Douglas Alan Mitchell

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Personal profile

Personal profile

Professor Mitchell received his undergraduate degree in chemistry from Carnegie Mellon University in 2002. After a short internship in medicinal chemistry at Merck Research Laboratories, he obtained his Ph.D. from the University of California, Berkeley in 2006. For postdoctoral studies, he worked with Jack Dixon at the University of California, San Diego. Professor Mitchell joined the University of Illinois faculty in 2009 and has research interests that span the interface of chemistry and biology.

To view the Mitchell Lab twitter page, see:

Research Interests

reactivity-based natural product discovery; complex molecule structural elucidation and derivatization; structure-activity relationships and mode of action determination of biomedically important compounds; natural product chemical biology: mechanistic enzymology of key biosynthetic enzymes; structure-function studies of complex small molecules; and development of bioinformatic and bioorganic methodology to accelerate the discovery of biomedically important compounds

Professional Information

Our primary objective is to use a blend of chemical and biological approaches to address the alarming rise in antibiotic resistance. In this endeavour, we seek to identify and characterize novel antibiotic compounds. Our research involves the characterization of novel natural products and employs synthetic methods to reveal both biological mode of action and structure-activity relationships. Further, we evaluate the mechanistic details of key biosynthetic enzymes for the purposes of analog generation. Taken together, our work aims to expedite the discovery of future medicines from biological sources. Of special interest are compounds that only kill pathogenic bacteria or directly target mechanisms of virulence. Unlike currently deployed antibiotics, which exclusively target essential life processes, our strategy holds great potential in delaying resistance. The Mitchell laboratory is a multidisciplinary team that draws methodology from the fields of chemical biology, organic chemistry, microbiology, pharmacology, structural biology, and bioinformatics.

For a more detailed research description see:

Honors & Awards

2015 National Fresenius Award, Phi Lambda Upsilon (National Chemistry Honor Society)
2015 Camille Dreyfus Teacher-Scholar Award
2015-2016 Helen Corley Petit Scholar (UIUC College of Liberal Arts and Sciences)
2015 Pfizer Award in Enzyme Chemistry (ACS Division of Biological Chemistry)
Tomorrow's PI: Genome Technology magazine
Packard Fellowship in Science and Engineering
NIH Director's New Innovator Award

Office Address

Department of Chemistry
University of Illinois
361 RAL, Box 22-5
600 South Mathews Avenue
Urbana, IL 61801

Office Phone

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Research Output

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Jan 1 2020, In : PLoS biology. 18, 2, e3000507.

Research output: Contribution to journalArticle

Open Access
  • Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach

    Sieber, S., Grendelmeier, S. M., Harris, L. A., Mitchell, D. A. & Gademann, K., Feb 28 2020, In : Journal of Natural Products. 83, 2, p. 438-446 9 p.

    Research output: Contribution to journalArticle

  • Biosynthesis and Chemical Applications of Thioamides

    Mahanta, N., Szantai-Kis, D. M., Petersson, E. J. & Mitchell, D. A., Jan 1 2019, In : ACS chemical biology.

    Research output: Contribution to journalArticle

  • Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

    Dicaprio, A. J., Firouzbakht, A., Hudson, G. A. & Mitchell, D. A., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 290-297 8 p.

    Research output: Contribution to journalArticle