David M Kranz

1975 …2019
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Research Output 1975 2019

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Design and characterization of a protein superagonist of IL-15 fused with IL-15Rα and a high-affinity T cell receptor

Stone, J. D., Chervin, A. S., Schreiber, H. & Kranz, D. M., Nov 1 2012, In : Biotechnology Progress. 28, 6, p. 1588-1597 10 p.

Research output: Contribution to journalArticle

Interleukin-15
T-Cell Antigen Receptor
Cytokines
Proteins
Cross-Priming

Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses

Chervin, A. S., Stone, J. D., Soto, C. M., Engels, B., Schreiber, H., Roy, E. J. & Kranz, D. M., Jun 1 2013, In : Gene therapy. 20, 6, p. 634-644 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Tumor-Infiltrating Lymphocytes
Neoplasm Antigens
Neoplasms

Detection of lipopolysaccharide components in isolated outer membranes of Serratia marcescens

Tsang, J. C., Brown, D. A. & Kranz, D. M., Jan 1 1976, In : Microbios Letters. 1, 3-4, p. 209-217 9 p.

Research output: Contribution to journalArticle

Serratia marcescens
Lipopolysaccharides
Carbocyanines
Membranes
Coloring Agents

Determination of the role of aromatic residues in the binding pocket of an antibody that binds a sweetener lioand

Harris, J. S., Brodnicki, T. C., Kranz, D. M. & Linthicum, D. S., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Sweetening Agents
sweeteners
aromatic compounds
Quenching
His-His-His-His-His-His

Development and applications of surface-linked single chain antibodies against T-cell antigens

Griffin, M. D., Holman, P. O., Tang, Q., Ashourian, N., Korthäuer, U., Kranz, D. M. & Bluestone, J. A., Feb 1 2001, In : Journal of Immunological Methods. 248, 1-2, p. 77-90 14 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Viral Tumor Antigens
T-Lymphocytes
Product Packaging
Mutagenesis

Development of a novel strategy for engineering high-affinity proteins by yeast display

Richman, S. A., Healan, S. J., Weber, K. S., Donermeyer, D. L., Dossett, M. L., Greenberg, P. D., Allen, P. M. & Kranz, D. M., Jun 1 2006, In : Protein Engineering, Design and Selection. 19, 6, p. 255-264 10 p.

Research output: Contribution to journalArticle

Fungal Proteins
T-cells
Yeast
T-Cell Antigen Receptor
Yeasts

Differences in antigen recognition and cytolytic activity of CD8+ and CD8- T cells that express the same antigen-specific receptor

Cho, B. K., Lian, K. C., Lee, P., Brunmark, A., McKinley, C., Chen, J., Kranz, D. M. & Eisen, H. N., Feb 13 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 4, p. 1723-1727 5 p.

Research output: Contribution to journalArticle

Antigen Receptors
T-Lymphocytes
Antigens
T-Cell Antigen Receptor
Peptides

Differences in crystal properties and ligand affinities of an antifluorescyl fab (4‐4‐20) in two solvent systems

Gibson, A. L., Herron, J. N., He, X. M., Patrick, V. A., Mason, M. L., Lin, J. N., Kranz, D. M., Voss, E. W. & Edmundson, A. B., 1988, In : Proteins: Structure, Function, and Bioinformatics. 3, 3, p. 155-160 6 p.

Research output: Contribution to journalArticle

Fluorescein
Ligands
Crystals
Immunoglobulin Fab Fragments
Antibody Affinity

Different strategies adopted by Kb and Ld to generate T cell specificity directed against their respective bound peptides

Bowerman, N. A., Colf, L. A., Garcia, K. C. & Kranz, D. M., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32551-32561 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor Specificity
T-cells
Histocompatibility
T-Cell Antigen Receptor
Peptides

Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors

Jones, L. L., Colf, L. A., Bankovich, A. J., Stone, J. D., Gao, Y. G., Choi, M. C., Huang, R. H., Garcia, K. C. & Kranz, D. M., Nov 25 2008, In : Biochemistry. 47, 47, p. 12398-12408 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thermodynamics
Peptides
Complementarity Determining Regions
Mutagenesis

Directed evolution of a single-chain class II MHC product by yeast display

Starwalt, S. E., Mastellela, E. L., Bluestone, J. A. & Kranz, D. M., Feb 1 2003, In : Protein Engineering. 16, 2, p. 147-156 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Yeast
T-cells
Yeasts
Display devices

Directed evolution of a stable scaffold for T-cell receptor engineering

Shusta, E. V., Holler, P. D., Kieke, M. C., Kranz, D. M. & Wittrup, K. D., Jul 1 2000, In : Nature Biotechnology. 18, 7, p. 754-759 6 p.

Research output: Contribution to journalArticle

Cell Engineering
T-cells
T-Cell Antigen Receptor
Scaffolds
Major Histocompatibility Complex

Directed evolution of T-cell receptors for binding superantigens.

Churchill, H. R. O. & Kranz, D. M., 2003, In : Methods in molecular biology (Clifton, N.J.). 214, p. 87-99 13 p.

Research output: Contribution to journalArticle

Directed Molecular Evolution
Superantigens
T-Cell Antigen Receptor
Saccharomyces cerevisiae
Flow Cytometry

Dissecting Cooperative and Additive Binding Energetics in the Affinity Maturation Pathway of a Protein-Protein Interface

Yang, J., Swaminathan, C. P., Huang, Y., Guan, R., Cho, S., Kieke, M. C., Kranz, D. M., Mariuzza, R. A. & Sundberg, E. J., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50412-50421 10 p.

Research output: Contribution to journalArticle

Proteins
Mutation
Complementarity Determining Regions
Superantigens
Mutagenesis

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation

Jones, L. L., Colf, L. A., Stone, J. D., Garcia, K. C. & Kranz, D. M., Nov 1 2008, In : Journal of Immunology. 181, 9, p. 6255-6264 10 p.

Research output: Contribution to journalArticle

Ligands
Antigens
Isoantigens
T-Lymphocytes
Peptides

Disulfide bond engineering to trap peptides in the MHC class I binding groove

Truscott, S. M., Lybarger, L., Martinko, J. M., Mitaksov, V. E., Kranz, D. M., Connolly, J. M., Fremont, D. H. & Hansen, T. H., May 15 2007, In : Journal of Immunology. 178, 10, p. 6280-6289 10 p.

Research output: Contribution to journalArticle

Disulfides
Peptides
T-Lymphocytes
Endoplasmic Reticulum
Vaccination

Diversity of T cell receptor-α chain transcripts from hyperimmune alloreactive T cells

Tjoa, B. & Kranz, D. M., Jan 1 1992, In : Journal of Immunology. 149, 1, p. 253-259 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Population
Clone Cells
Lymphocytes

Effect of saline on the releasability of alkaline phosphatase from cells of Serratia marcescens

Kranz, D. M. & Tsang, J. C., Dec 1 1976, In : Microbios. 15, 61-62, p. 165-175 11 p.

Research output: Contribution to journalArticle

Bacterial Polysaccharides
Polymyxins
Species Specificity
Serratia marcescens
Bacterial Proteins
Complementarity Determining Regions
T-Cell Antigen Receptor
Major Histocompatibility Complex
Mutation
Peptides

Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli

Gruber, M., Schodin, B. A., Wilson, E. R. & Kranz, D. M., Jun 1 1994, In : Journal of Immunology. 152, 11, p. 5368-5374 7 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Single-Chain Antibodies
Fluorescein
Escherichia coli
Neoplasms

Endogenous viral antigen processing generates pepvtide-specific MHC class I cell-surface clusters

Lu, X., Gibbs, J. S., Hickman, H. D., David, A., Dolan, B. P., Jin, Y., Kranz, D. M., Bennink, J. R., Yewdell, J. W. & Varma, R., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15407-15412 6 p.

Research output: Contribution to journalArticle

Viral Antigens
Antigen Presentation
Peptides
T-Lymphocytes
Antigen-Presenting Cells

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

Posey, A. D., Schwab, R. D., Boesteanu, A. C., Steentoft, C., Mandel, U., Engels, B., Stone, J. D., Madsen, T. D., Schreiber, K., Haines, K. M., Cogdill, A. P., Chen, T. J., Song, D., Scholler, J., Kranz, D. M., Feldman, M. D., Young, R., Keith, B., Schreiber, H., Clausen, H. & 2 others, Johnson, L. A. & June, C. H., Jun 21 2016, In : Immunity. 44, 6, p. 1444-1454 11 p.

Research output: Contribution to journalArticle

Mucins
T-Cell Antigen Receptor
Adenocarcinoma
Membranes
Antigen Receptors

Engineering and characterization of a stabilized α1/α2 module of the class I major histocompatibility complex product L d

Jones, L. L., Brophy, S. E., Bankovich, A. J., Colf, L. A., Hanick, N. A., Garcia, K. C. & Kranz, D. M., Sep 1 2006, In : Journal of Biological Chemistry. 281, 35, p. 25734-25744 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Yeasts
Yeast
Proteins

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease

Mattis, D. M., Spaulding, A. R., Chuang-Smith, O. N., Sundberg, E. J., Schlievert, P. M. & Kranz, D. M., Feb 1 2013, In : Protein Engineering, Design and Selection. 26, 2, p. 133-142 10 p.

Research output: Contribution to journalArticle

T-cells
Rabbits
Proteins
Superantigens
Antibiotics

Engineering higher affinity T cell receptors using a T cell display system

Chervin, A. S., Aggen, D. H., Raseman, J. M. & Kranz, D. M., Dec 31 2008, In : Journal of Immunological Methods. 339, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Hybridomas
CD3 Antigens
Protein Engineering

Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity

Bowerman, N. A., Crofts, T. S., Chlewicki, L., Do, P., Baker, B. M., Christopher Garcia, K. & Kranz, D. M., Sep 1 2009, In : Molecular Immunology. 46, 15, p. 3000-3008 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Yeasts
Ligands

Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection

Schmitt, T. M., Aggen, D. H., Stromnes, I. M., Dossett, M. L., Richman, S. A., Kranz, D. M. & Greenberg, P. D., Jul 18 2013, In : Blood. 122, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

Gene therapy
T-cells
Autoantigens
Neoplasm Antigens
T-Cell Antigen Receptor

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-12
Immunity
T-Lymphocytes
Interferons

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

Zhang, B., Zhang, Y., Bowerman, N. A., Schietinger, A., Fu, Y. X., Kranz, D. M., Rowley, D. A. & Schreiber, H., Mar 1 2008, In : Cancer Research. 68, 5, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Stromal Cells
Neoplasm Antigens
Myeloid Cells
Granzymes
Cytotoxic T-Lymphocytes
Natural Killer Cells
Estrogens
Peptide Hydrolases

Experimental manipulations of afferent immune responses influence efferent immune responses to brain tumors

Thomas, D. L., Kranz, D. M. & Roy, E. J., Sep 1 2008, In : Cancer Immunology, Immunotherapy. 57, 9, p. 1323-1333 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Lymph Nodes
Neoplasms
Brain
Radioactivity

Expression of defined idiotypes throughout the BALB/c anti-fluorescyl antibody response: Affinity and idiotype analyses of heterogeneous antibodies

Kranz, D. M., Ballard, D. W. & Voss, E. W., Dec 1983, In : Molecular Immunology. 20, 12, p. 1313-1323 11 p.

Research output: Contribution to journalArticle

Antibody Affinity
Antibody Formation
Clone Cells
Monoclonal Antibodies
Antibodies

Expression of structurally diverse Qa-2-encoded molecules on the surface cloned cytotoxic T lymphocytes

Sherman, D. H., Kranz, D. M. & Eisen, H. N., Nov 1 1984, In : Journal of Experimental Medicine. 160, 5, p. 1421-1430 10 p.

Research output: Contribution to journalArticle

Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants

Heilig, J. S., Glimcher, L. H., Kranz, D. M., Clayton, L. K., Greenstein, J. L., Saito, H., Maxam, A. M., Burakoff, S. J., Eisen, H. N. & Tonegawa, S., Dec 1 1985, In : Nature. 317, 6032, p. 68-70 3 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Genes
Clone Cells
Immunoglobulin Variable Region
Protein Sequence Analysis

Expression profiling using a hexamer-based universal microarray

Roth, M. E., Feng, L., McConnell, K. J., Schaffer, P. J., Guerra, C. E., Affourtit, J. P., Piper, K. R., Guccione, L., Hariharan, J., Ford, M. J., Powell, S. W., Krishnaswamy, H., Lane, J., Guccione, L., Intrieri, G., Merkel, J. S., Perbost, C., Valerio, A., Zolla, B., Graham, C. D. & 18 others, Hnath, J., Michaelson, C., Wang, R., Ying, B., Halling, C., Parman, C. E., Raha, D., Orr, B., Jedrzkiewicz, B., Liao, J., Tevelev, A., Mattessich, M. J., Kranz, D. M., Lacey, M., Kaufman, J. C., Kim, J., Latimer, D. R. & Lizardi, P. M., Apr 1 2004, In : Nature Biotechnology. 22, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

Microarrays
Transcriptome
Yeast
DNA
Technology

Folate-mediated targeting of T cells to tumors

Roy, E. J., Gawlick, U., Orr, B. A. & Kranz, D. M., Apr 29 2004, In : Advanced Drug Delivery Reviews. 56, 8, p. 1219-1231 13 p.

Research output: Contribution to journalArticle

Folic Acid
T-Lymphocytes
Neoplasms
Bispecific Antibodies
Vaccines

Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

Patrick, T. A., Kranz, D. M., Van Dyke, T. A. & Roy, E. J., Feb 25 1997, In : Journal of Neuro-Oncology. 32, 2, p. 111-123 13 p.

Research output: Contribution to journalArticle

Choroid Plexus Neoplasms
Folic Acid
Transgenic Mice
Choroid Plexus
Ependymoma

Generation of Cytotoxic T-Lymphocytes to a Self-Peptide/Class I Complex: A Model for Peptide-mediated Tumor Rejection

Tjoa, B. A. & Kranz, D. M., Jan 1994, In : Cancer Research. 54, 1, p. 204-208 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Peptides
Neoplasms
Neoplasm Antigens
Autoantigens

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor t cells in vitro

Schmitt, T. M., Aggen, D. H., Ishida-Tsubota, K., Ochsenreither, S., Kranz, D. M. & Greenberg, P. D., Jan 1 2017, In : Nature Biotechnology. 35, 12, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

T-cells
Antigens
T-Cell Antigen Receptor
Stem Cells
Autoantigens

Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity

Hubbard, S. C., Kranz, D. M., Longmore, G. D., Sitkovsky, M. V. & Eisen, H. N., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 6, p. 1852-1856 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Glycosylation
Lectins
Cytotoxic T-Lymphocytes
Clone Cells

Herman N. Eisen: Mentor to many

Kranz, D. M. & Sykulev, Y., Feb 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1650-1651 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Career Choice
Mentors
Allergy and Immunology

Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes

Liu, M. A., Kranz, D. M., Kurnick, J. T., Boyle, L. A., Levy, R. & Eisen, H. N., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 24, p. 8648-8652 5 p.

Research output: Contribution to journalArticle

Heterophile Antibodies
Cytotoxic T-Lymphocytes
T-Lymphocytes
Clone Cells
Antibodies

High-affinity, peptide-specific T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3

Chlewicki, L. K., Holler, P. D., Monti, B. C., Clutter, M. R. & Kranz, D. M., Feb 11 2005, In : Journal of Molecular Biology. 346, 1, p. 223-239 17 p.

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Mutation
Major Histocompatibility Complex
Peptides

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics

Persaud, S. P., Donermeyer, D. L., Weber, K. S., Kranz, D. M. & Allen, P. M., May 1 2010, In : Molecular Immunology. 47, 9, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Thermodynamics
Ligands
Peptides
Antigens

High affinity T cell receptors from yeast display libraries block T cell activation by superantigens

Kieke, M. C., Sundberg, E., Shusta, E. V., Mariuzza, R. A., Wittrup, K. D. & Kranz, D. M., Apr 13 2001, In : Journal of Molecular Biology. 307, 5, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Superantigens
Enterotoxins
T-Cell Antigen Receptor
Yeasts
T-Lymphocytes

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

Blaha, D. T., Anderson, S. D., Yoakum, D. M., Hager, M. V., Zha, Y., Gajewski, T. F. & Kranz, D. M., Jan 2019, In : Cancer Immunology Research. 7, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

Peptides
T-Lymphocytes
Peptide T
HLA-A2 Antigen
Fluorometry

Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

Fuertes, M. B., Kacha, A. K., Kline, J., Woo, S. R., Kranz, D. M., Murphy, K. M. & Gajewski, T. F., Sep 26 2011, In : Journal of Experimental Medicine. 208, 10, p. 2005-2016 12 p.

Research output: Contribution to journalArticle

Interferon Type I
Dendritic Cells
T-Lymphocytes
Interferons
Neoplasms

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

Colf, L. A., Bankovich, A. J., Hanick, N. A., Bowerman, N. A., Jones, L. L., Kranz, DM. M. & Garcia, K. C., Apr 6 2007, In : Cell. 129, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
Molecular Mimicry
Antigens

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Aggen, D. H., Chervin, A. S., Insaidoo, F. K., Piepenbrink, K. H., Baker, B. M. & Kranz, D. M., Apr 1 2011, In : Protein Engineering, Design and Selection. 24, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

Forensic Anthropology
T-cells
Human Engineering
T-Cell Antigen Receptor
HLA-A2 Antigen

Identification of peptide and T cell receptor residues involved in the interaction of CTL 2C and QL9/Ld

Schlueter, C., Manning, T., Brodnicki, T. & Kranz, D. M., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Peptide T
T-Cell Antigen Receptor
Alanine
alanine
T-lymphocytes