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Research Output 1987 2019

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2019

Cadherin Extracellular Domain Clustering in the Absence of Trans-Interactions

Thompson, C. J., Vu, V. H., Leckband, D. E. & Schwartz, D. K., Aug 15 2019, In : Journal of Physical Chemistry Letters. 10, 16, p. 4528-4534 7 p.

Research output: Contribution to journalArticle

Cadherins
Oligomers
Oligomerization
oligomers
Molecules

Graphene oxide substrates with N-cadherin stimulates neuronal growth and intracellular transport

Qin, E. C., Kandel, M. E., Liamas, E., Shah, T. B., Kim, C., Kaufman, C. D., Zhang, Z. J., Popescu, G., Gillette, M. L., Leckband, D. E. & Kong, H. J., May 2019, In : Acta Biomaterialia. 90, p. 412-423 12 p.

Research output: Contribution to journalArticle

Graphite
Cadherins
Oxides
Graphene
Neurons

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

Kruse, K., Lee, Q. S., Sun, Y., Klomp, J., Yang, X., Huang, F., Sun, M. Y., Zhao, S., Hong, Z., Vogel, S. M., Shin, J. W., Leckband, D. E., Tai, L. M., Malik, A. B. & Komarova, Y. A., Jan 1 2019, In : Journal of Cell Biology. 218, 1, p. 299-316 18 p.

Research output: Contribution to journalArticle

Adherens Junctions
Cadherins
Permeability
Pericytes
Endothelial Cells

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism

Juettner, V. V., Kruse, K., Dan, A., Vu, V. H., Khan, Y., Le, J., Leckband, D. E., Komarova, Y. & Malik, A. B., May 1 2019, In : Journal of Cell Biology. 218, 5, p. 1725-1742 18 p.

Research output: Contribution to journalArticle

Open Access
Class 3 Receptor-Like Protein Tyrosine Phosphatases
Phosphoric Monoester Hydrolases
Adherens Junctions
Blood Vessels
Rho Guanine Nucleotide Exchange Factors
2018

Epidermal growth factor receptor and integrins control forcedependent vinculin recruitment to E-cadherin junctions

Sehgal, P., Kong, X., Wu, J., Sunyer, R., Trepat, X. & Leckband, D. E., Mar 1 2018, In : Journal of cell science. 131, 6, jcs206656.

Research output: Contribution to journalArticle

Vinculin
Cadherins
Epidermal Growth Factor Receptor
Integrins
1-Phosphatidylinositol 4-Kinase

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

Adherens Junctions
Catenins
Actins
helices
Cadherins

Salt bridges gate ?-catenin activation at intercellular junctions

Barrick, S., Li, J., Kong, X., Ray, A., Tajkhorshid, E. & Leckband, D., Jan 15 2018, In : Molecular biology of the cell. 29, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Catenins
Intercellular Junctions
Salts
Vinculin
Cadherins

Soluble Zwitterionic Poly(sulfobetaine) Destabilizes Proteins

Kisley, L., Serrano, K. A., Davis, C. M., Guin, D., Murphy, E. A., Gruebele, M. H. W. & Leckband, D. E., Sep 10 2018, In : Biomacromolecules. 19, 9, p. 3894-3901 8 p.

Research output: Contribution to journalArticle

Proteins
Polymers
Polyethylene glycols
Protein folding
Tryptophan
2017

Direct Imaging of Protein Stability and Folding Kinetics in Hydrogels

Kisley, L., Serrano, K. A., Guin, D., Kong, X., Gruebele, M. & Leckband, D. E., Jul 5 2017, In : ACS Applied Materials and Interfaces. 9, 26, p. 21606-21617 12 p.

Research output: Contribution to journalArticle

Hydrogels
Proteins
Imaging techniques
Kinetics
Hydrogel

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity

Andresen Eguiluz, R. C., Kaylan, K. B., Underhill, G. H. & Leckband, D. E., Sep 2017, In : Biomaterials. 140, p. 45-57 13 p.

Research output: Contribution to journalArticle

Signal transduction
Rigidity
Monolayers
Stiffness
Signal Transduction
2016

A Computational Model for Kinetic Studies of Cadherin Binding and Clustering

Chen, J., Newhall, J., Xie, Z. R., Leckband, D. E. & Wu, Y., Oct 4 2016, In : Biophysical journal. 111, 7, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

Cadherins
Cluster Analysis
Glycosylation
Cell Adhesion
Adhesives

Cadherin Diffusion in Supported Lipid Bilayers Exhibits Calcium-Dependent Dynamic Heterogeneity

Cai, Y., Shashikanth, N., Leckband, D. E. & Schwartz, D. K., Dec 20 2016, In : Biophysical journal. 111, 12, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Lipid Bilayers
Cadherins
Calcium
Lipids
Adhesives

Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors

Wang, X., Rahil, Z., Li, I. T. S., Chowdhury, F., Leckband, D. E., Chemla, Y. R. & Ha, T., Feb 15 2016, In : Scientific reports. 6, 21584.

Research output: Contribution to journalArticle

Ligands
Proteins
Cadherins
P-Selectin
Gravitation

Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity

Dan, A., Huang, R. B. & Leckband, D. E., Dec 1 2016, In : Annals of Biomedical Engineering. 44, 12, p. 3655-3667 13 p.

Research output: Contribution to journalArticle

Stiffness
Imaging techniques
Monolayers
Substrates
Membranes

E-cadherin-mediated force transduction signals regulate global cell mechanics

Muhamed, I., Wu, J., Sehgal, P., Kong, X., Tajik, A., Wang, N. & Leckband, D. E., May 1 2016, In : Journal of cell science. 129, 9, p. 1843-1854 12 p.

Research output: Contribution to journalArticle

Cadherins
Mechanics
Signal Transduction
Catenins
1-Phosphatidylinositol 4-Kinase

Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions

Shashikanth, N., Kisting, M. A. & Leckband, D. E., Mar 24 2016, In : Scientific Reports. 6, 23623.

Research output: Contribution to journalArticle

Intercellular Junctions
Cadherins
Proteins
Adhesives
Wound Healing

Nanoscale mechanics guides cellular decision making

Rahil, Z., Pedron Haba, S., Wang, X., Ha, T., Harley, B. A. & Leckband, D. E., Sep 2016, In : Integrative Biology (United Kingdom). 8, 9, p. 929-935 7 p.

Research output: Contribution to journalArticle

Mechanics
Decision Making
Decision making
Stiffness
Substrates

Three dimensional conjugation of recombinant N-cadherin to a hydrogel for: In vitro anisotropic neural growth

Vega, J. C. M. L., Lee, M. K., Qin, E. C., Rich, M., Lee, K. Y., Kim, D. H., Chung, H. J., Leckband, D. E. & Kong, H., Jan 1 2016, In : Journal of Materials Chemistry B. 4, 42, p. 6803-6811 9 p.

Research output: Contribution to journalArticle

Hydrogel
Cadherins
Hydrogels
Gels
Neurons
2015

A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing

Choi, S., Camp, S. M., Dan, A., Garcia, J. G. N., Dudek, S. M. & Leckband, D. E., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 9, p. L983-L994

Research output: Contribution to journalArticle

Cortactin
Pseudopodia
Acute Lung Injury
Wound Healing
Single Nucleotide Polymorphism

Allosteric regulation of E-cadherin adhesion

Shashikanth, N., Petrova, Y. I., Park, S., Chekan, J., Maiden, S., Spano, M., Ha, T., Gumbiner, B. M. & Leckband, D. E., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21749-21761 13 p.

Research output: Contribution to journalArticle

Allosteric Regulation
Cadherins
Adhesion
Tissue
Cell Aggregation

Dynamic visualization of α-catenin reveals rapid, reversible conformation switching between tension states

Kim, T. J., Zheng, S., Sun, J., Muhamed, I., Wu, J., Lei, L., Kong, X., Leckband, D. E. & Wang, Y., Jan 19 2015, In : Current Biology. 25, 2, p. 218-224 7 p.

Research output: Contribution to journalArticle

Catenins
cadherins
Conformations
Visualization
intercellular junctions

Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers

Barry, A. K., Wang, N. & Leckband, D. E., Jan 1 2015, In : Journal of cell science. 128, 7, p. 1341-1351 11 p.

Research output: Contribution to journalArticle

Actomyosin
Intercellular Junctions
Cytoskeleton
Endothelium
Endothelial Cells

Structural determinants of the mechanical stability of α-Catenin

Li, J., Newhall, J., Ishiyama, N., Gottardi, C., Ikura, M., Leckband, D. E. & Tajkhorshid, E., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 18890-18903 14 p.

Research output: Contribution to journalArticle

Catenins
Mechanical stability
Cell adhesion
Molecular Dynamics Simulation
Cell Adhesion

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism

Escobar, D. J., Desai, R., Ishiyama, N., Folmsbee, S. S., Novak, M. N., Flozak, A. S., Daugherty, R. L., Mo, R., Nanavati, D., Sarpal, R., Leckband, D. E., Ikura, M., Tepass, U. & Gottardi, C. J., Jan 1 2015, In : Journal of cell science. 128, 6, p. 1150-1165 16 p.

Research output: Contribution to journalArticle

Catenins
Phosphotransferases
Phosphorylation
Cadherins
Drosophila
2014

Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand

Parreira, P., Shi, Q., Magalhaes, A., Reis, C. A., Bugaytsova, J., Borén, T., Leckband, D. E. & Martins, M. C. L., Dec 6 2014, In : Journal of the Royal Society Interface. 11, 101, 20141040.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Antigens
Blood Group Antigens
Helicobacter pylori
Atomic force microscopy

Biophysics of cadherin adhesion

Leckband, D. E. & Sivasankar, S., Jan 1 2014, In : Subcellular Biochemistry. 60, p. 63-88 26 p.

Research output: Contribution to journalArticle

Biophysics
Cadherins
Adhesion
Cell adhesion
Cell Adhesion

Recapitulating cell-cell adhesion using N-cadherin biologically tethered to substrates

Vega L., J. C. M., Lee, M. K., Jeong, J. H., Smith, C. E., Lee, K. Y., Chung, H. J., Leckband, D. E. & Kong, H., Jun 9 2014, In : Biomacromolecules. 15, 6, p. 2172-2179 8 p.

Research output: Contribution to journalArticle

Cell adhesion
Cadherins
Substrates
Adhesion
Gels

α-Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

Barry, A. K., Tabdili, H., Muhamed, I., Wu, J., Shashikanth, N., Gomez, G. A., Yap, A. S., Gottardi, C. J., De Rooij, J., Wang, N. & Leckband, D. E., 2014, In : Journal of cell science. 127, 8, p. 1779-1791 13 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Actins
Vinculin
Traction
2013

Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori

Parreira, P., Magalhães, A., Reis, C. A., Borén, T., Leckband, D. E. & Martins, M. C. L., Nov 1 2013, In : Acta Biomaterialia. 9, 11, p. 8885-8893 9 p.

Research output: Contribution to journalArticle

Self assembled monolayers
Pathogens
Helicobacter pylori
Polysaccharides
Stomach

Formin' cables under stress

Leckband, D. E., Apr 1 2013, In : Nature Cell Biology. 15, 4, p. 345-346 2 p.

Research output: Contribution to journalArticle

Actins
GTP Phosphohydrolases
Actin Cytoskeleton
Polymerization
Membranes

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways

Ouyang, M., Lu, S., Kim, T., Chen, C. E., Seong, J., Leckband, D. E., Wang, F., Reynolds, A. B., Schwartz, M. A. & Wang, Y., Apr 10 2013, In : Nature communications. 4, 1589.

Research output: Contribution to journalArticle

Catenins
1-Phosphatidylinositol 4-Kinase
Cadherins
Phosphatidylinositols
myosins

Poly(N-isopropyl acrylamide) brush topography: Dependence on grafting conditions and temperature

Choi, B. C., Choi, S. & Leckband, D. E., May 14 2013, In : Langmuir. 29, 19, p. 5841-5850 10 p.

Research output: Contribution to journalArticle

brushes
Brushes
Topography
topography
Ellipsometry

Protein adsorption mechanisms determine the efficiency of thermally controlled cell adhesion on poly(N -isopropyl acrylamide) brushes

Choi, S., Choi, B. C., Xue, C. & Leckband, D. E., Jan 14 2013, In : Biomacromolecules. 14, 1, p. 92-100 9 p.

Research output: Contribution to journalArticle

Cell adhesion
Brushes
Proteins
Adsorption
Polymers
2012

Cadherin-dependent mechanotransduction depends on ligand identity but not affinity

Tabdili, H., Langer, M., Shi, Q., Poh, Y. C., Wang, N. & Leckband, D. E., Dec 1 2012, In : Journal of Cell Science. 125, 18, p. 4362-4371 10 p.

Research output: Contribution to journalArticle

Cadherins
Ligands
Intercellular Junctions
Mechanics
Ligation

Cadherin point mutations alter cell sorting and modulate GTPase signaling

Tabdili, H., Barry, A. K., Langer, M. D., Chien, Y. H., Shi, Q., Lee, K. J., Lu, S. & Leckband, D. E., Jul 15 2012, In : Journal of Cell Science. 125, 14, p. 3299-3309 11 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Cadherins
Point Mutation
Cell Separation
Xenopus

N-glycosylation alters cadherin-mediated intercellular binding kinetics

Langer, M. D., Guo, H., Shashikanth, N., Pierce, J. M. & Leckband, D. E., Aug 14 2012, In : Journal of cell science. 125, 10, p. 2478-2485 8 p.

Research output: Contribution to journalArticle

Cadherins
Glycosylation
Mutation
Dermatoglyphics
Oncogenes

Protein adsorption modes determine reversible cell attachment on poly(N-isopropyl acrylamide) brushes

Xue, C., Choi, B. C., Choi, S., Braun, P. V. & Leckband, D. E., Jun 6 2012, In : Advanced Functional Materials. 22, 11, p. 2394-2401 8 p.

Research output: Contribution to journalArticle

brushes
Brushes
attachment
proteins
Proteins

Protein adsorption properties of OEG monolayers and dense PNIPAM brushes probed by neutron reflectivity

Brouette, N., Xue, C., Haertlein, M., Moulin, M., Fragneto, G., Leckband, D. E., Halperin, A. & Sferrazza, M., Dec 1 2012, In : European Physical Journal: Special Topics. 213, 1, p. 343-353 11 p.

Research output: Contribution to journalArticle

brushes
Brushes
Monolayers
Neutrons
proteins

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation

Twiss, F., Le Duc, Q., Van Der Horst, S., Tabdili, H., Van Der Krogt, G., Wang, N., Rehmann, H., Huveneers, S., Leckband, D. E. & De Rooij, J., Nov 15 2012, In : Biology Open. 1, 11, p. 1128-1140 13 p.

Research output: Contribution to journalArticle

Vinculin
cadherins
Cadherins
Actomyosin
Cell adhesion
2011

Acid-sensitive magnetic nanoparticles as potential drug depots

Wuang, S. C., Neoh, K. G., Kang, E. T., Leckband, D. E. & Pack, D. W., Jun 1 2011, In : AIChE Journal. 57, 6, p. 1638-1645 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Temperature
Acids
Pharmaceutical Preparations
Doxorubicin

Effect of surface chemistry on bacterial adhesion, viability, and morphology

Parreira, P., Magalhaes, A., Gonaçalves, I. C., Gomes, J., Vidal, R., Reis, C. A., Leckband, D. E. & Martins, M. C. L., Dec 1 2011, In : Journal of Biomedical Materials Research - Part A. 99 A, 3, p. 344-353 10 p.

Research output: Contribution to journalArticle

Surface chemistry
Adhesion
Self assembled monolayers
Bacteria
Functional groups

Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements

Leckband, D. E., Menon, S., Rosenberg, K., Graham, S. A., Taylor, M. E. & Drickamer, K., Jul 12 2011, In : Biochemistry. 50, 27, p. 6125-6132 8 p.

Research output: Contribution to journalArticle

Distance measurement
Force measurement
Neck
Adhesion
Geometry
Force measurement
Polysaccharides
Adhesion
Drug Delivery Systems
Lectins

Protein adsorption on poly(N -isopropylacrylamide) brushes: Dependence on grafting density and chain collapse

Xue, C., Yonet-Tanyeri, N., Brouette, N., Sferrazza, M., Braun, P. V. & Leckband, D. E., Jul 19 2011, In : Langmuir. 27, 14, p. 8810-8818 9 p.

Research output: Contribution to journalArticle

brushes
Brushes
proteins
Proteins
Adsorption

Single cell 3-D platform to study ligand mobility in cell-cell contact

Andreasson-Ochsner, M., Romano, G., Håkanson, M., Smith, M. L., Leckband, D. E., Textor, M. & Reimhult, E., Sep 7 2011, In : Lab on a Chip. 11, 17, p. 2876-2883 8 p.

Research output: Contribution to journalArticle

Cadherins
Lipid bilayers
Cell adhesion
Ligands
Cell membranes

Tissue organization by cadherin adhesion molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

Niessen, C. M., Leckband, D. E. & Yap, A. S., Apr 1 2011, In : Physiological Reviews. 91, 2, p. 691-731 41 p.

Research output: Contribution to journalArticle

Cell Physiological Phenomena
Cell Surface Receptors
Cadherins
Molecular Dynamics Simulation
Cytoskeleton
2010

Allosteric cross talk between cadherin extracellular domains

Shi, Q., Maruthamuthu, V., Li, F. & Leckband, D. E., Jul 7 2010, In : Biophysical journal. 99, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

Cadherins
Atomic Force Microscopy
Sequence Deletion
Point Mutation
Binding Sites
Force measurement
Cell adhesion
Adhesion
Proteins
Pathogens

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions

Li, D., Zhou, J., Wang, L., Shin, M. E., Su, P., Lei, X., Kuang, H., Guo, W., Yang, H., Cheng, L., Tanaka, T. S., Leckband, D. E., Reynolds, A. B., Duan, E. & Wang, F., Nov 1 2010, In : Journal of Cell Biology. 191, 3, p. 631-644 14 p.

Research output: Contribution to journalArticle

Cadherins
Nonmuscle Myosin Type IIA
Physiological Feedback
Intercellular Junctions
Survival

Measuring traction forces in long-term cell cultures

Mann, C. & Leckband, D. E., Mar 1 2010, In : Cellular and Molecular Bioengineering. 3, 1, p. 40-49 10 p.

Research output: Contribution to journalArticle

Cell Culture
Force measurement
Traction
Polyacrylates
Cell culture