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2010

Measuring traction forces in long-term cell cultures

Mann, C. & Leckband, D., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner

Le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D. & De Rooij, J., Jun 28 2010, In : Journal of Cell Biology. 189, 7, p. 1107-1115 9 p.

Research output: Contribution to journalArticle

2009

Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

Menon, S., Rosenberg, K., Graham, S. A., Ward, E. M., Taylor, M. E., Drickamer, K. & Leckband, D. E., Jul 14 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 28, p. 11524-11529 6 p.

Research output: Contribution to journalArticle

Cadherin and integrin regulation of epithelial cell migration

Silvestre, J., Kenis, P. J. A. & Leckband, D. E., Sep 1 2009, In : Langmuir. 25, 17, p. 10092-10099 8 p.

Research output: Contribution to journalArticle

Elasticity and rupture of a multi-domain neural cell adhesion molecule complex

Maruthamuthu, V., Schulten, K. & Leckband, D., Jan 1 2009, In : Biophysical journal. 96, 8, p. 3005-3014 10 p.

Research output: Contribution to journalArticle

2008

Beyond structure: Mechanism and dynamics of intercellular adhesion

Leckband, D. E., Apr 1 2008, In : Biochemical Society Transactions. 36, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Biophysical properties of cadherin bonds do not predict cell sorting

Shi, Q., Chien, Y. H. & Leckband, D., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28454-28463 10 p.

Research output: Contribution to journalArticle

HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., May 1 2008, In : Biomaterials. 29, 14, p. 2270-2279 10 p.

Research output: Contribution to journalArticle

Is cell rheology governed by nonequilibrium-to-equilibrium transition of noncovalent bonds?

Chowdhury, F., Na, S., Collin, O., Tay, B., Li, F., Tanaka, T., Leckband, D. E. & Wang, N., Dec 15 2008, In : Biophysical journal. 95, 12, p. 5719-5727 9 p.

Research output: Contribution to journalArticle

Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region

Chien, Y. H., Jiang, N., Li, F., Zhang, F., Zhu, C. & Leckband, D. E., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 1848-1856 9 p.

Research output: Contribution to journalArticle

2007

Dissecting subsecond cadherin bound states reveals an efficient way for cells to achieve ultrafast probing of their environment

Pierres, A., Prakasam, A., Touchard, D., Benoliel, A. M., Bongrand, P. & Leckband, D., May 1 2007, In : FEBS Letters. 581, 9, p. 1841-1846 6 p.

Research output: Contribution to journalArticle

End-grafted low-melecular-weight PNIPAM does not collapse above the LCST

Zhu, X., Yan, C., Winnik, F. M. & Leckband, D. E., Jan 2 2007, In : Langmuir. 23, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58

Bayas, M. V., Kearney, A., Avramovic, A., Van Der Merwe, P. A. & Leckband, D. E., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5589-5596 8 p.

Research output: Contribution to journalArticle

Memory in receptor-ligand-mediated cell adhesion

Zarnitsyna, V. I., Huang, J., Zhang, F., Chien, Y. H., Leckband, D. & Zhu, C., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18037-18042 6 p.

Research output: Contribution to journalArticle

Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Apr 2 2007, In : Macromolecular Rapid Communications. 28, 7, p. 816-821 6 p.

Research output: Contribution to journalArticle

Synthesis and functionalization of polypyrrole-Fe3O4 nanoparticles for applications in biomedicine

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Jul 31 2007, In : Journal of Materials Chemistry. 17, 31, p. 3354-3362 9 p.

Research output: Contribution to journalArticle

Variably elastic hydrogel patterned via capillary action in microchannels

Dong, R., Jensen, T. W., Engberg, K., Nuzzo, R. G. & Leckband, D. E., Jan 30 2007, In : Langmuir. 23, 3, p. 1483-1488 6 p.

Research output: Contribution to journalArticle

2006

Calcium site mutations in cadherin: Impact on adhesion and evidence of cooperativity

Prakasam, A., Chien, Y. H., Maruthamuthu, V. & Leckband, D. E., Jun 6 2006, In : Biochemistry. 45, 22, p. 6930-6939 10 p.

Research output: Contribution to journalArticle

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Gunawan, R. C., Silvestre, J., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4250-4258 9 p.

Research output: Contribution to journalArticle

Dynamic strength of molecularly bonded surfaces

Li, F. & Leckband, D., Dec 12 2006, In : Journal of Chemical Physics. 125, 19, 194702.

Research output: Contribution to journalArticle

Heparinized magnetic nanoparticles: In-vitro assessment for biomedical applications

Wuang, S. C., Neoh, K. G., Kang, E. T., Pack, D. W. & Leckband, D. E., Sep 5 2006, In : Advanced Functional Materials. 16, 13, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

Lifetime measurements reveal kinetic differences between homophilic cadherin bonds

Bayas, M. V., Leung, A., Evans, E. & Leckband, D., Feb 2006, In : Biophysical journal. 90, 4, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Mechanism and dynamics of cadherin adhesion

Leckband, D. E. & Prakasam, A., Sep 7 2006, In : Annual Review of Biomedical Engineering. 8, p. 259-287 29 p.

Research output: Contribution to journalArticle

PNIPAM chain collapse depends on the molecular weight and grafting density

Plunkett, K. N., Zhu, X., Moore, J. S. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4259-4266 8 p.

Research output: Contribution to journalArticle

Similarities between heterophilic and homophilic cadherin adhesion

Prakasam, A. K., Maruthamuthu, V. & Leckband, D. E., Oct 17 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 42, p. 15434-15439 6 p.

Research output: Contribution to journalArticle

Synthesis and characterization of an electroactive surface that releases γ-aminobutyric acid (GABA)

Yan, C., Matsuda, W., Pepperberg, D. R., Zimmerman, S. C. & Leckband, D. E., Apr 1 2006, In : Journal of Colloid And Interface Science. 296, 1, p. 165-177 13 p.

Research output: Contribution to journalArticle

2005

Direct evidence that Neural Cell Adhesion Molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion

Johnson, C. P., Fujimoto, I., Rutishauser, U. & Leckband, D. E., Jan 7 2005, In : Journal of Biological Chemistry. 280, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Multiple-bond kinetics from single-molecule pulling experiments: Evidence for multiple NCAM bonds

Hukkanen, E. J., Wieland, J. A., Gewirth, A., Leckband, D. E. & Braatz, R. D., Nov 2005, In : Biophysical journal. 89, 5, p. 3434-3445 12 p.

Research output: Contribution to journalArticle

Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins

Gunawan, R. C., Choban, E. R., Conour, J. E., Silvestre, J., Schook, L. B., Gaskins, H. R., Leckband, D. E. & Kenis, P. J. A., Mar 29 2005, In : Langmuir. 21, 7, p. 3061-3068 8 p.

Research output: Contribution to journalArticle

Single-molecule measurements of the impact of lipid phase behavior on anchor strengths

Wieland, J. A., Gewirth, A. A. & Leckband, D. E., Mar 31 2005, In : Journal of Physical Chemistry B. 109, 12, p. 5985-5993 9 p.

Research output: Contribution to journalArticle

Structural studies of the neural-cell-adhesion molecule by X-ray and neutron reflectivity

Johnson, C. P., Fragneto, G., Konovalov, O., Dubosclard, V., Legrand, J. F. & Leckband, D. E., Jan 18 2005, In : Biochemistry. 44, 2, p. 546-554 9 p.

Research output: Contribution to journalArticle

2004

Forced dissociation of the strand dimer interface between C-cadherin ectodomains.

Bayas, M. V., Schulten, K. & Leckband, D., Jun 2004, In : Mechanics & chemistry of biosystems : MCB. 1, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility

Johnson, C. P., Fujimoto, I., Perrin-Tricaud, C., Rutishauser, U. & Leckband, D. E., May 4 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 18, p. 6963-6968 6 p.

Research output: Contribution to journalArticle

Molecular mechanisms of cell adhesion: New perspectives from surface force measurements

Leckband, D., May 1 2004, In : Journal of Adhesion. 80, 5, p. 409-432 24 p.

Research output: Contribution to journalArticle

pH-dependent mucoadhesion of a poly(N-isopropylacrylamide) copolymer reveals design rules for drug delivery

Zhu, X., DeGraaf, J., Winnik, F. M. & Leckband, D., Nov 23 2004, In : Langmuir. 20, 24, p. 10648-10656 9 p.

Research output: Contribution to journalArticle

Structural and functional optical imaging of three-dimensional engineered tissue development

Tan, W., Sendemir-Urkmez, A., Fahrner, L. J., Jamison, R., Leckband, D. & Boppart, S. A., Jan 1 2004, In : Tissue Engineering. 10, 11-12, p. 1747-1756 10 p.

Research output: Contribution to journalArticle

Tuning the Interfacial Properties of Grafted Chains with a pH Switch

Zhu, X., DeGraaf, J., Winnik, F. M. & Leckband, D., Feb 17 2004, In : Langmuir. 20, 4, p. 1459-1465 7 p.

Research output: Contribution to journalArticle

2003

Engineered protein A for the orientational control of immobilized proteins

Johnson, C. P., Jensen, I. E., Prakasam, A., Vijayendran, R. & Leckband, D. E., Sep 1 2003, In : Bioconjugate Chemistry. 14, 5, p. 974-978 5 p.

Research output: Contribution to journalArticle

Evaluation of a three-dimensional micromixer in a surface-based biosensor

Vijayendran, R. A., Motsegood, K. M., Beebe, D. J. & Leckband, D. E., Mar 4 2003, In : Langmuir. 19, 5, p. 1824-1828 5 p.

Research output: Contribution to journalArticle

Forced detachment of the CD2-CD58 complex

Bayas, M. V., Schulten, K. & Leckband, D., Apr 1 2003, In : Biophysical journal. 84, 4, p. 2223-2233 11 p.

Research output: Contribution to journalArticle

Functional analysis of the structural basis of homophilic cadherin adhesion

Zhu, B., Chappuis-Flament, S., Wong, E., Jensen, I. E., Gumbiner, B. M. & Leckband, D., Jun 1 2003, In : Biophysical journal. 84, 6, p. 4033-4042 10 p.

Research output: Contribution to journalArticle

How biology uses polymers to regulate adhesion in vivo

Leckband, D. E., Johnson, C., Perrin-Tricaud, C., Fujimoto, I. & Rutishauser, U., Sep 1 2003, In : European Cells and Materials. 6, SUPPL. 1, 1 p.

Research output: Contribution to journalArticle

2002

Direct measurement of interactions between tethered poly(ethylene glycol) chains and adsorbed mucin layers

Efremova, N. V., Huang, Y., Peppas, N. A. & Leckband, D. E., Feb 5 2002, In : Langmuir. 18, 3, p. 836-845 10 p.

Research output: Contribution to journalArticle

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48

Zhu, B., Davies, E. A., Van der Merwe, P. A., Calvert, T. & Leckband, D. E., Oct 8 2002, In : Biochemistry. 41, 40, p. 12163-12170 8 p.

Research output: Contribution to journalArticle

X-ray reflectivity investigations of two-dimensional assemblies of C-cadherins: First steps in structural and functional studies

Martel, L., Johnson, C., Boutet, S., Al-Kurdi, R., Konovalov, O., Robinson, I., Leckband, D. & Legrand, J. F., Jul 1 2002, In : Journal De Physique. IV : JP. 12, 6, p. Pr6-365-Pr6-377

Research output: Contribution to journalArticle

2001

A quantitative assessment of heterogeneity for surface-immobilized proteins

Vijayendran, R. A. & Leckband, D. E., Feb 1 2001, In : Analytical chemistry. 73, 3, p. 471-480 10 p.

Research output: Contribution to journalArticle

Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold

Zhu, B., Eurell, T., Gunawan, R. & Leckband, D., Sep 5 2001, In : Journal of Biomedical Materials Research. 56, 3, p. 406-416 11 p.

Research output: Contribution to journalArticle

Development and characterization of an ELISA assay in PDMS microfluidic channels

Eteshola, E. & Leckband, D., Jan 25 2001, In : Sensors and Actuators, B: Chemical. 72, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains

Sivasankar, S., Gumbiner, B. & Leckband, D., Jan 1 2001, In : Biophysical journal. 80, 4, p. 1758-1768 11 p.

Research output: Contribution to journalArticle