Douglas Alan Mitchell

2024

Genome Mining for New Enzyme Chemistry

Nguyen, D. T., Mitchell, D. A. & van der Donk, W. A., Apr 5 2024, In: ACS Catalysis. 14, 7, p. 4536-4553 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides

Ongpipattanakul, C., Desormeaux, E. K., Dicaprio, A., Van Der Donk, W. A., Mitchell, D. A. & Nair, S. K., Sep 28 2022, In: Chemical reviews. 122, 18, p. 14722-14814 93 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry

Oberg, N., Precord, T. W., Mitchell, D. A. & Gerlt, J. A., Feb 16 2022, In: ACS Bio and Med Chem Au. 2, 1, p. 22-35 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2021

New developments in RiPP discovery, enzymology and engineering

Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y. & Rebuffat, S. & 16 others, Sahl, H.-G., Sareen, D., Schmidt, E. W., Schmitt, L., Severinov, K., Süssmuth, R. D., Truman, A. W., Wang, H., Weng, J.-K., van Wezel, G. P., Zhang, Q., Zhong, J., Piel, J., Mitchell, D. A., Kuipers, O. P. & van der Donk, W. A., 2021, In: Natural Product Reports. 38, 1, p. 130-239 110 p.

Research output: Contribution to journal › Review article › peer-review

2019

Biosynthesis and Chemical Applications of Thioamides

Mahanta, N., Szantai-Kis, D. M., Petersson, E. J. & Mitchell, D. A., 2019, In: ACS chemical biology. 14, 2, p. 142-163 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2018

RiPP antibiotics: biosynthesis and engineering potential

Hudson, G. A. & Mitchell, D. A., Oct 2018, In: Current Opinion in Microbiology. 45, p. 61-69 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2017

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

Burkhart, B. J., Schwalen, C. J., Mann, G., Naismith, J. H. & Mitchell, D. A., Apr 26 2017, In: Chemical reviews. 117, 8, p. 5389-5456 68 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2016

Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics

Maxson, T. & Mitchell, D. A., 2016, In: Tetrahedron. 72, 25, p. 3609-3624 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Using genomics for natural product structure elucidation

Tietz, J. I. & Mitchell, D. A., Jun 1 2016, In: Current Topics in Medicinal Chemistry. 16, 15, p. 1645-1694 50 p.

Research output: Contribution to journal › Review article › peer-review

2015

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A. & Hadjithomas, M. & 134 others, Haines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., Van Der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., Aug 18 2015, In: Nature chemical biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2014

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor

Deane, C. D. & Mitchell, D. A., Feb 2014, In: Journal of Industrial Microbiology and Biotechnology. 41, 2, p. 315-331 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Multitarget drug discovery for tuberculosis and other infectious diseases

Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L. & Ren, F. & 8 others, Sun, H., Jiang, T., Li, Y., Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C. & Oldfield, E., Apr 10 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 3126-3129 4 p.

Research output: Contribution to journal › Review article › peer-review

2013

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis

Dunbar, K. L. & Mitchell, D. A., Mar 15 2013, In: ACS chemical biology. 8, 3, p. 473-487 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., Cotter, P. D., Craik, D. J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P. C., Entian, K. D., Fischbach, M. A., Garavelli, J. S. & Göransson, U. & 45 others, Gruber, C. W., Haft, D. H., Hemscheidt, T. K., Hertweck, C., Hill, C., Horswill, A. R., Jaspars, M., Kelly, W. L., Klinman, J. P., Kuipers, O. P., Link, A. J., Liu, W., Marahiel, M. A., Mitchell, D. A., Moll, G. N., Moore, B. S., Müller, R., Nair, S. K., Nes, I. F., Norris, G. E., Olivera, B. M., Onaka, H., Patchett, M. L., Piel, J., Reaney, M. J. T., Rebuffat, S., Ross, R. P., Sahl, H. G., Schmidt, E. W., Selsted, M. E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R. D., Tagg, J. R., Tang, G. L., Truman, A. W., Vederas, J. C., Walsh, C. T., Walton, J. D., Wenzel, S. C., Willey, J. M. & Van Der Donk, W. A., Jan 2013, In: Natural Product Reports. 30, 1, p. 108-160 53 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2011

Streptolysin S-like virulence factors: The continuing sagA

Molloy, E. M., Cotter, P. D., Hill, C., Mitchell, D. A. & Ross, R. P., Sep 2011, In: Nature Reviews Microbiology. 9, 9, p. 670-681 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Thiazole/oxazole-modified microcins: Complex natural products from ribosomal templates

Melby, J. O., Nard, N. J. & Mitchell, D. A., Jun 2011, In: Current Opinion in Chemical Biology. 15, 3, p. 369-378 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Douglas Alan Mitchell

Research output

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