Douglas Alan Mitchell

20052018
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Biosynthesis Chemical Compounds
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Research Output 2005 2018

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics

Schwalen, C. J., Hudson, G. A., Kille, B. & Mitchell, D. A., Aug 1 2018, In : Journal of the American Chemical Society. 140, 30, p. 9494-9501 8 p.

Research output: Contribution to journalArticle

Thioamides
bioinformatics
Antibiotics
Bioinformatics
Multigene Family

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Hegemann, J. D., Schwalen, C. J., Mitchell, D. A. & Van der Donk, W. A., Jan 1 2018, In : Chemical Communications. 54, 65, p. 9007-9010 4 p.

Research output: Contribution to journalArticle

Peptide Biosynthesis
Peptides
Proteolysis
alachlor

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

Mahanta, N., Liu, A., Dong, S., Nair, S. K. & Mitchell, D. A., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. 3030-3035 6 p.

Research output: Contribution to journalArticle

Oxidoreductases
Peptides
Mutagenesis
Proteins
Nucleotides

RiPP antibiotics: biosynthesis and engineering potential

Hudson, G. A. & Mitchell, D. A., Oct 1 2018, In : Current Opinion in Microbiology. 45, p. 61-69 9 p.

Research output: Contribution to journalReview article

Anti-Bacterial Agents
Biosynthetic Pathways
Biological Products
Peptide Synthases
Synthetic Biology

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

Tietz, J. I., Schwalen, C. J., Patel, P. S., Maxson, T., Blair, P. M., Tai, H. C., Zakai, U. I. & Mitchell, D. A., May 1 2017, In : Nature Chemical Biology. 13, 5, p. 470-478 9 p.

Research output: Contribution to journalArticle

Genome
Peptides
Citrulline
Data Mining
Multigene Family