Douglas Alan Mitchell

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2020

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Feb 2020, In : PLoS biology. 18, 2, e3000507.

Research output: Contribution to journalArticle

Open Access

Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach

Sieber, S., Grendelmeier, S. M., Harris, L. A., Mitchell, D. A. & Gademann, K., Feb 28 2020, In : Journal of Natural Products. 83, 2, p. 438-446 9 p.

Research output: Contribution to journalArticle

2019

Biosynthesis and Chemical Applications of Thioamides

Mahanta, N., Szantai-Kis, D. M., Petersson, E. J. & Mitchell, D. A., Jan 1 2019, In : ACS chemical biology.

Research output: Contribution to journalArticle

Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

Dicaprio, A. J., Firouzbakht, A., Hudson, G. A. & Mitchell, D. A., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 290-297 8 p.

Research output: Contribution to journalArticle

Mechanistic Basis for Ribosomal Peptide Backbone Modifications

Dong, S. H., Liu, A., Mahanta, N., Mitchell, D. A. & Nair, S. K., May 22 2019, In : ACS Central Science. 5, 5, p. 842-851 10 p.

Research output: Contribution to journalArticle

Open Access

Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis

Precord, T. W., Mahanta, N. & Mitchell, D. A., Sep 20 2019, In : ACS chemical biology. 14, 9, p. 1981-1989 9 p.

Research output: Contribution to journalArticle

2018

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics

Schwalen, C. J., Hudson, G. A., Kille, B. & Mitchell, D. A., Aug 1 2018, In : Journal of the American Chemical Society. 140, 30, p. 9494-9501 8 p.

Research output: Contribution to journalArticle

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Hegemann, J. D., Schwalen, C. J., Mitchell, D. A. & Van der Donk, W. A., Jan 1 2018, In : Chemical Communications. 54, 65, p. 9007-9010 4 p.

Research output: Contribution to journalArticle

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

Mahanta, N., Liu, A., Dong, S., Nair, S. K. & Mitchell, D. A., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. 3030-3035 6 p.

Research output: Contribution to journalArticle

2017

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

Tietz, J. I., Schwalen, C. J., Patel, P. S., Maxson, T., Blair, P. M., Tai, H. C., Zakai, U. I. & Mitchell, D. A., May 1 2017, In : Nature chemical biology. 13, 5, p. 470-478 9 p.

Research output: Contribution to journalArticle

AntiSMASH 4.0 - improvements in chemistry prediction and gene cluster boundary identification

Blin, K., Wolf, T., Chevrette, M. G., Lu, X., Schwalen, C. J., Kautsar, S. A., Suarez Duran, H. G., De Los Santos, E. L. C., Kim, H. U., Nave, M., Dickschat, J. S., Mitchell, D. A., Shelest, E., Breitling, R., Takano, E., Lee, S. Y., Weber, T. & Medema, M. H., Jul 3 2017, In : Nucleic acids research. 45, W1, p. W36-W41

Research output: Contribution to journalArticle

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

Burkhart, B. J., Kakkar, N., Hudson, G. A., Van Der Donk, W. A. & Mitchell, D. A., Jun 28 2017, In : ACS Central Science. 3, 6, p. 629-638 10 p.

Research output: Contribution to journalArticle

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A. & Oldfield, E., Jun 1 2017, In : ChemBioChem. 18, 11, p. 985-991 7 p.

Research output: Contribution to journalArticle

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

Schwalen, C. J., Hudson, G. A., Kosol, S., Mahanta, N., Challis, G. L. & Mitchell, D. A., Dec 20 2017, In : Journal of the American Chemical Society. 139, 50, p. 18154-18157 4 p.

Research output: Contribution to journalArticle

Mechanism of a Class C Radical S-Adenosyl- l -methionine Thiazole Methyl Transferase

Zhang, Z., Mahanta, N., Hudson, G. A., Mitchell, D. A. & Van Der Donk, W. A., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18623-18631 9 p.

Research output: Contribution to journalArticle

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic archaea

Nayak, D. D., Mahanta, N., Mitchell, D. A. & Metcalf, W. W., Sep 7 2017, In : eLife. 6, e29218.

Research output: Contribution to journalArticle

Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis

Mahanta, N., Hudson, G. A. & Mitchell, D. A., Oct 10 2017, In : Biochemistry. 56, 40, p. 5229-5244 16 p.

Research output: Contribution to journalArticle

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis

Mahanta, N., Zhang, Z., Hudson, G. A., Van Der Donk, W. A. & Mitchell, D. A., Mar 29 2017, In : Journal of the American Chemical Society. 139, 12, p. 4310-4313 4 p.

Research output: Contribution to journalArticle

2016

Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products

Molloy, E. M., Tietz, J. I., Blair, P. M. & Mitchell, D. A., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 24, p. 6276-6290 15 p.

Research output: Contribution to journalArticle

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

Zhang, Z., Hudson, G. A., Mahanta, N., Tietz, J. I., Van der Donk, W. A. & Mitchell, D. A., Dec 7 2016, In : Journal of the American Chemical Society. 138, 48, p. 15511-15514 4 p.

Research output: Contribution to journalArticle

In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products

Deane, C. D., Burkhart, B. J., Blair, P. M., Tietz, J. I., Lin, A. & Mitchell, D. A., Aug 19 2016, In : ACS chemical biology. 11, 8, p. 2232-2243 12 p.

Research output: Contribution to journalArticle

Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane

Molohon, K. J., Blair, P. M., Park, S., Doroghazi, J. R., Maxson, T., Hershfield, J. R., Flatt, K. M., Schroeder, N. E., Ha, T. & Mitchell, D. A., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 207-220 14 p.

Research output: Contribution to journalArticle

Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins

Maxson, T., Tietz, J. I., Hudson, G. A., Guo, X. R., Tai, H. C. & Mitchell, D. A., Nov 23 2016, In : Journal of the American Chemical Society. 138, 46, p. 15157-15166 10 p.

Research output: Contribution to journalArticle

2015

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

Burkhart, B. J., Hudson, G. A., Dunbar, K. L. & Mitchell, D. A., Aug 23 2015, In : Nature chemical biology. 11, 8, p. 564-570 7 p.

Research output: Contribution to journalArticle

HIV protease inhibitors block Streptolysin S production

Maxson, T., Deane, C. D., Molloy, E. M., Cox, C. L., Markley, A. L., Lee, S. W. & Mitchell, D. A., May 15 2015, In : ACS chemical biology. 10, 5, p. 1217-1226 10 p.

Research output: Contribution to journalArticle

Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products

Dunbar, K. L., Tietz, J. I., Cox, C. L., Burkhart, B. J. & Mitchell, D. A., Jun 24 2015, In : Journal of the American Chemical Society. 137, 24, p. 7672-7677 6 p.

Research output: Contribution to journalArticle

Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family

Molloy, E. M., Casjens, S. R., Cox, C. L., Maxson, T., Ethridge, N. A., Margos, G., Fingerle, V. & Mitchell, D. A., Jul 24 2015, In : BMC microbiology. 15, 1, 141.

Research output: Contribution to journalArticle

Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

Hao, Y., Blair, P. M., Sharma, A., Mitchell, D. A. & Nair, S. K., May 15 2015, In : ACS chemical biology. 10, 5, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

Hudson, G. A., Zhang, Z., Tietz, J. I., Mitchell, D. A. & Van Der Donk, W. A., Dec 30 2015, In : Journal of the American Chemical Society. 137, 51, p. 16012-16015 4 p.

Research output: Contribution to journalArticle

Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso peptide from an understudied halophilic actinomycete

Metelev, M., Tietz, J. I., Melby, J. O., Blair, P. M., Zhu, L., Livnat, I., Severinov, K. & Mitchell, D. A., Feb 19 2015, In : Chemistry and Biology. 22, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles

Cox, C. L., Doroghazi, J. R. & Mitchell, D. A., Oct 13 2015, In : BMC genomics. 16, 1, 778.

Research output: Contribution to journalArticle

2014

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

Dunbar, K. L., Chekan, J. R., Cox, C. L., Burkhart, B. J., Nair, S. K. & Mitchell, D. A., Oct 1 2014, In : Nature chemical biology. 10, 10, p. 823-829 7 p.

Research output: Contribution to journalArticle

Nucleophilic 1,4-additions for natural product discovery

Cox, C. L., Tietz, J. I., Sokolowski, K., Melby, J. O., Doroghazi, J. R. & Mitchell, D. A., Sep 19 2014, In : ACS chemical biology. 9, 9, p. 2014-2022 9 p.

Research output: Contribution to journalArticle

Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases

Melby, J. O., Li, X. & Mitchell, D. A., Jan 21 2014, In : Biochemistry. 53, 2, p. 413-422 10 p.

Research output: Contribution to journalArticle

Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS

Zhang, Q., Ortega, M., Shi, Y., Wang, H., Melby, J. O., Tang, W., Mitchell, D. A. & Van Der Donk, W. A., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12031-12036 6 p.

Research output: Contribution to journalArticle

Undecaprenyl diphosphate synthase inhibitors: Antibacterial drug leads

Sinko, W., Wang, Y., Zhu, W., Zhang, Y., Feixas, F., Cox, C. L., Mitchell, D. A., Oldfield, E. & McCammon, J. A., Jul 10 2014, In : Journal of Medicinal Chemistry. 57, 13, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

2013

Antibacterial drug leads targeting isoprenoid biosynthesis

Zhu, W., Zhang, Y., Sinko, W., Hensler, M. E., Olson, J., Molohon, K. J., Lindert, S., Cao, R., Li, K., Wang, K., Wang, Y., Liu, Y. L., Sankovsky, A., De Oliveira, C. A. F., Mitchell, D. A., Nizet, V., McCammon, J. A. & Oldfield, E., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168

Hu, Y., Jia, S., Ren, F., Huang, C. H., Ko, T. P., Mitchell, D. A., Guo, R. T. & Zheng, Y., Jan 1 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 77-79 3 p.

Research output: Contribution to journalArticle

Engineering unnatural variants of plantazolicin through codon reprogramming

Deane, C. D., Melby, J. O., Molohon, K. J., Susarrey, A. R. & Mitchell, D. A., Sep 20 2013, In : ACS chemical biology. 8, 9, p. 1998-2008 11 p.

Research output: Contribution to journalArticle

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis

Lee, J., Hao, Y., Blair, P. M., Melby, J. O., Agarwal, V., Burkhart, B. J., Nair, S. K. & Mitchell, D. A., Aug 6 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12954-12959 6 p.

Research output: Contribution to journalArticle

Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase

Sharma, A., Blair, P. M. & Mitchell, D. A., Oct 4 2013, In : Organic Letters. 15, 19, p. 5076-5079 4 p.

Research output: Contribution to journalArticle

2012

HIV-1 integrase inhibitor-inspired antibacterials targeting isoprenoid biosynthesis

Zhang, Y., Lin, F. Y., Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V. & Oldfield, E., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 402-406 5 p.

Research output: Contribution to journalArticle

Selectivity, directionality, and promiscuity in peptide processing from a bacillus sp. Al Hakam cyclodehydratase

Melby, J. O., Dunbar, K. L., Trinh, N. Q. & Mitchell, D. A., Mar 21 2012, In : Journal of the American Chemical Society. 134, 11, p. 5309-5316 8 p.

Research output: Contribution to journalArticle

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

Dunbar, K. L., Melby, J. O. & Mitchell, D. A., Jun 2012, In : Nature chemical biology. 8, 6, p. 569-575 7 p.

Research output: Contribution to journalArticle

2011

Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1

Pei, J., Mitchell, D. A., Dixon, J. E. & Grishin, N. V., Jul 1 2011, In : Journal of Molecular Biology. 410, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle