Eric Oldfield

1971 …2019
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Nuclear magnetic resonance Chemical Compounds
Magnetic Resonance Spectroscopy Medicine & Life Sciences
Chemical shift Chemical Compounds
Diphosphonates Medicine & Life Sciences
Geranyltranstransferase Medicine & Life Sciences
Carbon Monoxide Chemical Compounds
Nuclear magnetic resonance spectroscopy Chemical Compounds
Carbon Chemical Compounds

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Research Output 1971 2019

Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition

Song, J., Shang, N., Baig, N., Yao, J., Shin, C., Kim, B. K., Li, Q., Malwal, S. R., Oldfield, E., Feng, X. & Guo, R. T., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 517-523 7 p.

Research output: Contribution to journalArticle

Farnesyl-Diphosphate Farnesyltransferase
Aspergillus flavus
Aspergillus
Ergosterol
Aspergillosis

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

Yang, Y., Li, L., Yuan, L., Zhou, X., Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y. & 3 others, Oldfield, E., Guo, R. T. & Zhang, Y., Apr 16 2019, In : Immunity. 50, 4, p. 1043-1053.e5

Research output: Contribution to journalArticle

T-Lymphocytes
Diphosphates
Atomic Force Microscopy
Drug Design
Molecular Dynamics Simulation

Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism

Zhang, L., Ko, T. P., Malwal, S. R., Liu, W., Zhou, S., Yu, X., Oldfield, E., Guo, R. T. & Chen, C. C., Apr 16 2019, In : Biochemical and Biophysical Research Communications. 511, 4, p. 800-805 6 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Branched-Chain Oligosaccharides
Substrates
Crystal structure
Derivatives

Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis

Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W. X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C., Guo, R. T., Abdelkhalek, A., Seleem, M. N. & Oldfield, E., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2564-2581 18 p.

Research output: Contribution to journalArticle

undecaprenyl pyrophosphate synthetase
trans-hexaprenyltranstransferase
Diphosphonates
Bacillus subtilis
Cell Wall

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

Elsebaei, M. M., Mohammad, H., Abouf, M., Abutaleb, N. S., Hegazy, Y. A., Ghiaty, A., Chen, L., Zhang, J., Malwal, S. R., Oldfield, E., Seleem, M. N. & Mayhoub, A. S., Mar 25 2018, In : European Journal of Medicinal Chemistry. 148, p. 195-209 15 p.

Research output: Contribution to journalArticle

Methicillin
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Metabolism
undecaprenyl pyrophosphate synthetase