David M Kranz

1975 …2019
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Research Output 1975 2019

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Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H. & Loh, D. Y., Jan 1 1988, In : Nature. 335, 6187, p. 271-274 4 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Cell Antigen Receptor Specificity
Transgenic Mice
Clone Cells
T-Lymphocytes

Sequence diversity of T cell receptor α chain transcripts from BALB/c thymus

Roth, M. E., Tjoa, B. A., Schlueter, C. J., Wilson, E. R., Lunn, B. C. & Kranz, D. M., Dec 1992, In : Molecular Immunology. 29, 12, p. 1447-1455 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thymus Gland
Genes
DNA Nucleotidylexotransferase
Immunoglobulins

Sequence restrictions in T cell receptor β-chains that have specificity for a self-peptide/Ld complex

Tjoa, B. A. & Kranz, D. M., Jul 1994, In : Molecular Immunology. 31, 10, p. 705-711 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
Cytotoxic T-Lymphocytes
Glutamic Acid
Oxidoreductases

Single-chain Fv/folate conjugates mediate efficient lysis of folate-receptor-positive tumor cells

Cho, B. K., Roy, E. J., Patrick, T. A. & Kranz, D. M., May 1 1997, In : Bioconjugate Chemistry. 8, 3, p. 338-346 9 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Folic Acid
Tumors
T-cells
Cells

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

Aggen, D. H., Chervin, A. S., Schmitt, T. M., Engels, B., Stone, J. D., Richman, S. A., Piepenbrink, K. H., Baker, B. M., Greenberg, P. D., Schreiber, H. & Kranz, D. M., Apr 1 2012, In : Gene therapy. 19, 4, p. 365-374 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
CD3 Antigens
T-Cell Receptor Genes
Virus Diseases

Solution mapping of T cell receptor docking footprints on peptide-MHC

Varani, L., Bankovich, A. J., Liu, C. W., Colf, L. A., Jones, L. L., Kranz, D. M., Puglisi, J. D. & Garcia, K. C., Aug 7 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 32, p. 13080-13085 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Peptides
T-Cell Receptor Genes
Molecular Dynamics Simulation
Cellular Immunity

Specificity and binding properties of a single-chain T cell receptor

Schlueter, C. J., Schodin, B. A., Tetin, S. Y. & Kranz, D. M., Mar 15 1996, In : Journal of Molecular Biology. 256, 5, p. 859-869 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Complementarity Determining Regions
Peptides
T-Cell Antigen Receptor Specificity

Staphylococcal superantigens cause lethal pulmonary disease in rabbits

Strandberg, K. L., Rotschafer, J. H., Vetter, S. M., Buonpane, R. A., Kranz, D. M. & Schlievert, P. M., Dec 1 2010, In : Journal of Infectious Diseases. 202, 11, p. 1690-1697 8 p.

Research output: Contribution to journalArticle

Superantigens
Lung Diseases
Methicillin Resistance
Rabbits
Lung

Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity

John, C. C., Niermann, M., Sharon, B., Peterson, M. L., Kranz, D. M. & Schlievert, P. M., Dec 1 2009, In : Clinical Infectious Diseases. 49, 12, p. 1893-1896 4 p.

Research output: Contribution to journalArticle

Exfoliative Dermatitis
Septic Shock
Hypersensitivity
Superantigens
Enterotoxins

Staphylococcus aureus isolates encode variant staphylococcal enterotoxin B proteins that are diverse in superantigenicity and lethality

Kohler, P. L., Greenwood, S. D., Nookala, S., Kotb, M., Kranz, D. M. & Schlievert, P. M., Jul 16 2012, In : PloS one. 7, 7, e41157.

Research output: Contribution to journalArticle

superantigens
septic shock
Superantigens
enterotoxins
Staphylococcus aureus

Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction

Cho, S., Swaminathan, C. P., Yang, J., Kerzic, M. C., Guan, R., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 1 2005, In : Structure. 13, 12, p. 1775-1787 13 p.

Research output: Contribution to journalArticle

Proteins
Molecular Structure
Protein Binding
X-Rays

Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1

Moza, B., Varma, A. K., Buonpane, R. A., Zhu, P., Herfst, C. A., Nicholson, M. J., Wilbuer, A. K., Seth, N. P., Wucherpfennig, K. W., McCormick, J. K., Kranz, D. M. & Sundberg, E. J., Feb 21 2007, In : EMBO Journal. 26, 4, p. 1187-1197 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
Superantigens
T-cells
T-Cell Antigen Receptor
Chemical activation

Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

Richman, S. A., Aggen, D. H., Dossett, M. L., Donermeyer, D. L., Allen, P. M., Greenberg, P. D. & Kranz, D. M., Feb 1 2009, In : Molecular Immunology. 46, 5, p. 902-916 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Yeasts
Single-Chain Antibodies
Mutation
Sequence Homology

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Adams, J. J., Narayanan, S., Birnbaum, M. E., Sidhu, S. S., Blevins, S. J., Gee, M. H., Sibener, L. V., Baker, B. M., Kranz, D. M. & Garcia, K. C., Jan 1 2016, In : Nature Immunology. 17, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
T-Lymphocytes
Antigens

Structure, organization, and somatic rearrangement of T cell gamma genes

Hayday, A. C., Saito, H., Gillies, S. D., Kranz, D. M., Tanigawa, G., Eisen, H. N. & Tonegawa, S., Feb 1985, In : Cell. 40, 2, p. 259-269 11 p.

Research output: Contribution to journalArticle

T-Lymphocyte Gene Rearrangement
T-cells
Genes
Gene Rearrangement
T-Lymphocytes

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses

Mattis, D. M., Chervin, A. S., Ranoa, D. R., Kelley, S. L., Tapping, R. I. & Kranz, D. M., May 8 2015, In : Molecular Immunology. 68, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Lipopolysaccharides
Yeasts
Proteins
Immune System

Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

Sharma, P. & Kranz, D. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 5, p. 1820-1834 15 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementarity Determining Regions
varespladib methyl
Binding Sites
Substitution reactions

Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells

Lynch, J. N., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Mar 1 2013, In : Molecular Immunology. 53, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Mutation
Peptides
T-Cell Antigen Receptor Specificity
Autoimmunity

Targeting T cells against brain tumors with a bispecific ligand-antibody conjugate

Roy, E. J., Cho, B. K., Rund, L. A., Patrick, T. A. & Kranz, D. M., Jun 10 1998, In : International Journal of Cancer. 76, 5, p. 761-766 6 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Folic Acid
Brain Neoplasms
Ligands
T-Lymphocytes

Targeting tumor cells with bispecific antibodies and T cells

Kranz, D. M., Manning, T. C., Rund, L. A., Cho, B. K., Gruber, M. M. & Roy, E. J., Apr 30 1998, In : Journal of Controlled Release. 53, 1-3, p. 77-84 8 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
T-Lymphocytes
Folic Acid
T-Cell Antigen Receptor
Neoplasms

Targeting virus entry and membrane fusion through specific peptide/MHC complexes using a high-affinity T-cell receptor

Peng, K. W., Holler, P. D., Orr, B. A., Kranz, D. M. & Russell, S. J., Aug 1 2004, In : Gene therapy. 11, 15, p. 1234-1239 6 p.

Research output: Contribution to journalArticle

Virus Internalization
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Cell Fusion

T cell receptor engineering and analysis using the yeast display platform

Smith, S. N., Harris, D. T. & Kranz, D. M., Jan 1 2015, In : Methods in Molecular Biology. 1319, p. 95-141 47 p.

Research output: Contribution to journalArticle

Cell Engineering
T-Cell Antigen Receptor
Yeasts
Antigens
Peptides

T Cell receptor rearrangements in various S49 lymphoma sublines

Johnson, N. A., Keeney, J. B., Hedayat, M., Clary, K. W., Kranz, D. M. & Hansen, T. H., Nov 1992, In : Molecular Immunology. 29, 11, p. 1325-1335 11 p.

Research output: Contribution to journalArticle

Thymoma
Gene Rearrangement
Thymocytes
T-Cell Antigen Receptor
Lymphoma

T cell receptors: Affinities, cross-reactivities, and a conformer model

Holler, P. D. & Kranz, D. M., Feb 2004, In : Molecular Immunology. 40, 14-15, p. 1027-1031 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Ligands
T-Lymphocytes
Amino Acid Sequence
Clone Cells

T cell receptors for gene transfer in adoptive T cell therapy

Sharma, P. & Kranz, D. M., Jan 1 2019, In : Critical Reviews in Immunology. 39, 2, p. 105-122 18 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Adoptive Transfer
Cell- and Tissue-Based Therapy
T-Lymphocytes
Antigen Receptors

T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex

Adams, J. J., Narayanan, S., Liu, B., Birnbaum, M. E., Kruse, A. C., Bowerman, N. A., Chen, W., Levin, A. M., Connolly, J. M., Zhu, C., Kranz, D. M. & Garcia, K. C., Nov 23 2011, In : Immunity. 35, 5, p. 681-693 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
Adaptive Immunity
Libraries

T-cell receptor δ-chain diversity in peripheral lymphocytes

Lacy, M. J., McNeil, L. K., Roth, M. E. & Kranz, D. M., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 3, p. 1023-1026 4 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thymus Gland
Lymphocytes
T-Lymphocytes
Immunoglobulin Genes

TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility

Hawse, W. F., De, S., Greenwood, A. I., Nicholson, L. K., Zajicek, J., Kovrigin, E. L., Kranz, D. M., Garcia, K. C. & Baker, B. M., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

Ligands
Peptides
Allergy and Immunology
Thermodynamics
Proteins

Tertiary and quaternary structure of the T cell receptor α β chain dimer

Novotny, J., Tonegawa, S. & Kranz, D. M., Jan 1 1985, In : Federation Proceedings. 44, 6

Research output: Contribution to journalArticle

Antigen Receptors, T-Cell, alpha-beta

The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes

Leifert, J. A., Holler, P. D., Harkins, S., Kranz, D. M. & Whitton, J. L., Dec 1 2003, In : Gene therapy. 10, 25, p. 2067-2073 7 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Epitopes
HIV
Immunization
Human Immunodeficiency Virus tat Gene Products

The central role of the antigen-specific receptor complex in triggering cytolytic activity of cytotoxic T lymphocytes

Eisen, H. N., Liu, M. A. & Kranz, D. M., Oct 1 1985, In : Bioscience Reports. 5, 10-11, p. 885-892 8 p.

Research output: Contribution to journalArticle

Clone cells
T-cells
T-Cell Antigen Receptor
Lectins
Monoclonal Antibodies

The Effect of Polymyxin B On Outer Membrane of Serratia Marcescens: Activation and Dissociation of Outer Membrane Associated Alkaline Phosphatase

Kranz, D. M., Brown, D. A. & Tsang, J. C., Jan 1 1977, In : Journal of Antibiotics. 30, 3, p. 270-271 2 p.

Research output: Contribution to journalArticle

Polymyxins
Polymyxin B
Serratia marcescens
Enzyme Activation
Alkaline Phosphatase

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

Chervin, A. S., Stone, J. D., Holler, P. D., Bai, A., Chen, J., Eisen, H. N. & Kranz, D. M., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

Antigen Presentation
T-Lymphocytes
Peptides
Gallopamil
Surface Plasmon Resonance

Thermodynamic Properties of Ligand Binding by Monoclonal Anti-fluorescyl Antibodies

Herron, J. N., Kranz, D. M., Jameson, D. M. & Voss, E. W., Aug 1986, In : Biochemistry. 25, 16, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

Thermodynamics
Anti-Idiotypic Antibodies
Thermodynamic properties
Monoclonal Antibodies
Entropy
Major Histocompatibility Complex
Polymorphism
HIV
Peptides
T-cells

The study of high-affinity TCRs reveals duality in T cell recognition of antigen: Specificity and degeneracy

Ponermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., Nov 15 2006, In : Journal of Immunology. 177, 10, p. 6911-6919 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigens
Peptides
Ligands
Moths

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

Dam, J., Guan, R., Natarajan, K., Dimasi, N., Chlewicki, L. K., Kranz, D. M., Schuck, P., Margulies, D. H. & Mariuzza, R. A., Dec 1 2003, In : Nature Immunology. 4, 12, p. 1213-1222 10 p.

Research output: Contribution to journalArticle

Natural Killer Cell Receptors
Major Histocompatibility Complex
Peptides
Peptide Receptors
Dimerization

Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency

Shusta, E. V., Kieke, M. C., Parke, E., Kranz, D. M. & Wittrup, K. D., Oct 8 1999, In : Journal of Molecular Biology. 292, 5, p. 949-956 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Hot Temperature
Yeasts
Peptides
Mutant Proteins