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Research Output 1987 2019

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Article

Evaluation of a three-dimensional micromixer in a surface-based biosensor

Vijayendran, R. A., Motsegood, K. M., Beebe, D. J. & Leckband, D. E., Mar 4 2003, In : Langmuir. 19, 5, p. 1824-1828 5 p.

Research output: Contribution to journalArticle

bioinstrumentation
Biosensors
microchannels
Microchannels
evaluation

Forced detachment of the CD2-CD58 complex

Bayas, M. V., Schulten, K. & Leckband, D., Apr 1 2003, In : Biophysical journal. 84, 4, p. 2223-2233 11 p.

Research output: Contribution to journalArticle

Salts
Protein Unfolding
Proteins
Tensile Strength
Molecular Dynamics Simulation

Forced dissociation of the strand dimer interface between C-cadherin ectodomains.

Bayas, M. V., Schulten, K. & Leckband, D. E., Jun 2004, In : Mechanics & chemistry of biosystems : MCB. 1, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

Cadherins
Tryptophan
Dimers
Mutagenesis
Molecular Dynamics Simulation

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

Adherens Junctions
Catenins
Actins
helices
Cadherins

Force probe measurements of antibody-antigen interactions

Leckband, D. E., Kuhl, T. L., Wang, H. K., Müller, W., Herron, J. & Ringsdorf, H., Jan 1 2000, In : Methods. 20, 3, p. 329-340 12 p.

Research output: Contribution to journalArticle

Antigens
Antibodies
Fluorescein
Antibody Binding Sites
Immunoglobulin Fab Fragments

Forces controlling protein interactions: Theory and experiment

Leckband, D. & Sivasankar, S., Aug 1999, In : Colloids and Surfaces B: Biointerfaces. 14, 1-4, p. 83-97 15 p.

Research output: Contribution to journalArticle

proteins
Proteins
Experiments
interactions
Computational methods

Formin' cables under stress

Leckband, D., Apr 1 2013, In : Nature Cell Biology. 15, 4, p. 345-346 2 p.

Research output: Contribution to journalArticle

Actins
GTP Phosphohydrolases
Actin Cytoskeleton
Polymerization
Membranes
ship hulls
contact lenses
proteins
adsorption
monomers

Functional analysis of the structural basis of homophilic cadherin adhesion

Zhu, B., Chappuis-Flament, S., Wong, E., Jensen, I. E., Gumbiner, B. M. & Leckband, D. E., Jun 1 2003, In : Biophysical journal. 84, 6, p. 4033-4042 10 p.

Research output: Contribution to journalArticle

Cadherins
Membrane Proteins
Tandem Repeat Sequences
Cell Adhesion
Glycoproteins

Function of Tightly Bound Nucleotides on Membrane-Bound Chloroplast Coupling Factor

Leckband, D. E. & Hammes, G. G., May 1 1988, In : Biochemistry. 27, 10, p. 3629-3633 5 p.

Research output: Contribution to journalArticle

Chloroplast Proton-Translocating ATPases
Nucleotides
Adenosine Triphosphate
Membranes
Adenosine Diphosphate

Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements

Leckband, D. E., Menon, S., Rosenberg, K., Graham, S. A., Taylor, M. E. & Drickamer, K., Jul 12 2011, In : Biochemistry. 50, 27, p. 6125-6132 8 p.

Research output: Contribution to journalArticle

Distance measurement
Force measurement
Neck
Adhesion
Geometry

Grafted poly(ethylene oxide) brushes as nonfouling surface coatings

Leckband, D., Sheth, S. & Halperin, A., Jan 1 1999, In : Journal of Biomaterials Science, Polymer Edition. 10, 10, p. 1125-1147 23 p.

Research output: Contribution to journalArticle

Ethylene Oxide
Brushes
Polyethylene oxides
Adsorption
Membrane Proteins

Graphene oxide substrates with N-cadherin stimulates neuronal growth and intracellular transport

Qin, E. C., Kandel, M. E., Liamas, E., Shah, T. B., Kim, C., Kaufman, C. D., Zhang, Z. J., Popescu, G., Gillette, M. L., Leckband, D. E. & Kong, H. J., May 2019, In : Acta Biomaterialia. 90, p. 412-423 12 p.

Research output: Contribution to journalArticle

Graphite
Cadherins
Oxides
Graphene
Neurons

Heparinase I from Flavobacterium heparinum: The Role of the Cysteine Residue in Catalysis as Probed by Chemical Modification and Site-Directed Mutagenesis

Sasisekharan, R., Leckband, D., Godavarti, R., Venkataraman, G., Cooney, C. L. & Langer, R., Nov 1995, In : Biochemistry. 34, 44, p. 14441-14448 8 p.

Research output: Contribution to journalArticle

Heparin Lyase
Flavobacterium
Mutagenesis
Chemical modification
Site-Directed Mutagenesis

Heparinized magnetic nanoparticles: In-vitro assessment for biomedical applications

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Sep 5 2006, In : Advanced Functional Materials. 16, 13, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

Magnetite Nanoparticles
Magnetite nanoparticles
Nanoparticles
magnetite
nanoparticles

HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., May 1 2008, In : Biomaterials. 29, 14, p. 2270-2279 10 p.

Research output: Contribution to journalArticle

Nanospheres
Endocytosis
Magnetization
Hyaluronic acid
Cells

Higher order self-assembly of vesicles by site-specific binding

Chiruvolu, S., Walker, S., Israelachvili, J., Schmitt, F. J., Leckband, D. & Zasadzinski, J. A., Jan 1 1994, In : Science. 264, 5166, p. 1753-1756 4 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Streptavidin
Biocompatible Materials
Binding Sites
Ligands

How biology uses polymers to regulate adhesion in vivo

Leckband, D. E., Johnson, C., Perrin-Tricaud, C., Fujimoto, I. & Rutishauser, U., Sep 1 2003, In : European Cells and Materials. 6, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

Polymers
Adhesion

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58

Bayas, M. V., Kearney, A., Avramovic, A., Van Der Merwe, P. A. & Leckband, D. E., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5589-5596 8 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Molecular dynamics
Adhesion
Salts
Cell Aggregation

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions

Li, D., Zhou, J., Wang, L., Shin, M. E., Su, P., Lei, X., Kuang, H., Guo, W., Yang, H., Cheng, L., Tanaka, T. S., Leckband, D. E., Reynolds, A. B., Duan, E. & Wang, F., Nov 1 2010, In : Journal of Cell Biology. 191, 3, p. 631-644 14 p.

Research output: Contribution to journalArticle

Cadherins
Nonmuscle Myosin Type IIA
Physiological Feedback
Intercellular Junctions
Survival

Interactions between Nucleotide Binding Sites on Chloroplast Coupling Factor 1 during ATP Hydrolysis

Leckband, D. E. & Hammes, G. G., Jan 1 1987, In : Biochemistry. 26, 8, p. 2306-2312 7 p.

Research output: Contribution to journalArticle

Chloroplast Proton-Translocating ATPases
Hydrolysis
Nucleotides
Adenosine Triphosphate
Binding Sites

Interactions of poly(ethylene oxide) brushes with chemically selective surfaces

Sheth, S. R., Efremova, N. & Leckband, D. E., Aug 17 2000, In : Journal of Physical Chemistry B. 104, 32, p. 7652-7662 11 p.

Research output: Contribution to journalArticle

Ethylene Oxide
selective surfaces
brushes
Brushes
ethylene oxide
Composition effects
Van der Waals forces
Force measurement
Polyethylene glycols
Proteins

Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds?

Chowdhury, F., Na, S., Collin, O., Tay, B., Li, F., Tanaka, T., Leckband, D. E. & Wang, N., Dec 15 2008, In : Biophysical journal. 95, 12, p. 5719-5727 9 p.

Research output: Contribution to journalArticle

Rheology
Embryonic Stem Cells
Mechanical Stress
Molecular Dynamics Simulation
Mechanics

Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions

Shashikanth, N., Kisting, M. A. & Leckband, D. E., Mar 24 2016, In : Scientific reports. 6, 23623.

Research output: Contribution to journalArticle

Intercellular Junctions
Cadherins
Proteins
Adhesives
Wound Healing

Lifetime measurements reveal kinetic differences between homophilic cadherin bonds

Bayas, M. V., Leung, A., Evans, E. & Leckband, D. E., Feb 2006, In : Biophysical journal. 90, 4, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Cell Communication
Spectrum Analysis

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers

Barry, A. K., Wang, N. & Leckband, D. E., Jan 1 2015, In : Journal of cell science. 128, 7, p. 1341-1351 11 p.

Research output: Contribution to journalArticle

Actomyosin
Intercellular Junctions
Cytoskeleton
Endothelium
Endothelial Cells

Long-range attraction and molecular rearrangements in receptor-ligand interactions

Leckband, D. E., Israelachvili, J. N., Schmitt, F. J. & Knoll, W., Jan 1 1992, In : Science. 255, 5050, p. 1419-1421 3 p.

Research output: Contribution to journalArticle

Ligands
Transition Temperature
Membranes
Proteins

Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and micro stamped poly lysine

Branch, D. W., Wheeler, B. C., Brewer, G. J. & Leckband, D. E., Dec 1 2000, In : IEEE Transactions on Biomedical Engineering. 47, 3, p. 290-300 11 p.

Research output: Contribution to journalArticle

Polyethylene glycols
Neurons
Substrates
Molecules
Amino acids

Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture

Branch, D. W., Wheeler, B. C., Brewer, G. J. & Leckband, D. E., Apr 2 2001, In : Biomaterials. 22, 10, p. 1035-1047 13 p.

Research output: Contribution to journalArticle

Cell culture
Polyethylene glycols
Cell Culture Techniques
Substrates
Ellipsometry
Ethylene Glycol
Polymers
Streptavidin
Proteins
Protein Denaturation

Measurements of conformational changes during adhesion of lipid and protein (polylysine and S‐layer) surfaces

Leckband, D., Chen, YL. L., Israelachvili, J., Wickman, H. H., Fletcher, M. & Zimmerman, R., Jun 20 1993, In : Biotechnology and bioengineering. 42, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Polylysine
Lipids
Adhesion
Humidity
Proteins

Measurements of interbilayer forces and protein adsorption on uncharged lipid bilayers displaying poly(ethylene glycol) chains

Efremova, N. V., Bondurant, B., O'Brien, D. F. & Leckband, D. E., Mar 28 2000, In : Biochemistry. 39, 12, p. 3441-3451 11 p.

Research output: Contribution to journalArticle

Lipid bilayers
Ethylene Glycol
Lipid Bilayers
Liposomes
Polyethylene glycols

Measuring traction forces in long-term cell cultures

Mann, C. & Leckband, D., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

Cell Culture
Force measurement
Traction
Polyacrylates
Cell culture

Mechanism and dynamics of cadherin adhesion

Leckband, D. E. & Prakasam, A., Sep 7 2006, In : Annual Review of Biomedical Engineering. 8, p. 259-287 29 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Tissue
Cell adhesion
Biochemical Phenomena

Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility

Johnson, C. P., Fujimoto, I., Perrin-Tricaud, C., Rutishauser, U. & Leckband, D. E., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 6963-6968 6 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Adhesives
Extracellular Space
Fibronectins
Immunoglobulins

Memory in receptor-ligand-mediated cell adhesion

Zarnitsyna, V. I., Huang, J., Zhang, F., Chien, Y. H., Leckband, D. & Zhu, C., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18037-18042 6 p.

Research output: Contribution to journalArticle

Cell Adhesion
Ligands
Statistical Data Interpretation
Aptitude
Cadherins

Modulation of interaction forces between bilayers exposing short-chained ethylene oxide headgroups

Kuhl, T. L., Leckband, D. E., Lasic, D. D. & Israelachvili, J. N., Jan 1 1994, In : Biophysical journal. 66, 5, p. 1479-1488 10 p.

Research output: Contribution to journalArticle

Ethylene Oxide
Lipids
Liposomes
Polymers
Mononuclear Phagocyte System

Molecular forces between membranes displaying neutral glycosphingolipids: Evidence for carbohydrate attraction

Yu, Z. W., Calvert, T. L. & Leckband, D. E., Feb 10 1998, In : Biochemistry. 37, 6, p. 1540-1550 11 p.

Research output: Contribution to journalArticle

Neutral Glycosphingolipids
Lactosylceramides
Carbohydrates
Glycolipids
Membranes

Molecular level characterization of microenvironmental influences on the properties of immobilized proteins

Yeung, C. & Leckband, D., Dec 10 1997, In : Langmuir. 13, 25, p. 6746-6754 9 p.

Research output: Contribution to journalArticle

Immobilized Proteins
proteins
Proteins
Electrostatics
Cytochromes b5

Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion

Leckband, D., Müller, W., Schmitt, F. J. & Ringsdorf, H., Jan 1 1995, In : Biophysical journal. 69, 3, p. 1162-1169 8 p.

Research output: Contribution to journalArticle

Membranes
Adhesives
Streptavidin
Tensile Strength
Ligands

Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Leckband, D., May 1 2004, In : Journal of Adhesion. 80, 5, p. 409-432 24 p.

Research output: Contribution to journalArticle

Force measurement
Surface measurement
Cell adhesion
adhesion
proteins

Multiple-bond kinetics from single-molecule pulling experiments: Evidence for multiple NCAM bonds

Hukkanen, E. J., Wieland, J. A., Gewirth, A., Leckband, D. E. & Braatz, R. D., Nov 2005, In : Biophysical journal. 89, 5, p. 3434-3445 12 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Proteins
Rupture
single bond

Nanoscale mechanics guides cellular decision making

Rahil, Z., Pedron, S., Wang, X., Ha, T., Harley, B. & Leckband, D., Sep 2016, In : Integrative Biology (United Kingdom). 8, 9, p. 929-935 7 p.

Research output: Contribution to journalArticle

Mechanics
Decision Making
Decision making
Stiffness
Substrates

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways

Ouyang, M., Lu, S., Kim, T., Chen, C. E., Seong, J., Leckband, D. E., Wang, F., Reynolds, A. B., Schwartz, M. A. & Wang, Y., Apr 10 2013, In : Nature communications. 4, 1589.

Research output: Contribution to journalArticle

Catenins
1-Phosphatidylinositol 4-Kinase
Cadherins
Phosphatidylinositols
myosins

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

Kruse, K., Lee, Q. S., Sun, Y., Klomp, J., Yang, X., Huang, F., Sun, M. Y., Zhao, S., Hong, Z., Vogel, S. M., Shin, J. W., Leckband, D. E., Tai, L. M., Malik, A. B. & Komarova, Y. A., Jan 1 2019, In : Journal of Cell Biology. 218, 1, p. 299-316 18 p.

Research output: Contribution to journalArticle

Adherens Junctions
Cadherins
Permeability
Pericytes
Endothelial Cells

N-glycosylation alters cadherin-mediated intercellular binding kinetics

Langer, M. D., Guo, H., Shashikanth, N., Pierce, J. M. & Leckband, D. E., Aug 14 2012, In : Journal of cell science. 125, 10, p. 2478-2485 8 p.

Research output: Contribution to journalArticle

Cadherins
Glycosylation
Mutation
Dermatoglyphics
Oncogenes
Force measurement
Polysaccharides
Adhesion
Drug Delivery Systems
Lectins

Optical and direct force measurements of the interactions between monolayers of aromatic macrocycles on surfactant monolayers

Lavrik, N. & Leckband, D. E., Feb 22 2000, In : Langmuir. 16, 4, p. 1842-1851 10 p.

Research output: Contribution to journalArticle

Force measurement
Surface-Active Agents
Monolayers
Surface active agents
Coloring Agents

pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery

Zhu, X., DeGraaf, J., Winnik, F. M. & Leckband, D., Nov 23 2004, In : Langmuir. 20, 24, p. 10648-10656 9 p.

Research output: Contribution to journalArticle

Drug delivery
delivery
copolymers
drugs
Mucins