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Research Output 1987 2019

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4-4-20 Anti-Fluorescyl IgG Fab’ Recognition of Membrane Bound Hapten: Direct Evidence for the Role of Protein and Interfacial Structure

Leckband, D. E., Kuhl, T., Wang, H. K., Herron, J., Muller, W. & Ringsdorf, H., Sep 1995, In : Biochemistry. 34, 36, p. 11467-11478 12 p.

Research output: Contribution to journalArticle

Haptens
Static Electricity
Fluorescein
Membranes
Membrane Proteins

Acid-sensitive magnetic nanoparticles as potential drug depots

Wuang, S. C., Neoh, K. G., Kang, E. T., Leckband, D. E. & Pack, D. W., Jun 1 2011, In : AIChE Journal. 57, 6, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Temperature
Acids
Pharmaceutical Preparations
Doxorubicin

A Computational Model for Kinetic Studies of Cadherin Binding and Clustering

Chen, J., Newhall, J., Xie, Z. R., Leckband, D. E. & Wu, Y., Oct 4 2016, In : Biophysical journal. 111, 7, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

Cadherins
Cluster Analysis
Glycosylation
Cell Adhesion
Adhesives

A computational reaction-diffusion model for the analysis of transport- limited kinetics

Vijayendran, R. A., Ligler, F. S. & Leckband, D. E., Dec 1 1999, In : Analytical chemistry. 71, 23, p. 5405-5412 8 p.

Research output: Contribution to journalArticle

Biosensors
Kinetics
Trinitrotoluene
Trinitrobenzenes
Antibodies

A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing

Choi, S., Camp, S. M., Dan, A., Garcia, J. G. N., Dudek, S. M. & Leckband, D. E., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 9, p. L983-L994

Research output: Contribution to journalArticle

Cortactin
Pseudopodia
Acute Lung Injury
Wound Healing
Single Nucleotide Polymorphism

Allosteric cross talk between cadherin extracellular domains

Shi, Q., Maruthamuthu, V., Li, F. & Leckband, D. E., Jul 7 2010, In : Biophysical journal. 99, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

Cadherins
Atomic Force Microscopy
Sequence Deletion
Point Mutation
Binding Sites

Allosteric regulation of E-cadherin adhesion

Shashikanth, N., Petrova, Y. I., Park, S., Chekan, J., Maiden, S., Spano, M., Ha, T., Gumbiner, B. M. & Leckband, D. E., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21749-21761 13 p.

Research output: Contribution to journalArticle

Allosteric Regulation
Cadherins
Adhesion
Tissue
Cell Aggregation

An approach for the stable immobilization of proteins

Leckband, D. & Langer, R., Feb 5 1991, In : Biotechnology and bioengineering. 37, 3, p. 227-237 11 p.

Research output: Contribution to journalArticle

Immobilization
Heparin Lyase
Proteins
Sepharose
Immobilized Proteins

A neutron reflectivity study of polymer-modified phospholipid monolayers at the solid-solution interface: Polyethylene glycol-lipids on silane- modified substrates

Kuhl, T. L., Majewski, J., Wong, J. Y., Steinberg, S., Leckband, D. E., Israelachvili, J. N. & Smith, G. S., Nov 1998, In : Biophysical journal. 75, 5, p. 2352-2362 11 p.

Research output: Contribution to journalArticle

Silanes
Neutrons
Phospholipids
Polymers
Lipids

A quantitative assessment of heterogeneity for surface-immobilized proteins

Vijayendran, R. A. & Leckband, D. E., Feb 1 2001, In : Analytical chemistry. 73, 3, p. 471-480 10 p.

Research output: Contribution to journalArticle

Immobilized Proteins
Kinetics
Antibodies
Fiber optics
Trinitrotoluene

Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand

Parreira, P., Shi, Q., Magalhaes, A., Reis, C. A., Bugaytsova, J., Borén, T., Leckband, D. E. & Martins, M. C. L., Dec 6 2014, In : Journal of the Royal Society Interface. 11, 101, 20141040.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Antigens
Blood Group Antigens
Helicobacter pylori
Atomic force microscopy

Beyond structure: Mechanism and dynamics of intercellular adhesion

Leckband, D. E., Apr 1 2008, In : Biochemical Society Transactions. 36, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Kinetics
Structural Models
Cell adhesion

Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

Menon, S., Rosenberg, K., Graham, S. A., Ward, E. M., Taylor, M. E., Drickamer, K. & Leckband, D. E., Jul 14 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 28, p. 11524-11529 6 p.

Research output: Contribution to journalArticle

Binding Sites
Ligands
Polysaccharides
Carbohydrates
Lipid Bilayers

Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori

Parreira, P., Magalhães, A., Reis, C. A., Borén, T., Leckband, D. E. & Martins, M. C. L., Nov 1 2013, In : Acta Biomaterialia. 9, 11, p. 8885-8893 9 p.

Research output: Contribution to journalArticle

Self assembled monolayers
Pathogens
Helicobacter pylori
Polysaccharides
Stomach

Biophysical properties of cadherin bonds do not predict cell sorting

Shi, Q., Chien, Y. H. & Leckband, D., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28454-28463 10 p.

Research output: Contribution to journalArticle

Cadherins
Sorting
Cells
Adhesion
Cell Aggregation

Biophysics of cadherin adhesion

Leckband, D. E. & Sivasankar, S., Jan 1 2014, In : Subcellular Biochemistry. 60, p. 63-88 26 p.

Research output: Contribution to journalArticle

Biophysics
Cadherins
Adhesion
Cell adhesion
Cell Adhesion

Cadherin and integrin regulation of epithelial cell migration

Silvestre, J., Kenis, P. J. A. & Leckband, D. E., Sep 1 2009, In : Langmuir. 25, 17, p. 10092-10099 8 p.

Research output: Contribution to journalArticle

Cadherins
Integrins
Adhesion
adhesion
cells

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity

Tabdili, H., Langer, M., Shi, Q., Poh, Y. C., Wang, N. & Leckband, D., Dec 1 2012, In : Journal of cell science. 125, 18, p. 4362-4371 10 p.

Research output: Contribution to journalArticle

Cadherins
Ligands
Intercellular Junctions
Mechanics
Ligation

Cadherin Diffusion in Supported Lipid Bilayers Exhibits Calcium-Dependent Dynamic Heterogeneity

Cai, Y., Shashikanth, N., Leckband, D. E. & Schwartz, D. K., Dec 20 2016, In : Biophysical journal. 111, 12, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Lipid Bilayers
Cadherins
Calcium
Lipids
Adhesives

Cadherin Extracellular Domain Clustering in the Absence of Trans-Interactions

Thompson, C. J., Vu, V. H., Leckband, D. E. & Schwartz, D. K., Aug 15 2019, In : Journal of Physical Chemistry Letters. 10, 16, p. 4528-4534 7 p.

Research output: Contribution to journalArticle

Cadherins
Oligomers
Oligomerization
oligomers
Molecules

Cadherin point mutations alter cell sorting and modulate GTPase signaling

Tabdili, H., Barry, A. K., Langer, M. D., Chien, Y. H., Shi, Q., Lee, K. J., Lu, S. & Leckband, D. E., Jul 15 2012, In : Journal of cell science. 125, 14, p. 3299-3309 11 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Cadherins
Point Mutation
Cell Separation
Xenopus

Calcium site mutations in cadherin: Impact on adhesion and evidence of cooperativity

Prakasam, A., Chien, Y. H., Maruthamuthu, V. & Leckband, D. E., Jun 6 2006, In : Biochemistry. 45, 22, p. 6930-6939 10 p.

Research output: Contribution to journalArticle

Cadherins
Adhesion
Calcium
Mutation
Proteins

Cell migration and polarity on microfabricated gradients of extracellular matrix proteins

Gunawan, R. C., Silvestre, J., Gaskins, H. R., Kenis, P. J. A. & Leckband, D. E., Apr 25 2006, In : Langmuir. 22, 9, p. 4250-4258 9 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Laminin
polarity
proteins
Proteins

Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold

Zhu, B., Eurell, T., Gunawan, R. & Leckband, D., Sep 5 2001, In : Journal of Biomedical Materials Research. 56, 3, p. 406-416 11 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Self assembled monolayers
Ethylene glycol
Chain length
Gold

Cold and hot denaturation of polysoaps

Leckband, D. E., Borisov, O. V. & Halperin, A., Apr 7 1998, In : Macromolecules. 31, 7, p. 2368-2374 7 p.

Research output: Contribution to journalArticle

Denaturation
Polymers
Proteins
Amphiphiles
Water

Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors

Wang, X., Rahil, Z., Li, I. T. S., Chowdhury, F., Leckband, D. E., Chemla, Y. R. & Ha, T., Feb 15 2016, In : Scientific reports. 6, 21584.

Research output: Contribution to journalArticle

Ligands
Proteins
Cadherins
P-Selectin
Gravitation

Cytochrome c recognition of immobilized, orientational variants of cytochrome b5: Direct force and equilibrium binding measurements

Yeung, C., Purves, T., Kloss, A. A., Kuhl, T. L., Sligar, S. & Leckband, D. E., Sep 28 1999, In : Langmuir. 15, 20, p. 6829-6836 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
cytochromes
Cytochromes c
Force measurement
Proteins
Force measurement
Cell adhesion
Adhesion
Proteins
Pathogens

Development and characterization of an ELISA assay in PDMS microfluidic channels

Eteshola, E. & Leckband, D. E., Jan 25 2001, In : Sensors and Actuators, B: Chemical. 72, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

immunoassay
Microfluidics
Assays
sheep
Adsorption

Direct evidence that Neural Cell Adhesion Molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion

Johnson, C. P., Fujimoto, I., Rutishauser, U. & Leckband, D. E., Jan 7 2005, In : Journal of Biological Chemistry. 280, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Adhesion
Cadherins
Cell adhesion
Ionic strength

Direct force measurements of polymerization-dependent changes in the properties of diacetylene films

Sheth, S. R. & Leckband, D. E., Oct 15 1997, In : Langmuir. 13, 21, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

Force measurement
polymerization
Polymerization
Contact angle
Polymers

Direct Force Measurements of Specific and Nonspecific Protein Interactions

Leckband, D. E., Schmitt, F. J., Israelachvili, J. N. & Knoll, W., Apr 1 1994, In : Biochemistry. 33, 15, p. 4611-4624 14 p.

Research output: Contribution to journalArticle

Streptavidin
Force measurement
Biotin
Ligands
Temperature

Direct Imaging of Protein Stability and Folding Kinetics in Hydrogels

Kisley, L., Serrano, K. A., Guin, D., Kong, X., Gruebele, M. & Leckband, D. E., Jul 5 2017, In : ACS Applied Materials and Interfaces. 9, 26, p. 21606-21617 12 p.

Research output: Contribution to journalArticle

Hydrogels
Proteins
Imaging techniques
Kinetics
Hydrogel

Direct measurement of interactions between tethered poly(ethylene glycol) chains and adsorbed mucin layers

Efremova, N. V., Huang, Y., Peppas, N. A. & Leckband, D. E., Feb 5 2002, In : Langmuir. 18, 3, p. 836-845 10 p.

Research output: Contribution to journalArticle

Mucins
Polyethylene glycols
glycols
ethylene
attraction

Direct measurement of polyethylene glycol induced depletion attraction between lipid bilayers

Kuhl, T., Guo, Y., Alderfer, J. L., Berman, A. D., Leckband, D. E., Israelachvili, J. & Hui, S. W., Jun 12 1996, In : Langmuir. 12, 12, p. 3003-3014 12 p.

Research output: Contribution to journalArticle

Lipid bilayers
Polyethylene glycols
attraction
lipids
glycols

Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48

Zhu, B., Davies, E. A., Van der Merwe, P. A., Calvert, T. & Leckband, D. E., Oct 8 2002, In : Biochemistry. 41, 40, p. 12163-12170 8 p.

Research output: Contribution to journalArticle

Membrane Proteins
Adhesion
Proteins
Protein Unfolding
Static Electricity

Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains

Sivasankar, S., Gumbiner, B. & Leckband, D. E., Jan 1 2001, In : Biophysical journal. 80, 4, p. 1758-1768 11 p.

Research output: Contribution to journalArticle

Cadherins
Adhesives
Proteins
Transducers
Rupture

Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains

Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B. & Leckband, D., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 11820-11824 5 p.

Research output: Contribution to journalArticle

Cadherins
Adhesives
Proteins
Xenopus
Rupture

Direct molecular level measurements of the electrostatic properties of a protein surface

Sivasankar, S., Subramaniam, S. & Leckband, D., Oct 27 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 22, p. 12961-12966 6 p.

Research output: Contribution to journalArticle

Static Electricity
Membrane Proteins
Streptavidin
Proteins

Dissecting subsecond cadherin bound states reveals an efficient way for cells to achieve ultrafast probing of their environment

Pierres, A., Prakasam, A., Touchard, D., Benoliel, A. M., Bongrand, P. & Leckband, D. E., May 1 2007, In : FEBS Letters. 581, 9, p. 1841-1846 6 p.

Research output: Contribution to journalArticle

Cadherins
Ligands
Lymphocyte Function-Associated Antigen-1
Lymphocytes
Chemotaxis

Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity

Dan, A., Huang, R. B. & Leckband, D. E., Dec 1 2016, In : Annals of Biomedical Engineering. 44, 12, p. 3655-3667 13 p.

Research output: Contribution to journalArticle

Stiffness
Imaging techniques
Monolayers
Substrates
Membranes

Dynamic strength of molecularly bonded surfaces

Li, F. & Leckband, D. E., Dec 12 2006, In : Journal of Chemical Physics. 125, 19, 194702.

Research output: Contribution to journalArticle

Kinetics
Adhesives
adhesives
kinetics
Relaxation time

Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states

Kim, T. J., Zheng, S., Sun, J., Muhamed, I., Wu, J., Lei, L., Kong, X., Leckband, D. E. & Wang, Y., Jan 19 2015, In : Current Biology. 25, 2, p. 218-224 7 p.

Research output: Contribution to journalArticle

Catenins
cadherins
Conformations
Visualization
intercellular junctions

E-cadherin-mediated force transduction signals regulate global cell mechanics

Muhamed, I., Wu, J., Sehgal, P., Kong, X., Tajik, A., Wang, N. & Leckband, D. E., May 1 2016, In : Journal of cell science. 129, 9, p. 1843-1854 12 p.

Research output: Contribution to journalArticle

Cadherins
Mechanics
Signal Transduction
Catenins
1-Phosphatidylinositol 4-Kinase

Effect of surface chemistry on bacterial adhesion, viability, and morphology

Parreira, P., Magalhaes, A., Gonaçalves, I. C., Gomes, J., Vidal, R., Reis, C. A., Leckband, D. E. & Martins, M. C. L., Dec 1 2011, In : Journal of Biomedical Materials Research - Part A. 99 A, 3, p. 344-353 10 p.

Research output: Contribution to journalArticle

Surface chemistry
Adhesion
Self assembled monolayers
Bacteria
Functional groups

Effect of the microenvironment on the recognition of immobilized cytochromes by soluble redox proteins

Kloss, A. A., Lavrik, N., Yeung, C. & Leckband, D. E., Apr 4 2000, In : Langmuir. 16, 7, p. 3414-3421 8 p.

Research output: Contribution to journalArticle

Streptavidin
cytochromes
Cytochromes
Monolayers
proteins

Elasticity and rupture of a multi-domain neural cell adhesion molecule complex

Maruthamuthu, V., Schulten, K. J. & Leckband, D. E., Jan 1 2009, In : Biophysical journal. 96, 8, p. 3005-3014 10 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecules
Elasticity
Rupture
Molecular Dynamics Simulation
Nervous System

End-grafted low-melecular-weight PNIPAM does not collapse above the LCST

Zhu, X., Yan, C., Winnik, F. M. & Leckband, D. E., Jan 2 2007, In : Langmuir. 23, 1, p. 162-169 8 p.

Research output: Contribution to journalArticle

low weight
Polymers
Temperature
temperature
molecular weight

Engineered protein A for the orientational control of immobilized proteins

Johnson, C. P., Jensen, I. E., Prakasam, A., Vijayendran, R. & Leckband, D. E., Sep 1 2003, In : Bioconjugate Chemistry. 14, 5, p. 974-978 5 p.

Research output: Contribution to journalArticle

Immobilized Proteins
Staphylococcal Protein A
Histidine
Proteins
Ligands

Epidermal growth factor receptor and integrins control forcedependent vinculin recruitment to E-cadherin junctions

Sehgal, P., Kong, X., Wu, J., Sunyer, R., Trepat, X. & Leckband, D. E., Mar 1 2018, In : Journal of cell science. 131, 6, jcs206656.

Research output: Contribution to journalArticle

Vinculin
Cadherins
Epidermal Growth Factor Receptor
Integrins
1-Phosphatidylinositol 4-Kinase