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Research Output 1975 2018

2018

A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes

Biswas, S., Smith, G. L., Roy, E. J., Ward, B. & Shisler, J. L., Feb 2018, In : Journal of General Virology. 99, 2, p. 246-252 7 p., 001006.

Research output: Contribution to journalArticle

Molluscum contagiosum virus
Vaccinia virus
Virulence
Infection
Virus Replication

Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade

Kowalsky, S. J., Liu, Z., Feist, M., Berkey, S. E., Ma, C., Ravindranathan, R., Dai, E., Roy, E. J., Guo, Z. S. & Bartlett, D. L., Oct 3 2018, In : Molecular Therapy. 26, 10, p. 2476-2486 11 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Interleukin-15
Immunity
Viruses
T-Lymphocytes
2017

Deletion of the K1L gene results in a vaccinia virus that is less pathogenic due to muted innate immune responses, yet still elicits protective immunity

Bravo Cruz, A. G., Han, A., Roy, E. J., Guzmán, A. B., Miller, R. J., Driskell, E. A., O'Brien, W. D. & Shisler, J. L., Aug 1 2017, In : Journal of virology. 91, 15, e00542-17.

Research output: Contribution to journalArticle

Vaccinia virus
gene deletion
Gene Deletion
Innate Immunity
Immunity
2016

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S., Dec 15 2016, In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Bromodeoxyuridine
Cognition
2014

A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control

Stone, J. D., Harris, D. T., Soto, C. M., Chervin, A. S., Aggen, D. H., Roy, E. J. & Kranz, D. M., Jan 1 2014, In : Cancer Immunology, Immunotherapy. 63, 11, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Antigens
Neoplasms
Immunoglobulin Fragments

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

Interleukin-15 Receptor alpha Subunit
Myxoma virus
viral fusion proteins
Interleukin-15
Viruses
2013

A polymeric fastener can easily functionalize liposome surfaces with gadolinium for enhanced magnetic resonance imaging

Smith, C. E., Shkumatov, A., Withers, S. G., Yang, B., Glockner, J. F., Misra, S., Roy, E. J., Wong, C. H., Zimmerman, S. C. & Kong, H., Nov 26 2013, In : ACS Nano. 7, 11, p. 9599-9610 12 p.

Research output: Contribution to journalArticle

fasteners
Liposomes
Gadolinium
Fasteners
Magnetic resonance

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 1 2013, In : Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Tumor-Infiltrating Lymphocytes
Neoplasm Antigens
Neoplasms

MHC-class I-restricted CD4 T cells: A nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

Soto, C. M., Stone, J. D., Chervin, A. S., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Feb 1 2013, In : Cancer Immunology, Immunotherapy. 62, 2, p. 359-369 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Neoplasms
Histocompatibility Antigens Class I
Helper-Inducer T-Lymphocytes
2011

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

Myxoma virus
Intraventricular Injections
Viral Proteins
Brain
Proteins

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 1 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

Myxoma virus
Sirolimus
Cell- and Tissue-Based Therapy
Brain Neoplasms
Melanoma

Tuning the non-equilibrium state of a drug-encapsulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization

Liang, Y., Jensen, T. W., Roy, E. J., Cha, C., DeVolder, R. J., Kohman, R. E., Zhang, B. Z., Textor, K. B., Rund, L. A., Schook, L. B., Tong, Y. W. & Kong, H., Mar 1 2011, In : Biomaterials. 32, 7, p. 2004-2012 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Ethylene Glycol
Hydrogel
Hydrogels
Polyethylene glycols
2009

Ag-doped manganite nanoparticles: New materials for temperature-controlled medical hyperthermia

Melnikov, O. V., Gorbenko, O. Y., M̌arkelova, M. N., Kaul, A. R., Atsarkin, V. A., Demidov, V. V., Soto, C., Roy, E. J. & Odintsov, B. M., Dec 15 2009, In : Journal of Biomedical Materials Research - Part A. 91, 4, p. 1048-1055 8 p.

Research output: Contribution to journalArticle

Silver
Manganites
Magnetic resonance imaging
Nanoparticles
Curie temperature
T-cells
brain
mice
Brain
Microscopes

Critical RF losses in fine particles of La1-xAgyMnO3+δ: Prospects for temperature-controlled hyperthermia

Atsarkin, V. A., Generalov, A. A., Demidov, V. V., Mefed, A. E., Markelova, M. N., Gorbenko, O. Y., Kaul, A. R., Roy, E. J. & Odintsov, B. M., Oct 1 2009, In : Journal of Magnetism and Magnetic Materials. 321, 19, p. 3198-3202 5 p.

Research output: Contribution to journalArticle

critical frequencies
hyperthermia
Manganites
radio frequencies
kinetic heating

Imaging membrane intercalating near infrared dyes to track multiple cell populations

Roy, E. J., Sivaguru, M., Fried, G. A., Gray, B. D. & Kranz, D. M., Aug 31 2009, In : Journal of Immunological Methods. 348, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

Coloring Agents
Cell Tracking
Membranes
Population
Light

Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits

Liu, J., Wennier, S., Reinhard, M., Roy, E. J., MacNeill, A. & McFadden, G., Jun 1 2009, In : Journal of virology. 83, 11, p. 5933-5938 6 p.

Research output: Contribution to journalArticle

Myxoma virus
myxomatosis
Interleukin-15
rabbits
Rabbits

Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells

Thomas, D. L., Kim, M., Bowerman, N. A., Narayanan, S., Kranz, D. M., Schreiber, H. & Roy, E. J., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1828-1837 10 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Stromal Cells
Cell- and Tissue-Based Therapy
T-Lymphocytes
Recurrence

Synthesis, composition, and properties of the solid solutions La 1 -x Ag y MnO3 + δ, promising materials for cell hyperthermia

Gorbenko, O. Y., Markelova, M. N., Mel'Nikov, O. V., Kaul, A. R., Atsarkin, V. A., Demidov, V. V., Mefed, A. E., Roy, E. J. & Odintsov, B. M., Jan 1 2009, In : Doklady Chemistry. 424, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

Solid solutions
Chemical analysis
2008
Transforming Growth Factors
Regulatory T-Lymphocytes
T-Lymphocytes
Lymphocytes
Cytokines

Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors

Thomas, D. L., Kranz, D. M. & Roy, E. J., Sep 1 2008, In : Cancer Immunology, Immunotherapy. 57, 9, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Lymph Nodes
Neoplasms
Brain
Radioactivity
2007

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-12
Immunity
T-Lymphocytes
Interferons
2005

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Roy, E. J., Takikawa, O., Kranz, D. M., Brown, A. R. & Thomas, D. L., Oct 21 2005, In : Neuroscience Letters. 387, 2, p. 95-99 5 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Neurons
Tryptophan
Interferons
2004

A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors

Gawlick, U., Kranz, D. M., Schepkin, V. D. & Roy, E. J., Sep 1 2004, In : Bioconjugate Chemistry. 15, 5, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

T-cells
Antibodies
Brain Neoplasms
Interleukin-12
Tumors

Folate-mediated targeting of T cells to tumors

Roy, E. J., Gawlick, U., Orr, B. A. & Kranz, D. M., Apr 29 2004, In : Advanced Drug Delivery Reviews. 56, 8, p. 1219-1231 13 p.

Research output: Contribution to journalArticle

Folic Acid
T-Lymphocytes
Neoplasms
Bispecific Antibodies
Vaccines
2003

Rapid method for measuring scFv thermal stability by yeast surface display

Orr, B. A., Carr, L. M., Wittrup, K. D., Roy, E. J. & Kranz, D. M., Mar 1 2003, In : Biotechnology Progress. 19, 2, p. 631-638 8 p.

Research output: Contribution to journalArticle

Hot Temperature
Yeasts
Single-Chain Antibodies
Immobilized Proteins
Protein Denaturation
2000

IL-12 treatment of endogenously arising murine brain tumors

Roy, E. J., Gawlick, U., Orr, B. A., Rund, L. A., Webb, A. G. & Kranz, D. M., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 7293-7299 7 p.

Research output: Contribution to journalArticle

Interleukin-12
Brain Neoplasms
T-Lymphocytes
Neoplasms
Therapeutics
1999

Bispecific agents target endogenous murine T cells against human tumor xenografts

Rund, L. A., Cho, B. K., Manning, T. C., Holler, P. D., Roy, E. J. & Kranz, D. M., Sep 7 1999, In : International Journal of Cancer. 83, 1, p. 141-149 9 p.

Research output: Contribution to journalArticle

Heterografts
T-Lymphocytes
T-Cell Antigen Receptor
Neoplasms
Bispecific Antibodies
1998

Intracerebral bispecific ligand-antibody conjugate increases survival of animals bearing endogenously arising brain tumors

Patrick, T. A., Kranz, D. M., Zachary, J. F. & Roy, E. J., Nov 2 1998, In : International Journal of Cancer. 78, 4, p. 470-479 10 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Brain Neoplasms
Ligands
Choroid Plexus Neoplasms
T-Lymphocytes

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate

Roy, E. J., Cho, B. K., Rund, L. A., Patrick, T. A. & Kranz, D. M., Jun 10 1998, In : International Journal of Cancer. 76, 5, p. 761-766 6 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Folic Acid
Brain Neoplasms
Ligands
T-Lymphocytes

Targeting tumor cells with bispecific antibodies and T cells

Kranz, D. M., Manning, T. C., Rund, L. A., Cho, B. K., Gruber, M. M. & Roy, E. J., Apr 30 1998, In : Journal of Controlled Release. 53, 1-3, p. 77-84 8 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
T-Lymphocytes
Folic Acid
T-Cell Antigen Receptor
Neoplasms
1997

Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

Patrick, T. A., Kranz, D. M., Van Dyke, T. A. & Roy, E. J., Feb 25 1997, In : Journal of Neuro-Oncology. 32, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Choroid Plexus Neoplasms
Folic Acid
Transgenic Mice
Choroid Plexus
Ependymoma

Long-term adrenalectomy can decrease or increase hippocampal dentate gyrus volumes

Conrad, C. D., Leone, D., Nemivant, R. R. & Roy, E. J., May 1 1997, In : Journal of Neuroendocrinology. 9, 5, p. 355-361 7 p.

Research output: Contribution to journalArticle

Parahippocampal Gyrus
Adrenalectomy
Dentate Gyrus
Long Evans Rats
Corticosterone

Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells

Cho, B. K., Roy, E. J., Patrick, T. A. & Kranz, D. M., May 1 1997, In : Bioconjugate Chemistry. 8, 3, p. 338-346 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Folic Acid
Tumors
T-cells
Cells
1995
T-Cell Antigen Receptor
Folic Acid
Antibodies
Neoplasms
Bispecific Antibodies

Dentate gyrus destruction and spatial learning impairment after corticosteroid removal in young and middle‐aged rats

Conrad, C. D. & Roy, E. J., 1995, In : Hippocampus. 5, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Adrenal Cortex Hormones
Water
Corticosterone
Spatial Learning
1993

Juvenile desipramine reduces adult sensitivity to imipramine in two behavioral tests

Dwyer, K. D. & Roy, E. J., May 1993, In : Pharmacology, Biochemistry and Behavior. 45, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Desipramine
Imipramine
Rats
Animal Behavior
Behavior Rating Scale

Selective loss of hippocampal granule cells following adrenalectomy: Implications for spatial memory

Conrad, C. D. & Roy, E. J., Jan 1 1993, In : Journal of Neuroscience. 13, 6, p. 2582-2590 9 p.

Research output: Contribution to journalArticle

Adrenalectomy
Dentate Gyrus
Hippocampus
Learning
Water
1991

Progesterone-dependent sexual behavior and protein patterns in the ventromedial hypothalamus of the adult female rat

Montemayor, M. E., Giometti, C. S., Taylor, J. & Roy, E. J., Dec 1991, In : Molecular and Cellular Neuroscience. 2, 6, p. 491-500 10 p.

Research output: Contribution to journalArticle

Sexual Behavior
Hypothalamus
Progesterone
Proteins
Photofluorography
1990

Characterization of a protein that appears in the nervous system of the moth Manduca sexta coincident with neuronal death

Montemayor, M. E., Fahrbach, S. E., Giometti, C. S. & Roy, E. J., Dec 10 1990, In : FEBS Letters. 276, 1-2, p. 219-222 4 p.

Research output: Contribution to journalArticle

Manduca
Moths
Neurology
Nervous System
Proteins

Estradiol in the striatum: Effects on behavior and dopamine receptors but no evidence for membrane steroid receptors

Roy, E. J., Buyer, D. R. & Licari, V. A., Aug 1990, In : Brain Research Bulletin. 25, 2, p. 221-227 7 p.

Research output: Contribution to journalArticle

Steroid Receptors
Dopamine Receptors
Estradiol
Membrane Fluidity
Membranes

Individual variations in hippocampal dentate degeneration following adrenalectomy

Roy, E. J., Lynn, D. M. & Bemm, C. W., Nov 1990, In : Behavioral and Neural Biology. 54, 3, p. 330-336 7 p.

Research output: Contribution to journalArticle

Adrenalectomy
Corticosterone
Body Weight
Hormones
Pyramidal Cells

Modulation by norepinephrine of neural responses to estradiol

Montemayor, M. E., Clark, A. S., Lynn, D. M. & Roy, E. J., Jan 1 1990, In : Neuroendocrinology. 52, 5, p. 473-480 8 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estradiol
Norepinephrine
Hypothalamus
Prazosin
1989

Direct effects of ovarian hormones on antidepressant binding sites

Wilson, M. A., Dwyer, K. D. & Roy, E. J., Feb 1989, In : Brain Research Bulletin. 22, 2, p. 181-185 5 p.

Research output: Contribution to journalArticle

Imipramine
Antidepressive Agents
Estradiol
Binding Sites
Hormones

Social stimuli augment estrogen receptor binding in preoptic area of female prairie voles

Cohen-Parsons, M. & Roy, E. J., Jan 9 1989, In : Brain Research. 476, 2, p. 363-366 4 p.

Research output: Contribution to journalArticle

Arvicolinae
Preoptic Area
Estrogen Receptors
Estrogens
Cell Nucleus
1988

Retention of masculine sexual behavior following castration in male B6D2F1 mice

Clemens, L. G., Wee, B. E. F., Weaver, D. R., Roy, E. J., Goldman, B. D. & Rakerd, B., 1988, In : Physiology and Behavior. 42, 1, p. 69-76 8 p.

Research output: Contribution to journalArticle

Orchiectomy
Castration
Sexual Behavior
Genotype
Gonadal Hormones
1987

Asymmetry in responsiveness of the hypothalamus of the female rat to estradiol

Roy, E. J. & Lynn, D. M., 1987, In : Physiology and Behavior. 40, 2, p. 267-269 3 p.

Research output: Contribution to journalArticle

Hypothalamus
Estradiol
Neuroanatomy
Hormones

Effective intervals for the administration of estradiol pulses and the induction of sexual behavior in female rats

Clark, A. S. & Roy, E. J., 1987, In : Physiology and Behavior. 39, 5, p. 665-667 3 p.

Research output: Contribution to journalArticle

Sexual Behavior
Estradiol
Estrogens
Progesterone
Corticosterone
Aldosterone
Cell Nucleus
Steroids
Brain
1986

Estrogen-induced progestin receptors in the brain and pituitary of the South African clawed frog, Xenopus laevis

Roy, E. J., Wilson, M. A. & Kelley, D. B., Jan 1 1986, In : Neuroendocrinology. 42, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Xenopus laevis
Progesterone Receptors
Anura
Estrogens
Preoptic Area