Elena Vikentievna Romanova

2024

Two C-terminal isoforms of Aplysia tachykinin–related peptide receptors exhibit phosphorylation-dependent and phosphorylation-independent desensitization mechanisms

Mao, R. T., Guo, S. Q., Zhang, G., Li, Y. D., Xu, J. P., Wang, H. Y., Fu, P., Liu, C. P., Wu, S. Q., Chen, P., Mei, Y. S., Jin, Q. C., Liu, C. Y., Zhang, Y. C. F., Ding, X. Y., Liu, W. J., Romanova, E. V., Zhou, H. B., Cropper, E. C. & Checco, J. W. & 2 others, Sweedler, J. V. & Jing, J., Aug 2024, In: Journal of Biological Chemistry. 300, 8, 107556.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice

Qiu, T., Lee, C. J., Huang, C., Lee, D. K., Rubakhin, S. S., Romanova, E. V. & Sweedler, J. V., Dec 2023, In: Communications biology. 6, 1, 851.

Research output: Contribution to journal › Article › peer-review

Open Access

Development of a cell‐free strategy to recover aged skeletal muscle after disuse

Wu, Y., Toba, E. A. D. L., Dvoretskiy, S., Jung, R., Kim, N., Daniels, L., Romanova, E. V., Drnevich, J., Sweedler, J. V. & Boppart, M. D., Nov 15 2023, In: The Journal of Physiology. 601, 22, p. 5011-5031 21 p.

Research output: Contribution to journal › Article › peer-review

Peptidomics

Hellinger, R., Sigurdsson, A., Wu, W., Romanova, E. V., Li, L., Sweedler, J. V., Süssmuth, R. D. & Gruber, C. W., Dec 2023, In: Nature Reviews Methods Primers. 3, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

Site-specific chirality-conferred structural compaction differentially mediates the cytotoxicity of Aβ42

Li, G., Jeon, C. K., Ma, M., Jia, Y., Zheng, Z., Delafield, D. G., Lu, G., Romanova, E. V., Sweedler, J. V., Ruotolo, B. T. & Li, L., May 8 2023, In: Chemical Science. 14, 22, p. 5936-5944 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics

Anapindi, K. D. B., Romanova, E. V., Checco, J. W. & Sweedler, J. V., 2022, In: Pharmacological Reviews. 74, 3, p. 662-679 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles

Chan-Andersen, P. C., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102254.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel

Lin, P., Gillard, B. T., Pauža, A. G., Iraizoz, F. A., Ali, M. A., Mecawi, A. S., Alim, F. Z. D., Romanova, E. V., Burger, P. A., Greenwood, M. P., Adem, A. & Murphy, D., Dec 2022, In: Communications biology. 5, 1, 1008.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Analysis of Peptide Stereochemistry in Single Cells by Capillary Electrophoresis–Trapped Ion Mobility Spectrometry Mass Spectrometry

Mast, D. H., Liao, H. W., Romanova, E. V. & Sweedler, J. V., Apr 20 2021, In: Analytical Chemistry. 93, 15, p. 6205-6213 9 p.

Research output: Contribution to journal › Article › peer-review

Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs

Lee, C. A., Romanova, E. V., Southey, B. R., Gillette, R. & Sweedler, J. V., Dec 23 2021, In: Frontiers in Physiology. 12, 809529.

Research output: Contribution to journal › Article › peer-review

Open Access

Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization

Castro, D. C., Xie, Y. R., Rubakhin, S. S., Romanova, E. V. & Sweedler, J. V., Oct 2021, In: Nature Methods. 18, 10, p. 1233-1238 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol

Park, H. M., Satta, R., Davis, R. G., Goo, Y. A., Leduc, R. D., Fellers, R. T., Greer, J. B., Romanova, E. V., Rubakhin, S. S., Tai, R., Thomas, P. M., Sweedler, J. V., Kelleher, N. L., Patrie, S. M. & Lasek, A. W., Nov 1 2019, In: Journal of Proteome Research. 18, 11, p. 3999-4012 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models

Anapindi, K. D. B., Yang, N., Romanova, E. V., Rubakhin, S. S., Tipton, A., Dripps, I., Sheets, Z., Sweedler, J. V. & Pradhan, A. A., 2019, In: Molecular and Cellular Proteomics. 18, 12, p. 2447-2458 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Seasonal adaptations of the hypothalamo-neurohypophyseal system of the dromedary camel

Alim, F. Z. D., Romanova, E. V., Tay, Y. L., Rahman, A. Y. B. A., Chan, K. G., Hong, K. W., Rogers, M., Southey, B. R., Greenwood, M. P., Mecawi, A. S., Mustafa, M. R., Mahy, N., Campbell, C., Antunes-Rodrigues, J., Sweedler, J. V., Murphy, D. & Hindmarch, C. C. T., Jun 2019, In: PloS one. 14, 6, e0216679.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

Rodriguez-Zas, S. L., Wu, C., Southey, B. R., O'Connor, J. C., Nixon, S. E., Garcia, R., Zavala, C., Lawson, M., McCusker, R. H., Romanova, E. V., Sweedler, J. V., Kelley, K. W. & Dantzer, R., Nov 2018, In: Psychoneuroendocrinology. 97, p. 47-58 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry

Dowd, S. E., Mustroph, M. L., Romanova, E. V., Southey, B. R., Pinardo, H., Rhodes, J. S. & Sweedler, J. V., Oct 24 2018, In: ACS Omega. 3, 10, p. 13817-13827 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring the Sea Urchin Neuropeptide Landscape by Mass Spectrometry

Monroe, E. B., Annangudi, S. P., Wadhams, A. A., Richmond, T. A., Yang, N., Southey, B. R., Romanova, E. V., Schoofs, L., Baggerman, G. & Sweedler, J. V., May 1 2018, In: Journal of the American Society for Mass Spectrometry. 29, 5, p. 923-934 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Gene network dysregulation in the trigeminal ganglia and nucleus accumbens of a model of chronic migraine-associated hyperalgesia

Jeong, H., Moye, L. S., Southey, B. R., Hernandez, A. G., Dripps, I., Romanova, E. V., Rubakhin, S. S., Sweedler, J. V., Pradhan, A. A. & Rodriguez-Zas, S. L., Dec 18 2018, In: Frontiers in Systems Neuroscience. 12, 63.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular and Physiological Characterization of a Receptor for d -Amino Acid-Containing Neuropeptides

Checco, J. W., Zhang, G., Yuan, W. D., Yu, K., Yin, S. Y., Roberts-Galbraith, R. H., Yau, P. M., Romanova, E. V., Jing, J. & Sweedler, J. V., May 18 2018, In: ACS chemical biology. 13, 5, p. 1343-1352 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function

Zhang, G., Yuan, W. D., Vilim, F. S., Romanova, E. V., Yu, K., Yin, S. Y., Le, Z. W., Xue, Y. Y., Chen, T. T., Chen, G. K., Chen, S. A., Cropper, E. C., Sweedler, J. V., Weiss, K. R. & Jing, J., Aug 15 2018, In: ACS Chemical Neuroscience. 9, 8, p. 2041-2053 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Peptide identifications and false discovery rates using different mass spectrometry platforms

Anapindi, K. D. B., Romanova, E. V., Southey, B. R. & Sweedler, J. V., May 15 2018, In: Talanta. 182, p. 456-463 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The effects of aging on biosynthetic processes in the rat hypothalamic osmoregulatory neuroendocrine system

Greenwood, M. P., Greenwood, M., Romanova, E. V., Mecawi, A. S., Paterson, A., Sarenac, O., Japundžić-Žigon, N., Antunes-Rodrigues, J., Paton, J. F. R., Sweedler, J. V. & Murphy, D., May 2018, In: Neurobiology of Aging. 65, p. 178-191 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms between Mouse Strains

Davis, R. G., Park, H. M., Kim, K., Greer, J. B., Fellers, R. T., Leduc, R. D., Romanova, E. V., Rubakhin, S. S., Zombeck, J. A., Wu, C., Yau, P. M., Gao, P., Van Nispen, A. J., Patrie, S. M., Thomas, P. M., Sweedler, J. V., Rhodes, J. S. & Kelleher, N. L., Mar 20 2018, In: Analytical Chemistry. 90, 6, p. 3802-3810 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia

Zhang, G., Vilim, F. S., Liu, D. D., Romanova, E. V., Yu, K., Yuan, W. D., Xiao, H., Hummon, A. B., Chen, T. T., Alexeeva, V., Yin, S. Y., Chen, S. A., Cropper, E. C., Sweedler, J. V., Weiss, K. R. & Jing, J., Nov 17 2017, In: Journal of Biological Chemistry. 292, 46, p. 18775-18789 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system

Yang, N., Anapindi, K. D. B., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Dec 7 2017, In: Analyst. 142, 23, p. 4476-4485 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A D-amino acid-containing neuropeptide discovery funnel

Livnat, I., Tai, H. C., Jansson, E. T., Bai, L., Romanova, E. V., Chen, T. T., Yu, K., Chen, S. A., Zhang, Y., Wang, Z. Y., Liu, D. D., Weiss, K. R., Jing, J. & Sweedler, J. V., Dec 6 2016, In: Analytical Chemistry. 88, 23, p. 11868-11876 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni

Hu, C. K., Southey, B. R., Romanova, E. V., Maruska, K. P., Sweedler, J. V. & Fernald, R. D., Aug 19 2016, In: BMC genomics. 17, 1, 660.

Research output: Contribution to journal › Article › peer-review

Open Access

Mass spectrometry imaging and identification of peptides associated with cephalic ganglia regeneration in Schmidtea mediterranea

Ong, T. H., Romanova, E. V., Roberts-Galbraith, R. H., Yang, N., Zimmerman, T. A., Collins, J. J., Lee, J. E., Kelleher, N. L., Newmark, P. A. & Sweedler, J. V., Apr 8 2016, In: Journal of Biological Chemistry. 291, 15, p. 8109-8120 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Classification of Large Cellular Populations and Discovery of Rare Cells Using Single Cell Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Ong, T. H., Kissick, D. J., Jansson, E. T., Comi, T. J., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Jul 21 2015, In: Analytical Chemistry. 87, 14, p. 7036-7042 7 p.

Research output: Contribution to journal › Article › peer-review

Differential peptidomics assessment of strain and age differences in mice in response to acute cocaine administration

Romanova, E. V., Rubakhin, S. S., Ossyra, J. R., Zombeck, J. A., Nosek, M. R., Sweedler, J. V. & Rhodes, J. S., Dec 1 2015, In: Journal of Neurochemistry. 135, 5, p. 1038-1048 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System

Tillmaand, E. G., Yang, N., Kindt, C. A. C., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Dec 1 2015, In: Journal of the American Society for Mass Spectrometry. 26, 12, p. 2051-2061 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit

Bai, L., Livnat, I., Romanova, E. V., Alexeeva, V., Yau, P. M., Vilim, F. S., Weiss, K. R., Jing, J. & Sweedler, J. V., Nov 15 2013, In: Journal of Biological Chemistry. 288, 46, p. 32837-32851 15 p.

Research output: Contribution to journal › Article › peer-review

Laminar stream of detergents for subcellular neurite damage in a microfluidic device: A simple tool for the study of neuroregeneration

Lee, C. Y., Romanova, E. V. & Sweedler, J. V., Jun 2013, In: Journal of Neural Engineering. 10, 3, 036020.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine

Romanova, E. V., Lee, J. E., Kelleher, N. L., Sweedler, J. V. & Gulley, J. M., Nov 2012, In: Journal of Neurochemistry. 123, 2, p. 276-287 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Urotensin II in Invertebrates: From Structure to Function in Aplysia californica

Romanova, E. V., Sasaki, K., Alexeeva, V., Vilim, F. S., Jing, J., Richmond, T. A., Weiss, K. R. & Sweedler, J. V., Nov 8 2012, In: PloS one. 7, 11, e48764.

Research output: Contribution to journal › Article › peer-review

2011

A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the aplysia californica central nervous system

Wang, L., Ota, N., Romanova, E. V. & Sweedler, J. V., Apr 15 2011, In: Journal of Biological Chemistry. 286, 15, p. 13765-13774 10 p.

Research output: Contribution to journal › Article › peer-review

Distinguishing endogenous d-amino acid-containing neuropeptides in individual neurons using tandem mass spectrometry

Bai, L., Romanova, E. V. & Sweedler, J. V., Apr 1 2011, In: Analytical Chemistry. 83, 7, p. 2794-2800 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Profiling metabolites and peptides in single cells

Rubakhin, S. S., Romanova, E. V., Nemes, P. & Sweedler, J. V., Apr 2011, In: Nature Methods. 8, 4, p. S20-S29

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits

Atkins, N., Mitchell, J. W., Romanova, E. V., Morgan, D. J., Cominski, T. P., Ecker, J. L., Pintar, J. E., Sweedler, J. V. & Gillette, M. U., 2010, In: PloS one. 5, 9, p. 1-13 13 p., e12612.

Research output: Contribution to journal › Article › peer-review

Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors

Vilim, F. S., Sasaki, K., Rybak, J., Alexeeva, V., Cropper, E. C., Jing, J., Orekhova, I. V., Brezina, V., Price, D., Romanova, E. V., Rubakhin, S. S., Hatcher, N., Sweedler, J. V. & Weiss, K. R., Jan 6 2010, In: Journal of Neuroscience. 30, 1, p. 131-147 17 p.

Research output: Contribution to journal › Article › peer-review

Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis

Jing, J., Sweedler, J. V., Cropper, E. C., Alexeeva, V., Park, J. H., Romanova, E. V., Xie, F., Dembrow, N. C., Ludwar, B. C., Weiss, K. R. & Vilim, F. S., Dec 8 2010, In: Journal of Neuroscience. 30, 49, p. 16545-16558 14 p.

Research output: Contribution to journal › Article › peer-review

Genome-wide analyses reveal a role for peptide hormones in planarian germline development

Collins, J. J., Hou, X., Romanova, E. V., Lambrus, B. G., Miller, C. M., Saberi, A., Sweedler, J. V. & Newmark, P. A., Oct 2010, In: PLoS biology. 8, 10, e1000509.

Research output: Contribution to journal › Article › peer-review

Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine

Romanova, E. V., Lee, J. E., Kelleher, N. L., Sweedler, J. V. & Gulley, J. M., Sep 2010, In: AAPS Journal. 12, 3, p. 443-454 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Production of nitric oxide within the aplysia californica nervous system

Ye, X., Xie, F., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Mar 17 2010, In: ACS Chemical Neuroscience. 1, 3, p. 182-193 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2009

MALDI mass spectrometric imaging using the stretched sample method to reveal neuropeptide distributions in Aplysia nervous tissue

Zimmerman, T. A., Rubakhin, S. S., Romanova, E. V., Tucker, K. R. & Sweedler, J. V., 2009, In: Analytical Chemistry. 81, 22, p. 9402-9409 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2008

One-step sampling, extraction, and storage protocol for peptidomics using dihydroxybenzoic acid

Romanova, E. V., Rubakhin, S. & Sweedler, J. V., May 1 2008, In: Analytical Chemistry. 80, 9, p. 3379-3386 8 p.

Research output: Contribution to journal › Article › peer-review

2007

Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides

Romanova, E. V., McKay, N., Weiss, K. R., Sweedler, J. V. & Koester, J., Jan 2007, In: Journal of neurophysiology. 97, 1, p. 481-491 11 p.

Research output: Contribution to journal › Article › peer-review

Direct immobilization of Fab′ in nanocapillaries for manipulating mass-limited samples

Bo, Y. K., Swearingen, C. B., Ho, J. A. A., Romanova, E. V., Bohn, P. W. & Sweedler, J. V., Jun 20 2007, In: Journal of the American Chemical Society. 129, 24, p. 7620-7626 7 p.

Research output: Contribution to journal › Article › peer-review

2006

Identification and characterization of homologues of vertebrate β-thymosin in the marine mollusk Aplysia californica

Romanova, E. V., Roth, M. J., Rubakhin, S., Jakubowski, J. A., Kelley, W. P., Kirk, M. D., Kelleher, N. L. & Sweedler, J. V., Aug 2006, In: Journal of Mass Spectrometry. 41, 8, p. 1030-1040 11 p.

Research output: Contribution to journal › Article › peer-review

Self-assembled monolayers of alkanethiols on gold modulate electrophysiological parameters and cellular morphology of cultured neurons

Romanova, E. V., Oxley, S. P., Rubakhin, S. S., Bohn, P. W. & Sweedler, J. V., Mar 2006, In: Biomaterials. 27, 8, p. 1665-1669 5 p.

Research output: Contribution to journal › Article › peer-review

Elena Vikentievna Romanova

Research output

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