David M Kranz

1975 …2019
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Research Output 1975 2019

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1988

Positive and negative selection of an antigen receptor on T cells in transgenic mice

Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H. & Loh, D. Y., Jan 1 1988, In : Nature. 336, 6194, p. 73-76 4 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Transgenic Mice
T-Lymphocytes
Major Histocompatibility Complex
T-Cell Antigen Receptor Specificity

Selection of variable-joining region combinations in the α chain of the T cell receptor

Roth, M. E., Lacy, M. J., Mcneil, L. K. & Kranz, D. M., Jan 1 1988, In : Science. 241, 4871, p. 1354-1358 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thymus Gland
T-Lymphocytes
Antigen Receptors
Spleen

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

Sha, W. C., Nelson, C. A., Newberry, R. D., Kranz, D. M., Russell, J. H. & Loh, D. Y., Jan 1 1988, In : Nature. 335, 6187, p. 271-274 4 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Cell Antigen Receptor Specificity
Transgenic Mice
Clone Cells
T-Lymphocytes
1987

Recognition and lysis of target cells by cytotoxic T lymphocytes

Kranz, D. M., Pasternack, M. S. & Eisen, H. N., 1987, In : Federation Proceedings. 46, 2, p. 309-312 4 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Antigens
Antibodies
Perforin
Complement System Proteins

Resistance of cytolytic T lymphocytes to the lytic components they release

Eisen, H. N., Verret, C. R., Firmenich, A. A. & Kranz, D. M., Jan 1 1987, In : Annales de l'Institut Pasteur - Immunology. 138, 2, p. 328-331 4 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Cytoplasmic Granules
Cytotoxic T-Lymphocytes
Adenosine Triphosphate
T-Lymphocytes
Cytotoxic T-Lymphocytes
Clone Cells
Cell Line
T-Lymphocytes
Antigen Receptors

Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granules

Reynold Verret, C., Firmenich, A. A., Kranz, D. M. & Eisen, H. N., Nov 1 1987, In : Journal of Experimental Medicine. 166, 5, p. 1536-1547 12 p.

Research output: Contribution to journalArticle

Poisons
Cytotoxic T-Lymphocytes
Cell Line
Azides
Deoxyglucose
1986

A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes

Reilly, E. B., Kranz, D. M., Tonegawa, S. & Eisen, H. N., Dec 1 1986, In : Nature. 321, 6073, p. 878-880 3 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Antigens
Genes
B-Cell Antigen Receptors
Immunoglobulin Genes

A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes

Lieberman, J., Verret, C. R., Kranz, D. M., Hubbard, S. C., Saito, H., Raulet, D. H., Tonegawa, S. & Eisen, H. N., Dec 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 20, p. 7870-7874 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Disulfides
Membrane Proteins
T-Lymphocytes
Phosphorylation

Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity

Hubbard, S. C., Kranz, D. M., Longmore, G. D., Sitkovsky, M. V. & Eisen, H. N., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 6, p. 1852-1856 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Glycosylation
Lectins
Cytotoxic T-Lymphocytes
Clone Cells

Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains

Novotný, J., Tonegawa, S., Saito, H., Kranz, D. M. & Eisen, H. N., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 3, p. 742-746 5 p.

Research output: Contribution to journalArticle

Immunoglobulin Subunits
T-Cell Antigen Receptor
Antibody Binding Sites
T-Lymphocytes
Antigens

Thermodynamic Properties of Ligand Binding by Monoclonal Anti-fluorescyl Antibodies

Herron, J. N., Kranz, D. M., Jameson, D. M. & Voss, E. W., Jan 1 1986, In : Biochemistry. 25, 16, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

Thermodynamics
Anti-Idiotypic Antibodies
Thermodynamic properties
Monoclonal Antibodies
Entropy
1985

Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene

Kranz, D. M., Saito, H., Disteche, C. M., Swisshelm, K., Pravtcheva, D., Ruddle, F. H., Eisen, H. N. & Tonegawa, S., Jan 1 1985, In : Science. 227, 4689, p. 941-945 5 p.

Research output: Contribution to journalArticle

T-Cell Receptor alpha Genes
Immunoglobulin Heavy Chains
T-Lymphocytes
T-Cell Receptor Genes
Multigene Family

Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants

Heilig, J. S., Glimcher, L. H., Kranz, D. M., Clayton, L. K., Greenstein, J. L., Saito, H., Maxam, A. M., Burakoff, S. J., Eisen, H. N. & Tonegawa, S., Dec 1 1985, In : Nature. 317, 6032, p. 68-70 3 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Genes
Clone Cells
Immunoglobulin Variable Region
Protein Sequence Analysis

Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes

Liu, M. A., Kranz, D. M., Kurnick, J. T., Boyle, L. A., Levy, R. & Eisen, H. N., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 24, p. 8648-8652 5 p.

Research output: Contribution to journalArticle

Heterophile Antibodies
Cytotoxic T-Lymphocytes
T-Lymphocytes
Clone Cells
Antibodies

Limited diversity of the rearranged T-cell γ gene

Kranz, D. M., Saito, H., Heller, M., Takagaki, Y., Haas, W., Eisen, H. N. & Tonegawa, S., Dec 1 1985, In : Nature. 313, 6005, p. 752-755 4 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Genes
Hybridomas
Cytotoxic T-Lymphocytes
Germ Cells

Structure, organization, and somatic rearrangement of T cell gamma genes

Hayday, A. C., Saito, H., Gillies, S. D., Kranz, D. M., Tanigawa, G., Eisen, H. N. & Tonegawa, S., Jan 1 1985, In : Cell. 40, 2, p. 259-269 11 p.

Research output: Contribution to journalArticle

T-Lymphocyte Gene Rearrangement
T-cells
Genes
Gene Rearrangement
T-Lymphocytes

Tertiary and quaternary structure of the T cell receptor α β chain dimer

Novotny, J., Tonegawa, S. & Kranz, D. M., Jan 1 1985, In : Federation Proceedings. 44, 6

Research output: Contribution to journalArticle

Antigen Receptors, T-Cell, alpha-beta

The central role of the antigen-specific receptor complex in triggering cytolytic activity of cytotoxic T lymphocytes

Eisen, H. N., Liu, M. A. & Kranz, D. M., Oct 1 1985, In : Bioscience Reports. 5, 10-11, p. 885-892 8 p.

Research output: Contribution to journalArticle

Immunologic Cytotoxicity
Antigen Receptors
Cytotoxic T-Lymphocytes
T-Cell Antigen Receptor
Lectins
1984

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

Saito, H., Kranz, D. M., Takagaki, Y., Hayday, A. C., Eisen, H. N. & Tonegawa, S., Dec 1 1984, In : Nature. 312, 5989, p. 36-40 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Clone Cells
Genes
Immunoglobulin Subunits
T-Cell Antigen Receptor
Cytotoxic T-Lymphocytes
Anti-Idiotypic Antibodies
Clone Cells
Lymphocyte Function-Associated Antigen-1
Monoclonal Antibodies

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Saito, H., Kranz, D. M., Takagaki, Y., Hayday, A. C., Eisen, H. N. & Tonegawa, S., Dec 1 1984, In : Nature. 309, 5971, p. 757-762 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Complementary DNA
Immunoglobulin Constant Regions
Clone Cells
Immunoglobulin Variable Region

Expression of structurally diverse Qa-2-encoded molecules on the surface cloned cytotoxic T lymphocytes

Sherman, D. H., Kranz, D. M. & Eisen, H. N., Nov 1 1984, In : Journal of Experimental Medicine. 160, 5, p. 1421-1430 10 p.

Research output: Contribution to journalArticle

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera

Kranz, D. M., Sherman, D. H., Sitkovsky, M. V., Pasternack, M. S. & Eisen, H. N., Jan 1 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 2 I, p. 573-577 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Immunoprecipitation
Immune Sera
Clone Cells
Antigens
1983

Expression of defined idiotypes throughout the BALB/c anti-fluorescyl antibody response: Affinity and idiotype analyses of heterogeneous antibodies

Kranz, D. M., Ballard, D. W. & Voss, E. W., Jan 1 1983, In : Molecular Immunology. 20, 12, p. 1313-1323 11 p.

Research output: Contribution to journalArticle

Antibody Affinity
Antibody Formation
Clone Cells
Monoclonal Antibodies
Antibodies

Idiotypic analysis of monoclonal anti-fluorescyl antibodies: Localization and characterization of idiotypic determinants

Kranz, D. M. & Voss, E. W., Jan 1 1983, In : Molecular Immunology. 20, 12, p. 1301-1312 12 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Clone Cells
Fluorescein
Monoclonal Antibodies
Ligands

Monoclonal IgM antibody exhibiting high-affinity binding and cryoglobulin properties.

Ballard, D. W., Kranz, D. M. & Voss, E. W., Jan 1 1983, In : Proceedings of the National Academy of Sciences of the United States of America. 80, 16, p. 5071-5074 4 p.

Research output: Contribution to journalArticle

Cryoglobulins
Immunoglobulin M
Monoclonal Antibodies
Secondary Immunization
Temperature
1982

Affinity maturation of NZB and BALB/cV mice anti-fluorescyl response

Jarvis, M. R., Casperson, G. F., Kranz, D. M. & Voss, E. W., Jan 1 1982, In : Molecular Immunology. 19, 4, p. 525-533 9 p.

Research output: Contribution to journalArticle

New Zealand
Immunoglobulins
Secondary Immunization
Fluorescein
Immunization

Mechanisms of ligand binding by monoclonal anti-fluorescyl antibodies.

Kranz, D. M., Herron, J. N. & Voss, E. W., Jun 25 1982, In : Journal of Biological Chemistry. 257, 12, p. 6987-6995 9 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Monoclonal Antibodies
Ligands
Fluorescein
Catalytic Domain
1981

Kinetics and mechanism of deuterium oxide-induced fluorescence enhancement of fluorescyl ligand bound to specific heterogeneous and homogeneous antibodies

Kranz, D. M., Herron, J. N., Giannis, D. E. & Voss, E. W., 1981, In : Journal of Biological Chemistry. 256, 9, p. 4433-4438 6 p.

Research output: Contribution to journalArticle

Fluoresceins
Inbred BALB C Mouse
Deuterium Oxide
Immunoelectrophoresis
Cell Fusion
Antibody Affinity
Haptens
Hybridomas
Fluorescein
Anti-Idiotypic Antibodies
Fluoresceins
Immunoglobulin gamma-Chains
Antibody Diversity
Immunoglobulin kappa-Chains
Antibody Binding Sites
1980

Modified hybridoma methodology: Antigen-directed chemically mediated cell fusion

Kranz, D. M., Herron, J. N., Billing, P. A. & Voss, E. W., Jan 1 1980, In : Immunological Investigations. 9, 7, p. 639-651 13 p.

Research output: Contribution to journalArticle

Cell Fusion
Hybridomas
Antigens
Ligands
Population
1977

The Effect of Polymyxin B On Outer Membrane of Serratia Marcescens: Activation and Dissociation of Outer Membrane Associated Alkaline Phosphatase

Kranz, D. M., Brown, D. A. & Tsang, J. C., Jan 1 1977, In : Journal of Antibiotics. 30, 3, p. 270-271 2 p.

Research output: Contribution to journalArticle

Polymyxins
Polymyxin B
Serratia marcescens
Enzyme Activation
Alkaline Phosphatase
1976

Detection of lipopolysaccharide components in isolated outer membranes of Serratia marcescens

Tsang, J. C., Brown, D. A. & Kranz, D. M., Jan 1 1976, In : Microbios Letters. 1, 3-4, p. 209-217 9 p.

Research output: Contribution to journalArticle

Serratia marcescens
Lipopolysaccharides
Carbocyanines
Membranes
Coloring Agents

Effect of saline on the releasability of alkaline phosphatase from cells of Serratia marcescens

Kranz, D. M. & Tsang, J. C., 1976, In : Microbios. 15, 61-62, p. 165-175 11 p.

Research output: Contribution to journalArticle

Bacterial Polysaccharides
Polymyxins
Species Specificity
Serratia marcescens
Bacterial Proteins
1975

Alkaline phosphatases from clinical and non clinical strains of Serratia marcescens grown in two types of media

Kranz, D. M., Page, L. V. & Tsang, J. C., Jan 1 1975, In : Microbios. 14, 58, p. 183-193 11 p.

Research output: Contribution to journalArticle

Serratia marcescens
Alkaline Phosphatase
Phosphates
Polymyxin B
Molecular Weight