Research output per year
Research output per year
Personal profile
Research Interests
Research Topics
Molecular Immunology
Education
B.A. 1970 Brown University
Ph.D. 1976 University of Massachusetts
Postdoc. 1976-1979 The Rockefeller University
Research Interests
Professional Information
Immunotherapy
We are committed to developing immunotherapies for brain tumors that are effective and selective. We use mice as experimental subjects because much is know about their immune system, and the murine system closely parallels the human immune system. When properly activated, the immune system has the characteristics of an ideal therapy: potent, precise killing of altered cells. But there is much to be learned about how to activate, direct, and control the immune response, particularly against tumors within the brain. We focus mostly on T cell mediated immune responses, and work in close collaboration with the laboratory of David Kranz, a T cell biochemist.
Office Address
Department of Pathology
College of Medicine, UIUC
506 S. Mathews Ave
Urbana, IL 61801
Office Phone
(217) 333-3375
Fingerprint
Fingerprint is based on mining the text of the expert's scholarly documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice
Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J. & Shapiro, D. J., Jul 21 2021, In: Science Translational Medicine. 13, 603, eabf1383.Research output: Contribution to journal › Article › peer-review
-
Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma
Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In: Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Cautionary Note on the Selectivity of Oncolytic Poxviruses
Tang, B., Guo, Z. S., Bartlett, D. L., Liu, J., McFadden, G., Shisler, J. L. & Roy, E. J., 2019, In: Oncolytic virotherapy. 8, p. 3-8 6 p.Research output: Contribution to journal › Article › peer-review
-
A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes
Biswas, S., Smith, G. L., Roy, E. J., Ward, B. & Shisler, J. L., Feb 2018, In: Journal of General Virology. 99, 2, p. 246-252 7 p., 001006.Research output: Contribution to journal › Article › peer-review
Open Access -
Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade
Kowalsky, S. J., Liu, Z., Feist, M., Berkey, S. E., Ma, C., Ravindranathan, R., Dai, E., Roy, E. J., Guo, Z. S. & Bartlett, D. L., Oct 3 2018, In: Molecular Therapy. 26, 10, p. 2476-2486 11 p.Research output: Contribution to journal › Article › peer-review
Open Access