Liang, P. H., Guo, R. T. & Ma, Y., Jan 1 2015, In : Proteins: Structure, Function and Bioinformatics. 83, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Chain length
Escherichia coli
Dimethylallyltranstransferase
Crystal structure
Ligands

Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries

Liu, Y. L., Cao, R., Wang, Y. & Oldfield, E., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 349-354 6 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Ligands
Trypanosoma brucei brucei
Geometry
Diphosphonates

In Vitro and in Vivo investigation of the inhibition of Trypanosoma brucei cell growth by lipophilic bisphosphonates

Yang, G., Zhu, W., Kim, K., Byun, S. Y., Choi, G., Wang, K., Cha, J. S., Cho, H. S., Oldfield, E. & No, J. H., Dec 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7530-7539 10 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Diphosphonates
Geranyltranstransferase
Growth
zoledronic acid

IspH-RPS1 and IspH-UbiA: "rosetta stone" proteins

Rao, G., O'Dowd, B., Li, J., Wang, K. & Oldfield, E., Jan 1 2015, In : Chemical Science. 6, 12, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

Proteins
Terpenes
Dimethylallyltranstransferase
Clostridium
Tandem Repeat Sequences

Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors

Li, K., Wang, Y., Yang, G., Byun, S., Rao, G., Shoen, C., Yang, H., Gulati, A., Crick, D. C., Cynamon, M., Huang, G., Docampo, R., No, J. H. & Oldfield, E., May 8 2015, In : ACS Infectious Diseases. 1, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Trypanosoma brucei brucei
ethylenediamine
Mycobacterium tuberculosis
African Trypanosomiasis

Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line

Saad, A., Zhu, W., Rousseau, G., Mialane, P., Marrot, J., Haouas, M., Taulelle, F., Dessapt, R., Serier-Brault, H., Rivière, E., Kubo, T., Oldfield, E. & Dolbecq, A., Jul 1 2015, In : Chemistry - A European Journal. 21, 29, p. 10537-10547 11 p.

Research output: Contribution to journalArticle

Diphosphonates
Cells
Biosynthesis
Magnetic variables measurement
Ions

SQ109, a new drug lead for chagas disease

Veiga-Santos, P., Li, K., Lameira, L., De Carvalho, T. M. U., Huang, G., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R. T., Urbina, J. A., Docampo, R., De Souza, W. & Oldfield, E., Apr 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 4, p. 1950-1961 12 p.

Research output: Contribution to journalArticle

Chagas Disease
Inhibitory Concentration 50
Multidrug-Resistant Tuberculosis
Pharmaceutical Preparations
Parasites

Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10-Oxogeranial: Reaction Mechanisms

Hu, Y., Liu, W., Malwal, S. R., Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E. & Guo, R. T., Dec 14 2015, In : Angewandte Chemie - International Edition. 54, 51, p. 15478-15482 5 p.

Research output: Contribution to journalArticle

NADP
Hydrides
NAD
Progesterone
Oxidoreductases
2014

A combination therapy for kras-Driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

Xia, Y., Liu, Y. L., Xie, Y., Zhu, W., Guerra, F., Shen, S., Yeddula, N., Fischer, W., Low, W., Zhou, X., Zhang, Y., Oldfield, E. & Verma, I. M., Nov 19 2014, In : Science Translational Medicine. 6, 263, 263ra161.

Research output: Contribution to journalArticle

Diphosphonates
Sirolimus
Autophagy
Neoplasms
Mutation

Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy

Benaim, G., Casanova, P., Hernandez-Rodriguez, V., Mujica-Gonzalez, S., Parra-Gimenez, N., Plaza-Rojas, L., Concepcion, J. L., Liu, Y. L., Oldfield, E., Paniz-Mondolfi, A. & Suarez, A. I., Apr 2014, In : Antimicrobial Agents and Chemotherapy. 58, 4, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Amiodarone
Ergosterol
Parasites
Trypanosoma cruzi

Inhibition of the 4Fe-4S proteins IspG and IspH: An EPR, ENDOR and HYSCORE investigation

Guerra, F., Wang, K., Li, J., Wang, W., Liu, Y. L., Amin, S. & Oldfield, E., Apr 1 2014, In : Chemical Science. 5, 4, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Paramagnetic resonance
Dithionite
Acetylene
Diphosphates
Proteins

Insights into the binding of pyridines to the iron-sulfur enzyme IspH

Span, I., Wang, K., Eisenreich, W., Bacher, A., Zhang, Y., Oldfield, E. & Groll, M., Jun 4 2014, In : Journal of the American Chemical Society. 136, 22, p. 7926-7932 7 p.

Research output: Contribution to journalArticle

Pyridines
Sulfur
Pyridine
Iron
Enzymes

Iron porphyrin carbenes as catalytic intermediates: Structures, mössbauer and NMR spectroscopic properties, and bonding

Khade, R. L., Fan, W., Ling, Y., Yang, L., Oldfield, E. & Zhang, Y., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7574-7578 5 p.

Research output: Contribution to journalArticle

Porphyrins
Iron
Nuclear magnetic resonance
Metalloporphyrins
Hemeproteins

Squalene Synthase As a Target for Chagas Disease Therapeutics

Shang, N., Li, Q., Ko, T. P., Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M. U., de Souza, W., Urbina, J. A., Wang, A. H. J., Docampo, R. & 4 others, Li, K., Liu, Y. L., Oldfield, E. & Guo, R. T., May 2014, In : PLoS pathogens. 10, 5, e1004114.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Chagas Disease
Trypanosoma cruzi
Quinuclidines
Diphosphonates

Structural and functional analysis of bacillus subtilis yisp reveals a role of its product in biofilm production

Feng, X., Hu, Y., Zheng, Y., Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., López, D., Kolter, R., Götz, F., Guo, R. T. & Oldfield, E., Nov 20 2014, In : Chemistry and Biology. 21, 11, p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Functional analysis
Biofilms
Bacilli
Bacillus subtilis
Farnesol

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Aripirala, S., Gonzalez-Pacanowska, D., Oldfield, E., Kaiser, M., Amzel, L. M. & Gabelli, S. B., Mar 1 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 3, p. 802-810 9 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Leishmania major
Diphosphonates
Thermodynamics
Nitrogen

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum

Liu, W., Feng, X., Zheng, Y., Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T. D., Oldfield, E. & Guo, R. T., 2014, In : Scientific reports. 4, 6214.

Research output: Contribution to journalArticle

Bradyrhizobium
Terpenes
Kaurane Diterpenes
Diterpenes
Bryopsida