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Research Output

2020

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2018

A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes

Biswas, S., Smith, G. L., Roy, E. J., Ward, B. & Shisler, J. L., Feb 2018, In : Journal of General Virology. 99, 2, p. 246-252 7 p., 001006.

Research output: Contribution to journalArticle

Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade

Kowalsky, S. J., Liu, Z., Feist, M., Berkey, S. E., Ma, C., Ravindranathan, R., Dai, E., Roy, E. J., Guo, Z. S. & Bartlett, D. L., Oct 3 2018, In : Molecular Therapy. 26, 10, p. 2476-2486 11 p.

Research output: Contribution to journalArticle

2017

Deletion of the K1L gene results in a vaccinia virus that is less pathogenic due to muted innate immune responses, yet still elicits protective immunity

Bravo Cruz, A. G., Han, A., Roy, E. J., Guzmán, A. B., Miller, R. J., Driskell, E. A., O'Brien, W. D. & Shisler, J. L., Aug 1 2017, In : Journal of virology. 91, 15, e00542-17.

Research output: Contribution to journalArticle

2016

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S., Dec 15 2016, In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

2014

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Stone, J. D., Harris, D. T., Soto, C. M., Chervin, A. S., Aggen, D. H., Roy, E. J. & Kranz, D. M., Jan 1 2014, In : Cancer Immunology, Immunotherapy. 63, 11, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

2013

A polymeric fastener can easily functionalize liposome surfaces with gadolinium for enhanced magnetic resonance imaging

Smith, C. E., Shkumatov, A., Withers, S. G., Yang, B., Glockner, J. F., Misra, S., Roy, E. J., Wong, C. H., Zimmerman, S. C. & Kong, H., Nov 26 2013, In : ACS Nano. 7, 11, p. 9599-9610 12 p.

Research output: Contribution to journalArticle

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 1 2013, In : Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journalArticle

MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Soto, C. M., Stone, J. D., Chervin, A. S., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Feb 1 2013, In : Cancer Immunology, Immunotherapy. 62, 2, p. 359-369 11 p.

Research output: Contribution to journalArticle

2011

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

Tuning the non-equilibrium state of a drug-encapsulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization

Liang, Y., Jensen, T. W., Roy, E. J., Cha, C., DeVolder, R. J., Kohman, R. E., Zhang, B. Z., Textor, K. B., Rund, L. A., Schook, L. B., Tong, Y. W. & Kong, H., Mar 1 2011, In : Biomaterials. 32, 7, p. 2004-2012 9 p.

Research output: Contribution to journalArticle

2009

Ag-doped manganite nanoparticles: New materials for temperature-controlled medical hyperthermia

Melnikov, O. V., Gorbenko, O. Y., M̌arkelova, M. N., Kaul, A. R., Atsarkin, V. A., Demidov, V. V., Soto, C., Roy, E. J. & Odintsov, B. M., Dec 15 2009, In : Journal of Biomedical Materials Research - Part A. 91, 4, p. 1048-1055 8 p.

Research output: Contribution to journalArticle

Critical RF losses in fine particles of La1-xAgyMnO3+δ: Prospects for temperature-controlled hyperthermia

Atsarkin, V. A., Generalov, A. A., Demidov, V. V., Mefed, A. E., Markelova, M. N., Gorbenko, O. Y., Kaul, A. R., Roy, E. J. & Odintsov, B. M., Oct 1 2009, In : Journal of Magnetism and Magnetic Materials. 321, 19, p. 3198-3202 5 p.

Research output: Contribution to journalArticle

Imaging membrane intercalating near infrared dyes to track multiple cell populations

Roy, E. J., Sivaguru, M., Fried, G., Gray, B. D. & Kranz, D. M., Aug 31 2009, In : Journal of Immunological Methods. 348, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits

Liu, J., Wennier, S., Reinhard, M., Roy, E., MacNeill, A. & McFadden, G., Jun 1 2009, In : Journal of virology. 83, 11, p. 5933-5938 6 p.

Research output: Contribution to journalArticle

Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells

Thomas, D. L., Kim, M., Bowerman, N. A., Narayanan, S., Kranz, D. M., Schreiber, H. & Roy, E. J., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

Synthesis, composition, and properties of the solid solutions La 1 -x Ag y MnO3 + δ, promising materials for cell hyperthermia

Gorbenko, O. Y., Markelova, M. N., Mel'Nikov, O. V., Kaul, A. R., Atsarkin, V. A., Demidov, V. V., Mefed, A. E., Roy, E. J. & Odintsov, B. M., Jan 1 2009, In : Doklady Chemistry. 424, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

2008

Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors

Thomas, D. L., Kranz, D. M. & Roy, E. J., Sep 1 2008, In : Cancer Immunology, Immunotherapy. 57, 9, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

2007

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

2005

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Roy, E. J., Takikawa, O., Kranz, D. M., Brown, A. R. & Thomas, D. L., Oct 21 2005, In : Neuroscience Letters. 387, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

2004

A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors

Gawlick, U., Kranz, D. M., Schepkin, V. D. & Roy, E. J., Sep 1 2004, In : Bioconjugate Chemistry. 15, 5, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

Folate-mediated targeting of T cells to tumors

Roy, E. J., Gawlick, U., Orr, B. A. & Kranz, D. M., Apr 29 2004, In : Advanced Drug Delivery Reviews. 56, 8, p. 1219-1231 13 p.

Research output: Contribution to journalArticle

2003

Rapid method for measuring scFv thermal stability by yeast surface display

Orr, B. A., Carr, L. M., Wittrup, K. D., Roy, E. J. & Kranz, D. M., Mar 1 2003, In : Biotechnology Progress. 19, 2, p. 631-638 8 p.

Research output: Contribution to journalArticle

2000

IL-12 treatment of endogenously arising murine brain tumors

Roy, E. J., Gawlick, U., Orr, B. A., Rund, L. A., Webb, A. G. & Kranz, D. M., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 7293-7299 7 p.

Research output: Contribution to journalArticle

1999

Bispecific agents target endogenous murine T cells against human tumor xenografts

Rund, L. A., Cho, B. K., Manning, T. C., Holler, P. D., Roy, E. J. & Kranz, D. M., Sep 7 1999, In : International Journal of Cancer. 83, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

1998

Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors

Patrick, T. A., Kranz, D. M., Zachary, J. F. & Roy, E. J., Nov 2 1998, In : International Journal of Cancer. 78, 4, p. 470-479 10 p.

Research output: Contribution to journalArticle

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate

Roy, E. J., Cho, B. K., Rund, L. A., Patrick, T. A. & Kranz, D. M., Jun 10 1998, In : International Journal of Cancer. 76, 5, p. 761-766 6 p.

Research output: Contribution to journalArticle

Targeting tumor cells with bispecific antibodies and T cells

Kranz, D. M., Manning, T. C., Rund, L. A., Cho, B. K., Gruber, M. M. & Roy, E. J., Apr 30 1998, In : Journal of Controlled Release. 53, 1-3, p. 77-84 8 p.

Research output: Contribution to journalArticle

1997

Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

Patrick, T. A., Kranz, D. M., Van Dyke, T. A. & Roy, E. J., Feb 25 1997, In : Journal of Neuro-Oncology. 32, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Long-term adrenalectomy can decrease or increase hippocampal dentate gyrus volumes

Conrad, C. D., Leone, D., Nemivant, R. R. & Roy, E. J., May 1997, In : Journal of Neuroendocrinology. 9, 5, p. 355-361 7 p.

Research output: Contribution to journalArticle

Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells

Cho, B. K., Roy, E. J., Patrick, T. A. & Kranz, D. M., May 1 1997, In : Bioconjugate Chemistry. 8, 3, p. 338-346 9 p.

Research output: Contribution to journalArticle

1995

Dentate gyrus destruction and spatial learning impairment after corticosteroid removal in young and middle‐aged rats

Conrad, C. D. & Roy, E. J., 1995, In : Hippocampus. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

1993

Juvenile desipramine reduces adult sensitivity to imipramine in two behavioral tests

Dwyer, K. D. & Roy, E. J., May 1993, In : Pharmacology, Biochemistry and Behavior. 45, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Selective loss of hippocampal granule cells following adrenalectomy: Implications for spatial memory

Conrad, C. D. & Roy, E. J., 1993, In : Journal of Neuroscience. 13, 6, p. 2582-2590 9 p.

Research output: Contribution to journalArticle

Open Access
1991

Progesterone-dependent sexual behavior and protein patterns in the ventromedial hypothalamus of the adult female rat

Montemayor, M. E., Giometti, C. S., Taylor, J. & Roy, E. J., Dec 1991, In : Molecular and Cellular Neuroscience. 2, 6, p. 491-500 10 p.

Research output: Contribution to journalArticle

1990

Characterization of a protein that appears in the nervous system of the moth Manduca sexta coincident with neuronal death

Montemayor, M. E., Fahrbach, S. E., Giometti, C. S. & Roy, E. J., Dec 10 1990, In : FEBS Letters. 276, 1-2, p. 219-222 4 p.

Research output: Contribution to journalArticle

Estradiol in the striatum: Effects on behavior and dopamine receptors but no evidence for membrane steroid receptors

Roy, E. J., Buyer, D. R. & Licari, V. A., Aug 1990, In : Brain Research Bulletin. 25, 2, p. 221-227 7 p.

Research output: Contribution to journalArticle

Individual variations in hippocampal dentate degeneration following adrenalectomy

Roy, E. J., Lynn, D. M. & Bemm, C. W., Nov 1990, In : Behavioral and Neural Biology. 54, 3, p. 330-336 7 p.

Research output: Contribution to journalArticle

Modulation by norepinephrine of neural responses to estradiol

Montemayor, M. E., Clark, A. S., Lynn, D. M. & Roy, E. J., Jan 1 1990, In : Neuroendocrinology. 52, 5, p. 473-480 8 p.

Research output: Contribution to journalArticle

1989

Direct effects of ovarian hormones on antidepressant binding sites

Wilson, M. A., Dwyer, K. D. & Roy, E. J., Feb 1989, In : Brain Research Bulletin. 22, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle

Social stimuli augment estrogen receptor binding in preoptic area of female prairie voles

Cohen-Parsons, M. & Roy, E. J., Jan 9 1989, In : Brain Research. 476, 2, p. 363-366 4 p.

Research output: Contribution to journalArticle

1988

Retention of masculine sexual behavior following castration in male B6D2F1 mice

Clemens, L. G., Wee, B. E. F., Weaver, D. R., Roy, E. J., Goldman, B. D. & Rakerd, B., 1988, In : Physiology and Behavior. 42, 1, p. 69-76 8 p.

Research output: Contribution to journalArticle

1987

Asymmetry in responsiveness of the hypothalamus of the female rat to estradiol

Roy, E. J. & Lynn, D. M., 1987, In : Physiology and Behavior. 40, 2, p. 267-269 3 p.

Research output: Contribution to journalArticle

Effective intervals for the administration of estradiol pulses and the induction of sexual behavior in female rats

Clark, A. S. & Roy, E. J., 1987, In : Physiology and Behavior. 39, 5, p. 665-667 3 p.

Research output: Contribution to journalArticle