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Research Output 1987 2019

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2010

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner

Le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D. & De Rooij, J., Jun 28 2010, In : Journal of Cell Biology. 189, 7, p. 1107-1115 9 p.

Research output: Contribution to journalArticle

Myosin Type II
Vinculin
Adherens Junctions
Cadherins
Actins
2009

Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

Menon, S., Rosenberg, K., Graham, S. A., Ward, E. M., Taylor, M. E., Drickamer, K. & Leckband, D. E., Jul 14 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 28, p. 11524-11529 6 p.

Research output: Contribution to journalArticle

Binding Sites
Ligands
Polysaccharides
Carbohydrates
Lipid Bilayers

Cadherin and integrin regulation of epithelial cell migration

Silvestre, J., Kenis, P. J. A. & Leckband, D. E., Sep 1 2009, In : Langmuir. 25, 17, p. 10092-10099 8 p.

Research output: Contribution to journalArticle

Cadherins
Integrins
Adhesion
adhesion
cells

Elasticity and rupture of a multi-domain neural cell adhesion molecule complex

Maruthamuthu, V., Schulten, K. J. & Leckband, D. E., Jan 1 2009, In : Biophysical journal. 96, 8, p. 3005-3014 10 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Elasticity
Rupture
Molecular Dynamics Simulation
Nervous System
2008

Beyond structure: Mechanism and dynamics of intercellular adhesion

Leckband, D. E., Apr 1 2008, In : Biochemical Society Transactions. 36, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Kinetics
Structural Models
Cell adhesion

Biophysical properties of cadherin bonds do not predict cell sorting

Shi, Q., Chien, Y. H. & Leckband, D., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28454-28463 10 p.

Research output: Contribution to journalArticle

Cadherins
Sorting
Cells
Adhesion
Cell Aggregation

HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., May 1 2008, In : Biomaterials. 29, 14, p. 2270-2279 10 p.

Research output: Contribution to journalArticle

Nanospheres
Endocytosis
Magnetization
Hyaluronic acid
Cells

Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds?

Chowdhury, F., Na, S., Collin, O., Tay, B., Li, F., Tanaka, T., Leckband, D. E. & Wang, N., Dec 15 2008, In : Biophysical journal. 95, 12, p. 5719-5727 9 p.

Research output: Contribution to journalArticle

Rheology
Embryonic Stem Cells
Mechanical Stress
Molecular Dynamics Simulation
Mechanics

Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region

Chien, Y. H., Jiang, N., Li, F., Zhang, F., Zhu, C. & Leckband, D. E., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 1848-1856 9 p.

Research output: Contribution to journalArticle

Cadherins
Kinetics
Xenopus
Adhesion
Binding Sites
2007

Dissecting subsecond cadherin bound states reveals an efficient way for cells to achieve ultrafast probing of their environment

Pierres, A., Prakasam, A., Touchard, D., Benoliel, A. M., Bongrand, P. & Leckband, D. E., May 1 2007, In : FEBS Letters. 581, 9, p. 1841-1846 6 p.

Research output: Contribution to journalArticle

Cadherins
Ligands
Lymphocyte Function-Associated Antigen-1
Lymphocytes
Chemotaxis

End-grafted low-melecular-weight PNIPAM does not collapse above the LCST

Zhu, X., Yan, C., Winnik, F. M. & Leckband, D. E., Jan 2 2007, In : Langmuir. 23, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

low weight
Polymers
Temperature
temperature
molecular weight

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58

Bayas, M. V., Kearney, A., Avramovic, A., Van Der Merwe, P. A. & Leckband, D. E., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5589-5596 8 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Molecular dynamics
Adhesion
Salts
Cell Aggregation

Memory in receptor-ligand-mediated cell adhesion

Zarnitsyna, V. I., Huang, J., Zhang, F., Chien, Y. H., Leckband, D. E. & Zhu, C., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18037-18042 6 p.

Research output: Contribution to journalArticle

Cell Adhesion
Ligands
Statistical Data Interpretation
Aptitude
Cadherins

Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Apr 2 2007, In : Macromolecular Rapid Communications. 28, 7, p. 816-821 6 p.

Research output: Contribution to journalArticle

Nanospheres
Polypyrroles
Hyaluronic acid
Hyaluronic Acid
Surface-Active Agents

Synthesis and functionalization of polypyrrole-Fe3O4 nanoparticles for applications in biomedicine

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Jul 31 2007, In : Journal of Materials Chemistry. 17, 31, p. 3354-3362 9 p.

Research output: Contribution to journalArticle

Polypyrroles
Nanoparticles
Cells
Folic Acid
Polyvinyl Alcohol

Variably elastic hydrogel patterned via capillary action in microchannels

Dong, R., Jensen, T. W., Engberg, K., Nuzzo, R. G. & Leckband, D. E., Jan 30 2007, In : Langmuir. 23, 3, p. 1483-1488 6 p.

Research output: Contribution to journalArticle

Hydrogels
Hydrogel
microchannels
Microchannels
Gels
2006

Calcium site mutations in cadherin: Impact on adhesion and evidence of cooperativity

Prakasam, A., Chien, Y. H., Maruthamuthu, V. & Leckband, D. E., Jun 6 2006, In : Biochemistry. 45, 22, p. 6930-6939 10 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Calcium
Mutation
Proteins

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Gunawan, R. C., Silvestre, J., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4250-4258 9 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Laminin
polarity
proteins
Proteins

Dynamic strength of molecularly bonded surfaces

Li, F. & Leckband, D. E., Dec 12 2006, In : Journal of Chemical Physics. 125, 19, 194702.

Research output: Contribution to journalArticle

Kinetics
Adhesives
adhesives
kinetics
Relaxation time

Heparinized magnetic nanoparticles: In-vitro assessment for biomedical applications

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Sep 5 2006, In : Advanced Functional Materials. 16, 13, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

Magnetite Nanoparticles
Magnetite nanoparticles
Nanoparticles
magnetite
nanoparticles

Lifetime measurements reveal kinetic differences between homophilic cadherin bonds

Bayas, M. V., Leung, A., Evans, E. & Leckband, D. E., Feb 2006, In : Biophysical journal. 90, 4, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Cell Communication
Spectrum Analysis

Mechanism and dynamics of cadherin adhesion

Leckband, D. E. & Prakasam, A., Sep 7 2006, In : Annual Review of Biomedical Engineering. 8, p. 259-287 29 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Tissue
Cell adhesion
Biochemical Phenomena

PNIPAM chain collapse depends on the molecular weight and grafting density

Plunkett, K. N., Zhu, X., Moore, J. S. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4259-4266 8 p.

Research output: Contribution to journalArticle

molecular weight
Molecular weight
initiators
Polymers
polymers

Similarities between heterophilic and homophilic cadherin adhesion

Prakasam, A. K., Maruthamuthu, V. & Leckband, D. E., Oct 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 42, p. 15434-15439 6 p.

Research output: Contribution to journalArticle

Cadherins
Cell Separation
Proteins
Xenopus
Morphogenesis

Synthesis and characterization of an electroactive surface that releases γ-aminobutyric acid (GABA)

Yan, C., Matsuda, W., Pepperberg, D. R., Zimmerman, S. C. & Leckband, D. E., Apr 1 2006, In : Journal of Colloid And Interface Science. 296, 1, p. 165-177 13 p.

Research output: Contribution to journalArticle

Aminobutyrates
quinones
gamma-Aminobutyric Acid
Self assembled monolayers
acids
2005

Direct evidence that Neural Cell Adhesion Molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion

Johnson, C. P., Fujimoto, I., Rutishauser, U. & Leckband, D. E., Jan 7 2005, In : Journal of Biological Chemistry. 280, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Adhesion
Cadherins
Cell adhesion
Ionic strength

Multiple-bond kinetics from single-molecule pulling experiments: Evidence for multiple NCAM bonds

Hukkanen, E. J., Wieland, J. A., Gewirth, A., Leckband, D. E. & Braatz, R. D., Nov 2005, In : Biophysical journal. 89, 5, p. 3434-3445 12 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Proteins
Rupture
single bond

Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins

Gunawan, R. C., Choban, E. R., Conour, J. E., Silvestre, J., Schook, L. B., Gaskins, H. R., Leckband, D. E. & Kenis, P. J. A., Mar 29 2005, In : Langmuir. 21, 7, p. 3061-3068 8 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
cultured cells
counters
Cytology
Immobilized Proteins
Neural Cell Adhesion Molecules
Adhesion
Molecules
Rupture
Nerve Tissue

Single-molecule measurements of the impact of lipid phase behavior on anchor strengths

Wieland, J. A., Gewirth, A. A. & Leckband, D. E., Mar 31 2005, In : Journal of Physical Chemistry B. 109, 12, p. 5985-5993 9 p.

Research output: Contribution to journalArticle

Phase behavior
Anchors
Lipids
lipids
Molecules

Structural studies of the neural-cell-adhesion molecule by X-ray and neutron reflectivity

Johnson, C. P., Fragneto, G., Konovalov, O., Dubosclard, V., Legrand, J. F. & Leckband, D. E., Jan 18 2005, In : Biochemistry. 44, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Neutrons
X-Rays
X rays
Ionic strength
2004

Forced dissociation of the strand dimer interface between C-cadherin ectodomains.

Bayas, M. V., Schulten, K. & Leckband, D. E., Jun 2004, In : Mechanics & chemistry of biosystems : MCB. 1, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

Cadherins
Tryptophan
Dimers
Mutagenesis
Molecular Dynamics Simulation

Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility

Johnson, C. P., Fujimoto, I., Perrin-Tricaud, C., Rutishauser, U. & Leckband, D. E., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 6963-6968 6 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Adhesives
Extracellular Space
Fibronectins
Immunoglobulins

Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Leckband, D. E., May 1 2004, In : Journal of Adhesion. 80, 5, p. 409-432 24 p.

Research output: Contribution to journalArticle

Force measurement
Surface measurement
Cell adhesion
adhesion
proteins

pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery

Zhu, X., DeGraaf, J., Winnik, F. M. & Leckband, D., Nov 23 2004, In : Langmuir. 20, 24, p. 10648-10656 9 p.

Research output: Contribution to journalArticle

Drug delivery
delivery
copolymers
drugs
Mucins

Structural and functional optical imaging of three-dimensional engineered tissue development

Tan, W., Sendemir-Urkmez, A., Fahrner, L. J., Jamison, R., Leckband, D. & Boppart, S. A., Jan 1 2004, In : Tissue Engineering. 10, 11-12, p. 1747-1756 10 p.

Research output: Contribution to journalArticle

Tissue
Imaging techniques
Optical tomography
Confocal microscopy
Structural dynamics

Tuning the Interfacial Properties of Grafted Chains with a pH Switch

Zhu, X., DeGraaf, J., Winnik, F. M. & Leckband, D., Feb 17 2004, In : Langmuir. 20, 4, p. 1459-1465 7 p.

Research output: Contribution to journalArticle

Polymer films
Glycine
Amino acids
Polymers
switches
2003

Engineered protein A for the orientational control of immobilized proteins

Johnson, C. P., Jensen, I. E., Prakasam, A., Vijayendran, R. & Leckband, D. E., Sep 1 2003, In : Bioconjugate Chemistry. 14, 5, p. 974-978 5 p.

Research output: Contribution to journalArticle

Immobilized Proteins
Staphylococcal Protein A
Histidine
Proteins
Ligands

Evaluation of a three-dimensional micromixer in a surface-based biosensor

Vijayendran, R. A., Motsegood, K. M., Beebe, D. J. & Leckband, D. E., Mar 4 2003, In : Langmuir. 19, 5, p. 1824-1828 5 p.

Research output: Contribution to journalArticle

bioinstrumentation
Biosensors
microchannels
Microchannels
evaluation

Forced detachment of the CD2-CD58 complex

Bayas, M. V., Schulten, K. J. & Leckband, D. E., Apr 1 2003, In : Biophysical journal. 84, 4, p. 2223-2233 11 p.

Research output: Contribution to journalArticle

Salts
Protein Unfolding
Proteins
Tensile Strength
Molecular Dynamics Simulation

Functional analysis of the structural basis of homophilic cadherin adhesion

Zhu, B., Chappuis-Flament, S., Wong, E., Jensen, I. E., Gumbiner, B. M. & Leckband, D. E., Jun 1 2003, In : Biophysical journal. 84, 6, p. 4033-4042 10 p.

Research output: Contribution to journalArticle

Cadherins
Membrane Proteins
Tandem Repeat Sequences
Cell Adhesion
Glycoproteins

How biology uses polymers to regulate adhesion in vivo

Leckband, D. E., Johnson, C., Perrin-Tricaud, C., Fujimoto, I. & Rutishauser, U., Sep 1 2003, In : European Cells and Materials. 6, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

Polymers
Adhesion
2002

Direct measurement of interactions between tethered poly(ethylene glycol) chains and adsorbed mucin layers

Efremova, N. V., Huang, Y., Peppas, N. A. & Leckband, D. E., Feb 5 2002, In : Langmuir. 18, 3, p. 836-845 10 p.

Research output: Contribution to journalArticle

Mucins
Polyethylene glycols
glycols
ethylene
attraction

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48

Zhu, B., Davies, E. A., Van der Merwe, P. A., Calvert, T. & Leckband, D. E., Oct 8 2002, In : Biochemistry. 41, 40, p. 12163-12170 8 p.

Research output: Contribution to journalArticle

Membrane Proteins
Adhesion
Proteins
Protein Unfolding
Static Electricity

X-ray reflectivity investigations of two-dimensional assemblies of C-cadherins: First steps in structural and functional studies

Martel, L., Johnson, C., Boutet, S., Al-Kurdi, R., Konovalov, O., Robinson, I., Leckband, D. E. & Legrand, J. F., Jul 1 2002, In : Journal De Physique. IV : JP. 12, 6

Research output: Contribution to journalArticle

Cadherins
assemblies
proteins
Proteins
reflectance
2001

A quantitative assessment of heterogeneity for surface-immobilized proteins

Vijayendran, R. A. & Leckband, D. E., Feb 1 2001, In : Analytical chemistry. 73, 3, p. 471-480 10 p.

Research output: Contribution to journalArticle

Immobilized Proteins
Kinetics
Antibodies
Fiber optics
Trinitrotoluene

Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold

Zhu, B., Eurell, T., Gunawan, R. & Leckband, D., Sep 5 2001, In : Journal of Biomedical Materials Research. 56, 3, p. 406-416 11 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Self assembled monolayers
Ethylene glycol
Chain length
Gold

Development and characterization of an ELISA assay in PDMS microfluidic channels

Eteshola, E. & Leckband, D. E., Jan 25 2001, In : Sensors and Actuators, B: Chemical. 72, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

immunoassay
Microfluidics
Assays
sheep
Adsorption

Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains

Sivasankar, S., Gumbiner, B. & Leckband, D. E., Jan 1 2001, In : Biophysical journal. 80, 4, p. 1758-1768 11 p.

Research output: Contribution to journalArticle

Cadherins
Adhesives
Proteins
Transducers
Rupture

Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture

Branch, D. W., Wheeler, B. C., Brewer, G. J. & Leckband, D. E., Apr 2 2001, In : Biomaterials. 22, 10, p. 1035-1047 13 p.

Research output: Contribution to journalArticle

Cell culture
Polyethylene glycols
Cell Culture Techniques
Substrates
Ellipsometry